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1. 发明申请

US20030186921A1 Recombinant gene expression vectors and methods for use of same to enhance the immune response of a host to an antigen 审中-公开
公开(公告)号：US20030186921A1
公开(公告)日：2003-10-02
申请号：US10402100
申请日：2003-03-26
申请人： The Regents of the University of California
发明人： Dennis A. Carson , Eyal Raz , Mark Roman
IPC分类号： A61K048/00 , C07H021/04
CPC分类号： A61B17/20 , A61K38/00 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/39 , A61K48/00 , A61K2039/53 , A61K2039/55561 , C07K14/005 , C07K14/495 , C07K14/5406 , C07K14/55 , C07K14/77 , C07K16/00 , C12N15/87 , C12N2760/16122 , C12N2760/16134 , C12N2830/002
摘要： The invention consists of recombinant gene expression vectors and vaccines useful in immunization of a host against an antigen and methods for use of such vectors and vaccines. In particular, the recombinant gene expression vectors of the invention are plasmids, cosmids or viruses which include non-coding, palindromic regions of single or double-stranded DNA or RNA polynucleotides which include at least one cytosine-guanine dinucleotide motif in each palindrome. These polynucleotide regions of each expression vector are immunostimulatory and serve as adjuvants to vaccination protocols against target antigens. Most preferably, the recombinant gene expression vectors of the invention are naked; i.e., non-viral vectors not associated with a delivery vehicle such as a liposome. The invention also includes live viral vaccines wherein the viruses include immunostimulatory polynucleotides of the invention. According to a preferred method of the invention, a target protein antigen is administered through its expression by a recombinant gene expression vector which contains the non-coding, immunostimulatory polynucleotides of the invention. In the most preferred embodiment of the method of the invention, the recombinant gene expression vector is administered to a tissues of the host which contain a relatively high concentration of antigen presenting cells (e.g., skin or mucosa) compared to other host tissues.

2. 发明申请

US20030143238A1 Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis 审中-公开
公开(公告)号：US20030143238A1
公开(公告)日：2003-07-31
申请号：US10299540
申请日：2002-11-18
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Dennis A. Carson , Salvatore Albani
IPC分类号： G01N033/53 , G01N033/567 , G01N033/554 , G01N033/569 , A61K039/00 , A61K039/02
CPC分类号： C07K16/12 , A61K38/00 , A61K39/00 , A61K39/0008 , A61K39/40 , A61K48/00 , C07K14/245 , C07K14/70539 , C07K16/04 , G01N33/6893 , G01N2800/102 , Y02A50/474 , Y02A50/482 , A61K2300/00
摘要： Vaccine compositions useful in inducing immune protection in a host against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis are disclosed. Each vaccine composition provides antigenic dnaJp1 peptide (by including the peptide or a polynucleotide which encodes the peptide) and, optionally, other peptide fragments of the microbial dnaJ protein and/or human homologs thereof. Methods for identifying persons who are predisposed to develop rheumatoid arthritis and methods for use of the inventive vaccines are also disclosed.

3. 发明申请

US20020165202A1 Compounds for inhibition of ceramide-mediated signal transduction 失效
标题翻译：用于抑制神经酰胺介导的信号转导的化合物
公开(公告)号：US20020165202A1
公开(公告)日：2002-11-07
申请号：US09951198
申请日：2001-09-13
申请人： The Regents of the University of California
发明人： Dennis A. Carson , Howard Cottam
IPC分类号： A61K031/675 , A61K031/522 , A61K031/519 , A61K031/4745 , C07D473/28 , C07D487/04 , C07F009/6512
CPC分类号： C07D239/545 , C07D213/76 , C07D217/24 , C07D239/96 , C07D473/06 , C07D473/10 , C07D475/02 , C07D513/04
摘要： Novel, heterocyclic compounds having at least one ring nitrogen, disclosed side chains and, in some embodiments, an oxygen ortho to the ring nitrogen inhibit inflammatory responses associated with TNF-null and fibroblast proliferation in vivo and in vitro. The compounds of the invention neither appreciably inhibit the activity of cAMP phosphodiesterase nor the hydrolysis of phosphatidic acid, and are neither cytotoxic nor cytostatic. Preferred compounds of the invention are esters. Methods for the use of the novel compounds to inhibit ceramide-mediated intracellular responses in stimuli in vivo (particularly TN-null) are also described. The methods are expected to be of use in reducing inflammatory responses (for example, after angioplasty), in limiting fibrosis (for example, of the liver in cirrhosis), in inhibiting cell senescence, cell apoptosis and UV induced cutaneous immune suppression. Compounds having enhanced water solubility are also described.
摘要翻译：新颖的，具有至少一个环氮的杂环化合物，在一些实施方案中，环氮原子上的氧被抑制与体内和体外TNF-α和成纤维细胞增殖相关的炎性反应。本发明的化合物既不明显地抑制cAMP磷酸二酯酶的活性也不抑制磷脂酸的水解，既不是细胞毒性的也不是细胞抑制的。本发明优选的化合物是酯。还描述了使用新化合物抑制体内刺激中神经酰胺介导的细胞内应答的方法（特别是TN-α）。预期这些方法可用于减少炎症反应（例如血管成形术后），限制纤维化（例如肝硬化），抑制细胞衰老，细胞凋亡和UV诱导的皮肤免疫抑制。还描述了具有增强的水溶性的化合物。

4. 发明申请

US20030147910A1 Vaccine compositions and methods useful in inducing immune protection against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis 失效
标题翻译：用于诱导涉及类风湿性关节炎发病机制的关节炎多肽的免疫保护的疫苗组合物和方法
公开(公告)号：US20030147910A1
公开(公告)日：2003-08-07
申请号：US10299184
申请日：2002-11-18
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Dennis A. Carson , Salvatore Albani
IPC分类号： G01N033/53 , G01N033/567 , G01N033/554 , G01N033/569 , A61K039/00 , A61K039/02
CPC分类号： C07K16/12 , A61K38/00 , A61K39/00 , A61K39/0008 , A61K39/40 , A61K48/00 , C07K14/245 , C07K14/70539 , C07K16/04 , G01N33/6893 , G01N2800/102 , Y02A50/474 , Y02A50/482 , A61K2300/00
摘要： Vaccine compositions useful in inducing immune protection in a host against arthritogenic peptides involved in the pathogenesis of rheumatoid arthritis are disclosed. Each vaccine composition provides antigenic dnaJp1 peptide (by including the peptide or a polynucleotide which encodes the peptide) and, optionally, other peptide fragments of the microbial dnaJ protein and/or human homologs thereof. Methods for identifying persons who are predisposed to develop rheumatoid arthritis and methods for use of the inventive vaccines are also disclosed.
摘要翻译：公开了可用于诱导宿主中针对涉及类风湿性关节炎发病机制的关节炎性肽的免疫保护的疫苗组合物。每种疫苗组合物提供抗原性dnaJp1肽（通过包括肽或编码肽的多核苷酸）和任选的其它微生物dnaJ蛋白和/或其同源物的其它肽片段。还公开了识别易患发展类风湿性关节炎的人的方法和本发明疫苗的使用方法。

5. 发明申请

US20030078293A1 Use of etodolac for the treatment of chronic lymphocytic leukemia 失效
公开(公告)号：US20030078293A1
公开(公告)日：2003-04-24
申请号：US10236221
申请日：2002-09-05
申请人： The Regents of the University of California
发明人： Dennis A. Carson , Howard B. Cottam , Souchi Adachi , Lorenzo M. Leoni
IPC分类号： A61K031/353
CPC分类号： G01N33/5011 , A61K31/198 , A61K31/407 , A61K45/06 , Y10S514/908 , Y10S514/922 , A61K2300/00
摘要： A method of treating cancer is provided comprising administering an amount of etodolac to a subject afflicted with cancer that is effective to reduce the viability and/or to sensitize the cancer to an anti-cancer agent.

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