专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

2. 发明申请

US20130022625A1 Stabilized Antibody-Containing Liquid Formulations 有权
标题翻译：含稳定抗体的液体制剂
公开(公告)号：US20130022625A1
公开(公告)日：2013-01-24
申请号：US13522848
申请日：2011-01-20
申请人： Tomoyuki Igawa , Chifumi Moriyama
发明人： Tomoyuki Igawa , Chifumi Moriyama
IPC分类号： C07K16/00 , A61K39/395 , C07K16/28 , C07K1/00
CPC分类号： A61K9/0019 , A61K9/19 , A61K39/395 , A61K39/39591 , A61K47/12 , A61K47/18 , A61K47/183 , A61K47/26
摘要： An objective of the present invention is to provide stable antibody-containing formulations which are suitable for subcutaneous administration and in which aggregation formation is suppressed during long-term storage.The present inventors discovered that a significant stabilization effect was achieved by using an acidic amino acid, aspartic acid or glutamic acid as a counter ion species in histidine buffer or tris(hydroxymethyl)aminomethane, specifically by using histidine-aspartate buffer or histidine-glutamate buffer, or tris(hydroxymethyl)aminomethane-aspartate or tris(hydroxymethyl)aminomethane-glutamate as a buffer. The present inventors also discovered that a significant stabilization effect was achieved by using an acidic amino acid, aspartic acid or glutamic acid, as a counter ion species to a basic amino acid such as arginine, specifically by using arginine-aspartate or arginine-glutamate.
摘要翻译：本发明的目的是提供适用于皮下给药的稳定的含抗体制剂，并且在长期保存期间抑制聚集形成。本发明人发现通过使用酸性氨基酸，天冬氨酸或谷氨酸作为组氨酸缓冲液或三（羟甲基）氨基甲烷中的抗衡离子物质，特别是通过使用组氨酸 - 天冬氨酸缓冲液或组氨酸 - 谷氨酸盐缓冲液，或三（羟甲基）氨基甲烷 - 天冬氨酸盐或三（羟甲基）氨基甲烷 - 谷氨酸盐缓冲液。本发明人还发现，通过使用酸性氨基酸，天冬氨酸或谷氨酸，作为对离子种类与碱性氨基酸如精氨酸，特别是使用精氨酸 - 天冬氨酸或精氨酸 - 谷氨酸，实现了显着的稳定化效果。

IPRDB

热门服务

关于我们

友情链接

联系方式