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1. 发明授权

US08620431B2 Prophylactic bactericidal implant 有权
标题翻译：预防性杀菌植入物
公开(公告)号：US08620431B2
公开(公告)日：2013-12-31
申请号：US13417269
申请日：2012-03-11
申请人： Thomas A. Fuller , Richard A. Wysk , Wayne J. Sebastianelli
发明人： Thomas A. Fuller , Richard A. Wysk , Wayne J. Sebastianelli
IPC分类号： A61N1/00
CPC分类号： A61N1/30 , A61B17/60 , A61B17/86 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00734 , A61F2/0077 , A61F2/0095 , A61F2/28 , A61F2/30 , A61F2/30724 , A61F2/30744 , A61F2/30767 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3609 , A61F2/3662 , A61F2/367 , A61F2/3676 , A61F2002/009 , A61F2002/2821 , A61F2002/30235 , A61F2002/30322 , A61F2002/30329 , A61F2002/30354 , A61F2002/30405 , A61F2002/30438 , A61F2002/305 , A61F2002/30535 , A61F2002/30589 , A61F2002/30604 , A61F2002/30668 , A61F2002/30677 , A61F2002/30718 , A61F2002/30795 , A61F2002/30932 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/368 , A61F2002/3692 , A61F2002/482 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2230/0069 , A61F2250/0001 , A61F2250/0026 , A61F2250/0043 , A61F2250/0058 , A61F2310/00029 , A61F2310/00059 , A61F2310/00065 , A61F2310/00071 , A61F2310/00077 , A61F2310/00083 , A61F2310/00107 , A61F2310/00113 , A61F2310/00149 , A61F2310/00155 , A61F2310/00395 , A61F2310/00413 , A61F2310/00449 , A61F2310/00455 , A61F2310/00461 , A61F2310/00467 , A61F2310/00473 , A61F2310/00514 , A61F2310/0052 , A61F2310/00562 , A61F2310/00568 , A61L2/0082 , A61L27/30 , A61L27/306 , A61L27/54 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/602 , A61L2300/606 , A61L2430/02 , A61N1/00 , A61N1/18 , A61N1/20 , A61N1/205
摘要： A medical implant system is described for inhibiting infection associated with a joint prosthesis implant. An inventive system includes an implant body made of a biocompatible material which has a metal component disposed on an external surface of the implant body. A current is allowed to flow to the metal component, stimulating release of metal ions toxic to microbes, such as bacteria, protozoa, fungi, and viruses. One detailed system is completely surgically implantable in the patient such that no part of the system is external to the patient while the system is in use. In addition, externally controlled devices are provided which allow for modulation of implanted components.
摘要翻译：描述了用于抑制与关节假体植入物相关联的感染的医疗植入系统。本发明的系统包括由生物相容性材料制成的植入体，其具有设置在植入物本体的外表面上的金属部件。允许电流流向金属部件，刺激金属离子释放对细菌，原生动物，真菌和病毒等微生物有毒。一个详细的系统完全可手术植入患者体内，使得在系统使用时，系统的任何部分都不在病人的外部。此外，提供允许植入部件的调制的外部控制装置。

2. 发明授权

US08609036B2 Ex vivo antimicrobial devices and methods 有权
标题翻译：离体抗菌装置及方法
公开(公告)号：US08609036B2
公开(公告)日：2013-12-17
申请号：US12005649
申请日：2007-12-27
申请人： Thomas A. Fuller , Richard A. Wysk , Wayne J. Sebastianelli , Paul H. Cohen , Robert C. Voigt
发明人： Thomas A. Fuller , Richard A. Wysk , Wayne J. Sebastianelli , Paul H. Cohen , Robert C. Voigt
IPC分类号： A61L2/00
CPC分类号： A61L2/03 , A61L2/14 , A61L2/238 , E05B1/0069 , H01J27/022 , H01J27/22 , H01J27/26
摘要： A method and device for destroying and inhibiting exposure to microbes and infection includes a first element and a second element, and a power source. At least one of the elements includes antimicrobial metal, which, when energized by the power source, produces ions that are lethal to microbes. The device can be incorporated into virtually any useful object. During normal use of the object, electrical communication is established between the two elements, causing current supplied from the power source to flow through the antimicrobial metal. The two elements are configured and arranged to ensure that ions flowing from the antimicrobial metal flow through the region in which it is desired to kill microbes. The antimicrobial metal can be on the surface of the element, incorporated into the material making up the element, or provided in any other way that allows the antimicrobial effect to be achieved.
摘要翻译：用于破坏和抑制暴露于微生物和感染的方法和装置包括第一元件和第二元件以及电源。至少一个元件包括抗微生物金属，当被电源激励时，其产生对微生物致死的离子。该装置可以并入实际上任何有用的对象。在物体的正常使用期间，在两个元件之间建立电连通，导致从电源供应的电流流过抗微生物金属。两个元件被配置和布置成确保从抗微生物金属流出的离子流过希望杀死微生物的区域。抗微生物金属可以在元件的表面上，并入构成元件的材料中，或以允许实现抗微生物效果的任何其它方式提供。

3. 发明申请

US20100198357A1 PROPHYLACTIC BACTERICIDAL IMPLANT 审中-公开
标题翻译：普通杀虫剂植物
公开(公告)号：US20100198357A1
公开(公告)日：2010-08-05
申请号：US12759455
申请日：2010-04-13
申请人： Thomas A. Fuller , Richard A. Wysk , Wayne J. Sebastianelli
发明人： Thomas A. Fuller , Richard A. Wysk , Wayne J. Sebastianelli
IPC分类号： A61F2/28 , A61N1/00
CPC分类号： A61N1/30 , A61B17/60 , A61B17/86 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00734 , A61F2/0077 , A61F2/0095 , A61F2/28 , A61F2/30 , A61F2/30724 , A61F2/30744 , A61F2/30767 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3609 , A61F2/3662 , A61F2/367 , A61F2/3676 , A61F2002/009 , A61F2002/2821 , A61F2002/30235 , A61F2002/30322 , A61F2002/30329 , A61F2002/30354 , A61F2002/30405 , A61F2002/30438 , A61F2002/305 , A61F2002/30535 , A61F2002/30589 , A61F2002/30604 , A61F2002/30668 , A61F2002/30677 , A61F2002/30718 , A61F2002/30795 , A61F2002/30932 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/368 , A61F2002/3692 , A61F2002/482 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2230/0069 , A61F2250/0001 , A61F2250/0026 , A61F2250/0043 , A61F2250/0058 , A61F2310/00029 , A61F2310/00059 , A61F2310/00065 , A61F2310/00071 , A61F2310/00077 , A61F2310/00083 , A61F2310/00107 , A61F2310/00113 , A61F2310/00149 , A61F2310/00155 , A61F2310/00395 , A61F2310/00413 , A61F2310/00449 , A61F2310/00455 , A61F2310/00461 , A61F2310/00467 , A61F2310/00473 , A61F2310/00514 , A61F2310/0052 , A61F2310/00562 , A61F2310/00568 , A61L2/0082 , A61L27/30 , A61L27/306 , A61L27/54 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/602 , A61L2300/606 , A61L2430/02 , A61N1/00 , A61N1/18 , A61N1/20 , A61N1/205
摘要： A medical implant system is described for inhibiting infection associated with a joint prosthesis implant. An inventive system includes an implant body made of a biocompatible material which has a metal component disposed on an external surface of the implant body. A current is allowed to flow to the metal component, stimulating release of metal ions toxic to microbes, such as bacteria, protozoa, fungi, and viruses. One detailed system is completely surgically implantable in the patient such that no part of the system is external to the patient while the system is in use. In addition, externally controlled devices are provided which allow for modulation of implanted components.
摘要翻译：描述了用于抑制与关节假体植入物相关联的感染的医疗植入系统。本发明的系统包括由生物相容性材料制成的植入体，其具有设置在植入物本体的外表面上的金属部件。允许电流流向金属部件，刺激金属离子释放对细菌，原生动物，真菌和病毒等微生物有毒。一个详细的系统完全可手术植入患者体内，使得在系统使用时，系统的任何部分都不在病人的外部。此外，提供允许植入部件的调制的外部控制装置。

4. 发明授权

US08135466B2 Prophylactic bactericidal implant 有权
标题翻译：预防性杀菌植入物
公开(公告)号：US08135466B2
公开(公告)日：2012-03-13
申请号：US11922979
申请日：2006-06-30
申请人： Thomas A. Fuller , Richard A. Wysk , Wayne J. Sebastianelli
发明人： Thomas A. Fuller , Richard A. Wysk , Wayne J. Sebastianelli
IPC分类号： A61N1/00
CPC分类号： A61N1/30 , A61B17/60 , A61B17/86 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00734 , A61F2/0077 , A61F2/0095 , A61F2/28 , A61F2/30 , A61F2/30724 , A61F2/30744 , A61F2/30767 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3609 , A61F2/3662 , A61F2/367 , A61F2/3676 , A61F2002/009 , A61F2002/2821 , A61F2002/30235 , A61F2002/30322 , A61F2002/30329 , A61F2002/30354 , A61F2002/30405 , A61F2002/30438 , A61F2002/305 , A61F2002/30535 , A61F2002/30589 , A61F2002/30604 , A61F2002/30668 , A61F2002/30677 , A61F2002/30718 , A61F2002/30795 , A61F2002/30932 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/368 , A61F2002/3692 , A61F2002/482 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2230/0069 , A61F2250/0001 , A61F2250/0026 , A61F2250/0043 , A61F2250/0058 , A61F2310/00029 , A61F2310/00059 , A61F2310/00065 , A61F2310/00071 , A61F2310/00077 , A61F2310/00083 , A61F2310/00107 , A61F2310/00113 , A61F2310/00149 , A61F2310/00155 , A61F2310/00395 , A61F2310/00413 , A61F2310/00449 , A61F2310/00455 , A61F2310/00461 , A61F2310/00467 , A61F2310/00473 , A61F2310/00514 , A61F2310/0052 , A61F2310/00562 , A61F2310/00568 , A61L2/0082 , A61L27/30 , A61L27/306 , A61L27/54 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/602 , A61L2300/606 , A61L2430/02 , A61N1/00 , A61N1/18 , A61N1/20 , A61N1/205
摘要： A medical implant system is described for inhibiting infection associated with a joint prosthesis implant. An inventive system includes an implant body made of a biocompatible material which has a metal component disposed on an external surface of the implant body. A current is allowed to flow to the metal component, stimulating release of metal ions toxic to microbes, such as bacteria, protozoa, fungi, and viruses. One detailed system is completely surgically implantable in the patient such that no part of the system is external to the patient while the system is in use. In addition, externally controlled devices are provided which allow for modulation of implanted components.
摘要翻译：描述了用于抑制与关节假体植入物相关联的感染的医疗植入系统。本发明的系统包括由生物相容性材料制成的植入体，其具有设置在植入物本体的外表面上的金属部件。允许电流流向金属部件，刺激金属离子释放对细菌，原生动物，真菌和病毒等微生物有毒。一个详细的系统完全可手术植入患者体内，使得在系统使用时，系统的任何部分都不在病人的外部。此外，提供允许植入部件的调制的外部控制装置。

5. 发明申请

US20100100188A1 Prophylactic Bactericidal Implant 有权
标题翻译：预防性杀菌植入物
公开(公告)号：US20100100188A1
公开(公告)日：2010-04-22
申请号：US11922979
申请日：2006-06-30
申请人： Thomas A. Fuller , Richard A. Wysk , Wayne J. Sebastianelli
发明人： Thomas A. Fuller , Richard A. Wysk , Wayne J. Sebastianelli
IPC分类号： A61F2/30 , A61N1/00 , A61B17/58
CPC分类号： A61N1/30 , A61B17/60 , A61B17/86 , A61B17/864 , A61B17/866 , A61B17/8685 , A61B2017/00734 , A61F2/0077 , A61F2/0095 , A61F2/28 , A61F2/30 , A61F2/30724 , A61F2/30744 , A61F2/30767 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3609 , A61F2/3662 , A61F2/367 , A61F2/3676 , A61F2002/009 , A61F2002/2821 , A61F2002/30235 , A61F2002/30322 , A61F2002/30329 , A61F2002/30354 , A61F2002/30405 , A61F2002/30438 , A61F2002/305 , A61F2002/30535 , A61F2002/30589 , A61F2002/30604 , A61F2002/30668 , A61F2002/30677 , A61F2002/30718 , A61F2002/30795 , A61F2002/30932 , A61F2002/3611 , A61F2002/3625 , A61F2002/3631 , A61F2002/368 , A61F2002/3692 , A61F2002/482 , A61F2220/0025 , A61F2220/0033 , A61F2220/0041 , A61F2230/0069 , A61F2250/0001 , A61F2250/0026 , A61F2250/0043 , A61F2250/0058 , A61F2310/00029 , A61F2310/00059 , A61F2310/00065 , A61F2310/00071 , A61F2310/00077 , A61F2310/00083 , A61F2310/00107 , A61F2310/00113 , A61F2310/00149 , A61F2310/00155 , A61F2310/00395 , A61F2310/00413 , A61F2310/00449 , A61F2310/00455 , A61F2310/00461 , A61F2310/00467 , A61F2310/00473 , A61F2310/00514 , A61F2310/0052 , A61F2310/00562 , A61F2310/00568 , A61L2/0082 , A61L27/30 , A61L27/306 , A61L27/54 , A61L2300/102 , A61L2300/104 , A61L2300/404 , A61L2300/602 , A61L2300/606 , A61L2430/02 , A61N1/00 , A61N1/18 , A61N1/20 , A61N1/205
摘要： A medical implant system is described for inhibiting infection associated with a joint prosthesis implant. An inventive system includes an implant body made of a biocompatible material which has a metal component disposed on an external surface of the implant body. A current is allowed to flow to the metal component, stimulating release of metal ions toxic to microbes, such as bacteria, protozoa, fungi, and viruses. One detailed system is completely surgically implantable in the patient such that no part of the system is external to the patient while the system is in use. In addition, externally controlled devices are provided which allow for modulation of implanted components.
摘要翻译：描述了用于抑制与关节假体植入物相关联的感染的医疗植入系统。本发明的系统包括由生物相容性材料制成的植入体，其具有设置在植入物本体的外表面上的金属部件。允许电流流向金属部件，刺激金属离子释放对细菌，原生动物，真菌和病毒等微生物有毒。一个详细的系统完全可手术植入患者体内，使得在系统使用时，系统的任何部分都不在病人的外部。此外，提供允许植入部件的调制的外部控制装置。

6. 发明申请

US20080199352A1 Ex vivo antimicrobial devices and methods 有权
标题翻译：离体抗菌装置及方法
公开(公告)号：US20080199352A1
公开(公告)日：2008-08-21
申请号：US12005649
申请日：2007-12-27
申请人： Thomas A. Fuller , Richard A. Wysk , Wayne J. Sebastianelli , Paul H. Cohen , Robert C. Voigt
发明人： Thomas A. Fuller , Richard A. Wysk , Wayne J. Sebastianelli , Paul H. Cohen , Robert C. Voigt
IPC分类号： A61L2/03
CPC分类号： A61L2/03 , A61L2/14 , A61L2/238 , E05B1/0069 , H01J27/022 , H01J27/22 , H01J27/26
摘要： A method and device for destroying and inhibiting exposure to microbes and infection includes a first element and a second element, and a power source. At least one of the elements includes antimicrobial metal, which, when energized by the power source, produces ions that are lethal to microbes. The device can be incorporated into virtually any useful object. During normal use of the object, electrical communication is established between the two elements, causing current supplied from the power source to flow through the antimicrobial metal. The two elements are configured and arranged to ensure that ions flowing from the antimicrobial metal flow through the region in which it is desired to kill microbes. The antimicrobial metal can be on the surface of the element, incorporated into the material making up the element, or provided in any other way that allows the antimicrobial effect to be achieved.
摘要翻译：用于破坏和抑制暴露于微生物和感染的方法和装置包括第一元件和第二元件以及电源。至少一个元件包括抗微生物金属，当被电源激励时，其产生对微生物致死的离子。该装置可以并入实际上任何有用的对象。在物体的正常使用期间，在两个元件之间建立电连通，导致从电源供应的电流流过抗微生物金属。这两个元件被配置和布置成确保从抗微生物金属流出的离子流过希望杀死微生物的区域。抗微生物金属可以在元件的表面上，并入构成元件的材料中，或以允许实现抗微生物效果的任何其它方式提供。

7. 发明申请

US20220143233A1 IMPROVED BATTERY-ACTIVATED METAL IONIC ANTIMICROBIAL SURFACES 有权
公开(公告)号：US20220143233A1
公开(公告)日：2022-05-12
申请号：US17606357
申请日：2020-04-23
申请人： Christopher M. Wharton , Zackary G. Lowe , Charles G. Rudolf , Thomas A. Fuller , David K. Tabbutt , Mark D. Loewen , Seth R. Zimmerman , Aionx Antimicrobial Technologies, Inc.
发明人： Christopher M. Wharton , Zackary G. Lowe , Charles G. Rudolf , Thomas A. Fuller , David K. Tabbutt , Mark D. Loewen , Seth R. Zimmerman
IPC分类号： A61L2/03 , A61L2/238
摘要： A metal ionic antimicrobial surface configured for external use on a surface location in an indoor environment. A surface structure includes a pair of opposed major surfaces, one surface forming an exposed layer having a pattern of conductive strips and corresponding insulative spacings with a power pod structure secured to the surface structure. The power pod structure houses a battery and a power control circuit electrically connected to the conductive strips. In embodiments, the battery has an amp-hour capacity of 150-1500 mAh, an average width of each conductive strip of copper and silver metallic ions and each insulative spacing is between 0.1 to 0.5 millimeters, and the power control circuit includes a voltage booster circuit that maintains a constant low voltage of 2.5V-4.5V. The antimicrobial surface provides a replaceable period of at least a month of generally continuous and consistent reduction in microbial contaminants when positioned on surface locations that correlate to a zone of high impact regions for transmission pathways of microbial contaminants. In embodiments, a continuous reduction of at least 99% in microbial contaminants and at least a 2× reduction in other contaminated surfaces in a zone within the indoor environment proximate the antimicrobial surface is achieved over the replaceable period.

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