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1. 发明授权

US4351830A Polymeric compound, MF-300, with protective activity against bacterial infections and its preparation 失效
标题翻译：高分子化合物，MF-300，具有抗细菌感染的保护作用及其制备
公开(公告)号：US4351830A
公开(公告)日：1982-09-28
申请号：US269609
申请日：1981-06-02
申请人： Takeo Miyazawa , Takahiro Ishii , Yuzo Kazuno , Eiichi Akita , Yujiro Yamada , Taro Niida
发明人： Takeo Miyazawa , Takahiro Ishii , Yuzo Kazuno , Eiichi Akita , Yujiro Yamada , Taro Niida
IPC分类号： C08G69/00 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61K31/785 , A61P31/04 , C07H15/23 , C08G73/02 , A61K31/73 , C07H15/22
CPC分类号： A61K31/785 , C08G73/0213
摘要： A new polymeric compound, MF-300, is provided, which possesses a specific protective activity against bacterial infections caused particularly by Pseudomonas aeruginosa. The compound is derived from the reaction of ribostamycin with crotonoyl chloride followed by concentration of the reaction product and by subsequent recovery therefrom of a fraction having a range of molecular weights of 10,000.about.100,000 when measured by ultrafiltration method.
摘要翻译：提供了一种新的高分子化合物MF-300，其具有特别的对铜绿假单胞菌引起的细菌感染的保护作用。该化合物衍生自核糖霉素与巴豆酰氯的反应，随后浓缩反应产物，然后通过超滤法测定分子量为10,000 DIFFERENCE 100,000范围的部分。

2. 发明授权

US4170641A 1-N-(.omega.-aminoalkanesulfonyl) derivative of aminoglycosidic antibiotic and process for preparation thereof 失效
标题翻译：氨基糖苷类抗生素的1-N - （{107-氨基烷基磺酰基）衍生物及其制备方法
公开(公告)号：US4170641A
公开(公告)日：1979-10-09
申请号：US911522
申请日：1978-06-01
申请人： Eiichi Akita , Yukio Horiuchi , Takeo Miyazawa , Hamao Umezawa
发明人： Eiichi Akita , Yukio Horiuchi , Takeo Miyazawa , Hamao Umezawa
IPC分类号： C07H15/23 , A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61P31/04 , C07H15/232 , C07H15/234 , C07H15/236 , A61K31/71 , C07H15/22
CPC分类号： C07H15/234 , Y02P20/55
摘要： A new 1-N-(.omega.-aminoalkanesulfonyl) derivative of an aminoglycosidic antibiotic such as ribostamycin, 3'-deoxy- or 3',4'-dideoxy-ribostamycin, kanamycin A or B, and 3'-deoxy- or 3',4'-dideoxy-kanamycin B exhibits a broader, antibacterial spectrum than the parent aminoglycosidic antibiotic and is useful in the therapeutic treatment of infections caused by gram-positive and gram-negative bacteria including drug-resistant strains thereof. The aforesaid derivative may be made by reaction between the parent antibiotic and an amino-protected .omega.-aminoalkanesulfonic acid halide and removal of the amino-protecting group from the condensation product.
摘要翻译：一种氨基糖苷类抗生素的新的1-N-（ω-氨基烷基磺酰基）衍生物，如核糖霉素，3'-脱氧-3或4'二脱氧核糖霉素，卡那霉素A或B，3'-脱氧-3或3' ，4'-双脱氧卡那霉素B比母体氨基糖苷类抗生素显示更广泛的抗菌谱，并且可用于治疗由革兰氏阳性和革兰氏阴性菌引起的感染的治疗性治疗，包括其耐药菌株。上述衍生物可以通过亲本抗生素与氨基保护的ω-氨基链烷磺酸卤化物之间的反应和从缩合产物中除去氨基保护基团而进行。

3. 发明授权

US4060682A Process for the synthetic production of 3-deoxy derivative of an aminoglycosidic antibiotic 失效
标题翻译：用于合成生产氨基糖苷类抗生素的3-脱氧衍生物的方法
公开(公告)号：US4060682A
公开(公告)日：1977-11-29
申请号：US598379
申请日：1975-07-23
申请人： Hamao Umezawa , Sumio Umezawa , Osamu Tsuchiya , Eiichi Akita , Takeo Miyazawa , Yukio Horiuchi , Shunzo Fukatsu
发明人： Hamao Umezawa , Sumio Umezawa , Osamu Tsuchiya , Eiichi Akita , Takeo Miyazawa , Yukio Horiuchi , Shunzo Fukatsu
IPC分类号： C07H15/224 , B01J25/00 , C07B61/00 , C07H15/222 , C07H15/23 , C07H15/234 , C07H15/244 , A61K31/71 , C07H15/22
CPC分类号： C07H15/222 , Y02P20/55
摘要： 3'-Deoxy derivatives of neamine, 6'-N-alkylneamine, kanamycin B, 6'-N-alkylkanamycin B, ribostamycin, 6'-N-alkylribostamycin and paromamine may be produced by a new process comprising reducing the 3',4'-.alpha.-anhydro derivative (namely, the 3',4'-epoxide derivative) of the aminoglycosidic antibiotics with hydrogen in an alkaline lower alkanol medium containing an alkali metal hydroxide or alkoxide dissolved therein and in the presence of a reducing catalyst such as Raney nickel. The 3',4'-.alpha.-anhydro derivative may be prepared by treating the 3'-sulfonylated derivative of the amino-protected and hydroxyl-protected neamine, 6'-N-alkylneamine, kanamycin B, 6'-N-alkylkanamycin B, ribostamycin, 6'-N-alkylribostamycin or paromamine with an alkali metal hydroxide or alkoxide in a lower alkanol to effect epoxidation between the 4'-hydroxyl group and the carbon atom substituted by the 3'-sulfonic ester group.
摘要翻译：神经胺，6'-N-烷基胺，卡那霉素B，6'-N-烷基卡那霉素B，核糖霉素，6'-N-烷基三苯甲酰霉素和帕罗明胺的3'-脱氧衍生物可以通过新的方法制备，包括将3'，4'- 在含有碱金属氢氧化物或醇盐的碱性低级烷醇介质中，在氨基糖苷类抗生素的α-脱氢衍生物（即3'，4'-环氧化物衍生物）阮内镍 3'，4'-α-脱水衍生物可以通过处理氨基保护的和羟基保护的神经胺，6'-N-烷基胺，卡那霉素B，6'-N-烷基卡那霉素B的3'-磺酰化衍生物，核糖霉素，6'-N-烷基三苯甲酰霉素或碱性金属氢氧化物或醇盐在低级链烷醇中进行环氧化，以实现4'-羟基和被3'-磺酸酯基取代的碳原子之间的环氧化。

4. 发明授权

US4169890A Pharmaceutical composition containing 5"-amino-3',5"-dideoxy-ribostamycin and intermediate compounds 失效
标题翻译：含有5“ - 氨基-3'，5” - 二羟基 - 酪氨酸蛋白酶和中间体化合物的药物组合物
公开(公告)号：US4169890A
公开(公告)日：1979-10-02
申请号：US800857
申请日：1977-05-26
申请人： Takeo Miyazawa , Yukio Horiuchi , Eiichi Akita , Hamao Umezawa , Sumio Umezawa
发明人： Takeo Miyazawa , Yukio Horiuchi , Eiichi Akita , Hamao Umezawa , Sumio Umezawa
IPC分类号： C07H15/23 , A61K31/71 , C07H15/22
CPC分类号： C07H15/23
摘要： A process for preparing a novel antibiotic, 5"-amino-3',5"-dideoxy-ribostamycin, which comprises subjecting a ribostamycin derivative represented by the formula: ##STR1## to selective sulfonylation to form a 3',5"-O-disulfonyl derivative, SUBJECTING THE THUS PRODUCED DERIVATIVE TO AZIDE-FORMING REACTION WITH SODIUM AZIDE,Subjecting the thus produced ribostamycin 3'-O-sulfonyl-5"-azido derivative to deoxylation by treating it with sodium borohydride in an aprotic and polar solvent,Subjecting the thus obtained 3' deoxy derivative to catalytic hydrogenation in the presence of a catalyst to form a 5"-amino derivativeAnd then, removing the remaining protective groups of the last-mentioned derivative.

5. 发明授权

US4078138A 3'-Epi-4'deoxykanamycin B 失效
标题翻译： 3-EPI-4脱氧卡那霉素B
公开(公告)号：US4078138A
公开(公告)日：1978-03-07
申请号：US638045
申请日：1975-12-05
申请人： Eiichi Akita , Yukio Horiuchi , Takeo Miyazawa , Toshio Yoneta , Sumio Umezawa , Hamao Umezawa
发明人： Eiichi Akita , Yukio Horiuchi , Takeo Miyazawa , Toshio Yoneta , Sumio Umezawa , Hamao Umezawa
IPC分类号： A61K31/70 , A61K31/7028 , A61K31/7034 , A61K31/7036 , A61K31/704 , A61P31/04 , C07H15/224 , C07H15/23 , C07H15/234 , C07H15/236 , C07H15/244 , C07H15/22
CPC分类号： C07H15/224 , C07H15/23 , C07H15/234
摘要： 3',4'-.alpha.-Epoxyneamine and its related aminoglycosidic antibiotic derivatives containing 3',4'-.alpha.-epoxyneamine moiety in the molecule thereof are now provided, which may be in the form of their amino-protected and partially hydroxyl-protected product and which are useful as intermediates for use in the synthetic production of therapeutically valuable 3'-deoxy derivatives of aminoglycosidic antibiotics.
摘要翻译：现在提供了分子中含有3'，4'-α-环氧基胺部分的3'，4'-α-氧苯胺及其相关的氨基糖苷类抗生素衍生物，其可以是其氨基保护和部分羟基保护的形式并且其可用作用于合成生产氨基糖苷类抗生素治疗有价值的3'-脱氧衍生物的中间体。

6. 发明申请

US20060120625A1 System and method for rectified mosaicing of images recorded by a moving camera 审中-公开
标题翻译：用于移动摄像机记录的图像的校正马赛克的系统和方法
公开(公告)号：US20060120625A1
公开(公告)日：2006-06-08
申请号：US11271465
申请日：2005-11-10
申请人： Shmuel Peleg , Assaf Zomet , Chetan Arora , Takeo Miyazawa
发明人： Shmuel Peleg , Assaf Zomet , Chetan Arora , Takeo Miyazawa
IPC分类号： G06K9/36 , G06K9/32
CPC分类号： G06T3/4038 , H04N5/23238 , H04N5/2628
摘要： A system is described for generating a rectified mosaic image from a plurality of individual images, the system comprising a quadrangular region defining module, a warping module and a mosaicing module. The quadrangular region defining module is configured to define in one individual image a quadrangular region in relation to two points on a vertical anchor in the one individual image and mappings of two points on a vertical anchor in at least one other individual image into the one individual image. The warping module is configured to warp the quadrangular region to a rectangular region. The mosaicing module configured to mosaic the quadrangular region to the mosaic image. The system further generates a mosaic from a plurality of panoramic images, the system comprising a motion determining module, a normalizing module, a strip selection module, and a mosaicing module. The motion determining module is configured to determine image motion between two panoramic images. The normalizing module is configured to normalize respective columns in the panoramic images in relation to the ratio of the image motion thereof to the image motion of a selected column, thereby to generate normalized panoramic images. The strip selection module is configured to select strips of the normalized panoramic images. The mosaicing module is configured to mosaic the selected strips together.
摘要翻译：描述了用于从多个单独图像生成整流马赛克图像的系统，该系统包括四边形区域定义模块，翘曲模块和镶嵌模块。四边形区域限定模块被配置为在一个单独的图像中定义与一个单独图像中的垂直锚点上的两个点相关的四边形区域，并且将至少一个其他单独图像中的垂直锚点上的两个点的映射转换成一个个体图片。翘曲模块被配置成将四边形区域扭曲成矩形区域。镶嵌模块被配置为将四边形区域镶嵌到马赛克图像。该系统还从多个全景图像生成马赛克，该系统包括运动确定模块，归一化模块，条选择模块和镶嵌模块。运动确定模块被配置为确定两个全景图像之间的图像运动。归一化模块被配置为相对于其图像运动与所选列的图像运动的比率来归一化全景图像中的相应列，从而生成归一化的全景图像。条带选择模块被配置为选择标准化全景图像的条带。镶嵌模块被配置为将所选择的条拼接在一起。

7. 发明授权

US4873301A Optically active, ethylenically unsaturated polymers of amino penicillanic acid compounds 失效
标题翻译：光学活性的氨基青霉烷酸化合物的烯属不饱和聚合物
公开(公告)号：US4873301A
公开(公告)日：1989-10-10
申请号：US147722
申请日：1988-01-25
申请人： Yasushi Saotome , Takeo Miyazawa , Takeshi Endo
发明人： Yasushi Saotome , Takeo Miyazawa , Takeshi Endo
IPC分类号： C07D499/46 , C07D499/00 , C07D499/32 , C07D499/42 , C07D499/44 , C07F7/18 , C08F12/26 , C08F18/02 , C08F18/22 , C08F20/00 , C08F20/52 , C08F20/60 , C08F26/00 , C08F26/02 , C08F30/08
CPC分类号： C08F20/60 , C07D499/00 , C08F12/26
摘要： Disclosed are an optically active, ethylenically unsaturated monomer represented by the following structural formula: ##STR1## wherein: A stands for S, SO or SO.sub.2 ; X and Y each stand for a hydrogen atom or a substituent selected from the group consisting of alkyl groups and acyl groups; Z stands for a substituent selected from the group consisting of alkoxy, alkylamino, hydroxyl and silyloxy groups; and X and Y can be bonded together to form a ring with the nitrogen atom to which they are bonded or X and Y can be a single group bonded to said nitrogen atom through a double bond, with the proviso that at least one of X and Z is an alkenyl equivalent to said group, and polymers of this monomer. One typical instance of the monomer is benzyl 6-acrylaminopenicillanate.

8. 发明授权

US06403986B1 Optical semiconductor device and method of fabricating the same 失效
公开(公告)号：US06403986B1
公开(公告)日：2002-06-11
申请号：US09027012
申请日：1998-02-18
申请人： Fumihiko Kobayashi , Takeo Miyazawa , Hidefumi Mori , Jun-ichi Nakano
发明人： Fumihiko Kobayashi , Takeo Miyazawa , Hidefumi Mori , Jun-ichi Nakano
IPC分类号： H01L29205
CPC分类号： H01S5/18347 , G02B6/125 , G02B2006/12121 , G02B2006/12123 , G02B2006/12147 , G02B2006/1215 , G02B2006/12159 , G02B2006/12176 , G02B2006/12178 , G02F1/025 , G02F1/2257 , H01L27/15 , H01L33/0062 , H01S5/026 , H01S5/0265 , H01S5/0425 , H01S5/0609 , H01S5/065 , H01S5/10 , H01S5/183 , H01S5/1835 , H01S5/2201 , H01S5/2224 , H01S5/227 , H01S5/2275 , H01S5/2277 , H01S5/3202 , H01S5/4056 , H01S5/423 , H01S5/50 , H01S2301/176
摘要： An optical semiconductor device includes an optical semiconductor element, a semiconductor region, and a buried layer. The optical semiconductor element is formed on a semiconductor substrate. The semiconductor region opposes the optical semiconductor element and essentially surrounds the optical semiconductor element to form walls. The buried layer is arranged between the walls of the semiconductor region and the optical semiconductor element and formed by vapor phase epitaxy. In this optical semiconductor device, a distance between the wall of the semiconductor region and a side wall of the optical semiconductor element is larger in a portion in which the growth rate of the vapor phase epitaxy in a horizontal direction from the side wall of the optical semiconductor element and the wall of the semiconductor region is higher.

9. 发明授权

US4747925A Apparatus for simultaneous generation of oxygen and hydrogen gases 失效
标题翻译：用于同时产生氧气和氢气的装置
公开(公告)号：US4747925A
公开(公告)日：1988-05-31
申请号：US878062
申请日：1986-06-24
申请人： Shigeta Hasebe , Takeo Miyazawa , Susumu Daidoji
发明人： Shigeta Hasebe , Takeo Miyazawa , Susumu Daidoji
IPC分类号： C25B9/00 , C25B1/04 , C25B9/06 , C25B1/06
CPC分类号： C25B1/04 , C25B9/06 , Y02E60/366 , Y10S204/05
摘要： While a large number of positive and negative electrodes are alternately arranged in an alignment on a same level in an electrolytic tank, a pair of magnets having the polarities thereof fixed in the same direction and which are disposed along the direction horizontally orthogonal to the arrangement of the electrodes of the same level, so that an electric field and a magnetic field will be generated on the horizontal directions orthogonal to each other and a force according to the Fleming's left-hand rule will be directed to the upward direction perpendicular to both the electric field and the magnetic field. The small bubbles adherent to the surface of the electrodes are enabled to be separated therefrom and allowed to float up owing to the addition of the upward force to their insufficient buoyancy.
摘要翻译：虽然大量的正极和负极在电解槽中的同一水平面上交替排列成一列，但是具有极性的一对磁体沿相同的方向固定，并且沿与水平正交的方向电极处于相同电平，从而在垂直于水平方向上产生电场和磁场，并且根据弗莱明左手规则的力将被引向垂直于两电场和磁场。粘附到电极表面的小气泡能够与其分离并且由于向上的力增加到它们不充分的浮力而允许浮起。

10. 发明申请

US20090002713A1 Optical Coherence Tomography System 审中-公开
标题翻译：光学相干断层扫描系统
公开(公告)号：US20090002713A1
公开(公告)日：2009-01-01
申请号：US11814219
申请日：2006-01-19
申请人： Kohji Ohbayashi , Kimiya Shimizu , Takeo Miyazawa , Ryoko Yoshimura , Hiroyuki Ishii
发明人： Kohji Ohbayashi , Kimiya Shimizu , Takeo Miyazawa , Ryoko Yoshimura , Hiroyuki Ishii
IPC分类号： G01B9/02
CPC分类号： G01N21/4795 , G01B9/02004 , G01B9/0201 , G01B9/02069 , G01B9/02078 , G01B9/02091
摘要： There is provided an optical coherent tomography device capable of enlarging a measurement range by removing the affect of a folded image. The device includes an optical phase modulator (14) enabling operation amplifiers (17, 18) and a calculation control device (21) to measure a first intensity as a cosine function for the wave number and a second intensity as a sine function or inverse code function for the wave number from the intensity of the output light multiplexed by a third coupler (16). The calculation control device (21) is based on a first intensity set and a second intensity set of the output light by the optical phase modulator (14) measured by the operation amplifiers (17, 18) and the like, so as to suppress generation of a folded image and identify reflection or a backscattering position and a reflection intensity or a back scattering intensity of the measurement light for the irradiation direction of the measurement light in the measurement object.
摘要翻译：提供了能够通过消除折叠图像的影响来扩大测量范围的光学相干断层摄影装置。该装置包括一个光学相位调制器（14），其使得运算放大器（17,18）和一个计算控制装置（21）能够测量作为波数的余弦函数的第一强度，而将第二强度作为正弦函数或反码根据由第三耦合器（16）复用的输出光的强度的波数的函数。计算控制装置（21）基于由运算放大器（17,18）等测量的由光相位调制器（14）输出的第一强度组和第二强度组，以抑制产生并且识别测量对象中测量光的照射方向的测量光的反射或反向散射位置以及反射强度或反射散射强度。

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