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1. 发明授权

US5498634A Thioformamide derivatives 失效
标题翻译：硫代甲酰胺衍生物
公开(公告)号：US5498634A
公开(公告)日：1996-03-12
申请号：US380589
申请日：1995-01-30
申请人： Yasuhiro Kabasawa , Fumihiro Ozaki , Keiji Ishibashi , Takashi Hasegawa , Hitoshi Oinuma , Toshiaki Ogawa , Hideyuki Adachi , Hiroshi Katoh , Kohtarou Kodama , Hideto Ohara , Nobuyuki Mori , Norio Minami
发明人： Yasuhiro Kabasawa , Fumihiro Ozaki , Keiji Ishibashi , Takashi Hasegawa , Hitoshi Oinuma , Toshiaki Ogawa , Hideyuki Adachi , Hiroshi Katoh , Kohtarou Kodama , Hideto Ohara , Nobuyuki Mori , Norio Minami
IPC分类号： C07D231/12 , C07D233/92 , C07D233/95 , C07D471/04 , A61K31/35 , C07D309/08
CPC分类号： C07D233/92 , C07D471/04
摘要： The present invention provides a thioformamide derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof, which is highly safe, easy to use, and useful as an excellent hypotensive or heart disease remedy: ##STR1## wherein Y represents ##STR2## or the like [wherein R.sup.7 represents benzyloxy or the like; R.sup.11 and R.sup.12 each represent hydrogen, hydroxyl, benzoyloxy, benzyloxy, ##STR3## (wherein R.sup.14 and R.sup.15 each represent hydrogen, benzyl or the like) or the like];Z represents --CH.sub.2 -- or the like; A represents imidazolyl or imidazopyridyl which may have one or two substituents, or the like; R.sup.1 and R.sup.2 each represent hydrogen, lower alkyl or the like; and R.sup.3 and R.sup.4 each represent hydrogen, lower alkyl or the like.
摘要翻译：本发明提供由下列通式（I）表示的硫代甲酰胺衍生物或其药学上可接受的盐，其安全性高，易于使用，可用作优异的降血压或心脏病治疗药物：其中 Y表示等[其中R7表示苄氧基等; R 11和R 12各自表示氢，羟基，苯甲酰氧基，苄氧基，（其中R 14和R 15各自表示氢，苄基等）等。 Z表示-CH 2 - 等; A表示可具有一个或两个取代基的咪唑基或咪唑并吡啶等; R 1和R 2各自表示氢，低级烷基等; R 3和R 4各自表示氢，低级烷基等。

2. 发明授权

US5444066A Thioformamide derivatives having hypotensive activity 失效
标题翻译：具有降血压活性的硫代甲酰胺衍生物
公开(公告)号：US5444066A
公开(公告)日：1995-08-22
申请号：US211701
申请日：1994-04-26
申请人： Yasuhiro Kabasawa , Fumihiro Ozaki , Keiji Ishibashi , Takashi Hasegawa , Hitoshi Oinuma , Toshiaki Ogawa , Hideyuki Adachi , Hiroshi Katoh , Kohtarou Kodama , Hideto Ohara , Nobuyuki Mori , Norio Minami
发明人： Yasuhiro Kabasawa , Fumihiro Ozaki , Keiji Ishibashi , Takashi Hasegawa , Hitoshi Oinuma , Toshiaki Ogawa , Hideyuki Adachi , Hiroshi Katoh , Kohtarou Kodama , Hideto Ohara , Nobuyuki Mori , Norio Minami
IPC分类号： C07D231/12 , C07D233/92 , C07D233/95 , C07D471/04 , A61K31/435
CPC分类号： C07D233/92 , C07D471/04
摘要： The present invention provides a thioformamide derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof, which is highly safe, easy to use, and useful as an excellent hypotensive or heart disease remedy: ##STR1## wherein Y represents ##STR2## or the like [wherein R.sup.7 represents benzyloxy or the like; R.sup.11 and R.sup.12 each represent hydrogen, hydroxyl, benzoyloxy, benzyloxy, ##STR3## (wherein R.sup.14 and R.sup.15 each represent hydrogen, benzyl or the like) or the like];Z represents --CH.sub.2 -- or the like; A represents imidazolyl or imidazopyridyl which may have one or two substituents, or the like; R.sup.1 and R.sup.2 each represent hydrogen, lower alkyl or the like; and R.sup.3 and R.sup.4 each represent hydrogen, lower alkyl or the like.
摘要翻译： PCT No.PCT / JP92 / 01297 Sec。 371日期1994年04月26日 102（e）日期1994年4月26日PCT提交1992年10月6日PCT公布。出版物WO93 / 08168 日本1994年4月29日。本发明提供由以下通式（I）表示的硫代甲酰胺衍生物或其药理学上可接受的盐，其是高度安全，易于使用的，并且可用作优异的降压药或心脏病药物：（I）其中Y表示酰氧基等; R 11和R 12各自表示氢，羟基，苯甲酰氧基，苄氧基，苯甲酰基等）等。 Z表示-CH 2 - 等; A表示可具有一个或两个取代基的咪唑基或咪唑并吡啶等; R 1和R 2各自表示氢，低级烷基等; R 3和R 4各自表示氢，低级烷基等。

3. 发明授权

US5606061A Thioformamide derivatives 失效
标题翻译：硫代甲酰胺衍生物
公开(公告)号：US5606061A
公开(公告)日：1997-02-25
申请号：US531335
申请日：1995-09-20
申请人： Yasuhiro Kabasawa , Fumihiro Ozaki , Keiji Ishibashi , Takashi Hasegawa , Hitoshi Oinuma , Toshiaki Ogawa , Hideyuki Adachi , Hiroshi Katoh , Kohtarou Kodama , Hideto Ohara , Nobuyuki Mori , Norio Minami
发明人： Yasuhiro Kabasawa , Fumihiro Ozaki , Keiji Ishibashi , Takashi Hasegawa , Hitoshi Oinuma , Toshiaki Ogawa , Hideyuki Adachi , Hiroshi Katoh , Kohtarou Kodama , Hideto Ohara , Nobuyuki Mori , Norio Minami
IPC分类号： C07D231/12 , C07D233/92 , C07D233/95 , C07D471/04
CPC分类号： C07D233/92 , C07D471/04
摘要： The present invention provides a thioformamide derivative represented by the following general formula (I) or a pharmacologically acceptable salt thereof, which is highly safe, easy to use, and useful as an excellent hypotensive or heart disease remedy: ##STR1## wherein Y represents ##STR2## or the like [wherein R.sup.7 represents benzyloxy or the like; R.sup.11 and R.sup.12 each represent hydrogen, hydroxyl, benzoyloxy, benzyloxy, ##STR3## (wherein R.sup.14 and R.sup.15 each represent hydrogen, benzyl or the like) or the like];Z represents --CH.sub.2 -- or the like; A represents imidazolyl or imidazopyridyl which may have one or two substituents, or the like; R.sup.1 and R.sup.2 each represent hydrogen, lower alkyl or the like; and R.sup.3 and R.sup.4 each represent hydrogen, lower alkyl or the like.
摘要翻译：本发明提供由下列通式（I）表示的硫代甲酰胺衍生物或其药理学上可接受的盐，其是高度安全，易于使用的，并且可用作优异的降血压或心脏病治疗药物：其中 Y表示等[其中R7表示苄氧基等; R 11和R 12各自表示氢，羟基，苯甲酰氧基，苄氧基，（其中R 14和R 15各自表示氢，苄基等）等。 Z表示-CH 2 - 等; A表示可具有一个或两个取代基的咪唑基或咪唑并吡啶等; R 1和R 2各自表示氢，低级烷基等; R 3和R 4各自表示氢，低级烷基等。

4. 发明授权

US4959376A 1,4-benzodioxane derivatives 失效
标题翻译： 1,4-苯并二恶烷衍生物
公开(公告)号：US4959376A
公开(公告)日：1990-09-25
申请号：US253023
申请日：1988-10-04
申请人： Toshinobu Kunii , Norio Minami , Fumihiro Ozaki , Nobuyuki Mori , Mikio Takeda , Hiroshi Katoh
发明人： Toshinobu Kunii , Norio Minami , Fumihiro Ozaki , Nobuyuki Mori , Mikio Takeda , Hiroshi Katoh
IPC分类号： C07D319/16 , A61K31/335 , A61K31/357 , A61P9/08 , A61P9/10 , A61P9/12 , C07D319/20 , C07D405/12
CPC分类号： C07D405/12 , C07D319/20
摘要： 1,4-Benzodioxane derivatives represented by the following general formula: ##STR1## wherein p stands for an integer of 0-2, X and Y are same or different, and each represent a hydrogen atom; or a group represented by the formula --OR in which R denotes a hydrogen atom, a lower alkyl, lower alkoxycarbonyl or acyl group, or a group represented by the formula ##STR2## m being an integer of 1 or 2; cyano group; or carboxy group, n is an integer of 1-3, exclusive of the case wherein p=0 and X=Y=H, or a pharmacologically acceptable salt thereof. Their process for the preparation, their use as therapeutic and/or preventive compositions for ischemic heart diseases and heart failure and their application for the control of blood pressure during surgical operations are also described.

5. 发明授权

US4794118A 1,4-benzodioxane derivatives 失效
公开(公告)号：US4794118A
公开(公告)日：1988-12-27
申请号：US887720
申请日：1986-07-18
申请人： Toshinobu Kunii , Norio Minami , Fumihiro Ozaki , Nobuyuki Mori , Mikio Takeda , Hiroshi Katoh
发明人： Toshinobu Kunii , Norio Minami , Fumihiro Ozaki , Nobuyuki Mori , Mikio Takeda , Hiroshi Katoh
IPC分类号： C07D319/16 , A61K31/335 , A61K31/357 , A61P9/08 , A61P9/10 , A61P9/12 , C07D319/20 , C07D405/12 , C07D413/12
CPC分类号： C07D405/12 , C07D319/20
摘要： 1,4-Benzodioxane derivatives represented by the following general formula: ##STR1## wherein p stands for an integer of 0-2, X and Y are same or different, and each represent a hydrogen atom; or a group represented by the formula --OR in which R denotes a hydrogen atom, a lower alkyl, lower alkoxycarbonyl or acyl group, or a group represented by the formula ##STR2## m being an integer of 1 or 2; cyano group; or carboxy group, n is an integer of 1-3, exclusive of the case wherein p=0 and X=Y=H, or a pharmacologically acceptable salt thereof. Their process for the preparation, their use as therpeutic and/or preventive compositions for ischemic heart diseases and heart failure and their application for the control of blood pressure during surgical operations are also described.

6. 发明授权

US06784192B2 Piperidine compound and pharmaceutical composition thereof 失效
标题翻译：新型哌啶化合物及其药物组合物。
公开(公告)号：US06784192B2
公开(公告)日：2004-08-31
申请号：US10181560
申请日：2002-07-19
申请人： Fumihiro Ozaki , Toshihiko Kaneko , Mutsuko Tabata , Yoshinori Takahashi , Kazuki Miyazaki , Junichi Kamata , Ichiro Yoshida , Masayuki Matsukura , Hiroyuki Suzuki , Takashi Yoshinaga , Hiroki Ishihara , Hiroshi Katoh , Kohei Sawada , Tatsuhiro Onogi , Kiyoaki Kobayashi , Miyuki Ohkubo
发明人： Fumihiro Ozaki , Toshihiko Kaneko , Mutsuko Tabata , Yoshinori Takahashi , Kazuki Miyazaki , Junichi Kamata , Ichiro Yoshida , Masayuki Matsukura , Hiroyuki Suzuki , Takashi Yoshinaga , Hiroki Ishihara , Hiroshi Katoh , Kohei Sawada , Tatsuhiro Onogi , Kiyoaki Kobayashi , Miyuki Ohkubo
IPC分类号： A61K31445
CPC分类号： C07D401/14 , C07D401/06 , C07D405/14 , C07D409/14 , C07D417/14
摘要： The present invention provides a novel compound having a superior Na+ channel inhibitory activity. Namely, it provides a compound represented by the following formula (I), a salt thereof or a hydrate of them. In the formula, the ring A represents a ring represented by the formula: (wherein R1 represents a hydrogen atom etc.; and R2 represents indicates a hydrogen atom and the like) etc.; W represents an optionally substituted C1-6 alkylene group etc.; Z represents an optionally substituted C6-14 aromatic hydrocarbon cyclic group etc.; and l represents an integer from 0 to 6.
摘要翻译：本发明提供具有优异的Na +通道抑制活性的新型化合物。即，它提供由下式（I）表示的化合物，其盐或它们的水合物。在该式中，环A表示由下式表示的环：其中R 1表示氢原子等 R 2表示氢原子等）等; W表示任选取代的C 1-6亚烷基等; Z表示任选取代的C 6-14芳烃环基等。 l表示0〜6的整数。

7. 发明授权

US08339400B2 Graphic display meter 有权
标题翻译：图形显示仪表
公开(公告)号：US08339400B2
公开(公告)日：2012-12-25
申请号：US11812802
申请日：2007-06-21
申请人： Hiroshi Katoh , Kenichi Nagahashi
发明人： Hiroshi Katoh , Kenichi Nagahashi
IPC分类号： G06T11/00
CPC分类号： B60K35/00 , B60K2350/1072 , G01D7/00 , G12B11/02
摘要： The object of the invention is to provide an improved graphic display meter which is prevented from causing inconvenience to the vehicle operator, when a motion blur display mode is switched to a normal display mode.When a motion blur pointer image 10 is switched to a normal pointer image 20a, multiple pointer images 20 including the normal pointer image 20a are displayed adjacent to or in abutment with a leading part of the motion blur pointer image 10 in a direction where the pointer is rotating. The multiple pointer images 20 are consisted of the normal pointer image 20a and a plurality of auxiliary pointer images 20b, which are aligned with one another and are positioned in close proximity to the normal pointer image 20a. The multiple pointer images 20, a plurality set of which have been stored as data in advance, are selected on the basis of a space between the motion blur pointer image 10 prior to the switching of the pointer image and the normal pointer image 20 after the switching of the pointer image.
摘要翻译：本发明的目的是提供一种改进的图形显示仪表，当运动模糊显示模式切换到正常的显示模式时，该显示仪被防止对车辆操作者造成不便。当运动模糊指针图像10被切换到普通指针图像20a时，包括普通指针图像20a的多个指针图像20被显示在与运动模糊指针图像10的前导部分相邻或邻接的位置上正在旋转。多指针图像20由正常指针图像20a和多个辅助指针图像20b组成，多个辅助指针图像20b彼此对准并且位于紧邻正常指针图像20a的位置。基于在指针图像切换前的运动模糊指针图像10和在指针图像切换后的正常指针图像20之间的空间，多个指针图像20被预先存储为数据的多个指针图像20被选择切换指针图像。

8. 发明申请

US20060112942A1 Engine air-fuel ratio control system 有权
标题翻译：发动机空燃比控制系统
公开(公告)号：US20060112942A1
公开(公告)日：2006-06-01
申请号：US11229574
申请日：2005-09-20
申请人： Hiroshi Katoh
发明人： Hiroshi Katoh
IPC分类号： F02D41/06 , F02D41/14
CPC分类号： F02D41/062 , F02D41/1489
摘要： An engine air-fuel ratio control system is configured to use a rich air-fuel ratio immediately after starting an engine such that the air-fuel ratio converge rapidly toward a stoichiometric value and then afterwards start an air-fuel ratio feedback control. Upon determining an air-fuel ratio sensor is active, a stabilization fuel quantity increasing factor that is a component of a target air-fuel ratio revising coefficient is decreased at a higher rate than the rate used before the air-fuel ratio sensor was determined to be active. Air-fuel ratio feedback control is started when the air-fuel ratio corresponds to a stoichiometric air-fuel ratio. After starting air-fuel ratio feedback control, an unburned fuel quantity compensating value is set based on the stabilization fuel quantity increasing factor in effect at that point in time and added to the target air-fuel ratio revising coefficient while, simultaneously, the stabilization fuel quantity increasing factor is set to zero.
摘要翻译：发动机空燃比控制系统被配置为在启动发动机之后立即使用浓空燃比，使得空燃比迅速地朝向化学计量值收敛，然后开始空燃比反馈控制。在确定空燃比传感器有效时，作为目标空燃比修正系数的分量的稳定化燃料量增加系数以比空燃比传感器确定前的使用率更高的速度降低积极点。当空燃比对应于理论空燃比时，开始空燃比反馈控制。在开始空燃比反馈控制之后，基于在该时间点上有效的稳定化燃料量增加因子来设定未燃燃料量补偿值，并将其与目标空燃比修正系数相加，同时确定稳定燃料数量增加因子设置为零。

9. 发明授权

US06959242B2 Engine fuel injection control device 失效
标题翻译：发动机燃油喷射控制装置
公开(公告)号：US06959242B2
公开(公告)日：2005-10-25
申请号：US10686627
申请日：2003-10-17
申请人： Hiroshi Katoh , Ritsuo Sato
发明人： Hiroshi Katoh , Ritsuo Sato
IPC分类号： F02D45/00 , F02D41/04 , F02D41/06 , B60T7/12
CPC分类号： F02D41/047 , F02D41/064 , F02D2200/1012
摘要： A spark ignition engine (2) has a fuel injector (8) in an intake port (7). An engine rotation speed sensor (9) detects the rotation speed of the engine (2). The controller (1) determines the target fuel injection amount of the fuel injector (8) during startup of the engine (2) by correcting the basic injection amount in response to the trend in the variation in the engine rotation speed. When the rotation speed of the engine (2) decreases, the controller (1) sets the target fuel injection amount to be smaller than when the rotation speed of the engine (2) is increasing at an identical rotation speed. As a result, effects on the air-fuel ratio related to wall flow relative to fluctuations in the rotation speed of the engine (2) are eliminated and the control accuracy of the air-fuel ratio of the engine (2) is improved.
摘要翻译：火花点火发动机（2）在进气口（7）中具有燃料喷射器（8）。发动机转速传感器（9）检测发动机（2）的转速。控制器（1）通过根据发动机转速变化的趋势校正基本喷射量来确定发动机（2）启动期间的燃料喷射器（8）的目标燃料喷射量。当发动机（2）的转速降低时，控制器（1）将目标燃料喷射量设定为小于当发动机（2）的转速以相同的转速增加时的喷射量。结果，消除了与相对于发动机（2）的转速的波动相关的壁流的空燃比的影响，并且提高了发动机（2）的空燃比的控制精度。

10. 发明授权

US06363313B1 Fuel property detecting system 失效
标题翻译：燃油特性检测系统
公开(公告)号：US06363313B1
公开(公告)日：2002-03-26
申请号：US09545166
申请日：2000-04-06
申请人： Hiroshi Katoh , Shigeaki Kakizaki , Takane Hayashi
发明人： Hiroshi Katoh , Shigeaki Kakizaki , Takane Hayashi
IPC分类号： F02D4114
CPC分类号： F02D41/02 , F02D41/1406 , F02D2200/0402 , G01N33/28
摘要： A fuel property detecting system comprises a control unit coupled to a fuel injector and an air-fuel ratio sensor. The control unit is arranged to sample data of a response wave-form of an exhaust air-fuel ratio in response to an injected fuel quantity at a transient period, to identify a plant model as to fuel in use by controlling a parameter of a previously constructed plant model on the basis of the input and output data so as to decrease a prediction error between the plant model and a norm model, to calculate a cutoff frequency of the identified plant model, and to estimate a fuel property of the fuel in use from the calculated cutoff frequency of the identified plant model and data previous stored in the control unit.
摘要翻译：燃料特性检测系统包括耦合到燃料喷射器和空燃比传感器的控制单元。控制单元被布置成响应于在瞬时期间的喷射燃料量而对排气空燃比的响应波形的数据进行采样，以通过控制先前的参数来识别在使用中的燃料的设备模型根据输入和输出数据构建植物模型，以减少植物模型和规范模型之间的预测误差，以计算所识别的植物模型的截止频率，并估计所使用的燃料的燃料性质从所识别的植物模型的计算的截止频率和先前存储在控制单元中的数据。

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