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1. 发明授权

US07945391B2 Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis 失效
标题翻译：计算机控制稀有细胞的方法和装置，包括胎儿细胞，基于诊断
公开(公告)号：US07945391B2
公开(公告)日：2011-05-17
申请号：US11273229
申请日：2005-11-14
申请人： Petros Tsipouras , Triantafyllos Tafas
发明人： Petros Tsipouras , Triantafyllos Tafas
IPC分类号： G06F19/00 , G06K9/00 , G06K9/20 , G06K9/78
CPC分类号： G06K9/00127 , B01J2219/00693 , B01J2219/00702 , C12Q1/6806 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N35/1002 , G01N35/1011 , G01N2015/1006 , G01N2035/1034 , G06K9/0014 , G06T7/0012 , G06T2207/30024
摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.
摘要翻译：提供了一种用于检测和诊断组织样本中的稀有细胞类型的计算机控制方法，所述方法包括处理组织样本，使得其产生指示在罕见细胞的位置存在的第一信号，检测第一信号，处理检测到第一信号的位置以产生指示诊断有用的细胞特征的第二信号并检测第二信号。在染色之前或之后，第一信号可以是形态学或寻找细胞中存在的颜色。第二信号可以通过原位PCR或PCR原位杂交产生。在一个优选实施方案中，稀有细胞类型是母体血液组织样品中的胎儿细胞，所述样品由未培养的母体血液的涂片组成。在另一个实施方案中，该方法用于诊断或基因型血液或组织活检样本中的癌细胞。

2. 发明授权

US07829868B2 Methods for detecting fluorescent signals in a biological sample 有权
标题翻译：用于检测生物样品中荧光信号的方法
公开(公告)号：US07829868B2
公开(公告)日：2010-11-09
申请号：US11833849
申请日：2007-08-03
申请人： Young Min Kim , Yanning Zhu , Yash Agarwal , Xiuzhong Wang , Aaron Armstrong , Robert Borgerding , Andrew MacGinitie , Antti Seppo , Ilia Ichetovkin , Michael Kilpatrick , Petros Tsipouras , Triantafyllos Tafas
发明人： Young Min Kim , Yanning Zhu , Yash Agarwal , Xiuzhong Wang , Aaron Armstrong , Robert Borgerding , Andrew MacGinitie , Antti Seppo , Ilia Ichetovkin , Michael Kilpatrick , Petros Tsipouras , Triantafyllos Tafas
IPC分类号： G01N21/64
CPC分类号： G01N35/00732 , G01J3/2803 , G01J3/4406 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6482 , G01N2035/00851 , G01N2201/06113 , G01N2201/12
摘要： A method for automated microscopic analysis wherein the test protocol is obtained from interrogatable data affixed to each microscope slide. The method further comprises the algorithms that implement the test protocol.
摘要翻译：一种用于自动显微镜分析的方法，其中从每个显微镜载片上的可询问数据获得测试方案。该方法还包括实现测试协议的算法。

3. 发明申请

US20060068376A1 Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis 有权
公开(公告)号：US20060068376A1
公开(公告)日：2006-03-30
申请号：US11272613
申请日：2005-11-14
申请人： Petros Tsipouras , Triantafyllos Tafas
发明人： Petros Tsipouras , Triantafyllos Tafas
IPC分类号： C12Q1/00 , G06F19/00
CPC分类号： G06K9/00127 , B01J2219/00693 , B01J2219/00702 , C12Q1/6806 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N35/1002 , G01N35/1011 , G01N2015/1006 , G01N2035/1034 , G06K9/0014 , G06T7/0012 , G06T2207/30024
摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.

4. 发明授权

US06956695B2 System and method for increasing the contrast of an image produced by an epifluorescence microscope 失效
标题翻译：用于增加由荧光显微镜产生的图像的对比度的系统和方法
公开(公告)号：US06956695B2
公开(公告)日：2005-10-18
申请号：US10102500
申请日：2002-03-19
申请人： Triantafyllos Tafas , Petros Tsipouras
发明人： Triantafyllos Tafas , Petros Tsipouras
IPC分类号： G02B21/16 , G02B21/34
CPC分类号： G02B21/16 , G01N21/6458 , G02B21/082 , G02B21/34
摘要： The contrast of an image produced by epifluorescence microscopy may be increased by placing a high-pass dichroic reflecting film behind the sample. The reflecting film reflects the emission light emitted by the fluorescent tags in the sample back through the objective lens while allowing the shorter wavelength excitation light to pass through the sample holder.
摘要翻译：通过在荧光显微镜下产生的图像的对比可以通过在样品后面放置高通二向色反射膜来增加。反射膜通过物镜反射由样品中的荧光标签发出的发射光，同时允许较短波长的激发光通过样品保持器。

5. 发明授权

US06320174B1 Composing microscope 失效
标题翻译：组成显微镜
公开(公告)号：US06320174B1
公开(公告)日：2001-11-20
申请号：US09442172
申请日：1999-11-16
申请人： Triantafyllos Tafas , Petros Tsipouras
发明人： Triantafyllos Tafas , Petros Tsipouras
IPC分类号： G02B606
CPC分类号： G02B26/105 , G02B6/06 , G02B21/002 , G02B21/361 , G02B21/364
摘要： The present invention provides a composing microscope for scanning a large area of a specimen in a minimal amount of time. In a first embodiment, the composing microscope has a plurality of optical sensors and a plurality of optical projecting systems arranged adjacent to each other. Each of the projecting systems acquires an image from one location of a specimen and projects the image on one of the optical sensors for digitalizing the image. An image acquisition device is connected to the optical sensors for simultaneously storing the digitalized images with information of their locations on the specimen. In a second embodiment, a composing microscope has an optical sensor and a plurality of optical projecting systems arranged adjacent to each other in rows. Each of the optical projecting systems has a first end for acquiring an image at one location of a specimen and a second end. An optical reflector moveable with respect to the second ends of the optical projecting systems receives the images from a row of the optical projecting systems at the second ends and projects the images on the optical sensor, and the optical sensor simultaneously digitalizes the images. An image acquisition device simultaneously receives and stores the digitalized images with information of their locations on the specimen. In a third embodiment, a composing microscope has an optical sensor and a plurality of optical projecting systems arranged adjacent to each other. The projecting system has a first end and a second end connected to the optical sensor. Each of the optical projecting systems acquires an image of one location of a specimen at the first end and projects the image on the optical sensor for digitalizing the image. An image acquisition device is connected to the optical sensor for storing the digitalized images with information of their locations on the specimen.
摘要翻译：本发明提供了一种用于以最小的时间扫描大面积的样本的组合显微镜。在第一实施例中，构图显微镜具有彼此相邻布置的多个光学传感器和多个光学投影系统。每个投影系统从样本的一个位置获取图像，并将图像投影在其中一个光学传感器上，以使图像数字化。图像获取装置连接到光学传感器，用于将数字化图像与其位置的信息同时存储在样本上。在第二实施例中，构图显微镜具有光学传感器和多个彼此相邻布置的光学投影系统。每个光学投影系统具有用于在样本的一个位置处获取图像的第一端和第二端。相对于光学投影系统的第二端可移动的光学反射器在第二端处接收来自一系列光学投影系统的图像，并将图像投射在光学传感器上，并且光学传感器同时对图像进行数字化。图像采集装置同时接收并存储具有它们在样本上的位置的信息的数字化图像。在第三实施例中，构图显微镜具有彼此相邻布置的光学传感器和多个光学投影系统。投影系统具有连接到光学传感器的第一端和第二端。每个光学投影系统获取在第一端处的样本的一个位置的图像，并将图像投影在用于数字化图像的光学传感器上。图像获取装置连接到光学传感器，用于将数字化图像存储在样本上的位置信息。

6. 发明授权

US07948676B2 Automated cassette and slide handling system for an automatic microscope 有权
标题翻译：自动显微镜自动盒式和滑动处理系统
公开(公告)号：US07948676B2
公开(公告)日：2011-05-24
申请号：US11833517
申请日：2007-08-03
申请人： Tibor Virag , Yash Agarwal , Wei Guo , Richard Eberle , Youngmin Kim , Michael Kilpatrick , Petros Tsipouras , Triantafyllos Tafas
发明人： Tibor Virag , Yash Agarwal , Wei Guo , Richard Eberle , Youngmin Kim , Michael Kilpatrick , Petros Tsipouras , Triantafyllos Tafas
IPC分类号： G02B21/26
CPC分类号： G02B21/34 , G01N35/026 , G01N35/04 , G01N2035/0425 , G01N2035/0427 , Y10S359/90
摘要： An automated cassette and slide handling system is disclosed which organizes microscope slides in cassettes, automatically and sequentially removes individual slides from their respective cassettes, positioned each slide under the microscope as provided by the protocol, and after examination returns the slide to its proper cassette.
摘要翻译：公开了一种自动化的盒式磁带和幻灯片处理系统，其在盒中组织显微镜幻灯片，自动地并且顺序地从其各自的盒中移除各个幻灯片，每个幻灯片根据协议设置在显微镜下放置，并且在检查后将幻灯片返回到其正确的盒。

7. 发明授权

US07835869B2 Method and apparatus for computer controlled rare cell, including fetal cell, based diagnosis 有权
标题翻译：计算机控制稀有细胞的方法和装置，包括胎儿细胞，基于诊断
公开(公告)号：US07835869B2
公开(公告)日：2010-11-16
申请号：US11272613
申请日：2005-11-14
申请人： Petros Tsipouras , Triantafyllos Tafas
发明人： Petros Tsipouras , Triantafyllos Tafas
IPC分类号： G06F19/00 , G06K9/00 , G06K9/20 , G06K9/78
CPC分类号： G06K9/00127 , B01J2219/00693 , B01J2219/00702 , C12Q1/6806 , G01N1/2813 , G01N1/312 , G01N15/1475 , G01N21/6428 , G01N21/6458 , G01N33/5005 , G01N35/1002 , G01N35/1011 , G01N2015/1006 , G01N2035/1034 , G06K9/0014 , G06T7/0012 , G06T2207/30024
摘要： A computer controlled method for detecting and diagnosing a rare cell type in a tissue sample is provided, said method comprising treating the tissue sample such that it generates a first signal indicative of the presence at a location of a rare cell, detecting the first signal, treating the location at which the first signal is detected to generate a second signal indicative of a diagnostically useful cellular characteristic and detecting the second signal. The first signal can be morphological or a color present in a sought cell either before or after staining. The second signal can be generated by in situ PCR or PCR in situ hybridization. In one preferred embodiment, the rare cell type is a fetal cell in a maternal blood tissue sample, said sample consisting of a smear of unenriched maternal blood. In another embodiment, the method is used to diagnose or genotype cancer cells in a blood or tissue biopsy sample.
摘要翻译：提供了一种用于检测和诊断组织样本中的稀有细胞类型的计算机控制方法，所述方法包括处理组织样本，使得其产生指示在罕见细胞的位置存在的第一信号，检测第一信号，处理检测到第一信号的位置以产生指示诊断有用的细胞特征的第二信号并检测第二信号。在染色之前或之后，第一信号可以是形态学或寻找细胞中存在的颜色。第二信号可以通过原位PCR或PCR原位杂交产生。在一个优选实施方案中，稀有细胞类型是母体血液组织样品中的胎儿细胞，所述样品由未培养的母体血液的涂片组成。在另一个实施方案中，该方法用于诊断或基因型血液或组织活检样本中的癌细胞。

8. 发明申请

US20090250629A1 Methods for Detecting Fluorescent Signals in a Biological Sample 有权
标题翻译：检测生物样品荧光信号的方法
公开(公告)号：US20090250629A1
公开(公告)日：2009-10-08
申请号：US11833849
申请日：2007-08-03
申请人： Young Min Kim , Yanning Zhu , Yash Agarwal , Xiuzhong Wang , Aaron Armstrong , Robert Borgerding , Andrew MacGinitie , Antti Seppo , Ilia Ichetovkin , Michael Kilpatrick , Petros Tsipouras , Triantafyllos Tafas
发明人： Young Min Kim , Yanning Zhu , Yash Agarwal , Xiuzhong Wang , Aaron Armstrong , Robert Borgerding , Andrew MacGinitie , Antti Seppo , Ilia Ichetovkin , Michael Kilpatrick , Petros Tsipouras , Triantafyllos Tafas
IPC分类号： G01N21/64 , G02B21/26
CPC分类号： G01N35/00732 , G01J3/2803 , G01J3/4406 , G01N21/6428 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6441 , G01N2021/6482 , G01N2035/00851 , G01N2201/06113 , G01N2201/12
摘要： Operational means for automatic microscopic detection and analysis of fluorescent signals from a treated biological sample.
摘要翻译：用于自动显微检测和分析来自经处理的生物样品的荧光信号的操作手段。

9. 发明申请

US20090123054A1 DETECTION OF CIRCULATING TUMOR CELLS IN PERIPHERAL BLOOD WITH AN AUTOMATED SCANNING FLUORESCENCE MICROSCOPE 有权
标题翻译：用自动扫描荧光显微镜检测外周血中循环肿瘤细胞
公开(公告)号：US20090123054A1
公开(公告)日：2009-05-14
申请号：US12270820
申请日：2008-11-13
申请人： Sir Walter Bodmer , Triantafyllos Tafas , Michael Kilpatrick , Petros Tsipouras , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Antti Seppo , Triantafyllia Ntouroupi , Changhua Yu , Charles Climer
发明人： Sir Walter Bodmer , Triantafyllos Tafas , Michael Kilpatrick , Petros Tsipouras , Xiuzhong Wang , Youngmin Kim , Michael Thomas , Antti Seppo , Triantafyllia Ntouroupi , Changhua Yu , Charles Climer
IPC分类号： G06K9/00
CPC分类号： G06K9/00127 , G01N21/6458
摘要： An automated, highly sensitive, specific and potentially quantitative detection method using an automated microscope for identifying and enumerating rare cancer cells in blood and other fluids.
摘要翻译：一种使用自动显微镜识别和列举血液和其他液体中稀有癌细胞的自动化，高灵敏度，特异性和潜在的定量检测方法。

10. 发明授权

US07471079B2 Microscope enclosure system 有权
标题翻译：显微镜外壳系统
公开(公告)号：US07471079B2
公开(公告)日：2008-12-30
申请号：US11833203
申请日：2007-08-02
申请人： Triantafyllos Tafas , Yash Agarwal , Youngmin Kim , Wei Guo , Richard Eberle , Joseph Turgeon , Michael Kilpatrick , Petros Tsipouras
发明人： Triantafyllos Tafas , Yash Agarwal , Youngmin Kim , Wei Guo , Richard Eberle , Joseph Turgeon , Michael Kilpatrick , Petros Tsipouras
IPC分类号： G01R31/302
CPC分类号： G02B21/24
摘要： A light-tight enclosure system, displaceable along a surface, for housing an automated microscope, having electronically controllable components and an image capturing device. The enclosure system may include device for displacement, a shelf for placement of the automated microscope, an externally viewable monitor, and a plurality of electrical power receptacles.
摘要翻译：一种不透光的外壳系统，可沿着表面移位，用于容纳自动显微镜，具有电子可控部件和图像捕获装置。外壳系统可以包括用于移位的装置，用于放置自动显微镜的搁架，外部可观察的监视器和多个电力插座。

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