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1. 发明授权

US4154956A Method for producing lysine ester 失效
标题翻译：生产赖氨酸酯的方法
公开(公告)号：US4154956A
公开(公告)日：1979-05-15
申请号：US807218
申请日：1977-06-16
申请人： Toshiaki Ueda , Shinzo Imamura
发明人： Toshiaki Ueda , Shinzo Imamura
IPC分类号： C07C101/26
CPC分类号： Y02P20/582
摘要： Lysine ester is produced by heating .alpha.-amino-.epsilon.-capro-lactam with an alcohol. The reaction can be accelerated by adding a small amount of water and an acid or base catalyst.
摘要翻译：赖氨酸酯是通过用醇加热α-氨基-ε-己内酰胺来制备的。可以通过加入少量的水和酸或碱催化剂来加速反应。

2. 发明授权

US6087527A Method for producing alkyl carboxylates by multi-stage esteridication interrupted with a dehydration step 失效
标题翻译：通过脱水步骤中断的多级酯化制备烷基羧酸盐的方法
公开(公告)号：US6087527A
公开(公告)日：2000-07-11
申请号：US43254
申请日：1998-09-21
申请人： Atsushi Niwa , Shinzo Imamura , Akio Hasebe , Ito Nobuhiko
发明人： Atsushi Niwa , Shinzo Imamura , Akio Hasebe , Ito Nobuhiko
IPC分类号： C07C67/08 , C07C69/34 , C07C69/00 , C07C69/02
CPC分类号： C07C67/08
摘要： Method for producing an alkyl carboxylate, in which a carboxylic acid and an alcohol are esterified by reaction in the presence of an acid catalyst, by removing water in a dehydration step established halfway in the esterification reaction using a solid acid catalyst as the acid catalyst, and restarting the esterification reaction to complete the esterification reaction.
摘要翻译： PCT No.PCT / JP97 / 02488第 371日期：1998年9月21日 102（e）1998年9月21日PCT PCT 1997年7月17日PCT公布。公开号WO98 / 03460 日本1998年1月29日制备羧酸和醇在酸催化剂存在下通过反应酯化的方法，其中使用固体酸催化剂在酯化反应中的脱水步骤中除去水作为酸催化剂，并重新开始酯化反应以完成酯化反应。

3. 发明授权

US06600070B2 Methods for making 2-(&ohgr;-alkoxycarbonylalkanoyl)-4-butanolide, ester of &ohgr;-hydroxy-(&ohgr;-3)-ketoaliphatic acid, and derivatives thereof 有权
公开(公告)号：US06600070B2
公开(公告)日：2003-07-29
申请号：US09997140
申请日：2001-11-29
申请人： Hideaki Takaoka , Sigeru Wada , Nobuhiko Ito , Akio Hasebe , Shinzo Imamura , Hideo Muraoka
发明人： Hideaki Takaoka , Sigeru Wada , Nobuhiko Ito , Akio Hasebe , Shinzo Imamura , Hideo Muraoka
IPC分类号： C07C5142
CPC分类号： C07D307/33 , C07C51/43 , C07C67/32 , C07C69/716 , C07C59/215
摘要： In industrial production of &ohgr;-hydroxyaliphatic acid being an important intermediate for large cyclic lactone-based perfumes, using dicarboxylate ester which is inexpensive and readily obtainable, a method, with high yield and improved selectively, for making a 2-(&ohgr;-alkoxycarbonylalkanoyl)-4-butanolide and an alkaline metal salt thereof, an ester of &ohgr;-hydroxy-(&ohgr;-3)-ketoaliphatic acid as a novel compound and a derivative thereof, and a method for making the same are provided. Condensation reaction of &ggr;-butyrolactone with a dicarboxylate ester represented by the general formula (1) ROOC(CH2)nCOOR wherein n is an integer of 7 to 13 and R is an alkyl group forms a condensation solution containing an alkaline metal salt of 2-(&ohgr;-alkoxycarbonylalkanoyl)-4-butanolide represented by the general formula (3): wherein n is an integer of 7 to 13, R is an alkyl group, and M is an alkaline metal; the solution is extracted with water or an aqueous alkaline solution and subjected to hydrolysis and decarboxylation to form an alkaline metal salt of &ohgr;-hydroxy-(&ohgr;-3)-ketoaliphatic acid represented by the general formula (5): wherein n is an integer of 7 to 13 and M is an alkaline metal; and the compound is selectively and effectively separated and recovered and then acidified to form an &ohgr;-hydroxy-(&ohgr;-3)-ketoaliphatic acid represented by the general formula (10): wherein n is an integer of 7 to 13.

4. 发明授权

US06475133B2 Methods for making 2-(&ohgr;-alkoxycarbonylalkanoyl)-4-butanolide, ester of omega-hydroxy-(&ohgr;-3)-ketoaliphatic acid, and derivatives thereof 有权
标题翻译：制备2-（ω-烷氧基羰基烷酰基）-4-丁醇酯，ω-羟基 - （ω-3） - 酮脂肪酸的酯及其衍生物的方法
公开(公告)号：US06475133B2
公开(公告)日：2002-11-05
申请号：US09894014
申请日：2001-06-28
申请人： Hideaki Takaoka , Sigeru Wada , Nobuhiko Ito , Akio Hasebe , Shinzo Imamura , Hideo Muraoka
发明人： Hideaki Takaoka , Sigeru Wada , Nobuhiko Ito , Akio Hasebe , Shinzo Imamura , Hideo Muraoka
IPC分类号： C07C5100
CPC分类号： C07D307/33 , C07C51/43 , C07C67/32 , C07C69/716 , C07C59/215
摘要： In industrial production of &ohgr;-hydroxyaliphatic acid being an important intermediate for large cyclic lactone-based perfumes, using dicarboxylate ester which is inexpensive and readily obtainable, a method, with high yield and improved selectively, for making a 2-(&ohgr;-alkoxycarbonylalkanoyl)-4-butanolide and an alkaline metal salt thereof, an ester of &ohgr;-hydroxy-(&ohgr;-3)-ketoaliphatic acid as a novel compound and a derivative thereof, and a method for making the same are provided. Condensation reaction of &ggr;-butyrolactone with a dicarboxylate ester represented by the general formula (1) ROOC(CH2)nCOOR wherein n is an integer of 7 to 13 and R is an alkyl group forms a condensation solution containing an alkaline metal salt of 2-(&ohgr;-alkoxycarbonylalkanoyl)-4-butanolide represented by the general formula (3): wherein n is an integer of 7 to 13, R is an alkyl group, and M is an alkaline metal; the solution is extracted with water or an aqueous alkaline solution and subjected to hydrolysis and decarboxylation to form an alkaline metal salt of &ohgr;-hydroxy-(&ohgr;-3)-ketoaliphatic acid represented by the general formula (5): wherein n is an integer of 7 to 13 and M is an alkaline metal; and the compound is selectively and effectively separated and recovered and then acidified to form an &ohgr;-hydroxy-(&ohgr;-3)-ketoaliphatic acid represented by the general formula (10): wherein n is an integer of 7 to 13.
摘要翻译：在工业生产中，ω-羟基脂肪酸是大环内酯基香料的重要中间体，使用廉价且易于获得的二羧酸酯，可以制备2-（ω-烷氧羰基烷酰基） -4-丁醇酸及其碱金属盐，作为新化合物的ω-羟基 - （ω-3） - 酮脂肪酸的酯及其衍生物及其制备方法。（1）ROOC（CH 2）n COOR表示的二羧酸酯的丁内酯，其中n为7〜13的整数，R为烷基，形成含有2-（ω-烷氧基羰基烷酰基）的碱金属盐的缩合溶液，由通式（3）表示的4-丁醇酯：其中n为7〜13的整数，R为烷基，M为碱金属; 溶液用水或碱性水溶液萃取，并进行水解和脱羧，形成由通式（5）表示的ω-羟基 - （ω-3） - 酮脂肪酸的碱金属盐：其中n为整数为7〜13，M为碱金属; 选择性且有效地分离和回收化合物，然后酸化以形成由通式（10）表示的ω-羟基 - （ω-3） - 酮脂肪酸：其中n为7至13的整数。

5. 发明授权

US4824964A Method for preparing optically active N-acetylindoline-2-carboxylic acid 失效
标题翻译：光学活性N-乙酰二氢吲哚-2-羧酸的制备方法
公开(公告)号：US4824964A
公开(公告)日：1989-04-25
申请号：US6312
申请日：1987-01-15
申请人： Satoru Miyata , Hiromi Fukuda , Shinzo Imamura
发明人： Satoru Miyata , Hiromi Fukuda , Shinzo Imamura
IPC分类号： C07B57/00 , C07D209/42 , C07D209/12
CPC分类号： C07D209/42
摘要： A resolving agent for N-acetylindoline-2-carboxylic acid, comprising an optically active .alpha.-amino-.epsilon.-caprolactam gives an optically active N-acetylindoline-2-carboxylic acid in both high yield and high optical purity.
摘要翻译：包含光学活性α-氨基ε-己内酰胺的N-乙酰基二氢吲哚-2-羧酸的拆分剂以高产率和高光学纯度得到光学活性N-乙酰二氢吲哚-2-羧酸。

6. 发明授权

US4399289A 2-Diphenylmethyleneamino-3-indolylpropionitrile and alkyl esters of 2-diphenylmethylene-amino-3-indolylpropionic acid 失效
标题翻译： 2-二苯基亚甲基氨基-3-吲哚基丙腈和2-二苯基亚甲基 - 氨基-3-吲哚基丙酸的烷基酯
公开(公告)号：US4399289A
公开(公告)日：1983-08-16
申请号：US247938
申请日：1981-03-26
申请人： Shinzo Imamura , Haruyo Sato , Hiroyoshi Kuramoto
发明人： Shinzo Imamura , Haruyo Sato , Hiroyoshi Kuramoto
IPC分类号： C07D209/20 , C07D209/18
CPC分类号： C07D209/20 , Y02P20/582
摘要： Novel indole derivatives of the general formula I can be obtained by reacting, directly or indirectly, N,N-dimethyl-3-indolemethylamine with a Schiff base of the general formula II, ##STR1## in which R.sup.1 is cyano or methoxycarbonyl, ethoxycarbonyl, propoxycarbonyl or butoxycarbonyl, and .phi. is phenyl. The successive hydrolysis of the indole derivatives of the general formula I in the presence of an acid and of a base gives tryptophane.
摘要翻译：通式I的新型吲哚衍生物可以通过直接或间接地使N，N-二甲基-3-吲哚甲胺与通式II的希夫碱反应获得，其中R 1是氰基或甲氧基羰基，乙氧基羰基，丙氧基羰基或丁氧基羰基，而phi为苯基。在酸和碱的存在下，通式I的吲哚衍生物的连续水解得到色氨酸。

7. 发明授权

US4297477A Polyamide having --NH--(CH.sub.2).sub.4 --CH(NRR')--CO--units 失效
标题翻译：具有-NH-（CH 2）4 -CH（NRR'） - CO-单元的聚酰胺
公开(公告)号：US4297477A
公开(公告)日：1981-10-27
申请号：US108941
申请日：1979-12-31
申请人： Minoru Nakata , Haruyo Sato , Shinzo Imamura
发明人： Minoru Nakata , Haruyo Sato , Shinzo Imamura
IPC分类号： C08G69/14
CPC分类号： C08G69/14
摘要： Provided are polyamides having properties which make them useful as adhesives, sizing agents, paper strength enhancers and as resins. These polyamides are prepared by heating an alpha-(N,N-disubstituted amino)-E-caprolactam, alone or in combination with one or more comonomers, in the presence of an anionic polymerization catalyst, and are characterized by a repeating unit reprsented by the formula ##STR1## wherein R and R' are each a lower alkyl group or a cyclic amine residue, and also having a relative viscosity of at leasrt 1.5.
摘要翻译：提供了具有使其用作粘合剂，上浆剂，纸强度增强剂和树脂的性质的聚酰胺。这些聚酰胺通过在阴离子聚合催化剂的存在下单独或与一种或多种共聚单体组合加热α-（N，N-二取代氨基）-E-己内酰胺而制备，并且其特征在于重复单元由其中R和R'各自为低级烷基或环状胺残基，并且还具有1.5的相对粘度。

8. 发明授权

US06528668B2 Methods for making 2-(&ohgr;-alkoxycarbonylalkanoyl)-4-butanolide, ester of &ohgr;-hydroxy-(&ohgr;-3)-ketoaliphatic acid, and derivatives thereof 有权
标题翻译：制备2-（ω-烷氧基羰基烷酰基）-4-丁醇酯，ω-羟基 - （ω-3） - 酮脂肪酸的酯及其衍生物的方法
公开(公告)号：US06528668B2
公开(公告)日：2003-03-04
申请号：US10047895
申请日：2002-01-14
申请人： Hideaki Takaoka , Sigeru Wada , Nobuhiko Ito , Akio Hasebe , Shinzo Imamura , Hideo Muraoka
发明人： Hideaki Takaoka , Sigeru Wada , Nobuhiko Ito , Akio Hasebe , Shinzo Imamura , Hideo Muraoka
IPC分类号： C07C5100
CPC分类号： C07D307/33 , C07C51/43 , C07C67/32 , C07C69/716 , C07C59/215
摘要： Methods for making 2-(&ohgr;-alkoxycarbonylalkanoyl)-4-butanolide and derivatives thereof, esters of &ohgr;-hydroxy-(&ohgr;-3)-ketoaliphatic acid and derivatives thereof, which are useful as a variety of synthetic raw materials and intermediates, and are prepared as intermediates in the production step of &ohgr;-hydroxyaliphatic acid being important intermediates of large cyclic lactone-based perfumes in the perfume industry.
摘要翻译：制备2-（ω-烷氧基羰基烷酰基）-4-丁醇酸及其衍生物的方法，可用作各种合成原料和中间体的ω-羟基 - （ω-3） - 酮脂肪酸及其衍生物的酯，以及在生产步骤中作为中间体被制备成ω-羟基脂肪酸，是香料工业中大环内酯类香料的重要中间体。

9. 发明授权

US06291688B1 Processes for preparing 2-(omega-alkoxycarbonylalkanoyl)-4- butanolides omega-hydroxy-(omega-3)-keto fatty esters, and derivatives thereof 有权
标题翻译：制备2-（ω-烷氧基羰基烷酰基）-4-丁酸酯ω-羟基 - （ω-3） - 酮脂肪酯及其衍生物的方法
公开(公告)号：US06291688B1
公开(公告)日：2001-09-18
申请号：US09242805
申请日：1999-02-24
申请人： Hideaki Takaoka , Sigeru Wada , Nobuhiko Ito , Akio Hasebe , Shinzo Imamura , Hideo Muraoka
发明人： Hideaki Takaoka , Sigeru Wada , Nobuhiko Ito , Akio Hasebe , Shinzo Imamura , Hideo Muraoka
IPC分类号： C07D30726
CPC分类号： C07D307/33 , C07C51/43 , C07C67/32 , C07C69/716 , C07C59/215
摘要： A method, with high yield and improved selectively, for making a 2-(&ohgr;-alkoxycarbonylalkanoyl)-4-butanolide and an alkaline metal salt thereof, an ester of &ohgr;-hydroxy-(&ohgr;-3)-ketoaliphatic acid as a novel compound and a derivative thereof, and a method for making the same are provided.
摘要翻译：一种制备2-（ω-烷氧基羰基烷酰基）-4-丁醇和其碱金属盐的高产率和选择性改进的方法，作为新化合物的ω-羟基 - （ω-3） - 脂肪酸的酯及其衍生物及其制备方法。

10. 发明授权

US5422255A Method for producing D-alanine 失效
标题翻译： D-丙氨酸生产方法
公开(公告)号：US5422255A
公开(公告)日：1995-06-06
申请号：US27551
申请日：1993-03-05
申请人： Noriko Ito , Shinzo Imamura , Haruyo Sato
发明人： Noriko Ito , Shinzo Imamura , Haruyo Sato
IPC分类号： C12P13/06 , C12P41/00 , C12N1/16
CPC分类号： C12P13/06 , C12P41/001 , Y10S435/911 , Y10S435/921 , Y10S435/938 , Y10S435/944
摘要： A high concentration of DL-alanine can be supplied in a culture medium and D-alanine can be efficiently obtained with high yield for a short time by cultivating a yeast which belongs to the genus Candida, the genus Cryptococcus, the genus Hansenura or the genus Trichosporon and has an ability to assimilate L-alanine and not to assimilate substantially D-alanine in a culture medium containing substantially DL-alanine as a single carbon source and a single nitrogen source under an acidic condition. Moreover, because very little other organic by-product and organic impurity exists in the culture medium when the cultivation is completed, it becomes easy to separate and refine the D-alanine.
摘要翻译：可以在培养基中提供高浓度的DL-丙氨酸，通过培育属于假丝酵母属，隐球菌属，汉逊酵母属或类属的酵母，可以在短时间内以高产率有效地获得D-丙氨酸 Trichosporon具有吸收L-丙氨酸的能力，并且在酸性条件下，在基本上含有作为单一碳源的DL-丙氨酸和单一氮源的培养基中基本上不能同化D-丙氨酸。此外，由于培养完成后培养基中存在少量其他有机副产物和有机杂质，所以容易分离和精制D-丙氨酸。

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