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1. 发明申请

US20110223486A1 BIAXIALLY ORIENTED POROUS MEMBRANES, COMPOSITES, AND METHODS OF MANUFACTURE AND USE 审中-公开
标题翻译：双向面向多孔膜，复合材料及其制造方法和用途
公开(公告)号：US20110223486A1
公开(公告)日：2011-09-15
申请号：US13044708
申请日：2011-03-10
申请人： Xiaomin Zhang , Gerald P. Rumierz , Karl F. Humiston , Charles E. Haire , Tyrone S. Fields , Michael A. Braswell , Ronald A. Proctor
发明人： Xiaomin Zhang , Gerald P. Rumierz , Karl F. Humiston , Charles E. Haire , Tyrone S. Fields , Michael A. Braswell , Ronald A. Proctor
IPC分类号： H01M2/18 , B29D7/01 , B01D69/02 , B01D71/06 , B32B5/18 , C08F110/00 , C08F116/06 , C08G63/00 , C08G69/00 , C08G4/00 , C08J9/00
CPC分类号： B29C55/143 , B01D67/0027 , B01D2325/02 , B01D2325/021 , B29C55/16 , B29L2031/755 , C08G69/00 , H01M2/145 , H01M2/1653 , H01M2/1686 , H01M2/34 , H01M2/348 , H01M10/0525 , H01M10/0565 , Y10T428/249978 , Y10T442/3854 , Y10T442/40 , Y10T442/674
摘要： At least a selected microporous membrane is made by a dry-stretch process and has substantially round shaped pores and a ratio of machine direction tensile strength to transverse direction tensile strength in the range of 0.5 to 6.0. The method of making the foregoing microporous membrane may include the steps of: extruding a polymer into a nonporous precursor, and biaxially stretching the nonporous precursor, the biaxial stretching including a machine direction stretching and a transverse direction stretching, the transverse direction including a simultaneous controlled machine direction relax. At least selected embodiments of the invention may be directed to biaxially oriented porous membranes, composites including biaxially oriented porous membranes, biaxially oriented microporous membranes, biaxially oriented macroporous membranes, battery separators, filtration media, humidity control media, flat sheet membranes, liquid retention media, and the like, related methods, methods of manufacture, methods of use, and the like.
摘要翻译：至少所选择的微孔膜是通过干拉伸方法制成的，并且具有基本圆形的孔，并且机器方向拉伸强度与横向拉伸强度之比在0.5至6.0的范围内。制造上述微多孔膜的方法可以包括以下步骤：将聚合物挤出到无孔前体中，双轴拉伸无孔前体，双轴拉伸包括纵向拉伸和横向拉伸，横向包括同时控制的机器方向放松。本发明的至少选定的实施方案可以涉及双轴取向多孔膜，包括双轴取向多孔膜，双轴取向微孔膜，双轴取向大孔膜，电池隔板，过滤介质，湿度控制介质，平片膜，液体保留介质等，相关方法，制造方法，使用方法等。

2. 发明授权

US09089624B2 Ultrathin fluid-absorbent cores comprising adhesive and having very low dry SAP loss 有权
标题翻译：超薄流体吸收芯包含粘合剂并具有非常低的干燥SAP损失
公开(公告)号：US09089624B2
公开(公告)日：2015-07-28
申请号：US13208690
申请日：2011-08-12
申请人： Darryl L. Whitmore , Xiaomin Zhang
发明人： Darryl L. Whitmore , Xiaomin Zhang
IPC分类号： A61F13/15 , B32B5/16 , A61L15/60 , A61F13/53 , B22F9/04 , C22C1/04 , C22C33/02
CPC分类号： A61L15/60 , A61F13/15 , A61F13/53 , B22F2009/041 , C22C1/0433 , C22C33/02 , Y10T428/254
摘要： The present invention relates to ultrathin fluid-absorbent cores comprising a substrate layer, water-absorbent polymer particles and an adhesive, wherein dry SAP shake out of water-absorbent polymer particles out of the fluid-absorbent core is less than 0.6% by weight.
摘要翻译：本发明涉及包含基材层，吸水性聚合物颗粒和粘合剂的超薄流体吸收芯，其中从吸收液体的芯中吸收水分的聚合物颗粒中的干燥SAP挥发小于0.6重量％。

3. 发明授权

US08829039B2 Dihydroindolinone derivatives 有权
标题翻译：二氢吲哚啉酮衍生物
公开(公告)号：US08829039B2
公开(公告)日：2014-09-09
申请号：US12994442
申请日：2009-05-25
申请人： Zhedong Yuan , Xiaomin Zhang , Hubo Wang , Xueyan Zhu , Hongjiang Xu , Hui Fu , Wei Song
发明人： Zhedong Yuan , Xiaomin Zhang , Hubo Wang , Xueyan Zhu , Hongjiang Xu , Hui Fu , Wei Song
IPC分类号： A61K31/33 , C07D209/10 , C07D403/06
CPC分类号： C07D403/06 , C07D401/14 , C07D403/14
摘要： Disclosed are dihydroindolone compounds which can modulate the activity of protein tyrosine kinases, a method for preparing the same, and pharmaceutical compositions comprising the same. Also disclosed are use of such compounds and pharmaceutical compositions thereof in the treatment and/or prophylaxis of protein tyrosine kinase associated diseases in an organism, particularly in the treatment and/or prophylaxis of tumors and fibroblast proliferation associated diseases.
摘要翻译：公开了可以调节蛋白酪氨酸激酶活性的二氢吲哚酮化合物，其制备方法和包含其的药物组合物。还公开了这样的化合物及其药物组合物用于治疗和/或预防生物体中蛋白质酪氨酸激酶相关疾病的用途，特别是治疗和/或预防肿瘤和成纤维细胞增殖相关疾病。

4. 发明授权

US08710293B2 Ultrathin fluid-absorbent cores 失效
标题翻译：超薄吸液芯
公开(公告)号：US08710293B2
公开(公告)日：2014-04-29
申请号：US13232767
申请日：2011-09-14
申请人： Xiaomin Zhang , Michael A. Mitchell
发明人： Xiaomin Zhang , Michael A. Mitchell
IPC分类号： A61F13/15
CPC分类号： A61L15/60 , A61F13/53 , A61F13/5323 , A61F2013/530481 , A61L15/24 , Y10T428/31504 , Y10T442/674
摘要： The present invention relates to ultrathin fluid-absorbent cores comprising a substrate layer, multicomponent superabsorbent particles and an adhesive, wherein the wet SAP shake-out of superabsorbent particles out of the fluid-absorbent core is less than 10% by weight.
摘要翻译：本发明涉及包含基材层，多组分超吸收性颗粒和粘合剂的超薄流体吸收芯，其中超吸收性颗粒从流体吸收芯中脱落的湿SAP小于10重量％。

5. 发明授权

US08269060B2 Absorbent materials and absorbent articles incorporating such absorbent materials 有权
标题翻译：吸收材料和吸收性物品
公开(公告)号：US08269060B2
公开(公告)日：2012-09-18
申请号：US12636440
申请日：2009-12-11
申请人： Jian Qin , Xiaomin Zhang , Debra Ann Graverson
发明人： Jian Qin , Xiaomin Zhang , Debra Ann Graverson
IPC分类号： A61F13/15 , A61F13/20
CPC分类号： A61L15/60 , Y10S522/909
摘要： An absorbent material formed at least in part of a crosslinked polymer. The absorbent material has a centrifuge retention capacity as determined by a Centrifuge Retention Capacity Test of at least about 20 g/g and a gel bed permeability under load as determined by a Gel Bed Permeability Under Load Test of at least about 300×10−9 cm2 or a free swell gel bed permeability as determined by a Free Swell Gel Bed Permeability Test of at least about 2,500×10−9 cm2. The crosslinked polymer may comprise either at least about 75 weight percent anionic polymer or at least about 75 weight percent cationic polymer. In one embodiment, the cross-linked polymer is surface treated with a water soluble non-cross-linked polymer having a potential for becoming charged opposite that of the cross-linked polymer.
摘要翻译：至少部分形成交联聚合物的吸收材料。吸收材料具有通过离心保留容量试验测定的至少约20g / g的离心保留能力和通过凝胶渗透性负载试验测定的凝胶渗透性在至少约300×10-9 cm 2或通过自由溶胀凝胶床渗透性试验测定的自由溶胀凝胶层渗透性为至少约2,500×10 -9 cm 2。交联聚合物可以包含至少约75重量％的阴离子聚合物或至少约75重量％的阳离子聚合物。在一个实施方案中，交联聚合物用具有与交联聚合物相反的电位的水溶性非交联聚合物进行表面处理。

6. 发明申请

US20090035850A1 P49/STRAP is a novel protein involved in gene regulation and cell proliferation 有权
公开(公告)号：US20090035850A1
公开(公告)日：2009-02-05
申请号：US12283347
申请日：2008-09-11
申请人： Jeanne Y. Wei , Xiaomin Zhang
发明人： Jeanne Y. Wei , Xiaomin Zhang
IPC分类号： C12N5/10 , C07H21/04
CPC分类号： C07K14/4702 , A61K38/00
摘要： The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in the heart. p49/STRAP is also discovered to inhibit tumor cell proliferation, and thus the invention provides a method of inhibiting cancer cell proliferation by contacting the cells with p49/STRAP.

7. 发明申请

US20060004336A1 Stretchable absorbent composite with low superaborbent shake-out 有权
标题翻译：具有低超吸收剂振动的可拉伸吸收复合材料
公开(公告)号：US20060004336A1
公开(公告)日：2006-01-05
申请号：US10883174
申请日：2004-06-30
申请人： Xiaomin Zhang , David Jackson , Lisa Jacobsen , Jian Qin , Dave Soerens
发明人： Xiaomin Zhang , David Jackson , Lisa Jacobsen , Jian Qin , Dave Soerens
IPC分类号： A61F13/15
CPC分类号： A61L15/60
摘要： An article comprises a stretchable absorbent composite (30) that includes a quantity of superabsorbent particles (32) which are operatively contained within a matrix of elastomeric polymer fibers (34). In particular aspects, the composite article can include at least about 60 wt % of the superabsorbent particles and not more than about 40 wt % of the elastomeric polymer fibers, based on a total weight of the composite. In other aspects, the composite article can provide a high stretchability. Additional aspects can provide a low shake-out. Particular configurations can, for example, provide a stretchability value of at least about 30%. Additional aspects can include a configuration that provides a shake-out value of not more than about 2%. In other aspects, the invention can provide a shake-out value of not more than about 1.2%. In further aspects, the absorbent composite can include superabsorbent particles having a coating of treatment-material that is thermally processible. Additional aspects can include a treatment-material which is water soluble.
摘要翻译：一种制品包括可拉伸吸收复合材料（30），其包括一定量的超吸收颗粒（32），其可操作地包含在弹性体聚合物纤维（34）的基体内。在具体方面，基于复合材料的总重量，复合制品可以包括至少约60重量％的超吸收颗粒和不超过约40重量％的弹性体聚合物纤维。在其它方面，复合制品可以提供高的拉伸性。其他方面可以提供低抖动。具体的配置可以例如提供至少约30％的拉伸性值。另外的方面可以包括提供不大于约2％的振荡值的配置。在其它方面，本发明可以提供不超过约1.2％的振荡值。在另外的方面，吸收性复合材料可以包括具有热处理材料的涂层的超吸收颗粒。另外的方面可以包括水溶性的处理材料。

8. 发明授权

US08871928B2 Tricyclic compounds, preparation methods, and their uses 有权
标题翻译：三环化合物，制备方法及其用途
公开(公告)号：US08871928B2
公开(公告)日：2014-10-28
申请号：US13825034
申请日：2011-09-20
申请人： Zehong Wan , Xiaomin Zhang , Zhaolong Tong , Kai Long , Sarah E. Dowdell , Eric Steven Manas , Krista Beaver Goodman
发明人： Zehong Wan , Xiaomin Zhang , Zhaolong Tong , Kai Long , Sarah E. Dowdell , Eric Steven Manas , Krista Beaver Goodman
IPC分类号： C07D471/00 , C07D487/00 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease, and/or diabetic macular edema.
摘要翻译：本发明涉及抑制Lp-PLA2活性的新型化合物，其制备方法，含有它们的组合物及其用于治疗与Lp-PLA2的活性有关的疾病，例如动脉粥样硬化，阿尔茨海默氏病和/ 或糖尿病性黄斑水肿。

9. 发明授权

US08232098B2 p49/STRAP is a novel protein involved in gene regulation and cell proliferation 有权
标题翻译： p49 / STRAP是一种涉及基因调控和细胞增殖的新型蛋白质
公开(公告)号：US08232098B2
公开(公告)日：2012-07-31
申请号：US12283347
申请日：2008-09-11
申请人： Jeanne Y. Wei , Xiaomin Zhang
发明人： Jeanne Y. Wei , Xiaomin Zhang
IPC分类号： C12N15/00 , C07H21/02
CPC分类号： C07K14/4702 , A61K38/00
摘要： The invention provides isolated p49/STRAP protein, and isolated nucleic acids encoding a p49/STRAP protein. The inventors have discovered a new protein, named p49/STRAP that is expressed in cardiac tissue and other tissues in mammals. The p49/STRAP protein binds to serum response factor (SRF) and regulates transcription of SRF-responsive genes in the heart. p49/STRAP is also discovered to inhibit tumor cell proliferation, and thus the invention provides a method of inhibiting cancer cell proliferation by contacting the cells with p49/STRAP.
摘要翻译：本发明提供分离的p49 / STRAP蛋白和编码p49 / STRAP蛋白的分离的核酸。本发明人发现了一种新的蛋白质，命名为p49 / STRAP，其在哺乳动物的心脏组织和其他组织中表达。 p49 / STRAP蛋白与血清反应因子（SRF）结合并调节心脏中SRF反应基因的转录。还发现p49 / STRAP抑制肿瘤细胞增殖，因此本发明通过使细胞与p49 / STRAP接触来提供抑制癌细胞增殖的方法。

10. 发明申请

US20090187998A1 Method of screening for agents to treat heart failure 有权
标题翻译：筛查治疗心力衰竭的药物的方法
公开(公告)号：US20090187998A1
公开(公告)日：2009-07-23
申请号：US12313539
申请日：2008-11-22
申请人： Jeanne Y. Wei , Gohar Azhar , Xiaomin Zhang
发明人： Jeanne Y. Wei , Gohar Azhar , Xiaomin Zhang
IPC分类号： A61K49/00 , G01N33/53 , C12Q1/02 , C12Q1/68
CPC分类号： A61K49/0008 , G01N33/5008 , G01N33/5088 , G01N2333/4703
摘要： The invention provides a method of identifying candidate agents to test for treating heart failure involving diastolic impairment, the method comprising: testing an agent to determine whether it (a) binds to serum response factor (SRF), (b) reduces SRF binding to a serum response element (SRE), or (c) reduces SRF protein levels in a cell; wherein if the agent does one or more of (a), (b), and (c), it is identified as a candidate agent.
摘要翻译：本发明提供了一种鉴定候选试剂以测试涉及舒张功能障碍的心力衰竭的方法，所述方法包括：测试试剂以确定其是否（a）是否结合血清反应因子（SRF），（b）降低SRF与血清反应元件（SRE）或（c）降低细胞中的SRF蛋白水平; 其中如果代理人执行（a），（b）和（c）中的一个或多个，则将其识别为候选代理。

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