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1. 发明授权

US4797287A Cylindrical microtablets 失效
标题翻译：圆柱形微片
公开(公告)号：US4797287A
公开(公告)日：1989-01-10
申请号：US45194
申请日：1987-04-30
申请人： Claus H. Pich , Thomas Moest
发明人： Claus H. Pich , Thomas Moest
IPC分类号： A61J3/10 , A61K9/16 , A61K9/20 , A61K9/28 , B30B11/00 , B30B11/08 , B30B15/00
CPC分类号： B30B15/0094 , A61J3/10 , A61K9/2072 , A61K9/2866 , B30B11/005 , B30B11/08
摘要： Cylindrical microtablets which have a convex upper face and a convex lower face and whose cylinder diameter and height independently of one another are each from 1.0 to 2.5 mm and the ratio of the said diameter to said height is from 1:0.5 to 1:1.5, and a process for their preparation.
摘要翻译：具有凸上表面和凸下表面以及圆柱体直径和高度彼此独立的圆柱形微片分别为1.0至2.5mm，所述直径与所述高度之比为1:0.5至1:1.5，及其准备过程。

2. 发明授权

US5160469A Manufacture of pellets of xanthine derivatives 失效
标题翻译： XANTHINE衍生物颗粒的制备
公开(公告)号：US5160469A
公开(公告)日：1992-11-03
申请号：US578442
申请日：1990-09-07
申请人： Thomas Moest , Claus H. Pich
发明人： Thomas Moest , Claus H. Pich
IPC分类号： A61K9/16 , A61K9/20 , A61K9/32 , A61K9/52 , A61K31/52
CPC分类号： A61K9/1688 , A61K31/52
摘要： A process for the manufacture of pellets which are composed of xanthine derivatives and are predominantly spherical, have a particle size in the range of 0.3 to 4 mm and have a bulk density above 0.5 g/cm.sup.3 by reacting the appropriate xanthine derivative with water or a water/alcohol mixture, entails anhydrous powdered xanthine derivative with an average particle size of from 20 to 200 .mu.m being suspended by stirring at from 40.degree. to 70.degree. C. in a nonsolvent which is immiscible with water and has a boiling point in the range from 60.degree. to 160.degree. C., then adding from 10 to 40% by weight, based on the anhydrous xanthine derivative, of water or a water/alcohol mixture and subsequently allowing to cool to room temperature at from 5.degree. to 20.degree. C. per hour, it being possible to reduce the stirring speed after agglomeration to about 1/3 to 2/3 of the original, and the pellets being separated from the liquid and dried, the pellets being used, possibly with a delayed release coating, as active compound in a drug.
摘要翻译：制造由黄嘌呤衍生物构成的并且主要为球形的颗粒的方法具有0.3-4mm的粒径，并且通过使适当的黄嘌呤衍生物与水或水/醇混合物，使平均粒度为20〜200μm的无水粉末黄嘌呤衍生物在40℃至70℃下搅拌悬浮，在与水不混溶的非溶剂中，并且沸点在范围为60〜160℃，然后以无水黄嘌呤衍生物为基础，以无水黄嘌呤衍生物为10〜40重量％的水或水/醇混合物，然后在5〜20℃下冷却至室温。每小时可以将凝聚后的搅拌速度降低到原料的约1/3至2/3，并将颗粒与液体分离并干燥，使用颗粒，可能具有延迟释放涂层，as 药物中的活性化合物。

3. 发明授权

US4828843A Cylindrical microtablets 失效
标题翻译：圆柱形微片
公开(公告)号：US4828843A
公开(公告)日：1989-05-09
申请号：US210852
申请日：1988-06-24
申请人： Claus H. Pich , Thomas Moest
发明人： Claus H. Pich , Thomas Moest
IPC分类号： A61J3/10 , A61K9/16 , A61K9/20 , A61K9/28 , B30B11/00 , B30B11/08 , B30B15/00
CPC分类号： B30B15/0094 , A61J3/10 , A61K9/2072 , A61K9/2866 , B30B11/005 , B30B11/08
摘要： Cylindrical microtablets which have a convex upper face and a convex lower face and whose cylinder diameter and height independently of one another are each from 1.0 to 2.5 mm and the ratio of the said diameter to said height is from 1:0.5 to 1:1.5, an a process for their preparation.
摘要翻译：具有凸上表面和凸下表面以及圆柱体直径和高度彼此独立的圆柱形微片分别为1.0至2.5mm，所述直径与所述高度之比为1:0.5至1:1.5，一个他们准备的过程。

4. 发明授权

US4632843A Process for the preparation of solid pharmaceutical products 失效
标题翻译：固体药物制剂的制备方法
公开(公告)号：US4632843A
公开(公告)日：1986-12-30
申请号：US581714
申请日：1984-02-21
申请人： Claus H. Pich , Thomas Moest
发明人： Claus H. Pich , Thomas Moest
IPC分类号： C07C67/055 , A61K9/16 , A61K9/54 , A61K31/26 , A61K33/06 , A61K33/14 , C01D3/22 , C01F5/40 , C01G49/14 , C07C51/00 , C07C51/43 , C07C67/00 , C30B7/08 , C30B29/60 , A61K9/48
CPC分类号： A61K9/1688 , C30B7/00 , Y10S514/951 , Y10S514/963 , Y10S514/965
摘要： A process for the preparation of solid pharmaceutical products, wherein, in a first step, spherical single crystals of a pharmaceutical active compound or assistant are prepared by agitating a saturated aqueous, organic or organic-aqueous solution in high speed stirred crystallizers or draft-tube crystallizers at 50-500 revolutions per minute and seeding the solution with finely ground seed crystals of particle size less than 100 .mu.m, while ensuring that at the time of addition of the seed crystals and during the growth thereof the solution is at all times only minimally supersaturated, this being achieved by slow cooling at a rate of not more than 50 K/h or corresponding slow evaporation of the solution, and in a second step the resulting spherical single crystals with diameters of 0.1-3 mm, preferably 0.5-2 mm, are separated from the solution, dried at 40.degree.-200.degree. C., compounded, where appropriate, with suitable pharmaceutical assistants or, if the single crystals serve as assistants, with suitable pharmaceutical active compounds, and then converted to solid pharmaceutical products by coating, tableting or filling into hard gelatin capsules.
摘要翻译：一种制备固体药物产品的方法，其中在第一步中，通过在高速搅拌结晶器或引流管中搅拌饱和水溶液，有机或有机水溶液来制备药物活性化合物或助剂的球形单晶结晶器以50-500转/分钟的速度接种，并用晶粒尺寸小于100微米的精细研磨晶种接种溶液，同时确保在加入晶种时，在其生长过程中溶液始终处于最低限度过饱和，这是通过以不超过50K / h的速度缓慢冷却或相应的溶液缓慢蒸发来实现的，而在第二步中，得到的直径为0.1-3mm，优选为0.5-2的球形单晶 mm，与溶液分离，在40℃-200℃下干燥，在合适的情况下，用合适的药物助剂混合，或者如果单晶作为助剂与合适的药物活性化合物混合，然后通过涂布，压片或填充到硬明胶胶囊中转化为固体药物产品。

5. 发明授权

US4340614A Stringently sodium-restricted dietetic salt and its preparation 失效
标题翻译：严格限钠饮食及其制备
公开(公告)号：US4340614A
公开(公告)日：1982-07-20
申请号：US267870
申请日：1981-05-28
申请人： Claus H. Pich , Thomas Moest
发明人： Claus H. Pich , Thomas Moest
IPC分类号： A23L27/23 , A23L27/40 , A23L1/237
CPC分类号： A23L27/45 , A23L27/235
摘要： A stringently sodium-restricted dietetic salt consisting of a mixture of from 60 to 85% by weight of potassium chloride, from 10 to 30% by weight of potassium adipate, from 2 to 5% by weight of potassium tartrate, from 0.5 to 2% by weight of potassium glutamate, from 0.5 to 2% by weight of adipic acid and a total of from 0.004 to 0.06% by weight of potassium inosate and/or potassium guanylate, and the preparation of the salt in a fluidized bed apparatus.
摘要翻译：严格的钠限制饮食盐，其由60至85重量％的氯化钾，10至30重量％的己二酸钾，2至5重量％的酒石酸钾，0.5至2重量％的谷氨酸钾，0.5至2重量％的己二酸和总计0.004至0.06重量％的氢氧化钾和/或鸟苷酸钾，以及在流化床装置中制备该盐。

6. 发明授权

US09107966B2 Method for reducing the viral and microbial load of biological extracts containing solids 有权
标题翻译：减少包含固体的生物提取物的病毒和微生物负荷的方法
公开(公告)号：US09107966B2
公开(公告)日：2015-08-18
申请号：US13060712
申请日：2009-08-27
申请人： Christian Rämsch , Thomas Schräder , Thomas Moest , Manfred Kurfürst
发明人： Christian Rämsch , Thomas Schräder , Thomas Moest , Manfred Kurfürst
IPC分类号： C12N9/00 , A23L1/305 , A23L1/28 , A61L2/00 , C12N9/94 , A61K38/00
CPC分类号： A61L2/0011 , A61K38/00 , C12N9/94
摘要： The invention is a method for reducing the viral and microbial content of biological extracts which contain solids. The method comprises the steps of, (1), providing a biological extract which contains solids that comprise a biologically active substance, selected from enzymes, proteins and peptides, or a mixture of such substances; and (2) subjecting the biological extract to a high-pressure treatment; wherein the biological activity of the biological extract after the high-pressure treatment is at least 50% of the biological activity of the biological extract before the high-pressure treatment.
摘要翻译：本发明是减少含有固体的生物提取物的病毒和微生物含量的方法。该方法包括以下步骤：（1）提供含有选自酶，蛋白质和肽或这些物质的混合物的生物活性物质的固体的生物提取物; 和（2）对生物提取物进行高压处理; 其中，高压处理后的生物提取物的生物活性为高压处理前生物提取物的生物活性的至少50％。

7. 发明授权

US06811054B1 Dosing spoon for micro-tablets 有权
标题翻译：微量滴定汤匙
公开(公告)号：US06811054B1
公开(公告)日：2004-11-02
申请号：US10009061
申请日：2002-04-11
申请人： Thomas Moest , Ludwig Matz
发明人： Thomas Moest , Ludwig Matz
IPC分类号： G07F1156
CPC分类号： A61J7/0023 , A61J7/0053 , A61J7/02
摘要： A dosing spoon for microtablets is described for which the lower part (1) of the spoon consists of an even polygone which possesses a border (2) on all sides with exception of one side and whereby the polygone has a number of individual recesses (3) which are formed in such a way that an individual microtablet fits in each individual recess.
摘要翻译：描述了用于微片的计量匙，其中勺子的下部（1）由均匀的多边形组成，除了一侧之外，所有侧面都具有边界（2），并且由此多边形具有多个单独的凹部（3 ），其以这样的方式形成，使得各个微片安装在每个单独的凹部中。

8. 发明申请

US20120213857A1 Method for Producing Pancreatin Pellets 有权
标题翻译：生产胰岛素颗粒的方法
公开(公告)号：US20120213857A1
公开(公告)日：2012-08-23
申请号：US13368415
申请日：2012-02-08
申请人： Thomas Moest , Walter Doleschal , Manfred Kurfürst
发明人： Thomas Moest , Walter Doleschal , Manfred Kurfürst
IPC分类号： A61K9/14 , A61P1/18 , B29B9/00 , A61K38/54
CPC分类号： A61K9/1688 , A61K9/5021 , A61K9/5073 , A61K9/5089 , A61K35/39 , A61K38/00 , A61K38/48 , C12N9/94
摘要： In order to avoid compromising the pharmacological effect of pancreatin caused by the addition of auxiliary materials or binding agents, a pancreatin pellet having a 100% pancreatin content consists exclusively of pancreatin with a residual moisture content of less than 3% by weight, preferably less than 1% by weight or less than 0.5% by weight.
摘要翻译：为了避免由于添加辅助材料或粘合剂而导致的胰酶的药理作用的损害，具有100％胰酶含量的胰酶颗粒仅由胰酶组成，残留水分含量小于3重量％，优选小于 1重量％或小于0.5重量％。

9. 发明授权

US5320852A Antacid microtablets 失效
标题翻译：抗酸微片
公开(公告)号：US5320852A
公开(公告)日：1994-06-14
申请号：US987559
申请日：1992-12-08
申请人： Thomas Moest
发明人： Thomas Moest
IPC分类号： A61J3/10 , A61K9/20 , A61K33/06 , A61K33/10 , A61K45/08 , A61P1/00 , A61K33/08 , A61K33/12
CPC分类号： A61K33/06 , A61K9/2072 , Y10S514/819 , Y10S514/96
摘要： A biconvex tablet whose height and diameter are approximately equal and are from 1.5 to 4 mm and which, besides conventional pharmaceutical auxiliaries, contains an antacid as active substance is described.
摘要翻译：描述了其高度和直径近似相等并且为1.5至4mm的双凸片，并且除了常规药物助剂之外，还含有作为活性物质的抗酸剂。

10. 发明授权

US08283147B2 Pancreatin and method for reducing the viral and microbial contamination of pancreatin 有权
标题翻译：胰蛋白酶和减少胰腺炎病毒和微生物污染的方法
公开(公告)号：US08283147B2
公开(公告)日：2012-10-09
申请号：US12403697
申请日：2009-03-13
申请人： Manfred Kurfürst , Christian Rämsch , Thomas Schräder , Thomas Moest
发明人： Manfred Kurfürst , Christian Rämsch , Thomas Schräder , Thomas Moest
IPC分类号： C12N9/94
CPC分类号： C12N9/94 , A61L2/0023
摘要： The invention relates to a method for producing pancreatin with reduced viral and microbial contamination, comprising the steps of (a) providing the pancreatin in solid form with a residual moisture of 0.5 weight % or less, down to almost zero, based on the pancreatin provided; (b) subjecting the pancreatin provided in step (a) to a heat treatment at a temperature of 84° C., preferably 80° C. and below; wherein, the biological activity of the pancreatin obtained in step (b) corresponds to at least 50% of the biological activity of the pancreatin provided in step (a); and the viral infectiousness of the pancreatin obtained in step (b) has been reduced by a factor of more than 1 log10 in comparison with the viral infectiousness of the pancreatin provided in step (a), as well as a pancreatin produced according to this method and its use for producing a medicine or a nutritional supplement.
摘要翻译：本发明涉及一种生产具有减少的病毒和微生物污染的胰酶的方法，其包括以下步骤：（a）基于所提供的胰酶，提供固体形式的胰酶，残留水分为0.5重量％或更少，至少几乎为零 ; （b）使步骤（a）中提供的胰酶在84℃，优选80℃及以下的温度下进行热处理; 其中，步骤（b）中获得的胰酶的生物活性对应于步骤（a）中提供的胰酶的生物活性的至少50％。与步骤（a）中提供的胰酶的病毒感染性相比，步骤（b）中获得的胰酶的病毒感染性已经降低了大于1log10的因子，以及根据该方法制备的胰酶及其用于生产药物或营养补充剂的用途。

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