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1. 发明授权

US09791402B2 Nanostructured microelectrodes and biosensing devices incorporating the same 有权
公开(公告)号：US09791402B2
公开(公告)日：2017-10-17
申请号：US14514139
申请日：2014-10-14
申请人： The Governing Council of the University of Toronto
发明人： Leyla Soleymani , Zhichao Fang , Shana Kelley , Edward Sargent , Bradford Taft
IPC分类号： G01N27/327 , G01N33/543 , G01N27/30
CPC分类号： G01N27/3272 , G01N27/30 , G01N27/3275 , G01N27/3278 , G01N33/5438 , Y10S977/754 , Y10S977/925
摘要： Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.

2. 发明申请

US20150168337A1 NANOSTRUCTURED MICROELECTRODES AND BIOSENSING DEVICES INCORPORATING THE SAME 有权
标题翻译：纳米微电极和生物传感器件
公开(公告)号：US20150168337A1
公开(公告)日：2015-06-18
申请号：US14514139
申请日：2014-10-14
申请人： The Governing Council of the University of Toronto
发明人： Leyla Soleymani , Zhichao Fang , Shana Kelley , Edward Sargent , Bradford Taft
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , G01N27/30 , G01N27/3275 , G01N27/3278 , G01N33/5438 , Y10S977/754 , Y10S977/925
摘要： Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.
摘要翻译：本文公开了纳米结构微电极和结合其的生物感测装置。

3. 发明申请

US20160298177A1 BIOPROBES AND METHODS OF USE THEREOF 有权
标题翻译：生物学及其使用方法
公开(公告)号：US20160298177A1
公开(公告)日：2016-10-13
申请号：US15091369
申请日：2016-04-05
申请人： The Governing Council of the University of Toronto
发明人： Shana O. Kelley , Zhichao Fang , Elizaveta Vasilyeva
IPC分类号： C12Q1/68 , G01N27/327
CPC分类号： C12Q1/6816 , C12N2310/3181 , C12Q1/6837 , C12Q1/6886 , G01N27/26 , G01N27/3276 , G01N27/3277 , C12Q2523/31
摘要： Disclosed are biomolecule based bioprobes that exhibit improved water solubility and mono layer-forming properties with substantially little or no aggregation that can appreciably interfere with binding of the bioprobes to a target nucleotide. The bioprobes may be used in conjunction with a suitable reporter system to detect very small quantities of biological markers. The bio-probes comprise a nucleobase sequence capable of hybridizing to a target nucleotide; and at least one charged functional group attached to said nucleobase sequence. Also disclosed are biosensors, and sensing devices that comprise the bin-probe. Further disclosed are suitable electrochemical reporter systems for use with the bioprobes. Methods of use of these devices and probes, including for the detection of target biomarkers, including biomarkers for cancer cells or pathogens, are also included.
摘要翻译：公开了基于生物分子的生物探针，其表现出改善的水溶性和单层形成性质，其基本上很少或没有聚集，其可以明显地干扰生物探针与靶核苷酸的结合。生物探针可以与合适的报道系统结合使用以检测非常少量的生物标志物。生物探针包含能与靶核苷酸杂交的核碱基序列; 和至少一个连接到所述核碱基序列的带电官能团。还公开了生物传感器和包括二探针的感测装置。进一步公开的是用于生物探针的合适的电化学报告体系。还包括使用这些装置和探针的方法，包括用于检测靶标生物标志物，包括癌细胞或病原体的生物标志物。

4. 发明授权

US09816129B2 Bioprobes and methods of use thereof 有权
公开(公告)号：US09816129B2
公开(公告)日：2017-11-14
申请号：US15091369
申请日：2016-04-05
申请人： The Governing Council of the University of Toronto
发明人： Shana O. Kelley , Zhichao Fang , Elizaveta Vasilyeva
IPC分类号： C12Q1/68 , G01N27/26 , G01N27/327
CPC分类号： C12Q1/6816 , C12N2310/3181 , C12Q1/6837 , C12Q1/6886 , G01N27/26 , G01N27/3276 , G01N27/3277 , C12Q2523/31
摘要： Disclosed are biomolecule based bioprobes that exhibit improved water solubility and mono layer-forming properties with substantially little or no aggregation that can appreciably interfere with binding of the bioprobes to a target nucleotide. The bioprobes may be used in conjunction with a suitable reporter system to detect very small quantities of biological markers. The bio-probes comprise a nucleobase sequence capable of hybridizing to a target nucleotide; and at least one charged functional group attached to said nucleobase sequence. Also disclosed are biosensors, and sensing devices that comprise the bin-probe. Further disclosed are suitable electrochemical reporter systems for use with the bioprobes. Methods of use of these devices and probes, including for the detection of target biomarkers, including biomarkers for cancer cells or pathogens, are also included.

5. 发明授权

US10274453B2 Nanostructured microelectrodes and biosensing devices incorporating the same 有权
公开(公告)号：US10274453B2
公开(公告)日：2019-04-30
申请号：US15703120
申请日：2017-09-13
申请人： The Governing Council of the University of Toronto
发明人： Leyla Soleymani , Zhichao Fang , Shana Kelley , Edward Sargent , Bradford Taft
IPC分类号： G01N27/327 , G01N33/543 , G01N27/30
摘要： Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.

6. 发明申请

US20180003665A1 NANOSTRUCTURED MICROELECTRODES AND BIOSENSING DEVICES INCORPORATING THE SAME 审中-公开
公开(公告)号：US20180003665A1
公开(公告)日：2018-01-04
申请号：US15703120
申请日：2017-09-13
申请人： The Governing Council of the University of Toronto
发明人： Leyla Soleymani , Zhichao Fang , Shana Kelley , Edward Sargent , Bradford Taft
IPC分类号： G01N27/327 , G01N27/30 , G01N33/543
CPC分类号： G01N27/3272 , G01N27/30 , G01N27/3275 , G01N27/3278 , G01N33/5438 , Y10S977/754 , Y10S977/925
摘要： Nanostructured microelectrodes and biosensing devices incorporating the same are disclosed herein.

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