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1. 发明授权

US08126649B2 Methods for generating a distribution of optimal solutions to nondeterministic polynomial optimization problems 有权
标题翻译：用于生成非确定性多项式优化问题的最优解的分布的方法
公开(公告)号：US08126649B2
公开(公告)日：2012-02-28
申请号：US12181056
申请日：2008-07-28
申请人： Wayne Frasch , David Spetzler , Justin York , Fusheng Xiong
发明人： Wayne Frasch , David Spetzler , Justin York , Fusheng Xiong
IPC分类号： G01N33/48 , C12Q1/68 , G06G7/58
CPC分类号： G06F19/24 , G06F19/22
摘要： The present invention provides methods for generating a distribution of optimal answers to a nondeterministic polynomial optimization problem by providing a plurality of solutions comprising input polynucleotides, wherein each solution comprises identical input polynucleotides; and wherein the number of solutions comprising polynucleotides equals a number of data inputs in the problem to be answered, and wherein each input polynucleotide comprises an x segment and a y segment; providing a plurality of solutions comprising connection polynucleotides wherein each solution comprises identical connection polynucleotides; and wherein the number of solutions comprising connection polynucleotides equals a number of unique connections that can be made between the different data inputs, and wherein each polynucleotide in the set of connection polynucleotides is complementary to the x segment of one input polynucleotide and to the y segment of one different input polynucleotide; combining the solutions comprising the input polynucleotides with the solutions comprising the connection polynucleotides to form a hybridization mixture, wherein the combining is done under conditions to promote formation of hybridization complexes between complementary polynucleotides, and wherein each individual connection polynucleotide is added at a concentration based on a weighted value assigned to the individual connection polynucleotide; ligating the polynucleotides that are present in the hybridization complexes to form ligation products; and determining a concentration of the ligation products, wherein the ligation products present at the highest concentration represent optimal answers to the nondeterministic polynomial optimization problem.
摘要翻译：本发明提供了通过提供包括输入多核苷酸的多种解决方案来产生对非确定性多项式优化问题的最优答案的分布的方法，其中每个溶液包含相同的输入多核苷酸; 并且其中包含多核苷酸的溶液的数量等于要回答的问题中的多个数据输入，并且其中每个输入多核苷酸包括x区段和y区段; 提供包含连接多核苷酸的多种溶液，其中每种溶液包含相同的连接多核苷酸; 并且其中包含连接多核苷酸的溶液的数量等于可以在不同数据输入之间进行的多个唯一连接，并且其中连接多核苷酸组中的每个多核苷酸与一个输入多核苷酸的x片段和y片段互补的一种不同的输入多核苷酸; 将包含输入多核苷酸的溶液与包含连接多核苷酸的溶液组合以形成杂交混合物，其中组合在促进互补多核苷酸之间形成杂交复合物的条件下进行，并且其中每个单独的连接多核苷酸以基于分配给个体连接多核苷酸的加权值; 连接存在于杂交复合物中的多核苷酸以形成连接产物; 并确定连接产物的浓度，其中以最高浓度存在的连接产物表示非确定性多项式优化问题的最佳答案。

2. 发明申请

US20090047677A1 METHODS FOR GENERATING A DISTRIBUTION OF OPTIMAL SOLUTIONS TO NONDETERMINISTIC POLYNOMIAL OPTIMIZATION PROBLEMS 有权
标题翻译：用于生成优化解决方案到非定常多项优化问题的方法
公开(公告)号：US20090047677A1
公开(公告)日：2009-02-19
申请号：US12181056
申请日：2008-07-28
申请人： Wayne Frasch , David Spetzler , Justin York , Fusheng Xiong
发明人： Wayne Frasch , David Spetzler , Justin York , Fusheng Xiong
IPC分类号： C12Q1/68
CPC分类号： G06F19/24 , G06F19/22
摘要： The present invention overcomes problems in prior art DNA-based computing methods for solving non-deterministic polynomial optimization problems, by providing methods that derive the most probable answers in a statistically significant manner that makes the methods scalable with increases in the number of data inputs, and thus makes the methods practical.
摘要翻译：本发明克服了现有技术的基于DNA的计算方法中用于解决非确定性多项式优化问题的问题，通过提供以统计有意义的方式导出最可能的答案的方法，使方法随着数据输入数量的增加而可扩展，从而使方法切实可行。

3. 发明申请

US20100015616A1 High Speed, High Fidelity, High Sensitivity Nucleic Acid Detection 有权
标题翻译：高速，高保真，高灵敏度的核酸检测
公开(公告)号：US20100015616A1
公开(公告)日：2010-01-21
申请号：US12439061
申请日：2007-08-29
申请人： Wayne Frasch , David Spetzler , Justin York
发明人： Wayne Frasch , David Spetzler , Justin York
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6816 , C12Q1/6832 , C12Q2561/125 , C12Q2521/325
摘要： The present invention provides methods, compositions, and kits for nucleic acid detection.
摘要翻译：本发明提供用于核酸检测的方法，组合物和试剂盒。

4. 发明申请

US20120196771A1 HIGH SPEED, HIGH FIDELITY, HIGH SENSITIVITY NUCLEIC ACID DETECTION 失效
标题翻译：高速，高灵敏度，高灵敏度的核酸检测
公开(公告)号：US20120196771A1
公开(公告)日：2012-08-02
申请号：US13299126
申请日：2011-11-17
申请人： Wayne Frasch , David Spetzler , Justin York
发明人： Wayne Frasch , David Spetzler , Justin York
IPC分类号： C40B40/00 , C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6816 , C12Q1/6832 , C12Q2561/125 , C12Q2521/325
摘要： Methods, compositions, and kits for nucleic acid detection.
摘要翻译：用于核酸检测的方法，组合物和试剂盒。

5. 发明授权

US08084206B2 High speed, high fidelity, high sensitivity nucleic acid detection 有权
标题翻译：高速，高保真，高灵敏度的核酸检测
公开(公告)号：US08084206B2
公开(公告)日：2011-12-27
申请号：US12439061
申请日：2007-08-29
申请人： Wayne Frasch , David Spetzler , Justin York
发明人： Wayne Frasch , David Spetzler , Justin York
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6837 , C12Q1/6816 , C12Q1/6832 , C12Q2561/125 , C12Q2521/325
摘要： The present invention provides methods, compositions, and kits for nucleic acid detection.
摘要翻译：本发明提供用于核酸检测的方法，组合物和试剂盒。

6. 发明授权

US08530199B2 High speed, high fidelity, high sensitivity nucleic acid detection 失效
标题翻译：高速，高保真，高灵敏度的核酸检测
公开(公告)号：US08530199B2
公开(公告)日：2013-09-10
申请号：US13299126
申请日：2011-11-17
申请人： Wayne D. Frasch , David Spetzler , Justin York
发明人： Wayne D. Frasch , David Spetzler , Justin York
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6816 , C12Q1/6832 , C12Q2561/125 , C12Q2521/325
摘要： Methods, compositions, and kits for nucleic acid detection.
摘要翻译：用于核酸检测的方法，组合物和试剂盒。

7. 发明申请

US20140220580A1 BIOMARKER COMPOSITIONS AND METHODS 审中-公开
标题翻译：生物标记物组合物和方法
公开(公告)号：US20140220580A1
公开(公告)日：2014-08-07
申请号：US14125937
申请日：2012-07-14
申请人： Kirk Brown , Traci Pawlowski , David Spetzler
发明人： Kirk Brown , Traci Pawlowski , David Spetzler
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6804 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178 , G01N33/57434 , G01N33/57484 , G01N33/6893
摘要： Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease, select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and to determine treatment efficacy. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles, and nucleic acid-protein complexes.
摘要翻译：可以评估生物标志物的诊断，治疗相关或预后的方法来鉴定表型，如病情或疾病，或疾病的阶段或进展，选择疾病，病情，疾病阶段和疾病阶段的候选治疗方案，并确定治疗效果。来自体液的循环生物标志物可用于生理状态的分析或确定表型。这些包括核酸，蛋白质和循环结构如囊泡和核酸 - 蛋白质复合物。

8. 发明授权

US09128101B2 Biomarkers for theranostics 有权
标题翻译：生物标志物
公开(公告)号：US09128101B2
公开(公告)日：2015-09-08
申请号：US13581795
申请日：2011-03-01
申请人： David D. Halbert , George Poste , Michael Klass , David Spetzler , Traci Pawlowski , Daniel Holterman
发明人： David D. Halbert , Christine Kuslich , George Poste , Michael Klass , David Spetzler , Traci Pawlowski , Andrea Tasinato , Daniel Holterman
IPC分类号： G01N33/53 , G01N33/68 , C12Q1/68 , G01N33/574
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178 , G01N33/57484 , G01N33/6872 , G01N2333/705 , G01N2800/52 , G01N2800/60
摘要： Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.
摘要翻译：可以评估生物标志物的诊断，治疗相关或预后的方法来鉴定表型，如病情或疾病，或疾病的阶段或进展。来自体液的循环生物标志物可用于生理状态的分析或确定表型。这些包括核酸，蛋白质和循环结构如囊泡。生物标志物可以用于选择用于疾病，病症，疾病阶段和病症阶段的候选治疗方案，并且还可以用于确定治疗功效。生物标志物可以是循环生物标志物，包括囊泡和微小RNA。

9. 发明申请

US20140148350A1 CIRCULATING BIOMARKERS FOR DISEASE 审中-公开
标题翻译：循环生物标志物治疗疾病
公开(公告)号：US20140148350A1
公开(公告)日：2014-05-29
申请号：US13817383
申请日：2011-08-18
申请人： David Spetzler , Daniel Holterman , Traci Pawlowski , Christine Kuslich
发明人： David Spetzler , Daniel Holterman , Traci Pawlowski , Christine Kuslich
IPC分类号： G01N33/68
CPC分类号： G01N33/57484 , G01N33/574 , G01N33/6893 , G01N2333/705 , G01N2400/40
摘要： Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.
摘要翻译：可以评估生物标志物的诊断，治疗相关或预后的方法来鉴定表型，如病情或疾病，或疾病的阶段或进展。来自体液的循环生物标志物可用于生理状态的分析或确定表型。这些包括核酸，蛋白质和循环结构如囊泡。生物标志物可以用于选择用于疾病，病症，疾病阶段和病症阶段的候选治疗方案，并且还可以用于确定治疗功效。生物标志物可以是循环生物标志物，包括囊泡和微小RNA。

10. 发明申请

US20140148348A1 DECTECTION OF GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：胃肠道疾病的保护
公开(公告)号：US20140148348A1
公开(公告)日：2014-05-29
申请号：US13521592
申请日：2011-01-13
申请人： Christine Kuslich , Traci Pawlowski , David Spetzler
发明人： Christine Kuslich , Traci Pawlowski , David Spetzler
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , C12Q2600/178
摘要： Provided herein are methods and systems for characterizing a phenotype by detecting microRNAs, vesicles, or biomarkers that are indicative of disease or disease progress. The disease can be a gastrointestinal disorder, such as colorectal cancer. The microRNAs, vesicles, or biomarkers can be detected in a bodily fluid.
摘要翻译：本文提供了通过检测指示疾病或疾病进展的微小RNA，小泡或生物标志物来表征表型的方法和系统。该疾病可以是胃肠道疾病，如结肠直肠癌。可以在体液中检测微小RNA，小泡或生物标志物。

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