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1. 发明授权

US08936630B2 Optical stimulation therapy 有权
标题翻译：光刺激疗法
公开(公告)号：US08936630B2
公开(公告)日：2015-01-20
申请号：US12951766
申请日：2010-11-22
申请人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton
发明人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton
IPC分类号： A61N5/06 , A61B17/00 , A61M5/142 , A61N1/365 , A61N1/08 , A61B18/00
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2018/00839 , A61M5/14276 , A61N1/086 , A61N1/365 , A61N5/062 , A61N5/0622 , A61N2005/0612 , A61N2005/0626 , A61N2005/063 , A61N2005/0651
摘要： Methods of delivering optical stimulation to a target tissue from an optical stimulation device are provided. One method comprises sensing a temperature at the optical stimulation device or proximate to the optical stimulation device, and adjusting the delivery of light to the target tissue based on the sensed temperature. Another method comprises delivering the light to the target tissue with an optical light guide and sensing bioelectric signals with a sense electrode, wherein the optical light guide and the sense electrode each comprise a material that produces substantially no induced current in an electromagnetic field. Another method comprises delivering light from a light source of an optical stimulation device to a window of the optical stimulation device, delivering the light from the window to an optical light guide optically connected to the window, and delivering the light to a target tissue via the optical light guide.
摘要翻译：提供了从光学刺激装置向目标组织递送光学刺激的方法。一种方法包括感测光学刺激装置处的温度或接近光学刺激装置的温度，以及基于感测的温度调节到目标组织的光的传送。另一种方法包括用光学光导将光传送到目标组织，并用感测电极感测生物电信号，其中光学光导和感测电极各自包括在电磁场中基本上不产生感应电流的材料。另一种方法包括将光从光学刺激装置的光源传送到光学刺激装置的窗口，将光从窗口传送到光学连接到窗户的光学导光板，并经由光学光导。

2. 发明申请

US20110125077A1 OPTICAL STIMULATION THERAPY 有权
标题翻译：光刺激治疗
公开(公告)号：US20110125077A1
公开(公告)日：2011-05-26
申请号：US12951766
申请日：2010-11-22
申请人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton
发明人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton
IPC分类号： A61N5/06 , A61N1/36 , A61M37/00
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2018/00839 , A61M5/14276 , A61N1/086 , A61N1/365 , A61N5/062 , A61N5/0622 , A61N2005/0612 , A61N2005/0626 , A61N2005/063 , A61N2005/0651
摘要： Methods of delivering optical stimulation to a target tissue from an optical stimulation device are provided. One method comprises sensing a temperature at the optical stimulation device or proximate to the optical stimulation device, and adjusting the delivery of light to the target tissue based on the sensed temperature. Another method comprises delivering the light to the target tissue with an optical light guide and sensing bioelectric signals with a sense electrode, wherein the optical light guide and the sense electrode each comprise a material that produces substantially no induced current in an electromagnetic field. Another method comprises delivering light from a light source of an optical stimulation device to a window of the optical stimulation device, delivering the light from the window to an optical light guide optically connected to the window, and delivering the light to a target tissue via the optical light guide.
摘要翻译：提供了从光学刺激装置向目标组织递送光学刺激的方法。一种方法包括感测光学刺激装置处的温度或接近光学刺激装置的温度，以及基于感测的温度调节到目标组织的光的传送。另一种方法包括用光学光导将光传送到目标组织，并用感测电极感测生物电信号，其中光学光导和感测电极各自包括在电磁场中基本上不产生感应电流的材料。另一种方法包括将光从光学刺激装置的光源传送到光学刺激装置的窗口，将光从窗口传送到光学连接到窗户的光学导光板，并经由光学光导。

3. 发明申请

US20110125078A1 OPTICAL STIMULATION THERAPY 审中-公开
标题翻译：光刺激治疗
公开(公告)号：US20110125078A1
公开(公告)日：2011-05-26
申请号：US12951852
申请日：2010-11-22
申请人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton , John G. Keimel
发明人： Timothy J. Denison , Kunal Paralikar , Gordon O. Munns , Wesley A. Santa , Peng Cong , Christian S. Nielsen , John D. Norton , John G. Keimel
IPC分类号： A61M37/00 , A61N5/06
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2018/00839 , A61M5/14276 , A61N1/086 , A61N1/365 , A61N5/062 , A61N5/0622 , A61N2005/0612 , A61N2005/0626 , A61N2005/063 , A61N2005/0651
摘要： A method for delivering optical stimulation comprises transfecting a target tissue with a light-sensitive channel protein sensitive to light in a wavelength range, delivering light in the wavelength range to the target tissue via an optical stimulation device, substantially simultaneously with delivering light to the target tissue, sensing bioelectric signals, determining a patient therapeutic state based on the bioelectric signals, and adjusting the delivery of the light to the target tissue based on the sensed patient therapeutic state.
摘要翻译：用于递送光学刺激的方法包括用对波长范围内的光敏感的光敏通道蛋白转染靶组织，通过光学刺激装置将波长范围内的光传送到目标组织，基本上同时将光传递到靶组织，感测生物电信号，基于生物电信号确定患者治疗状态，以及基于感测到的患者治疗状态来调整到目标组织的光的传送。

4. 发明授权

US09149635B2 Stimulation waveform generator for an implantable medical device 有权
标题翻译：用于植入式医疗设备的刺激波形发生器
公开(公告)号：US09149635B2
公开(公告)日：2015-10-06
申请号：US13458109
申请日：2012-04-27
申请人： Timothy J. Denison , Robert W. Hocken, Jr. , Gabriela C. Molnar , Wesley A. Santa , Jalpa S. Shah , Larry E. Tyler
发明人： Timothy J. Denison , Robert W. Hocken, Jr. , Gabriela C. Molnar , Wesley A. Santa , Jalpa S. Shah , Larry E. Tyler
IPC分类号： A61N1/36 , A61N1/378
CPC分类号： A61N1/36125 , A61N1/378 , A61N1/3787
摘要： This disclosure describes techniques for generating stimulation current pulses that have differing pulse shapes in a medical device. A circuit architecture is described that is configured to charge a capacitor to an initial amount of charge, modulate the amount of charge stored in the capacitor based on a control signal, and generate a stimulation current pulse that has an amplitude based on the amount charge stored in the capacitor. The circuit architecture may be configured to generate complex pulse shapes, such as, e.g., steps, ramps, bursts, and combinations thereof.
摘要翻译：本公开描述了用于在医疗装置中产生具有不同脉冲形状的刺激电流脉冲的技术。描述了一种电路架构，其被配置为基于控制信号对电容器充电至初始电荷量，并且基于控制信号调制存储在电容器中的电荷量，并且产生具有基于存储的电荷量的幅度的刺激电流脉冲在电容器中。电路架构可以被配置为产生复数脉冲形状，例如步骤，斜坡，脉冲串及其组合。

5. 发明申请

US20100327887A1 CHOPPER-STABILIZED INSTRUMENTATION AMPLIFIER FOR IMPEDANCE MEASUREMENT 有权
标题翻译：用于阻抗测量的CHOPPER-STABILIZED INSTRUMENTATION AMPLIFIER
公开(公告)号：US20100327887A1
公开(公告)日：2010-12-30
申请号：US12872552
申请日：2010-08-31
申请人： Timothy J. Denison , Wesley A. Santa
发明人： Timothy J. Denison , Wesley A. Santa
IPC分类号： G01R27/08 , G01R19/00 , G01R19/18 , A61N1/00
CPC分类号： A61B5/0002 , A61B5/04004 , A61B5/0428 , A61B5/053 , A61B5/103 , A61B5/7203 , A61B5/7228 , A61B2560/0209 , A61N1/36521 , A61N1/3702 , A61N1/3704 , A61N2001/083 , H03F1/26 , H03F3/387 , H03F3/45183 , H03F3/45192 , H03F3/45475 , H03F3/45744 , H03F3/45968 , H03F2200/153 , H03F2200/252 , H03F2200/261 , H03F2200/271 , H03F2200/372 , H03F2200/375 , H03F2203/45028 , H03F2203/45138 , H03F2203/45212 , H03F2203/45264 , H03F2203/45396 , H03F2203/45512 , H03F2203/45534 , H03F2203/45551
摘要： In general, this disclosure is directed to a mixer amplifier that can be utilized within a chopper stabilized instrumentation amplifier. The chopper stabilized instrumentation amplifier may be used for physiological signal sensing, impedance sensing, telemetry or other test and measurement applications. In some examples, the mixer amplifier may include a current source configured to generate a modulated current at a modulation frequency for application to a load to produce an input signal, an amplifier configured to amplify the input signal to produce an amplified signal, and a demodulator configured to demodulate the amplified signal at the modulation frequency to produce an output signal indicating an impedance of the load.
摘要翻译：通常，本公开涉及可以在斩波稳定仪表放大器内使用的混频器放大器。斩波器稳定仪表放大器可用于生理信号感测，阻抗检测，遥测或其他测试和测量应用。在一些示例中，混频器放大器可以包括电流源，其被配置为以调制频率产生用于施加到负载以产生输入信号的调制电流，被配置为放大输入信号以产生放大信号的放大器和解调器被配置为以调制频率解调放大的信号以产生指示负载的阻抗的输出信号。

6. 发明申请

US20100033240A1 CHOPPER-STABILIZED INSTRUMENTATION AMPLIFIER FOR IMPEDANCE MEASUREMENT 审中-公开
标题翻译：用于阻抗测量的CHOPPER-STABILIZED INSTRUMENTATION AMPLIFIER
公开(公告)号：US20100033240A1
公开(公告)日：2010-02-11
申请号：US12579276
申请日：2009-10-14
申请人： Timothy J. Denison , Wesley A. Santa
发明人： Timothy J. Denison , Wesley A. Santa
IPC分类号： H03F1/02
CPC分类号： H03F3/387 , A61B5/0002 , A61B5/04004 , A61B5/0428 , A61B5/053 , A61B5/103 , A61B5/7203 , A61B5/7217 , A61B5/7228 , A61B2560/0209 , A61N1/36521 , A61N1/3702 , A61N1/3704 , A61N2001/083 , H03F1/26 , H03F3/45183 , H03F3/45192 , H03F3/45475 , H03F3/45744 , H03F3/45968 , H03F2200/153 , H03F2200/252 , H03F2200/261 , H03F2200/271 , H03F2200/372 , H03F2200/375 , H03F2203/45028 , H03F2203/45138 , H03F2203/45212 , H03F2203/45264 , H03F2203/45396 , H03F2203/45512 , H03F2203/45534 , H03F2203/45551
摘要： This disclosure describes a chopper stabilized instrumentation amplifier. The amplifier is configured to achieve stable measurements at low frequency with very low power consumption. The instrumentation amplifier uses a differential architecture and a mixer amplifier to substantially eliminate noise and offset from an output signal produced by the amplifier. Dynamic limitations, i.e., glitching, that result from chopper stabilization at low power are substantially eliminated through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the amplifier operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. The amplifier can be used in a low power system, such as an implantable medical device, to provide a stable, low-noise output signal.
摘要翻译：本公开描述了一种斩波稳定仪表放大器。放大器被配置为以低功耗实现稳定的低频测量。仪表放大器使用差分架构和混频器放大器来基本上消除由放大器产生的输出信号的噪声和偏移。通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除了在低功率下由斩波器稳定所产生的动态限制，即，短路。放大器的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或外部信号的最小混叠进入信号通路。该放大器可用于诸如可植入医疗设备的低功率系统中，以提供稳定的低噪声输出信号。

7. 发明授权

US07622988B2 Chopper-stabilized instrumentation amplifier for impedance measurement 有权
标题翻译：用于阻抗测量的斩波稳定仪表放大器
公开(公告)号：US07622988B2
公开(公告)日：2009-11-24
申请号：US12058066
申请日：2008-03-28
申请人： Timothy J. Denison , Wesley A. Santa
发明人： Timothy J. Denison , Wesley A. Santa
IPC分类号： H03F1/02
CPC分类号： H03F3/387 , A61B5/0002 , A61B5/04004 , A61B5/0428 , A61B5/053 , A61B5/103 , A61B5/7203 , A61B5/7217 , A61B5/7228 , A61B2560/0209 , A61N1/36521 , A61N1/3702 , A61N1/3704 , A61N2001/083 , H03F1/26 , H03F3/45183 , H03F3/45192 , H03F3/45475 , H03F3/45744 , H03F3/45968 , H03F2200/153 , H03F2200/252 , H03F2200/261 , H03F2200/271 , H03F2200/372 , H03F2200/375 , H03F2203/45028 , H03F2203/45138 , H03F2203/45212 , H03F2203/45264 , H03F2203/45396 , H03F2203/45512 , H03F2203/45534 , H03F2203/45551
摘要： This disclosure describes a chopper stabilized instrumentation amplifier. The amplifier is configured to achieve stable measurements at low frequency with very low power consumption. The instrumentation amplifier uses a differential architecture and a mixer amplifier to substantially eliminate noise and offset from an output signal produced by the amplifier. Dynamic limitations, i.e., glitching, that result from chopper stabilization at low power are substantially eliminated through a combination of chopping at low impedance nodes within the mixer amplifier and feedback. The signal path of the amplifier operates as a continuous time system, providing minimal aliasing of noise or external signals entering the signal pathway at the chop frequency or its harmonics. The amplifier can be used in a low power system, such as an implantable medical device, to provide a stable, low-noise output signal.
摘要翻译：本公开描述了一种斩波稳定仪表放大器。放大器被配置为以低功耗实现稳定的低频测量。仪表放大器使用差分架构和混频器放大器来基本上消除由放大器产生的输出信号的噪声和偏移。通过在混频放大器和反馈中的低阻抗节点处的斩波的组合，基本上消除了在低功率下由斩波器稳定所产生的动态限制，即，短路。放大器的信号路径作为连续时间系统工作，在斩波频率或其谐波处提供噪声或外部信号的最小混叠进入信号通路。该放大器可用于诸如可植入医疗设备的低功率系统中，以提供稳定的低噪声输出信号。

8. 发明授权

US09615744B2 Chopper-stabilized instrumentation amplifier for impedance measurement 有权
公开(公告)号：US09615744B2
公开(公告)日：2017-04-11
申请号：US12872552
申请日：2010-08-31
申请人： Timothy J. Denison , Wesley A. Santa
发明人： Timothy J. Denison , Wesley A. Santa
IPC分类号： H03F1/02 , A61B5/00 , A61B5/04 , A61B5/0428 , A61B5/053 , A61N1/37 , H03F1/26 , H03F3/387 , H03F3/45 , A61B5/103 , A61N1/365 , A61N1/08
CPC分类号： A61B5/0002 , A61B5/04004 , A61B5/0428 , A61B5/053 , A61B5/103 , A61B5/7203 , A61B5/7228 , A61B2560/0209 , A61N1/36521 , A61N1/3702 , A61N1/3704 , A61N2001/083 , H03F1/26 , H03F3/387 , H03F3/45183 , H03F3/45192 , H03F3/45475 , H03F3/45744 , H03F3/45968 , H03F2200/153 , H03F2200/252 , H03F2200/261 , H03F2200/271 , H03F2200/372 , H03F2200/375 , H03F2203/45028 , H03F2203/45138 , H03F2203/45212 , H03F2203/45264 , H03F2203/45396 , H03F2203/45512 , H03F2203/45534 , H03F2203/45551
摘要： In general, this disclosure is directed to a mixer amplifier that can be utilized within a chopper stabilized instrumentation amplifier. The chopper stabilized instrumentation amplifier may be used for physiological signal sensing, impedance sensing, telemetry or other test and measurement applications. In some examples, the mixer amplifier may include a current source configured to generate a modulated current at a modulation frequency for application to a load to produce an input signal, an amplifier configured to amplify the input signal to produce an amplified signal, and a demodulator configured to demodulate the amplified signal at the modulation frequency to produce an output signal indicating an impedance of the load.

9. 发明授权

US08478402B2 Determining intercardiac impedance 有权
标题翻译：确定心脏阻力
公开(公告)号：US08478402B2
公开(公告)日：2013-07-02
申请号：US12263346
申请日：2008-10-31
申请人： John D. Wahlstrand , Timothy J. Denison , Wesley A. Santa
发明人： John D. Wahlstrand , Timothy J. Denison , Wesley A. Santa
IPC分类号： A61N1/00
CPC分类号： A61B5/053 , A61B5/026 , A61B5/0538 , A61B5/6846 , A61B5/7217 , A61N1/36521
摘要： A system and method for determining complex intercardiac impedance to detect various cardiac functions are disclosed involving a signal generator means for providing an adjustable direct current signal, a modulator for modulating the adjustable direct current signal to produce a modulated signal, at least one electrode for propagating the modulated signal across a myocardium, at least one sensor for detecting an outputted modulated signal from the myocardium, and at least one circuit to reduce the influence of process noise (aggressors) in the outputted modulated signal. The at least one circuit comprises an amplifier, a demodulator, and an integrator. The amplitude and phase of the final outputted modulated signal indicate the complex impedance of the myocardium. Changes in the complex impedance patterns of the myocardium provide indication of reduced oxygen and blood flow to the myocardium. The apparatus can be employed in implantable devices, including cardiac pacemakers and implantable cardioverter defibrillators.
摘要翻译：公开了一种用于确定复杂心脏阻抗以检测各种心脏功能的系统和方法，其涉及用于提供可调节直流电流信号的信号发生器装置，用于调制可调直流电信号以产生调制信号的调制器，用于传播的至少一个电极跨越心肌的调制信号，用于检测来自心肌的输出的调制信号的至少一个传感器，以及至少一个电路，以减少输出的调制信号中的过程噪声（侵略者）的影响。所述至少一个电路包括放大器，解调器和积分器。最终输出的调制信号的振幅和相位表示心肌的复阻抗。心肌复合阻抗模式的变化提供氧气和血液流向心肌的指示。该装置可用于可植入装置，包括心脏起搏器和可植入的心律转复除颤器。

10. 发明申请

US20080269630A1 Seizure prediction 有权
标题翻译：缉获预测
公开(公告)号：US20080269630A1
公开(公告)日：2008-10-30
申请号：US11799031
申请日：2007-04-30
申请人： Timothy J. Denison , Wesley A. Santa
发明人： Timothy J. Denison , Wesley A. Santa
IPC分类号： A61B5/04
CPC分类号： A61B5/053 , A61B5/024 , A61B5/0402 , A61B5/0478 , A61B5/0488 , A61B5/4094 , A61B5/4839 , A61B5/7203 , A61B5/7225 , A61B5/7228 , A61B5/7275 , A61N1/08 , A61N1/36025 , A61N1/36082 , G06F19/00
摘要： Seizure prediction systems and methods include measuring impedance and a potential within a brain of a patient to determine whether the brain is in a state indicative of a possibility of seizure. In some embodiments, at least one of the measured impedance or the measured potential may be used as a primary indication of the brain state indicative of a possibility of seizure. In one embodiment, if one of the measured impedance or the measured potential indicates a seizure, the other measurement (impedance or potential) may be used to validate whether the brain is in the state indicative of the possibility of seizure.
摘要翻译：缉获预测系统和方法包括测量患者的脑中的阻抗和潜力，以确定大脑是否处于指示癫痫发作可能性的状态。在一些实施例中，测量的阻抗或测量电位中的至少一个可以用作指示发作可能性的脑状态的主要指示。在一个实施例中，如果所测量的阻抗或测量的电位之一表示发作，则可以使用另一测量（阻抗或电位）来验证大脑是否处于表示发作可能性的状态。

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