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1. 发明授权

US07331926B2 Ultrasonic elastography providing axial, orthogonal, and shear strain 有权
标题翻译：超声弹性成像提供轴向，正交和剪切应变
公开(公告)号：US07331926B2
公开(公告)日：2008-02-19
申请号：US10784526
申请日：2004-02-23
申请人： Tomy Varghese , Udomchai Techavipoo , Quan Chen , James A. Zagzebski
发明人： Tomy Varghese , Udomchai Techavipoo , Quan Chen , James A. Zagzebski
IPC分类号： A61B8/00
CPC分类号： G01S7/52042 , A61B8/00 , A61B8/08 , A61B8/4209 , A61B8/485 , G01S15/8995
摘要： Ultrasonic signals obtained at a range of angles are fit to a material independent model to derive both axial and lateral strain and thus parameters dependent on lateral strain including Poisson's ratio and shear strain.
摘要翻译：在一定范围的角度获得的超声波信号适合材料无关模型，以导出轴向和横向应变，因此导致参数取决于横向应变，包括泊松比和剪切应变。

2. 发明授权

US07166075B2 Elastographic imaging of in vivo soft tissue 有权
标题翻译：体内软组织的弹性成像
公开(公告)号：US07166075B2
公开(公告)日：2007-01-23
申请号：US10094844
申请日：2002-03-08
申请人： Tomy Varghese , James A. Zagzebski , Udomchai Techavipoo , Quan Chen
发明人： Tomy Varghese , James A. Zagzebski , Udomchai Techavipoo , Quan Chen
IPC分类号： A61B8/00
CPC分类号： A61B8/485 , A61B5/0051 , A61B5/015 , A61B8/0833 , A61B8/14 , A61B8/466 , A61B8/483 , A61B8/5223 , A61B18/14 , A61B2018/00577 , G01S7/52046
摘要： Elastographic images provide visualization in two or three dimensions of RF ablation lesions to guide in the ablation process. Compression may be applied using the RF probe. A similar technique may be applied to in vivo imaging of soft tissue without ablation.
摘要翻译：弹性图像提供RF消融损伤的两个或三个维度的可视化，以引导消融过程。使用RF探头可以应用压缩。类似的技术可以应用于没有消融的软组织的体内成像。

3. 发明授权

US07601122B2 Ultrasonic elastography with angular compounding 有权
标题翻译：超声弹性成像与角度复合
公开(公告)号：US07601122B2
公开(公告)日：2009-10-13
申请号：US10765293
申请日：2004-01-27
申请人： James A. Zagzebski , Tomy Varghese
发明人： James A. Zagzebski , Tomy Varghese
IPC分类号： A61B8/00
CPC分类号： G01S7/52042 , A61B8/00 , A61B8/08 , A61B8/4209 , A61B8/485 , G01S15/8995
摘要： Ultrasonic strain measurements, which characterize the structure of tissue, may be obtained by combining multiple echo signals acquired at different compressions and at different angles. Such angular compounding may improve the quality of the elastic signal and provide at one time both an axial and lateral strain measurement.
摘要翻译：可以通过组合在不同压缩和不同角度获得的多个回波信号来获得表征组织结构的超声应变测量。这种角度复合可以改善弹性信号的质量，同时提供轴向和横向应变测量。

4. 发明授权

US07275439B2 Parametric ultrasound imaging using angular compounding 有权
标题翻译：参数超声成像使用角复合
公开(公告)号：US07275439B2
公开(公告)日：2007-10-02
申请号：US10772663
申请日：2004-02-04
申请人： James A. Zagzebski , Tomy Varghese , Anthony L. Gerig
发明人： James A. Zagzebski , Tomy Varghese , Anthony L. Gerig
IPC分类号： G01N29/036 , A61B1/00
CPC分类号： G01S7/52042 , A61B8/00 , A61B8/4254 , G01S7/52036 , G01S15/8977 , G01S15/8995
摘要： Parametric ultrasonic measurements which characterize the structure of tissue, using information from an ultrasonic signal beyond amplitude information, are obtained by combining multiple ultrasonic signals acquired at different angles, thereby reducing the variance of the calculations. Such angular compounding may be applied to detecting scatterer size, spacing, density, and attenuation.
摘要翻译：通过组合以不同角度获取的多个超声波信号，通过使用来自超声波信号超过振幅信息的信息来表征组织结构的参数超声波测量，从而减少计算的方差。这种角度复合可以应用于检测散射体的尺寸，间距，密度和衰减。

5. 发明授权

US07297116B2 Method and apparatus for imaging the cervix and uterine wall 有权
标题翻译：宫颈和子宫壁成像的方法和装置
公开(公告)号：US07297116B2
公开(公告)日：2007-11-20
申请号：US10420125
申请日：2003-04-21
申请人： Tomy Varghese , Mark Alan Kliewer , James A. Zagzebski
发明人： Tomy Varghese , Mark Alan Kliewer , James A. Zagzebski
IPC分类号： A61B8/00
CPC分类号： A61B8/485 , A61B5/0048 , A61B5/4325 , A61B5/4331 , A61B5/4519 , A61B8/08 , A61B8/12 , A61B8/445 , G01S7/52036 , G01S15/899
摘要： Elastography is used to examine soft tissue of the uterus to detect tumors and to evaluate the strength of the cervix of the uterus based on its elastographic properties.
摘要翻译：使用弹性检查来检查子宫的软组织以检测肿瘤并且基于其弹性学特性来评估子宫颈的强度。

6. 发明授权

US06749571B2 Method and apparatus for cardiac elastography 有权
公开(公告)号：US06749571B2
公开(公告)日：2004-06-15
申请号：US10247693
申请日：2002-09-19
申请人： Tomy Varghese , Christian S. Breburda , James A. Zagzebski , Peter Samuel Rahko
发明人： Tomy Varghese , Christian S. Breburda , James A. Zagzebski , Peter Samuel Rahko
IPC分类号： A61B806
CPC分类号： A61B8/485 , A61B8/08 , A61B8/0883 , A61B8/14 , A61B8/463 , A61B8/467 , A61B8/469 , A61B8/543 , G01S7/52042 , G01S7/52071 , G01S7/52073 , G01S7/52084 , G01S7/52087 , G01S15/8977
摘要： Elastographic imaging of heart tissue may be used to provide strain images by mapping strain magnitude to brightness and strain sign to hue and thus provide improved clinical indication of compression and distension of heart muscle. An areal cursor may be used to obtain quantitative measurements of strain at predetermined periods in the heart cycle. Multiple area measurements of strain may be combined to provide a quantitative index of cardiac health.

7. 发明授权

US08111810B2 Method for producing highly constrained ultrasound images 有权
标题翻译：用于生产高度约束的超声图像的方法
公开(公告)号：US08111810B2
公开(公告)日：2012-02-07
申请号：US12270631
申请日：2008-11-13
申请人： James A. Zagzebski , Charles A. Mistretta
发明人： James A. Zagzebski , Charles A. Mistretta
IPC分类号： G06K9/00
CPC分类号： G06T3/4076 , G01S7/52046 , G01S15/8995
摘要： A highly constrained image processing method is used to improve the quality, including spatial resolution and signal-to-noise ratio (SNR), of ultrasound image frames. Ultrasound image frames are accumulated to form a composite image that contains a priori information about the subject being imaged. This composite image is used in a HYPR processing method to improve the quality of the ultrasound image frame. For example, the SNR of the composite image is increased as a function of the number of ultrasound image frames used to produce it, and this increased SNR is passed on to each highly constrained image frame. Additionally, high spatial resolution ultrasound images are produced using an undersampled sampling density, and the quality of these images is restored to substantially the same level as a fully sampled image.
摘要翻译：使用高度受限的图像处理方法来提高超声图像帧的质量，包括空间分辨率和信噪比（SNR）。累积超声图像帧以形成包含关于被成像对象的先验信息的合成图像。该复合图像用于HYPR处理方法以提高超声图像帧的质量。例如，根据用于产生它的超声图像帧的数量，合成图像的SNR增加，并且将增加的SNR传递到每个高度约束的图像帧。此外，使用欠采样密度产生高空间分辨率超声图像，并且将这些图像的质量恢复到与完全采样图像基本相同的水平。

8. 发明授权

US5574212A Automated system and method for testing resolution of ultrasound scanners 失效
标题翻译：超声波扫描仪分辨率的自动化系统和方法
公开(公告)号：US5574212A
公开(公告)日：1996-11-12
申请号：US490319
申请日：1995-06-14
申请人： Ernest L. Madsen , James A. Zagzebski , Gary R. Frank , Jason J. Rownd
发明人： Ernest L. Madsen , James A. Zagzebski , Gary R. Frank , Jason J. Rownd
IPC分类号： G01H3/00 , G01N29/06 , G01S7/52 , G01N29/00
CPC分类号： G01S7/5205 , G01H3/005 , G01N29/06 , G01N2291/02475 , G01S7/52036 , G01S7/52046
摘要： In accordance with the present invention there is presented an automated system for testing the ability of clinical ultrasound scanners to detect focal lesions in human tissue. An ultrasound scanner phantom containing background material mimicking the ultrasonic characteristics of human tissue and coplanar spherical target lesions ultrasonically contrasting with the background material is scanned using the ultrasound scanner to be tested. Digitized images are made of the ultrasound scan of slices in the ultrasound phantom containing background material only and of slices on which the focal lesions are centered. A lesion signal to noise ratio (SNR).sub.L is then calculated at each defined pixel coordinate in the target lesion slice. This calculation employs (1) a pixel value average calculated over a sample area of the target image slice centered at a pixel location and which is of a size approximately that of the cross-sectional area of the target lesions, (2) an average pixel value calculated over an averaging area centered at the same pixel coordinate but containing mostly background image data, and (3) a standard deviation of averaged pixel values calculated in the background material image plane. The proximal and distal depth range limits of detectability of an ultrasound scanner, for a given lesion diameter and contrast, may then be determined based on the number of pixel locations in a depth range of the scanned plane having an absolute value SNR greater than a threshold value.
摘要翻译：根据本发明，提出了一种用于测试临床超声扫描仪检测人体组织中局灶性病变的能力的自动化系统。使用超声扫描仪扫描包含背景材料的模拟人体组织的超声波特征的超声波扫描器体模和与背景材料超声波对比的共面球面目标病变。数字化图像由仅含有超声模型的背景材料中的切片的超声波扫描和局部病变位于其上的切片构成。然后在目标病变切片中的每个定义的像素坐标处计算病变信噪比（SNR）L。该计算使用（1）以像素位置为中心的目标图像切片的样本区域计算的像素值平均值，其大小与目标病变的横截面面积的像素值平均值相等，（2）平均像素通过以相同像素坐标为中心的平均区域计算的值，并且主要包含背景图像数据，以及（3）在背景材料图像平面中计算的平均像素值的标准偏差。然后，可以基于在绝对值SNR大于阈值的扫描平面的深度范围内的像素位置的数量来确定针对给定病变直径和对比度的超声扫描仪的可检测性的近端和远端深度范围限度值。

9. 发明申请

US20090129651A1 METHOD FOR PRODUCING HIGHLY CONSTRAINED ULTRASOUND IMAGES 有权
标题翻译：用于生产高约束超声图像的方法
公开(公告)号：US20090129651A1
公开(公告)日：2009-05-21
申请号：US12270631
申请日：2008-11-13
申请人： James A. Zagzebski , Charles A. Mistretta
发明人： James A. Zagzebski , Charles A. Mistretta
IPC分类号： G06K9/00
CPC分类号： G06T3/4076 , G01S7/52046 , G01S15/8995
摘要： A highly constrained image processing method is used to improve the quality, including spatial resolution and signal-to-noise ratio (SNR), of ultrasound image frames. Ultrasound image frames are accumulated to form a composite image that contains a priori information about the subject being imaged. This composite image is used in a HYPR processing method to improve the quality of the ultrasound image frame. For example, the SNR of the composite image is increased as a function of the number of ultrasound image frames used to produce it, and this increased SNR is passed on to each highly constrained image frame. Additionally, high spatial resolution ultrasound images are produced using an undersampled sampling density, and the quality of these images is restored to substantially the same level as a fully sampled image.
摘要翻译：使用高度受限的图像处理方法来提高超声图像帧的质量，包括空间分辨率和信噪比（SNR）。累积超声图像帧以形成包含关于被成像对象的先验信息的合成图像。该复合图像用于HYPR处理方法以提高超声图像帧的质量。例如，根据用于产生它的超声图像帧的数量，合成图像的SNR增加，并且将增加的SNR传递到每个高度约束的图像帧。此外，使用欠采样密度产生高空间分辨率超声图像，并且将这些图像的质量恢复到与完全采样图像基本相同的水平。

10. 发明授权

US4277367A Phantom material and method 失效
标题翻译：幻影材料和方法
公开(公告)号：US4277367A
公开(公告)日：1981-07-07
申请号：US953761
申请日：1978-10-23
申请人： Ernest L. Madsen , James A. Zagzebski , Richard A. Banjavic , Michele M. Burlew
发明人： Ernest L. Madsen , James A. Zagzebski , Richard A. Banjavic , Michele M. Burlew
IPC分类号： A61B17/00 , G01N29/30 , G09B23/28 , G10K11/02 , C09K3/00 , A61B10/00 , G01N31/00 , G01N33/00
CPC分类号： G10K11/02 , G01N29/30 , G09B23/286 , A61B2017/00716 , Y10T436/10
摘要： Tissue mimicking material for use in ultrasound phantoms formulated as a uniform suspension of solid particles of graphite, talc, pumice, polyethylene microspheres, or liquid particles of vegetable oils, kerosine, or combinations thereof described as scatterers in a congealed gelatin-water-alcohol-preservative matrix; containing detergents to create the liquid particles.
摘要翻译：配制成石墨，滑石，浮石，聚乙烯微球或植物油，煤油或其组合的液体颗粒的固体颗粒的均匀悬浮液的超声模型中的组织模拟材料，其被描述为在凝固的明胶 - 水 - 醇 - 防腐剂基质; 含有洗涤剂以产生液体颗粒。

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