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1. 发明申请

US20070167924A1 Pre-curved guiding catheter with eccentric balloon for supplemental backup support 审中-公开
标题翻译：预弯曲引导导管与偏心气球补充支持
公开(公告)号：US20070167924A1
公开(公告)日：2007-07-19
申请号：US11322152
申请日：2005-12-29
申请人： Thierry Benjamin , James Coyle , Raymond Godaire
发明人： Thierry Benjamin , James Coyle , Raymond Godaire
IPC分类号： A61M25/00
CPC分类号： A61M25/0043 , A61M25/0041 , A61M25/1002 , A61M2025/0081
摘要： A guiding catheter includes an elongate shaft with a main lumen and a pre-shaped curve adjacent the distal end of the shaft. The pre-shaped curve is sized and shaped for positioning in a main vessel to provide intubation of a branch vessel with a distal end of the catheter. An eccentric balloon is disposed on the shaft for selective inflation against a wall of the main vessel opposite the entrance into the branch vessel to provide supplemental backup support during interventional catheterization of the branch vessel. Methods of using the guiding catheter are also disclosed.
摘要翻译：引导导管包括具有主腔的细长轴和邻近轴的远端的预形曲线。预形状曲线的尺寸和形状用于定位在主容器中以提供分支容器与导管远端的插管。偏心气球设置在轴上用于选择性地充气抵靠与分支容器的入口相对的主容器的壁，以在分支容器的介入导管期间提供补充支撑支撑。还公开了使用引导导管的方法。

2. 发明申请

US20070123925A1 Pre-curved guiding catheter with mechanically actuated anchor 审中-公开
标题翻译：具有机械致动锚的预弯曲导向导管
公开(公告)号：US20070123925A1
公开(公告)日：2007-05-31
申请号：US11287879
申请日：2005-11-28
申请人： Thierry Benjamin , James Coyle
发明人： Thierry Benjamin , James Coyle
IPC分类号： A61M29/00
CPC分类号： A61M25/0041 , A61M25/005 , A61M25/0053 , A61M25/04 , A61M25/0662 , A61M2025/0004
摘要： A guiding catheter includes an elongate shaft with a central bore and a mechanically expandable braided anchor mounted about the distal end of the shaft. The guiding catheter has a pre-formed curve adjacent the distal end of the shaft. A sheath disposed about the catheter is selectively slidable along the catheter shaft to expand the anchor into engagement with the wall of an artery. Methods of using the guiding catheter are also disclosed.
摘要翻译：引导导管包括具有中心孔的细长轴和围绕轴的远端安装的机械可扩展的编织锚。引导导管具有邻近轴远端的预先形成的曲线。围绕导管设置的护套可选择性地沿导管轴滑动，以使锚固件与动脉壁接合。还公开了使用引导导管的方法。

3. 发明授权

US06245053B1 Soft tip guiding catheter and method of fabrication 有权
标题翻译：软尖引导导管及其制造方法
公开(公告)号：US06245053B1
公开(公告)日：2001-06-12
申请号：US09188760
申请日：1998-11-09
申请人： Thierry Benjamin
发明人： Thierry Benjamin
IPC分类号： A61M2500
CPC分类号： A61M25/0014 , A61M25/001 , A61M25/0054 , A61M25/0069 , A61M2025/0081
摘要： The present invention relates to medical vascular catheters adapted to be inserted into a blood vessel from an incision through the skin of a patient for introducing ther devices or fluids for diagnostic or therapeutic purposes, and particularly to an improved distal soft tip or segment attachment with a relatively stiff proximal catheter shaft. A tubular sleeve is bonded through the application of pressure and heat to a distal portion of the catheter shaft and a proximal portion of the distal segment of soft distal tip bridging the attachment junction. In the preferred method, the catheter shaft distal end is aligned with the distal segment or soft tip proximal end and the sleeve is fitted over the attachment junction. A heat shrink tube is fitted over the sleeve and adjoining portions of the catheter shaft and the distal segment or distal soft tip and heat is applied. The shrinkage force of the heat shrink tube over the assembly of the tubular sleeve overlying and bridging the attachment junction and the applied heat melts and force the materials of the tubular sleeve and the catheter shaft and the distal segment or distal soft tip together to fill interstitial spaces of the attachment junction and reduces the outer diameter of the sleeve. The heat shrink tube is removed after the assembly cools and solidifies. Preferably, the catheter shaft distal end and the soft tip or intermediate segment proximal end are each formed with a like plurality of ungular cut sections that are complementary in shape to one another, whereby the ungular cut sections are aligned with and mated together along the attachment junction.
摘要翻译：本发明涉及适于从切口穿过患者皮肤插入血管的医用血管导管，用于引入用于诊断或治疗目的的装置或流体，特别涉及一种改进的远侧软尖端或段附件，其具有相对僵硬的近端导管轴。通过施加压力和热量将管状套筒粘合到导管轴的远端部分，以及桥接连接接头的软远端尖端的远侧段的近端部分。在优选的方法中，导管轴远端与远侧段或软尖端近端对准，并且套筒安装在附接结上。将热收缩管装配在套管上并且导管轴和远侧段或远侧软尖端的相邻部分并且施加热量。热收缩管在管状套管的组件上的覆盖和桥接连接结和所施加的热量的收缩力熔化并且迫使管状套管和导管轴以及远侧段或远端软尖端的材料在一起以填充间隙连接处的空间并减小套筒的外径。在组装冷却并固化之后，热收缩管被去除。优选地，导管轴远端和柔软尖端或中间段近端各自形成有相似的多个不规则的切割部分，其彼此形状互补，由此，不规则切割部分沿着附件对准并配合在一起交界处

4. 发明申请

US20100179588A1 VASCULAR PUNCTURE CLOSURE SYSTEM WITH GUIDE SHEATH STABILIZER 审中-公开
标题翻译：具有导向稳定器的血管闭塞系统
公开(公告)号：US20100179588A1
公开(公告)日：2010-07-15
申请号：US12353624
申请日：2009-01-14
申请人： Ghaleb Sater , Thierry Benjamin , Timothy J. Wood , Richard Lobello
发明人： Ghaleb Sater , Thierry Benjamin , Timothy J. Wood , Richard Lobello
IPC分类号： A61B17/10
CPC分类号： A61B17/0057 , A61B2017/00659 , A61B2017/3488
摘要： A guide sheath for use in guiding a vascular puncture closure device to and in registry with a vascular puncture includes a stabilization system having retention wires deployable from the sheath and engageable with the vessel wall. The retention wires pierce the vessel wall at spaced locations, proximally and distally, about the puncture and form anchors to retain the sheath in registry with the puncture.
摘要翻译：用于将血管穿刺闭合装置引导到血管穿刺并与注射管血管穿刺中使用的引导护套包括具有可从护套展开并可与血管壁接合的保留线的稳定系统。保持线围绕穿刺在相邻的位置以近端和远端分开的位置刺穿血管壁，并形成锚固件，以将鞘保持与穿刺对齐。

5. 发明申请

US20090228040A1 Mechanism and Method for Closing an Arteriotomy 审中-公开
标题翻译：关闭动脉切开术的机制和方法
公开(公告)号：US20090228040A1
公开(公告)日：2009-09-10
申请号：US12041777
申请日：2008-03-04
申请人： Juan-Pablo Mas , David Yann , Matthew Spurchise , Thierry Benjamin , Richard Rego
发明人： Juan-Pablo Mas , David Yann , Matthew Spurchise , Thierry Benjamin , Richard Rego
IPC分类号： A61B17/08 , A61B17/064
CPC分类号： A61B17/0057 , A61B17/1227 , A61B2017/00637 , A61B2017/00654 , A61B2017/00668 , A61B2017/12018 , A61B2017/22047 , A61B2017/306
摘要： Devices and methods for closing an arteriotomy include a percutaneously placeable central tube deployable about the arteriotomy by which an array of radially expandable fingers having suction ports can be engaged with the surface of tissue about the arteriotomy enabling the fingers to grip the tissue without piercing it. A delivery tube can advance a closure element along the outside surface of the central tube, thereby radially contracting the fingers and puckering the gripped tissue to approximate the edges of the arteriotomy. The closure element is further advanced until it is forced off of the distal tips of the fingers such that the closure element surrounds the puckered tissue and secures permanent closure of the arteriotomy.
摘要翻译：用于闭合动脉切开术的装置和方法包括可围绕动脉切开术展开的经皮放置的中心管，具有吸入口的可径向扩张的指状物阵列可以通过其与动脉切开术的组织表面接合，使得手指能够抓住组织而不刺穿它。输送管可以沿着中心管的外表面前进闭合元件，从而使手指径向收缩并使夹持的组织皱褶以接近动脉切开术的边缘。闭合元件进一步前进，直到其被迫离开手指的远端，使得闭合元件围绕折叠组织并确保动脉切开术的永久闭合。

6. 发明授权

US08162975B2 Systems and methods for closing a percutaneous vascular puncture 失效
标题翻译：关闭经皮血管穿刺的系统和方法
公开(公告)号：US08162975B2
公开(公告)日：2012-04-24
申请号：US12437652
申请日：2009-05-08
申请人： Thierry Benjamin , Matthew Spurchise , Juan-Pablo Mas
发明人： Thierry Benjamin , Matthew Spurchise , Juan-Pablo Mas
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00557 , A61B2017/00597 , A61B2017/00623 , A61B2017/00659 , A61B2017/00672
摘要： A system and method for closing a percutaneous vessel puncture at the conclusion of a vascular catheterization procedure includes placement of an intravascular closure device having a radially and axially expandable tubular membrane and a radially expandable anchor at the distal end of the membrane. The closure device is placed, by a delivery catheter extending through the puncture site, with its anchor radially expanded in a location upstream of the puncture site to enable the force of a patient's blood flow to deploy the tubular membrane to a proximally extended configuration closing the puncture from within the vessel.
摘要翻译：在血管导管术过程结束时关闭经皮血管穿刺的系统和方法包括在膜的远端放置具有径向和轴向可扩张的管状膜和可径向扩张的锚固体的血管内闭合装置。闭合装置通过延伸穿过穿刺部位的输送导管放置，其锚固件在穿刺部位的上游位置径向扩张，以使得患者的血液流动的力能够将管状膜展开至近端延伸的构型，从船内穿刺。

7. 发明申请

US20100286725A1 Systems and Methods for Closing a Percutaneous Vascular Puncture 失效
标题翻译：闭合经皮血管穿刺的系统和方法
公开(公告)号：US20100286725A1
公开(公告)日：2010-11-11
申请号：US12437652
申请日：2009-05-08
申请人： Thierry Benjamin , Mathew Spurchise , Juan-Pablo Mas
发明人： Thierry Benjamin , Mathew Spurchise , Juan-Pablo Mas
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00557 , A61B2017/00597 , A61B2017/00623 , A61B2017/00659 , A61B2017/00672
摘要： A system and method for closing a percutaneous vessel puncture at the conclusion of a vascular catheterization procedure includes placement of an intravascular closure device having a radially and axially expandable tubular membrane and a radially expandable anchor at the distal sad of the membrane. The closure device is placed, by a delivery catheter extending through the puncture site, with its anchor radially expanded in a location upstream of the puncture site to enable the force of a patient's blood flow to deploy the tubular membrane to a proximally extended configuration closing the puncture from within the vessel.
摘要翻译：在血管导管插入术结束时闭合经皮血管穿刺的系统和方法包括在膜的远端伤口处放置具有径向和轴向可扩张的管状膜和径向可扩张的锚固体的血管内闭合装置。闭合装置通过延伸穿过穿刺部位的输送导管放置，其锚固件在穿刺部位的上游位置径向扩张，以使得患者的血液流动的力能够将管状膜展开至近端延伸的构型，从船内穿刺。

8. 发明申请

US20090082802A1 Mechanism and Method for Closing an Arteriotomy 审中-公开
标题翻译：关闭动脉切开术的机制和方法
公开(公告)号：US20090082802A1
公开(公告)日：2009-03-26
申请号：US11861726
申请日：2007-09-26
申请人： Thierry Benjamin , David Yann , Matthew Spurchise , Juan-Pablo Mas , Richard Rego
发明人： Thierry Benjamin , David Yann , Matthew Spurchise , Juan-Pablo Mas , Richard Rego
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B17/00491 , A61B17/0218 , A61B17/068 , A61B17/29 , A61B2017/0065 , A61B2017/00663 , A61B2017/00668
摘要： Devices and methods for closing an arteriotomy by gripping surfaces of tissue disposed about the arteriotomy, without piercing the tissue, and drawing the gripped tissue together to approximate the edges of the arteriotomy, and, while holding the tissue, applying a more permanent closure to the tissue.
摘要翻译：用于通过夹持设置在动脉切开术周围的组织的表面来闭合动脉切开术的装置和方法，而不刺穿组织，并将夹持的组织拉近在一起以近似于动脉切开术的边缘，并且在保持组织的同时，向组织。

9. 发明申请

US20050187517A1 Inflation adaptor with alignment grooves 审中-公开
标题翻译：带对准凹槽的充气适配器
公开(公告)号：US20050187517A1
公开(公告)日：2005-08-25
申请号：US10784441
申请日：2004-02-23
申请人： Gregory Dion , Thierry Benjamin
发明人： Gregory Dion , Thierry Benjamin
IPC分类号： A61M25/09 , A61M29/00
CPC分类号： A61M25/09041
摘要： A system for treating a vascular condition, including an inflation adaptor having a housing, a clamping device positioned within the housing, and a medial v-groove alignment block. The clamping device includes a jaw and an anvil. An extended portion of a valve stem and a hollow guidewire are received in the medial v-groove alignment block. The extended valve stem and hollow guidewire are engaged by the clamping device to allow the extended valve stem and the hollow guidewire to be axially translated relative to each other to control a flow of an inflation fluid through the hollow guidewire when the clamping device is in a clamped position. A method of operation is also disclosed.
摘要翻译：一种用于治疗血管病症的系统，包括具有壳体的充气适配器，定位在所述壳体内的夹紧装置和内侧V形槽对准块。夹紧装置包括钳口和砧座。阀杆和空心导丝的延伸部分被容纳在中间的V形槽对准块中。延伸的阀杆和空心导丝通过夹紧装置接合，以允许延伸的阀杆和空心导丝相对于彼此轴向平移，以在夹紧装置处于相对位置时控制通过中空导丝的充气流体的流动夹紧位置。还公开了一种操作方法。

10. 发明授权

US06852261B2 Soft tip guiding catheter and method of fabrication 有权
标题翻译：软尖引导导管及其制造方法
公开(公告)号：US06852261B2
公开(公告)日：2005-02-08
申请号：US09843748
申请日：2001-04-30
申请人： Thierry Benjamin
发明人： Thierry Benjamin
IPC分类号： A61M25/00 , A61M25/08 , A61M25/088 , A61M25/16 , B29C65/02 , B29C43/12
CPC分类号： A61M25/0014 , A61M25/001 , A61M25/0054 , A61M25/0069 , A61M2025/0081
摘要： The present invention relates to medical vascular catheters adapted to be inserted into a blood vessel from an incision through the skin of a patient for introducing other devices or fluids for diagnostic or therapeutic purposes, and particularly to an improved distal soft tip or segment attachment with a relatively stiff proximal catheter shaft. A tubular sleeve is bonded through the application of pressure and heat to a distal portion of the catheter shaft and a proximal portion of the distal segment of soft distal tip bridging the attachment junction. In the preferred method, the catheter shaft distal end is aligned with the distal segment or soft tip proximal end and the sleeve is fitted over the attachment junction. A heat shrink tube is fitted over the sleeve and adjoining portions of the catheter shaft and the distal segment or distal soft tip and heat is applied. The shrinkage force of the heat shrink tube over the assembly of the tubular sleeve overlying and bridging the attachment junction and the applied heat melts and force the materials of the tubular sleeve and the catheter shaft and the distal segment or distal soft tip together to fill interstitial spaces of the attachment junction and reduces the outer diameter of the sleeve. The heat shrink tube is removed after the assembly cools and solidifies. Preferably, the catheter shaft distal end and the soft tip or intermediate segment proximal end are each formed with a like plurality of ungular cut sections that are complementary in shape to one another, whereby the ungular cut sections are aligned with and mated together along the attachment junction.
摘要翻译：本发明涉及适于从切口穿过患者皮肤插入血管的医用血管导管，用于引入用于诊断或治疗目的的其它装置或液体，特别涉及一种改进的远端软尖端或段附件相对僵硬的近端导管轴。通过施加压力和热量将管状套筒粘合到导管轴的远端部分，以及桥接连接接头的软远端尖端的远侧段的近端部分。在优选的方法中，导管轴远端与远侧段或软尖端近端对准，并且套筒安装在附接结上。将热收缩管装配在套管上并且导管轴和远侧段或远侧软尖端的相邻部分并且施加热量。热收缩管在管状套管的组件上的覆盖和桥接连接结和所施加的热量的收缩力熔化并且迫使管状套管和导管轴以及远端段或远端软尖端的材料在一起以填充间隙连接处的空间并减小套筒的外径。在组装冷却并固化之后，热收缩管被去除。优选地，导管轴远端和柔软尖端或中间段近端各自形成有相似的多个不规则的切割部分，其彼此形状互补，由此，不规则切割部分沿着附件对准并配合在一起交界处

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