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1. 发明授权

US11591640B2 Photonic resonator absorption microscopy (PRAM) for digital resolution biomolecular diagnostics 有权
公开(公告)号：US11591640B2
公开(公告)日：2023-02-28
申请号：US17328752
申请日：2021-05-24
申请人： The Board of Trustees of the University of Illinois
发明人： Brian T. Cunningham , Yue Zhuo , Brendan Harley , Ji Sun Choi , Thibault Marin , Yi Lu
IPC分类号： C12Q1/6825 , G01N21/552 , G01N21/77 , C12Q1/6886
摘要： A digital assay for a micro RNA (miRNA) or other target analyte in a sample makes use of nanoparticles that absorb light at the resonant wavelength of a photonic crystal (PC). Such nanoparticles locally quench the resonant reflection of light from the PC when present on the surface of the PC. The nanoparticles are functionalized to specifically bind to the target analyte, and the PC surface is functionalized to specifically bind to the nanoparticles that have bound to the target analyte. The sample is exposed to the functionalized nanoparticles, and the individual nanoparticles bound to the PC surface can be identified and counted based on reduced intensity values in the reflected light from the PC. The number of bound nanoparticles that are counted in this way can be correlated to the abundance of the target analyte in the sample.

2. 发明授权

US10605735B2 Photonic resonator outcoupler microscopy (PROM) 有权
公开(公告)号：US10605735B2
公开(公告)日：2020-03-31
申请号：US16164302
申请日：2018-10-18
申请人： The Board of Trustees of the University of Illinois
发明人： Brian T. Cunningham , Yue Zhuo , Brendan Harley , Ji Sun Choi , Thibault Marin
IPC分类号： G01J3/28 , G01N21/64 , G01N21/25 , G01N21/27 , G02B21/00 , G01N21/552
摘要： Photonic Resonator Outcoupler Microscopy (PROM) is a novel, label-free approach for dynamic, long-term, quantitative imaging of a sample on a surface of a photonic crystal (PC) biosensor, in which components of the sample outcouple photons from the resonant evanescent field, resulting in highly localized reductions of the reflected light intensity. By mapping changes in the resonant reflected peak intensity from the PC surface, components of a sample (e.g., focal adhesions) can be detected and dynamically tracked. To demonstrate the simplicity and utility of PROM for focal adhesion imaging, PROM images are compared with biosensor images of surface-bound dielectric permittivity and with fluorescence microscopy images of labeled adhesion molecules in dental stem cells. PROM can dynamically quantify the surface-attached cellular mass density and lateral dimensions of focal adhesion clusters.

3. 发明申请

US20150349194A1 NANOSTRUCTURE MATERIAL METHODS AND DEVICES 审中-公开
标题翻译：纳米结构材料的方法和装置
公开(公告)号：US20150349194A1
公开(公告)日：2015-12-03
申请号：US14722845
申请日：2015-05-27
申请人： The Board of Trustees of the University of Illinois , Dow Global Technologies LLC , Rohm and Haas Electronic Materials, LLC
发明人： Brian T. Cunningham , Gloria G. See , Peter Trefonas , Jong Keun Park , Kishori Deshpande , Jieqian Zhang , Jaebum Joo
IPC分类号： H01L33/00 , H01L33/50
CPC分类号： H01L33/50 , G02B6/00 , H01L27/322 , H01L31/0203 , H01L31/02327 , H01L31/054 , H01L33/005 , H01L33/02 , H01L2251/5369 , Y02E10/52
摘要： In one aspect, structures are provided comprising: a substrate having a first surface and a second surface; and a polymeric layer disposed on the first surface of the substrate, the polymeric layer comprising a polymer and a plurality of light-emitting nanocrystals; the polymeric layer having a patterned surface, the patterned surface having a patterned first region having a first plurality of recesses and a patterned second region having a second plurality of recesses, wherein the plurality of recesses in each region has a first periodicity in a first direction, and a second periodicity in a second direction which intersects the first direction, wherein the first periodicity of the first region is different from the first periodicity of the second region.
摘要翻译：一方面，提供了包括：具有第一表面和第二表面的基底的结构; 以及设置在所述基板的第一表面上的聚合物层，所述聚合物层包含聚合物和多个发光纳米晶体; 所述聚合物层具有图案化表面，所述图案化表面具有带有第一多个凹部的图案化的第一区域和具有第二多个凹部的图案化的第二区域，其中，每个区域中的多个凹部在第一方向上具有第一周期性以及与第一方向相交的第二方向的第二周期，其中第一区域的第一周期与第二区域的第一周期不同。

4. 发明授权

US08947656B2 Smartphone biosensor 有权
标题翻译：智能手机生物传感器
公开(公告)号：US08947656B2
公开(公告)日：2015-02-03
申请号：US13801978
申请日：2013-03-13
申请人： The Board of Trustees of the University of Illinois
发明人： Brian T. Cunningham
IPC分类号： G01J3/28 , G01J3/44 , G01N21/63
CPC分类号： H04M1/72527 , G01J3/0202 , G01J3/0264 , G01J3/0272 , G01J3/28 , G01J3/44 , G01J3/4406 , G01N21/25 , G01N21/31 , G01N21/553 , G01N21/63 , G01N21/6428 , G01N21/6445 , G01N21/6486 , G01N21/658 , G01N21/7746 , G01N2021/6417 , G01N2201/0612 , G01N2201/062
摘要： A mobile computing device that includes an image sensor may be used to detect the result of a biomolecular assay. The biomolecular assay may be performed in an optical assay medium that provides an optical output in response to light from a light source, with the optical output indicating result. A wavelength-dispersive element may be used to disperse the optical output into spatially-separated wavelength components. The mobile computing device may be positioned relative to the wavelength-dispersive element such that different wavelength components are received at different locations on the image sensor. With the mobile computing device positioned in this way, the image sensor may be used to obtain one or more images that include the separated wavelength components of the optical output. A wavelength spectrum of the optical output may be determined from the one or more images, and the result may be determined from the wavelength spectrum.
摘要翻译：可以使用包括图像传感器的移动计算设备来检测生物分子测定的结果。生物分子测定可以在光学测定介质中进行，光学测定介质响应于来自光源的光而提供光学输出，光学输出指示结果。波长分散元件可以用于将光输出分散到空间分离的波长分量中。移动计算设备可以相对于波长分散元件定位，使得在图像传感器上的不同位置处接收不同的波长分量。利用以这种方式定位的移动计算设备，可以使用图像传感器来获得包括光输出的分离的波长分量的一个或多个图像。可以从一个或多个图像确定光学输出的波长谱，并且可以根据波长谱确定结果。

5. 发明申请

US20210324456A1 Photonic Resonator Absorption Microscopy (PRAM) for Digital Resolution Biomolecular Diagnostics 有权
公开(公告)号：US20210324456A1
公开(公告)日：2021-10-21
申请号：US17328752
申请日：2021-05-24
申请人： The Board of Trustees of the University of Illinois
发明人： Brian T. Cunningham , Yue Zhuo , Brendan Harley , Ji Sun Choi , Thibault Marin , Yi Lu
IPC分类号： C12Q1/6825 , G01N21/552 , C12Q1/6886 , G01N21/77
摘要： A digital assay for a micro RNA (miRNA) or other target analyte in a sample makes use of nanoparticles that absorb light at the resonant wavelength of a photonic crystal (PC). Such nanoparticles locally quench the resonant reflection of light from the PC when present on the surface of the PC. The nanoparticles are functionalized to specifically bind to the target analyte, and the PC surface is functionalized to specifically bind to the nanoparticles that have bound to the target analyte. The sample is exposed to the functionalized nanoparticles, and the individual nanoparticles bound to the PC surface can be identified and counted based on reduced intensity values in the reflected light from the PC. The number of bound nanoparticles that are counted in this way can be correlated to the abundance of the target analyte in the sample.

6. 发明授权

US09478713B2 Nanostructure material methods and devices 有权
标题翻译：纳米结构材料的方法和装置
公开(公告)号：US09478713B2
公开(公告)日：2016-10-25
申请号：US14723433
申请日：2015-05-27
申请人： The Board of Trustees of the University of Illinois , Dow Global Technologies LLC , Rohm and Haas Electronic Materials, LLC
发明人： Brian T. Cunningham , Gloria G. See , Peter Trefonas , Jong Keun Park , Kishori Deshpande , Jieqian Zhang , Jaebum Joo
IPC分类号： H01L33/50 , H01L33/02 , H01L33/00 , H01L31/0203 , H01L27/32
CPC分类号： H01L33/50 , G02B6/00 , H01L27/322 , H01L31/0203 , H01L31/02327 , H01L31/054 , H01L33/005 , H01L33/02 , H01L2251/5369 , Y02E10/52
摘要： In one aspect, structures are provided comprising: a substrate having a first surface and a second surface; and a polymeric layer disposed on the first surface of the substrate, the polymeric layer comprising a polymer and a plurality of light-emitting nanocrystals; the polymeric layer having a patterned surface, the patterned surface having a patterned first region having a first plurality of recesses and a patterned second region having a second plurality of recesses, wherein the plurality of recesses in each region has a first periodicity in a first direction, and a second periodicity in a second direction which intersects the first direction, wherein the first periodicity of the first region is different from the first periodicity of the second region.
摘要翻译：一方面，提供了包括：具有第一表面和第二表面的基底的结构; 以及设置在所述基板的第一表面上的聚合物层，所述聚合物层包含聚合物和多个发光纳米晶体; 所述聚合物层具有图案化表面，所述图案化表面具有带有第一多个凹部的图案化的第一区域和具有第二多个凹部的图案化的第二区域，其中，每个区域中的多个凹部在第一方向上具有第一周期性以及与第一方向相交的第二方向的第二周期，其中第一区域的第一周期与第二区域的第一周期不同。

7. 发明授权

US09185200B2 Smartphone biosensor 有权
公开(公告)号：US09185200B2
公开(公告)日：2015-11-10
申请号：US14579804
申请日：2014-12-22
申请人： The Board of Trustees of the University of Illinois
发明人： Brian T. Cunningham
IPC分类号： G01J3/28 , H04M1/725 , G01J3/44 , G01N21/25 , G01N21/64 , G01J3/02 , G01N21/31 , G01N21/552 , G01N21/65 , G01N21/77 , G01N21/63
CPC分类号： H04M1/72527 , G01J3/0202 , G01J3/0264 , G01J3/0272 , G01J3/28 , G01J3/44 , G01J3/4406 , G01N21/25 , G01N21/31 , G01N21/553 , G01N21/63 , G01N21/6428 , G01N21/6445 , G01N21/6486 , G01N21/658 , G01N21/7746 , G01N2021/6417 , G01N2201/0612 , G01N2201/062
摘要： A mobile computing device that includes an image sensor may be used to detect the result of a biomolecular assay. The biomolecular assay may be performed in an optical assay medium that provides an optical output in response to light from a light source, with the optical output indicating result. A wavelength-dispersive element may be used to disperse the optical output into spatially-separated wavelength components. The mobile computing device may be positioned relative to the wavelength-dispersive element such that different wavelength components are received at different locations on the image sensor. With the mobile computing device positioned in this way, the image sensor may be used to obtain one or more images that include the separated wavelength components of the optical output. A wavelength spectrum of the optical output may be determined from the one or more images, and the result may be determined from the wavelength spectrum.

8. 发明授权

US08687187B2 Surface enhanced raman spectroscopy on optical resonator (e.g., photonic crystal) surfaces 有权
标题翻译：在光学谐振器（例如，光子晶体）表面上的表面增强拉曼光谱
公开(公告)号：US08687187B2
公开(公告)日：2014-04-01
申请号：US13775326
申请日：2013-02-25
申请人： The Board of Trustees of the University of Illinois
发明人： Brian T. Cunningham
IPC分类号： G01J3/44
CPC分类号： G01J3/44 , G01N21/658 , G02B1/005
摘要： Highly sensitive Surface Enhanced Raman Spectroscopy (SERS) sensors are described in the form of a optical resonator and a metal nanostructure deposited on surface of the optical resonator. In one embodiment the optical resonator is in the form of a photonic crystal, but other optical resonators are contemplated. Examples are described in which the resonant near-fields of a large-area replica molded photonic crystal efficiently couples light from a laser to dielectric-metal “post-cap” nanostructures deposited on the photonic crystal surface by a glancing angle evaporation technique, achieving a high SERS enhancement factor. Other constructions are also contemplated a metal nanostructure formed on a dielectric support deposited on the photonic crystal, including a metallic film deposited over close-packed surface of nanospheres, arrays of metallic nanotriangles, metallic nanorods, metallic nanohelices, arrays of metallic nanospheres, and roughened metal surfaces.
摘要翻译：高灵敏度表面增强拉曼光谱（SERS）传感器以沉积在光学谐振器表面上的光学谐振器和金属纳米结构的形式进行描述。在一个实施例中，光学谐振器是光子晶体的形式，但是可以考虑其它光学谐振器。描述了大面积复制光子晶体的共振近场效应地将光从激光耦合到通过扫掠角蒸发技术沉积在光子晶体表面上的电介质金属“后盖”纳米结构，实现了高SERS增强因子。还考虑了其它结构，其形成在沉积在光子晶体上的电介质载体上，包括沉积在纳米球的紧密堆积表面上的金属膜，金属纳米管阵列，金属纳米棒，金属纳米螺旋，金属纳米球阵列和粗糙化金属表面。

9. 发明授权

US11175222B2 Integrated spectroscopic analysis system with low vertical height for measuring liquid or solid assays 有权
公开(公告)号：US11175222B2
公开(公告)日：2021-11-16
申请号：US16191732
申请日：2018-11-15
申请人： The Board of Trustees of the University of Illinois
发明人： Brian T. Cunningham , John Michael Dallesasse
IPC分类号： G01N21/27 , G01N21/25 , B01L3/00 , H04M1/02 , G01J3/46
摘要： The present disclosure describes the design, fabrication, and demonstration of a compact spectroscopic analysis system that utilizes a linear variable filter chip attached directly over an image sensor array, and an integrated broadband LED illuminator that supplies light from the edge of the system to provide a low vertical dimension. The instrument is capable of accurately measuring the optical absorption spectra of colored liquids or the scattered spectra from solid objects that are placed in the illumination pathway. Due to the small vertical thickness of the system, the low cost of its components, and the accuracy with which it renders spectra in comparison to conventional spectrometers, we envision potential incorporation of the system into mobile communication devices, such as smartphones and tablets, as a means for providing a dedicated sensor for health diagnostic, environmental monitoring, and general-purpose color sensing applications.

10. 发明授权

US11041187B2 Photonic resonator absorption microscopy (PRAM) for digital resolution biomolecular diagnostics 有权
公开(公告)号：US11041187B2
公开(公告)日：2021-06-22
申请号：US16170111
申请日：2018-10-25
申请人： The Board of Trustees of the University of Illinois
发明人： Brian T. Cunningham , Yue Zhuo , Brendan Harley , Ji Sun Choi , Thibault Marin , Yi Lu
IPC分类号： C12Q1/6825 , G01N21/552 , G01N21/77 , C12Q1/6886
摘要： A digital assay for a micro RNA (miRNA) or other target analyte in a sample makes use of nanoparticles that absorb light at the resonant wavelength of a photonic crystal (PC). Such nanoparticles locally quench the resonant reflection of light from the PC when present on the surface of the PC. The nanoparticles are functionalized to specifically bind to the target analyte, and the PC surface is functionalized to specifically bind to the nanoparticles that have bound to the target analyte. The sample is exposed to the functionalized nanoparticles, and the individual nanoparticles bound to the PC surface can be identified and counted based on reduced intensity values in the reflected light from the PC. The number of bound nanoparticles that are counted in this way can be correlated to the abundance of the target analyte in the sample.

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