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1. 发明申请

US20130085270A1 MANUFACTURING METHOD FOR POLYPHENOL COMPOSITION 有权
公开(公告)号：US20130085270A1
公开(公告)日：2013-04-04
申请号：US13703220
申请日：2011-06-08
申请人： Yasushi Yamada , Keigo Hanaki , Toshiteru Komatsu
发明人： Yasushi Yamada , Keigo Hanaki , Toshiteru Komatsu
IPC分类号： C07H17/07
CPC分类号： C07H17/07 , A61K31/05 , A61K31/192 , A61K31/366 , A61K31/7048 , Y02P20/582
摘要： A method for producing a polyphenol composition including a step of subjecting (A) a hardly water-soluble polyphenol and (B) one or more selected from cathechins, chlorogenic acids and methylated compounds of hardly water-soluble polyphenols to a heat treatment at from 100 to 180° C. in the presence of an aqueous medium.

2. 发明授权

US09079933B2 Manufacturing method for polyphenol composition 有权
标题翻译：多酚组合物的制备方法
公开(公告)号：US09079933B2
公开(公告)日：2015-07-14
申请号：US13703220
申请日：2011-06-08
申请人： Yasushi Yamada , Keigo Hanaki , Toshiteru Komatsu
发明人： Yasushi Yamada , Keigo Hanaki , Toshiteru Komatsu
IPC分类号： C07H17/07 , A61K31/05 , A61K31/192 , A61K31/366 , A61K31/7048
CPC分类号： C07H17/07 , A61K31/05 , A61K31/192 , A61K31/366 , A61K31/7048 , Y02P20/582
摘要： A method for producing a polyphenol composition including a step of subjecting (A) a hardly water-soluble polyphenol and (B) one or more selected from cathechins, chlorogenic acids and methylated compounds of hardly water-soluble polyphenols to a heat treatment at from 100 to 180° C. in the presence of an aqueous medium.
摘要翻译：一种多酚组合物的制造方法，其特征在于，包括使（A）几乎不溶于水的多酚和（B）一种或多种选自几何水溶性多酚的导管链，绿原酸和甲基化化合物中的一种以上的热处理在水介质的存在下为180℃。

3. 发明授权

US08252560B2 Process for producing useful substance with immobilized enzyme 失效
标题翻译：用固定化酶生产有用物质的方法
公开(公告)号：US08252560B2
公开(公告)日：2012-08-28
申请号：US12518285
申请日：2007-12-14
申请人： Jun Saito , Yoshitaka Senda , Keigo Hanaki , Toshiteru Komatsu
发明人： Jun Saito , Yoshitaka Senda , Keigo Hanaki , Toshiteru Komatsu
IPC分类号： C12P7/64 , C12N11/00 , C12N11/14
CPC分类号： C12P7/6418 , C12N11/00
摘要： The present invention relates to a process for producing a fatty acid, which includes feeding a liquid mixture formed of two liquid phases that flow in a co-current manner into a fixed bed-type reaction column packed with immobilized lipase, and performing a hydrolysis reaction when the two liquid phases are in contact with the immobilized lipase in the fixed-bed reaction column; wherein the fixed-bed reaction column comprises partition plates so as to comprise a plurality of tube- shaped structures, wherein each tube-shaped structure has a cross -section which is rectangular, circular, oval, or polygonal in shape with at least a part being unclosed and the cross-section has a representative length of 100 mm or less.
摘要翻译：本发明涉及一种脂肪酸的制造方法，其特征在于，将由以流动方式流动的两个液相形成的液体混合物输送到填充有固定化脂肪酶的固定床型反应塔中，进行水解反应当两个液相与固定床反应塔中的固定化脂肪酶接触时; 其中所述固定床反应塔包括分隔板，以便包括多个管状结构，其中每个管状结构具有矩形，圆形，椭圆形或多边形形状的横截面，至少部分未封闭，横截面长度为100mm以下。

4. 发明授权

US08173403B2 Process for producing useful substance using immobilized enzyme 失效
标题翻译：使用固定化酶生产有用物质的方法
公开(公告)号：US08173403B2
公开(公告)日：2012-05-08
申请号：US12517574
申请日：2007-12-14
申请人： Yoshitaka Senda , Jun Saito , Keigo Hanaki , Toshiteru Komatsu
发明人： Yoshitaka Senda , Jun Saito , Keigo Hanaki , Toshiteru Komatsu
IPC分类号： C12P7/64 , C12N11/00 , C12N11/14
CPC分类号： C12P7/40 , C12N11/00 , C12P7/62
摘要： The present invention relates to a process for producing a useful substance, the process includes feeding a liquid mixture formed of two liquid phases into a fixed bed-type reaction column packed with an immobilized enzyme, and allowing the liquid mixture to flow in the same direction in a co-current manner to perform a reaction. The packing thickness of the immobilized enzyme per stage of the fixed bed-type reaction column having an equivalent circular diameter of 35 mmφ or larger is 10 to 200 mm. The flow of the reaction liquid inside the column can be made uniform, and as a result, reactivity and productivity is enhanced.
摘要翻译：本发明涉及一种生产有用物质的方法，该方法包括将由两个液相形成的液体混合物进料到装有固定化酶的固定床型反应塔中，并使液体混合物沿相同方向流动以同时的方式进行反应。固定床型反应塔每个阶段的固定化酶的包装厚度为等效圆直径为35mm＆phgr; 以上为10〜200mm。可以使柱内的反应液的流动均匀，结果提高了反应性和生产率。

5. 发明申请

US20100041114A1 PROCESS FOR PRODUCING USEFUL SUBSTANCE WITH IMMOBILIZED ENZYME 失效
标题翻译：生产有益物质的方法，具有固定的酶
公开(公告)号：US20100041114A1
公开(公告)日：2010-02-18
申请号：US12518285
申请日：2007-12-14
申请人： Jun Saito , Yoshitaka Senda , Keigo Hanaki , Toshiteru Komatsu
发明人： Jun Saito , Yoshitaka Senda , Keigo Hanaki , Toshiteru Komatsu
IPC分类号： C12P7/64
CPC分类号： C12P7/6418 , C12N11/00
摘要： The present invention relates to a process for producing a useful substance, which includes feeding a liquid mixture formed of two liquid phases into a fixed bed-type reaction column packed with an immobilized enzyme, and performing a reaction while allowing the liquid mixture to flow in the same direction in a co-current manner, wherein the fixed bed-type reaction column has partition plates inserted in the longitudinal direction of the fixed bed-type reaction column so as to form a plurality of tube-shaped structures, wherein each tube-shaped structure has a lateral cross-section which is circular or polygonal in shape with at least a part being unclosed and has a representative length of 100 mm or less, wherein the immobilized enzyme is packed into the tube-shaped structures, and wherein the liquid mixture is fed into the tube-shaped structures.Even when a reaction column having a large column diameter is used in the reaction performed by feeding a liquid mixture formed of two liquid phases into a fixed bed-type reaction column packed with an immobilized enzyme, the flow of the whole reaction liquid inside the column can be made uniform, and the enzymatic activity can be effectively appeared. As a result, reactivity and productivity can be enhanced. Particularly, in the hydrolysis of oils and fats, the enzymatic activity can be effectively appeared, so that fatty acids can be effectively produced. Furthermore, the operability at the time of removing the immobilized enzyme packed in the reaction column is good.
摘要翻译：本发明涉及一种生产有用物质的方法，包括将由两个液相形成的液体混合物进料到装有固定化酶的固定床型反应塔中，并进行反应同时使液体混合物流入相同的方向，其中固定床型反应塔具有沿固定床型反应塔的纵向方向插入的隔板，以形成多个管状结构，所述圆形结构具有圆形或多边形的横截面，其至少一部分未封闭并且具有100mm或更小的代表性长度，其中所述固定化酶被包装在所述管状结构体中，并且其中所述液体混合物被送入管状结构。即使在通过将由两个液相形成的液体混合物进料到装有固定化酶的固定床型反应塔中进行的反应中使用具有大柱直径的反应塔时，柱内的整个反应液体的流动可以均匀，可以有效地出现酶活性。因此，可以提高反应性和生产率。特别是在油脂的水解中，能够有效地发挥酶活性，能够有效地制造脂肪酸。此外，除去反应塔中填充的固定化酶时的操作性良好。

6. 发明申请

US20100047883A1 PROCESS FOR PRODUCING USEFUL SUBSTANCE USING IMMOBILIZED ENZYME 失效
标题翻译：使用固定化学品生产有用物质的方法
公开(公告)号：US20100047883A1
公开(公告)日：2010-02-25
申请号：US12517574
申请日：2007-12-14
申请人： Yoshitaka Senda , Jun Saito , Keigo Hanaki , Toshiteru Komatsu
发明人： Yoshitaka Senda , Jun Saito , Keigo Hanaki , Toshiteru Komatsu
IPC分类号： C12P7/64 , C12M1/00
CPC分类号： C12P7/40 , C12N11/00 , C12P7/62
摘要： The present invention relates to a process for producing a useful substance, the process including feeding a liquid mixture formed of two liquid phases into a fixed bed-type reaction column packed with an immobilized enzyme, and allowing the liquid mixture to flow in the same direction in a co-current manner to perform a reaction, wherein the packing thickness of the immobilized enzyme per stage of the fixed bed-type reaction column having an equivalent circular diameter of 35 mmφ or larger is 10 to 200 mm.In the process for producing a useful substance, which is performed by feeding a liquid mixture formed of two liquid phases into a fixed bed-type reaction column packed with an immobilized enzyme, the flow of the reaction liquid inside the column can be made uniform, and as a result, reactivity and productivity can be enhanced.
摘要翻译：本发明涉及一种生产有用物质的方法，该方法包括将由两个液相形成的液体混合物进料到装有固定化酶的固定床型反应塔中，并使液体混合物沿相同方向流动以同时的方式进行反应，其中每个固定床型反应塔的固定化酶的包装厚度具有等效的圆直径为35mm＆phgr; 以上为10〜200mm。在通过将由两个液相形成的液体混合物进料到填充有固定化酶的固定床型反应塔中进行的有用物质的制造方法中，能够使柱内的反应液的流动均匀，结果可以提高反应性和生产率。

7. 发明授权

US08927039B2 Method for manufacturing refined fat or oil 有权
标题翻译：制造精制脂肪或油的方法
公开(公告)号：US08927039B2
公开(公告)日：2015-01-06
申请号：US13516415
申请日：2010-12-14
申请人： Minoru Kase , Tetsuya Abe , Shinpei Fukuhara , Toshiteru Komatsu , Keiji Shibata
发明人： Minoru Kase , Tetsuya Abe , Shinpei Fukuhara , Toshiteru Komatsu , Keiji Shibata
IPC分类号： C11B3/10 , C11B3/14 , A23D9/02 , A23D7/02
CPC分类号： A23D7/02 , C11B3/10 , C11B3/14
摘要： Provided is a method for manufacturing refined fats and oils. Here fats and oils are brought into contact with an adsorbent and subsequently treated with water vapor under at least one condition of the following conditions. In condition I, the time for which the fats and oils are brought into contact with the water vapor in a temperature range of 175° C. to 205° C. for from 5 to 110 minutes. In condition 2, the fats and oils are brought into contact with the water vapor in a temperature range of 205° C. to 215° C. for from 5 to 50 minutes. In condition 3, the fats and oils are brought into contact with the water vapor in a temperature range of 215° C. to 230° C. for from 5 to 30 minutes.
摘要翻译：提供了一种制造精炼脂肪和油的方法。这里使脂肪和油与吸附剂接触，随后在至少一种以下条件的条件下用水蒸气处理。在条件I中，使脂肪和油在175℃至205℃的温度范围内与水蒸气接触的时间为5至110分钟。在条件2中，使油脂与水蒸汽在205〜215℃的温度范围内接触5〜50分钟。在条件3中，使油脂与水蒸气在215〜230℃的温度范围内接触5〜30分钟。

8. 发明申请

US20120259133A1 OIL OR FAT COMPOSITION 有权
标题翻译：油或脂肪组合物
公开(公告)号：US20120259133A1
公开(公告)日：2012-10-11
申请号：US13516560
申请日：2010-12-14
申请人： Rika Homma , Masao Shimizu , Junya Moriwaki , Minoru Kase , Tetsuya Abe , Shinpei Fukuhara , Toshiteru Komatsu , Keiji Shibata
发明人： Rika Homma , Masao Shimizu , Junya Moriwaki , Minoru Kase , Tetsuya Abe , Shinpei Fukuhara , Toshiteru Komatsu , Keiji Shibata
IPC分类号： C11C3/00
CPC分类号： A23D7/001 , A23D7/003 , A23D9/007 , A23D9/02 , C11B3/14
摘要： Provided is an oil or fat composition, which has an MCPD-FS content (ppm) of 13 ppm or less, the content being measured by a Deutsche Gesellschaft für Fettwissenschaft (DGF) standard method C-III 18(09), has a diacylglycerol content of 15 mass % or more, and is subjected to deodorization treatment.
摘要翻译：本发明提供一种油或脂肪组合物，其具有13ppm或更低的MCPD-FS含量（ppm），其含量由Deutsche GesellschaftfürFettwissenschaft（DGF）标准方法C-III 18（09）测量）具有二酰基甘油含量为15质量％以上，进行除臭处理。

9. 发明授权

US08241875B2 Method for producing fatty acids with an immobilized enzyme packed column 失效
标题翻译：用固定化酶填充柱生产脂肪酸的方法
公开(公告)号：US08241875B2
公开(公告)日：2012-08-14
申请号：US11450356
申请日：2006-06-12
申请人： Jun Saito , Yoshitaka Senda , Toshiteru Komatsu
发明人： Jun Saito , Yoshitaka Senda , Toshiteru Komatsu
IPC分类号： C12P7/64 , C12N11/14 , C12N11/02 , C12N11/08
CPC分类号： C11C1/045 , C12P7/6418
摘要： A process for producing fatty acids, which comprises supplying an oil phase substrate and a water phase substrate to an enzyme column packed with an immobilized enzyme, concurrently flowing them in the same direction, and hydrolyzing a fat and/or oil, wherein the oil phase substrate and the water phase substrate are alternately supplied to the enzyme column.
摘要翻译：一种生产脂肪酸的方法，其包括将油相底物和水相底物供给到装有固定化酶的酶柱，同时沿相同方向流动，并水解脂肪和/或油，其中所述油相底物和水相底物交替供应到酶柱。

10. 发明授权

US09006474B2 Method for producing refined a fat or oil 有权
标题翻译：生产精制脂肪或油的方法
公开(公告)号：US09006474B2
公开(公告)日：2015-04-14
申请号：US13635542
申请日：2011-02-25
申请人： Shinpei Fukuhara , Minoru Kase , Tetsuya Abe , Toshiteru Komatsu , Keiji Shibata
发明人： Shinpei Fukuhara , Minoru Kase , Tetsuya Abe , Toshiteru Komatsu , Keiji Shibata
IPC分类号： C11B3/04 , A23D9/013 , C11B3/00 , C11B3/14
CPC分类号： A23D9/013 , C11B3/001 , C11B3/04 , C11B3/14
摘要： A method for manufacturing a refined fat or oil, including: carrying out a first steam treatment of bringing a fat or oil into contact with water vapor; and subsequently carrying out a second steam treatment of bringing the fat or oil having a temperature lower by 10° C. or more than a temperature of the fat or oil in the first steam treatment into contact with water vapor in the presence of an organic acid.
摘要翻译：一种精制油脂的制造方法，其特征在于，包括：进行使油脂与水蒸气接触的第一蒸汽处理; 然后进行第二次蒸汽处理，使第一蒸汽处理中的脂肪或油的温度低于10℃或更高的脂肪或油，在有机酸存在下与水蒸气接触。

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