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1. 发明申请

US20080021503A1 NEUROSTIMULATION AND CORONARY ARTERY DISEASE TREATMENT 有权
标题翻译：神经病学和冠状动脉疾病治疗
公开(公告)号：US20080021503A1
公开(公告)日：2008-01-24
申请号：US11779769
申请日：2007-07-18
申请人： Todd Whitehurst , James Thacker , James McGivern , Kelly McClure
发明人： Todd Whitehurst , James Thacker , James McGivern , Kelly McClure
IPC分类号： A61N1/05
CPC分类号： A61N1/36114 , A61M5/14276 , A61M2205/054 , A61M2205/3523 , A61M2205/8206 , A61M2230/06
摘要： A method for treating a patient may include treating coronary artery disease in combination with angina pectoris and/or the control of angina pain by delivering chemical and/or electrical stimulation pulses to the cardiac and/or nervous tissue of the patient in a coordinated manner. A system for treating a patient suffering from coronary artery disease and angina may include a stimulator that generates at least one pulse in accordance with prescribed parameters, a catheter, a lead, and/or a sensor.
摘要翻译：用于治疗患者的方法可以包括通过以协调的方式将化学和/或电刺激脉冲递送到患者的心脏和/或神经组织来治疗与心绞痛联合的冠状动脉疾病和/或控制心绞痛。用于治疗患有冠状动脉疾病和心绞痛的患者的系统可以包括根据规定参数产生至少一个脉冲的刺激器，导管，引线和/或传感器。

2. 发明申请

US20060241717A1 Treatment of movement disorders by extra dural motor cortex stimulation 审中-公开
标题翻译：通过额外的硬脑膜运动皮层刺激治疗运动障碍
公开(公告)号：US20060241717A1
公开(公告)日：2006-10-26
申请号：US10224021
申请日：2002-08-19
申请人： Todd Whitehurst , James McGivern
发明人： Todd Whitehurst , James McGivern
IPC分类号： A61N1/36
CPC分类号： A61N1/36082 , A61N1/37288 , A61N1/3756 , A61N1/3787
摘要： System and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to the cortex of the brain to treat movement disorders uses at least one implantable system control unit (SCU), specifically an implantable signal/pulse generator (IPG) or microstimulator with two or more electrodes in the case of electrical stimulation, and an implantable pump with one or more infusion outlets in the case of drug infusion. In certain embodiments, a single SCU provides both electrical stimulation and one or more stimulating drugs. In some embodiments, one or more sensed conditions are used to adjust stimulation parameters.
摘要翻译：用于引入一种或多种刺激性药物和/或对大脑皮层施加电刺激以治疗运动障碍的系统和方法使用至少一个可植入系统控制单元（SCU），特别是可植入信号/脉冲发生器（IPG）或微刺激器在电刺激的情况下具有两个或更多个电极，以及在药物输注的情况下具有一个或多个输注出口的可植入泵。在某些实施方案中，单个SCU提供电刺激和一种或多种刺激性药物。在一些实施例中，使用一个或多个感测到的条件来调整刺激参数。

3. 发明申请

US20060036293A1 Methods for treating gastrointestinal disorders 有权
公开(公告)号：US20060036293A1
公开(公告)日：2006-02-16
申请号：US11192750
申请日：2005-07-29
申请人： Todd Whitehurst , James McGivern , Rafael Carbunaru
发明人： Todd Whitehurst , James McGivern , Rafael Carbunaru
IPC分类号： A61N1/18
CPC分类号： A61N1/375 , A61N1/36007 , A61N1/372 , A61N1/37205
摘要： A small implantable stimulator(s) having at least two electrodes is implanted adjacent to a gastrointestinal nerve and/or muscle for the stimulation treatment of gastrointestinal disorders, including gastrointestinal motility, sphincteric disorders, and/or eating disorders. The stimulator provides a means of stimulating tissue at a stimulation site when desired, and may be implanted via a minimal surgical procedure.

4. 发明申请

US20050165465A1 Lead assembly for implantable microstimulator 有权
标题翻译：可植入微型激励器的导线组件
公开(公告)号：US20050165465A1
公开(公告)日：2005-07-28
申请号：US10503281
申请日：2003-01-29
申请人： Anne Pianca , Todd Whitehurst , James McGivern
发明人： Anne Pianca , Todd Whitehurst , James McGivern
IPC分类号： A61N1/05
CPC分类号： H01R43/16 , A61N1/05 , H01R13/5224 , Y10T29/49204
摘要： A lead assembly (20) for a small implantable medical device (10) (a.k.a., microdevice (10) provides means to attach a remote electrode (14) to microdevice (10), which means inhibit fluid ingress when microdevice (10) is not attached to lead assembly (20). Microdevices may provide either or both tissue stimulation and sensing. Known microdevices (10) include spaced apart electrodes (12a, 12b) on the outer surface of the microdevice. Lead assembly (20) includes an insulated lead (16) including a proximal end and a distal end, with at least one conductor therebetween; at least one electrode (14) at the distal end of the lead and electrically connected to the at least one conductor, and a connector (18) attached to the proximal end of the lead and adapted to be removably connectable to microdevice (10). Connector (18) includes at least one contact (22) to electrically connect at least one device electrode (12a) on microdevice (10) to at least one conductor, thereby electrically connecting at least electrode (12a) and the at least one electrode (14) at the distal end of lead (16). Lead assembly (20) is configured to inhibit fluid ingress into the connector (18). A number of embodiments of the invention, capable of inhibiting fluid ingress into connector (18), are taught.
摘要翻译：用于小型可植入医疗装置（10）（也称为微型装置（10））的引导组件（20）提供将远程电极（14）附接到微型装置（10）的装置，这意味着当微型装置（10）不是微型装置可以提供组织刺激和感测之一或两者，已知的微型装置（10）在微型装置的外表面上包括间隔开的电极（12a，12b），引线组件（20）包括包括近端和远端的绝缘引线（16），其间具有至少一个导体;在所述引线的远端处电连接到所述至少一个导体的至少一个电极（14）和连接器（18）连接器（18）包括至少一个接触件（22），用于将至少一个设备电极（12a）电连接到微器件（10）上，所述至少一个触点（22）被连接到引线的近端，并且适于可移除地连接到微器件（10）至少一个导管从而在引线（16）的远端处至少电连接电极（12a）和至少一个电极（14）。引线组件（20）被配置为阻止流体进入连接器（18）。教导了能够抑制流体进入连接器（18）的本发明的许多实施例。

5. 发明申请

US20050119713A1 Methods for implanting a spinal cord stimulator 审中-公开
标题翻译：植入脊髓刺激器的方法
公开(公告)号：US20050119713A1
公开(公告)日：2005-06-02
申请号：US11027227
申请日：2004-12-30
申请人： Todd Whitehurst , James McGivern , Carla Mann , Janusz Kuzma
发明人： Todd Whitehurst , James McGivern , Carla Mann , Janusz Kuzma
IPC分类号： A61N1/34 , A61N1/18
CPC分类号： A61N1/36071
摘要： Methods for implanting spinal cord stimulators are provided, including implanting at least one electrode in an anterolateral area of the spine. Stimulation provided by the stimulator(s) may be used to treat patients with chronic pain. The stimulator(s) use a power source/storage device, such as a rechargeable battery. Periodic recharging of such a power source/storage device is accomplished, for example, by inductive coupling with an external applience. The stimulators provide means of stimulating a nerve(s) or other tissue when desired, without the need for external appliances during the stimulation session. When necessary, external appliances are used for the transmission of data to and/or from the stimulator(s) and for the transmission of power, if necessary. In a preferred embodiment, the system is capable of open- and closed-loop operation. In closed-loop operation, at least one implant includes at least one sensor, and the sensed condition is used to adjust stimulation parameters.
摘要翻译：提供了用于植入脊髓刺激器的方法，包括在脊柱的前外侧区域植入至少一个电极。刺激器提供的刺激可用于治疗慢性疼痛患者。刺激器使用诸如可充电电池的电源/存储设备。这样的电源/存储装置的定期再充电例如通过与外部应用的感应耦合来实现。刺激器提供在需要时刺激神经或其他组织的手段，而不需要在刺激期间的外部器具。必要时，如果需要，外部设备用于向刺激器传送数据和/或从刺激器传输数据。在优选实施例中，系统能够进行开环和闭环操作。在闭环操作中，至少一个植入物包括至少一个传感器，并且所感测到的条件用于调整刺激参数。

6. 发明申请

US20070021800A1 CAVERNOUS NERVE STIMULATION VIA UNIDIRECTIONAL PROPAGATION OF ACTION POTENTIALS 有权
标题翻译：通过行动潜力的联合传播促进神经刺激
公开(公告)号：US20070021800A1
公开(公告)日：2007-01-25
申请号：US11536565
申请日：2006-09-28
申请人： Todd Whitehurst , James McGivern , Rafael Carbunaru , Matthew Haller , Tom He , Kerry Bradley
发明人： Todd Whitehurst , James McGivern , Rafael Carbunaru , Matthew Haller , Tom He , Kerry Bradley
IPC分类号： A61N1/00
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/36071 , A61N1/37205
摘要： Methods of using unidirectionally propagating action potentials (UPAPs) for cavernous nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes.
摘要翻译：提供了使用单向传播动作电位（UPAP）用于海绵神经刺激和某些疾病的方法。能够产生这种UPAP的刺激器包括但不限于微型可植入刺激器（即，微型刺激器），可能具有可编程配置的电极。

7. 发明申请

US20080065183A1 Vagus nerve stimulation via unidirectional propagation of action potentials 有权
标题翻译：迷走神经刺激通过动作电位的单向传播
公开(公告)号：US20080065183A1
公开(公告)日：2008-03-13
申请号：US11935921
申请日：2007-11-06
申请人： Todd Whitehurst , James McGivern , Rafael Carbunaru , Matthew Haller , Tom He , Kerry Bradley
发明人： Todd Whitehurst , James McGivern , Rafael Carbunaru , Matthew Haller , Tom He , Kerry Bradley
IPC分类号： A61N1/05
CPC分类号： A61N1/0556 , A61N1/0551 , A61N1/08 , A61N1/36071 , Y10S128/903
摘要： Methods of using unidirectionally propagating action potentials (UPAPs) for vagus nerve stimulation and for certain disorders are provided. Stimulators capable of creating such UPAPs include, but are not limited to, miniature implantable stimulators (i.e., microstimulators), possibly with programmably configurable electrodes.
摘要翻译：提供了使用单向传播动作电位（UPAP）用于迷走神经刺激和某些疾病的方法。能够产生这种UPAP的刺激器包括但不限于微型可植入刺激器（即，微型刺激器），可能具有可编程配置的电极。

8. 发明申请

US20060194724A1 Methods and systems for nerve regeneration 审中-公开
标题翻译：神经再生的方法和系统
公开(公告)号：US20060194724A1
公开(公告)日：2006-08-31
申请号：US11066993
申请日：2005-02-25
申请人： Todd Whitehurst , James McGivern , Rafael Carbunaru , Kelly McClure , Kristen Jaax
发明人： Todd Whitehurst , James McGivern , Rafael Carbunaru , Kelly McClure , Kristen Jaax
IPC分类号： A61K38/18 , A61N1/18
CPC分类号： A61K38/185 , A61K9/0024 , A61K38/45 , A61N1/326
摘要： An exemplary method of regenerating a nerve within a patient includes implanting a system control unit within the patient and applying a stimulus to the nerve with the system control unit in accordance with one or more control parameters. The stimulus is configured to promote regeneration of the nerve. An exemplary system for regenerating a nerve within a patient includes a system control unit configured to apply a stimulus to the nerve in accordance with one or more control parameters. The system control unit is implanted within the patient and the stimulus promotes the regeneration of the nerve.
摘要翻译：在患者内再生神经的示例性方法包括将系统控制单元植入患者体内，并根据一个或多个控制参数与系统控制单元向神经施加刺激。刺激被配置成促进神经再生。用于再生患者内的神经的示例性系统包括系统控制单元，其被配置为根据一个或多个控制参数将刺激应用于神经。系统控制单元植入患者体内，刺激促进神经再生。

9. 发明申请

US20050209652A1 Methods and systems for electrical and/or drug stimulation as a therapy for erectile dysfunction 失效
标题翻译：用于电和/或药物刺激作为勃起功能障碍治疗的方法和系统
公开(公告)号：US20050209652A1
公开(公告)日：2005-09-22
申请号：US11112630
申请日：2005-04-22
申请人： Todd Whitehurst , James McGivern
发明人： Todd Whitehurst , James McGivern
IPC分类号： A61N1/08 , A61N1/18 , A61N1/36 , A61N1/372
CPC分类号： A61N1/37211 , A61N1/36007 , A61N1/372 , A61N1/37205
摘要： Systems and methods for introducing one or more stimulating drugs and/or applying electrical stimulation to tissue affecting the penis to treat erectile dysfunction (for instance, following prostate surgery) uses at least one implantable system control unit (SCU) producing electrical pulses delivered via electrodes and/or producing drug infusion pulses, wherein the stimulating drug(s) are delivered via one or more pumps and infusion outlets.
摘要翻译：用于引入一种或多种刺激性药物和/或对影响阴茎治疗勃起功能障碍的组织施加电刺激的系统和方法（例如，在前列腺手术之后）使用至少一个可植入系统控制单元（SCU），其产生经由电极传送的电脉冲和/或产生药物输注脉冲，其中所述刺激性药物通过一个或多个泵和输注口输送。

10. 发明申请

US20070100393A1 Treatment of movement disorders by brain stimulation 审中-公开
标题翻译：通过脑刺激治疗运动障碍
公开(公告)号：US20070100393A1
公开(公告)日：2007-05-03
申请号：US11641977
申请日：2006-12-19
申请人： Todd Whitehurst , James McGivern , Kelly McClure
发明人： Todd Whitehurst , James McGivern , Kelly McClure
IPC分类号： A61N1/18
CPC分类号： A61M5/14276 , A61K9/0085 , A61M2205/3523 , A61M2205/3569 , A61M2210/0693 , A61N1/0529 , A61N1/0534 , A61N1/325 , A61N1/36082 , A61N1/37205
摘要： Systems for treating a movement disorder include a system control unit configured to be implanted at least partially within a patient and to generate at least one stimulus in accordance with one or more stimulation parameters adjusted to treat the movement disorder. The systems further include a programmable memory unit in communication with the system control unit and programmed to store the one or more stimulation parameters to at least partially define the stimulus such that the stimulus is configured to treat the movement disorder. A means for applying the stimulus to one or more stimulation sites within the patient is operably connected to the system control unit.
摘要翻译：用于治疗运动障碍的系统包括系统控制单元，该系统控制单元被配置为至少部分地植入患者体内，并根据被调整以治疗运动障碍的一个或多个刺激参数产生至少一个刺激。系统还包括与系统控制单元通信的可编程存储器单元，并被编程为存储一个或多个刺激参数以至少部分地限定刺激，使得刺激被配置为治疗运动障碍。将刺激施加到患者体内的一个或多个刺激部位的手段可操作地连接到系统控制单元。

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