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1. 发明授权

US08855765B2 Fault tolerant methods and architectures for embedded intelligence in medical leads 有权
标题翻译：用于医疗线索嵌入式智能的容错方法和体系结构
公开(公告)号：US08855765B2
公开(公告)日：2014-10-07
申请号：US13156632
申请日：2011-06-09
申请人： Thomas H. Spear , Nancy M. Germanson , Patrick D. Miller
发明人： Thomas H. Spear , Nancy M. Germanson , Patrick D. Miller
IPC分类号： A61N1/08 , A61N1/05 , A61N1/04 , A61B5/0402 , A61B5/00
CPC分类号： A61N1/056 , A61B5/0402 , A61B5/7217 , A61N1/0488 , A61N1/08 , A61N2001/083
摘要： The present disclosure pertains to methods, devices and systems for detection of a lead-related condition in a medical electrical lead. In accordance with the disclosure, a physiological waveform interpreter module embedded within the lead functions to sense the occurrence of a cardiac event and to generate a minimal impact signal. In an example implementation, the physiological waveform interpreter module is disposed proximate to the sensing site or vicinity of cardiac signals. The physiological waveform interpreter module transmits the minimal impact signal that may include one or more predetermined properties to a remotely located lead monitoring module upon sensing a cardiac event. The lead monitoring module receives and processes the minimal impact signal to determine whether a cardiac depolarization has occurred and simultaneously verify the integrity of the transmission medium.
摘要翻译：本公开涉及用于检测医疗电线中的引线相关状况的方法，装置和系统。根据本公开，嵌入在引线内的生理波形解释器模块用于感测心脏事件的发生并产生最小的冲击信号。在示例实现中，生理波形解释器模块设置在心脏信号的感测位置附近。生理波形解释器模块在感测到心脏事件时将可能包括一个或多个预定属性的最小影响信号发送到位于远程的引导监视模块。引导监测模块接收并处理最小影响信号，以确定心脏去极化是否发生，并同时验证传输介质的完整性。

2. 发明授权

US08798751B2 Method and apparatus to manage lead-related conditions for fault tolerance enhancements 有权
标题翻译：管理引线相关条件以进行容错增强的方法和设备
公开(公告)号：US08798751B2
公开(公告)日：2014-08-05
申请号：US13156660
申请日：2011-06-09
申请人： Thomas H. Spear , Nancy M. Germanson , Patrick D. Miller
发明人： Thomas H. Spear , Nancy M. Germanson , Patrick D. Miller
IPC分类号： A61N1/37
CPC分类号： A61N1/37 , A61N1/3925 , A61N2001/083
摘要： The disclosure describes methods and devices for providing early indicators of a lead-related condition in a medical electrical lead. Among other things, the methods and devices will detect, obtain, or provide indicators of static or intermittent disruptions in a conductive pathway of the lead based on changes in conductive continuity properties of a medical electrical lead. The conductive behaviors and properties will be managed to facilitate signal stability and fidelity. In some embodiments, the methods and devices may include functions to enable one or more of monitoring a lead's conductive pathway, detecting static and transient behaviors of the conductive pathway, stabilizing the monitored pathway, reconfiguring the pathway, and providing lead-related condition data to an associated implantable medical device. The early indicators may be generated in a real-time, continuous manner to provide early detection and notification of lead degradation.
摘要翻译：本公开描述了用于提供医疗电引线中引线相关状况的早期指示的方法和装置。除其他之外，所述方法和装置将基于医疗电引线的导电连续性的变化来检测，获得或提供导线的导电路径中的静态或间歇性中断的指标。导电行为和性能将被管理，以促进信号的稳定性和保真度。在一些实施例中，所述方法和装置可以包括以下功能：使一个或多个监测导联的导电通路，检测导电通路的静态和瞬时行为，稳定所监测的途径，重新配置该途径，以及提供与铅相关的条件数据相关的可植入医疗装置。早期指标可能会以实时，连续的方式产生，以提供铅降解的早期检测和通知。

3. 发明申请

US20120316621A1 Method and Apparatus to Manage Lead-Related Conditions for Fault Tolerance Enhancements 有权
标题翻译：管理容错增强的铅相关条件的方法和装置
公开(公告)号：US20120316621A1
公开(公告)日：2012-12-13
申请号：US13156660
申请日：2011-06-09
申请人： Thomas H. Spear , Nancy M. Germanson , Patrick D. Miller
发明人： Thomas H. Spear , Nancy M. Germanson , Patrick D. Miller
IPC分类号： A61N1/36
CPC分类号： A61N1/37 , A61N1/3925 , A61N2001/083
摘要： The disclosure describes methods and devices for providing early indicators of a lead-related condition in a medical electrical lead. Among other things, the methods and devices will detect, obtain, or provide indicators of static or intermittent disruptions in a conductive pathway of the lead based on changes in conductive continuity properties of a medical electrical lead. The conductive behaviors and properties will be managed to facilitate signal stability and fidelity. In some embodiments, the methods and devices may include functions to enable one or more of monitoring a lead's conductive pathway, detecting static and transient behaviors of the conductive pathway, stabilizing the monitored pathway, reconfiguring the pathway, and providing lead-related condition data to an associated implantable medical device. The early indicators may be generated in a real-time, continuous manner to provide early detection and notification of lead degradation.
摘要翻译：本公开描述了用于提供医疗电引线中引线相关状况的早期指示的方法和装置。除其他之外，所述方法和装置将基于医疗电引线的导电连续性的变化来检测，获得或提供导线的导电路径中的静态或间歇性中断的指标。导电行为和性能将被管理，以促进信号的稳定性和保真度。在一些实施例中，所述方法和装置可以包括以下功能：使一个或多个监测导联的导电通路，检测导电通路的静态和瞬时行为，稳定所监测的途径，重新配置该途径，以及提供与铅相关的条件数据相关的可植入医疗装置。早期指标可能以实时，连续的方式产生，以提供早期检测和通知铅降解。

4. 发明申请

US20120316416A1 Fault Tolerant Methods and Architectures for Embedded Intelligence in Medical Leads 有权
标题翻译：医疗领域嵌入式智能的容错方法和架构
公开(公告)号：US20120316416A1
公开(公告)日：2012-12-13
申请号：US13156632
申请日：2011-06-09
申请人： Thomas H. Spear , Nancy M. Germanson , Patrick D. Miller
发明人： Thomas H. Spear , Nancy M. Germanson , Patrick D. Miller
IPC分类号： A61B5/042
CPC分类号： A61N1/056 , A61B5/0402 , A61B5/7217 , A61N1/0488 , A61N1/08 , A61N2001/083
摘要： The present disclosure pertains to methods, devices and systems for detection of a lead-related condition in a medical electrical lead. In accordance with the disclosure, a physiological waveform interpreter module embedded within the lead functions to sense the occurrence of a cardiac event and to generate a minimal impact signal. In an example implementation, the physiological waveform interpreter module is disposed proximate to the sensing site or vicinity of cardiac signals. The physiological waveform interpreter module transmits the minimal impact signal that may include one or more predetermined properties to a remotely located lead monitoring module upon sensing a cardiac event. The lead monitoring module receives and processes the minimal impact signal to determine whether a cardiac depolarization has occurred and simultaneously verify the integrity of the transmission medium.
摘要翻译：本公开涉及用于检测医疗电线中的引线相关状况的方法，装置和系统。根据本公开，嵌入在引线内的生理波形解释器模块用于感测心脏事件的发生并产生最小的冲击信号。在示例实现中，生理波形解释器模块设置在心脏信号的感测位置附近。生理波形解释器模块在感测到心脏事件时将可能包括一个或多个预定属性的最小影响信号发送到位于远程的引导监视模块。引导监测模块接收并处理最小影响信号，以确定心脏去极化是否发生，并同时验证传输介质的完整性。

5. 发明授权

US08577457B2 Isolating lead body for fault detection 有权
标题翻译：隔离铅体进行故障检测
公开(公告)号：US08577457B2
公开(公告)日：2013-11-05
申请号：US13177753
申请日：2011-07-07
申请人： Patrick D. Miller , Thomas H. Spear , Nancy M. Germanson
发明人： Patrick D. Miller , Thomas H. Spear , Nancy M. Germanson
IPC分类号： A61N1/37
CPC分类号： A61B5/042 , A61N1/0587 , A61N1/3706 , A61N2001/083 , G01R31/024
摘要： Techniques are described for detecting lead-related conditions for implantable electrical leads. In some of the described embodiments, an implantable electrical lead assembly is provided with a coupling member for connecting a conductor and associated insulator(s) to an electrode/sensing element. The implantable medical device controls and performs a measurement of an electrical property of the electrical lead during periods when the conductor is decoupled from the electrode/sensing element. An indication of a lead-related condition is derived based on the measured electrical property. The lead-related condition may be associated with an insulator of a lead body of the electrical lead.
摘要翻译：描述了用于检测可植入电引线的铅相关条件的技术。在一些所描述的实施例中，可植入电引线组件设置有用于将导体和相关联的绝缘体连接到电极/感测元件的耦合构件。在导体与电极/感测元件分离的期间，可植入医疗装置控制和执行电引线的电性质的测量。基于测量的电气性质导出铅相关条件的指示。引线相关状态可以与电引线的引线体的绝缘体相关联。

6. 发明授权

US07515961B2 Method and apparatus for dynamically monitoring, detecting and diagnosing lead conditions 有权
标题翻译：用于动态监测，检测和诊断铅条件的方法和装置
公开(公告)号：US07515961B2
公开(公告)日：2009-04-07
申请号：US11119529
申请日：2005-04-29
申请人： Nancy M. Germanson , Thomas H. Spear , Alan R. Braly , Rick D. McVenes
发明人： Nancy M. Germanson , Thomas H. Spear , Alan R. Braly , Rick D. McVenes
IPC分类号： A61N1/08
CPC分类号： A61N1/3706 , A61N1/37258 , A61N2001/083
摘要： The present invention provides diverse methods and apparatus for in vivo monitoring, detecting and/or predicting potential failure modes or deleterious trends of chronically implanted medical electrical leads prior to actual failure of said leads. Certain embodiments of the invention involve applying a relatively increased data sampling rate at various time intervals (e.g., periodically, randomly, and/or manually-triggered and the like) prior to actual detection of a deleterious trend, to thereby increase the probability of detecting one or more parameters indicative of a potential lead performance issue. At least some of the parameters are utilized because they are not typically reliably detected at relatively lower data sampling rates. In addition to an initial relatively increased data sampling rate, certain embodiments provide for adjusting the sampling rate and storing and/or adjusting data pattern template-based data to execute pattern related triggers so that additional information regarding a medical electrical lead can be obtained.
摘要翻译：本发明提供了用于在所述引线的实际故障之前体内监测，检测和/或预测长期植入的医用电线的潜在故障模式或有害趋势的多种方法和装置。本发明的某些实施例涉及在实际检测到有害趋势之前以各种时间间隔（例如，周期性地，随机地和/或手动触发等）应用相对增加的数据采样率，从而增加检测的可能性指示潜在的铅性能问题的一个或多个参数。使用至少一些参数，因为它们通常在相对较低的数据采样率下不可靠地被检测。除了初始相对增加的数据采样率之外，某些实施例提供了调整采样率并存储和/或调整基于数据模式模板的数据以执行与模式相关的触发，从而可以获得关于医疗电线的附加信息。

7. 发明授权

US09539428B2 Isolating lead conductor for fault detection 有权
标题翻译：隔离引线用于故障检测
公开(公告)号：US09539428B2
公开(公告)日：2017-01-10
申请号：US13014965
申请日：2011-01-27
申请人： Nancy M. Germanson , Thomas H. Spear , Patrick David Miller
发明人： Nancy M. Germanson , Thomas H. Spear , Patrick David Miller
IPC分类号： A61N1/37 , A61B6/00 , A61N1/39 , A61N1/08 , G01R31/02
CPC分类号： A61N1/3706 , A61N1/3925 , A61N2001/083 , G01R31/024
摘要： Systems and methods for providing a cardiac stimulus device lead having fault tolerance and fault isolation are disclosed. A medical electrical lead is provided according to one aspect. According to one embodiment, the lead includes a first conductor and a second conductor for transmitting an electrical pulse from a pulse generator. The lead further includes a switching mechanism, a first electrode, and a lead assessment circuit. The switching mechanism selectively couples the first conductor to the first electrode. The first electrode is decoupled during a test phase and the switching mechanism directly couples the first conductor to the second conductor. The lead assessment circuit processes a signal associated with the electrical properties of the lead to determine whether the lead is exhibiting a lead related condition.
摘要翻译：公开了用于提供具有容错和故障隔离的心脏刺激装置引线的系统和方法。根据一个方面提供了医疗用电线。根据一个实施例，引线包括用于从脉冲发生器传输电脉冲的第一导体和第二导体。引线还包括开关机构，第一电极和引线评估电路。切换机构将第一导体选择性地耦合到第一电极。第一电极在测试阶段被解耦，并且开关机构将第一导体直接耦合到第二导体。引线评估电路处理与引线的电性能相关联的信号，以确定引线是否呈现引线相关状态。

8. 发明授权

US08463384B2 Isolated lead conductor measurements for fault detection 有权
标题翻译：用于故障检测的隔离导线测量
公开(公告)号：US08463384B2
公开(公告)日：2013-06-11
申请号：US13015042
申请日：2011-01-27
申请人： Nancy M. Germanson , Thomas H. Spear , Patrick David Miller
发明人： Nancy M. Germanson , Thomas H. Spear , Patrick David Miller
IPC分类号： A61N1/08
CPC分类号： A61N1/0563 , A61N1/3706 , A61N1/3925 , A61N2001/083 , G01R31/021
摘要： This disclosure relates to a medical electrical lead having fault detection and fault isolation. The lead may include a first conductor coupled to a first electrode and a second conductor coupled to a second electrode. A capacitor is disposed within the lead and selectively coupled to the first and second conductors of the lead. The capacitor is charged in a test mode of operation after the first and second electrodes have been isolated from the conductors via an isolation mechanism and the capacitor will discharge through the first and second conductors. The capacitor discharge morphology is processed to detect lead-related conditions.
摘要翻译：本公开涉及具有故障检测和故障隔离的医疗电线。引线可以包括耦合到第一电极的第一导体和耦合到第二电极的第二导体。电容器设置在引线内并选择性地耦合到引线的第一和第二导体。在第一和第二电极经由隔离机构与导体隔离之后，电容器在测试操作模式下充电，并且电容器将通过第一和第二导体放电。处理电容放电形态以检测铅相关条件。

9. 发明申请

US20120197365A1 ISOLATED LEAD CONDUCTOR MEASUREMENTS FOR FAULT DETECTION 有权
标题翻译：用于故障检测的隔离导线导体测量
公开(公告)号：US20120197365A1
公开(公告)日：2012-08-02
申请号：US13015042
申请日：2011-01-27
申请人： Nancy M. Germanson , Thomas H. Spear , Patrick David Miller
发明人： Nancy M. Germanson , Thomas H. Spear , Patrick David Miller
IPC分类号： A61N1/05
CPC分类号： A61N1/0563 , A61N1/3706 , A61N1/3925 , A61N2001/083 , G01R31/021
摘要： This disclosure relates to a medical electrical lead having fault detection and fault isolation. The lead may include a first conductor coupled to a first electrode and a second conductor coupled to a second electrode. A capacitor is disposed within the lead and selectively coupled to the first and second conductors of the lead. The capacitor is charged in a test mode of operation after the first and second electrodes have been isolated from the conductors via an isolation mechanism and the capacitor will discharge through the first and second conductors. The capacitor discharge morphology is processed to detect lead-related conditions.
摘要翻译：本公开涉及具有故障检测和故障隔离的医疗电线。引线可以包括耦合到第一电极的第一导体和耦合到第二电极的第二导体。电容器设置在引线内并选择性地耦合到引线的第一和第二导体。在第一和第二电极经由隔离机构与导体隔离之后，电容器在测试操作模式下充电，并且电容器将通过第一和第二导体放电。处理电容放电形态以检测铅相关条件。

10. 发明申请

US20120197331A1 ISOLATING LEAD CONDUCTOR FOR FAULT DETECTION 有权
标题翻译：隔离导线导体故障检测
公开(公告)号：US20120197331A1
公开(公告)日：2012-08-02
申请号：US13014965
申请日：2011-01-27
申请人： Nancy M. Germanson , Thomas H. Spear , Patrick David Miller
发明人： Nancy M. Germanson , Thomas H. Spear , Patrick David Miller
IPC分类号： A61N1/36 , A61N1/00
CPC分类号： A61N1/3706 , A61N1/3925 , A61N2001/083 , G01R31/024
摘要： Systems and methods for providing a cardiac stimulus device lead having fault tolerance and fault isolation are disclosed. A medical electrical lead is provided according to one aspect. According to one embodiment, the lead includes a first conductor and a second conductor for transmitting an electrical pulse from a pulse generator. The lead further includes a switching mechanism, a first electrode, and a lead assessment circuit. The switching mechanism selectively couples the first conductor to the first electrode. The first electrode is decoupled during a test phase and the switching mechanism directly couples the first conductor to the second conductor. The lead assessment circuit processes a signal associated with the electrical properties of the lead to determine whether the lead is exhibiting a lead related condition.
摘要翻译：公开了用于提供具有容错和故障隔离的心脏刺激装置引线的系统和方法。根据一个方面提供了医疗用电线。根据一个实施例，引线包括用于从脉冲发生器传输电脉冲的第一导体和第二导体。引线还包括开关机构，第一电极和引线评估电路。切换机构将第一导体选择性地耦合到第一电极。第一电极在测试阶段被解耦，并且开关机构将第一导体直接耦合到第二导体。引线评估电路处理与引线的电性能相关联的信号，以确定引线是否呈现引线相关状态。

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