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1. 发明申请

US20210275833A1 DOSIMETRY SYSTEMS FOR RADIATION TREATMENT USING RADIATION-DETECTOR-TRIGGERED CAMERAS TO IMAGE CHERENKOV EMISSIONS OR THIN-SHEET SCINTILLATORS 有权
公开(公告)号：US20210275833A1
公开(公告)日：2021-09-09
申请号：US17313838
申请日：2021-05-06
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE , DOSEOPTICS, LLC
发明人： Venkataramanan Krishnaswamy , Petr Bruza, JR. , Michael Jermyn , Brian W. Pogue , David Gladstone , Lesley A. Jarvis , Irwin Tendler
IPC分类号： A61N5/10 , G01T1/20 , G01T1/22
摘要： A Cherenkov-based or thin-sheet scintillator-based imaging system uses a radio-optical triggering unit (RTU) that detects scattered radiation in a fast-response scintillator to detect pulses of radiation to permit capture of Cherenkov-light or scintillator-light images during pulses of radiation and background images at times when pulses of radiation are not present without need for electrical interface to the accelerator that provides the pulses of radiation. The Cherenkov images are corrected by background subtraction and used for purposes including optimization of treatment, commissioning, routine quality auditing, R&D, and manufacture. The radio-optical triggering unit employs high-speed, highly sensitive radio-optical sensing to generate a digital timing signal which is synchronous with the treatment beam for use in triggering Cherenkov light or scintillator light imaging.

2. 发明申请

US20200346041A1 IMAGING SYSTEM AND METHODS OF HIGH RESOLUTION CHERENKOV DOSE IMAGES UTILIZING RADIO-OPTICAL TRIGGERING 审中-公开
公开(公告)号：US20200346041A1
公开(公告)日：2020-11-05
申请号：US16932757
申请日：2020-07-18
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE , DOSEOPTICS, LLC
发明人： Venkataramanan Krishnaswamy , Petr Bruza , Michael Jermyn , Brian W. Pogue
IPC分类号： A61N5/10 , G01T1/22 , G01T1/20
摘要： A Cherenkov-based imaging system uses a radio-optical triggering unit (RTU) that detects scattered radiation in a fast-response scintillator to detect pulses of radiation to permit capture of Cherenkov-light images during pulses of radiation and background images at times when pulses of radiation are not present without need for electrical interface to the accelerator that provides the pulses of radiation. The Cherenkov images are corrected by background subtraction and used for purposes including optimization of treatment, commissioning, routine quality auditing, R&D, and manufacture. The radio-optical triggering unit employs high-speed, highly sensitive radio-optical sensing to generate a digital timing signal which is synchronous with the treatment beam for use in triggering Cherenkov radiation detection.

3. 发明授权

US11633627B2 Dosimetry systems for radiation treatment using radiation-detector-triggered cameras to image Cherenkov emissions or thin-sheet scintillators 有权
公开(公告)号：US11633627B2
公开(公告)日：2023-04-25
申请号：US17313838
申请日：2021-05-06
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE , DOSEOPTICS, LLC
发明人： Venkataramanan Krishnaswamy , Petr Bruza, Jr. , Michael Jermyn , Brian W. Pogue , David Gladstone , Lesley A. Jarvis , Irwin Tendler
IPC分类号： A61N5/10 , G01T1/20 , G01T1/22
摘要： A Cherenkov-based or thin-sheet scintillator-based imaging system uses a radio-optical triggering unit (RTU) that detects scattered radiation in a fast-response scintillator to detect pulses of radiation to permit capture of Cherenkov-light or scintillator-light images during pulses of radiation and background images at times when pulses of radiation are not present without need for electrical interface to the accelerator that provides the pulses of radiation. The Cherenkov images are corrected by background subtraction and used for purposes including optimization of treatment, commissioning, routine quality auditing, R&D, and manufacture. The radio-optical triggering unit employs high-speed, highly sensitive radio-optical sensing to generate a digital timing signal which is synchronous with the treatment beam for use in triggering Cherenkov light or scintillator light imaging.

4. 发明授权

US11000703B2 Imaging system and methods of high resolution Cherenkov dose images utilizing radio-optical triggering 有权
公开(公告)号：US11000703B2
公开(公告)日：2021-05-11
申请号：US16932757
申请日：2020-07-18
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE , DOSEOPTICS, LLC
发明人： Venkataramanan Krishnaswamy , Petr Bruza , Michael Jermyn , Brian W. Pogue
IPC分类号： A61N5/10 , G01T1/20 , G01T1/22
摘要： A Cherenkov-based imaging system uses a radio-optical triggering unit (RTU) that detects scattered radiation in a fast-response scintillator to detect pulses of radiation to permit capture of Cherenkov-light images during pulses of radiation and background images at times when pulses of radiation are not present without need for electrical interface to the accelerator that provides the pulses of radiation. The Cherenkov images are corrected by background subtraction and used for purposes including optimization of treatment, commissioning, routine quality auditing, R&D, and manufacture. The radio-optical triggering unit employs high-speed, highly sensitive radio-optical sensing to generate a digital timing signal which is synchronous with the treatment beam for use in triggering Cherenkov radiation detection.

5. 发明申请

US20210001153A1 APPARATUS AND METHODS FOR MAPPING HIGH ENERGY RADIATION DOSE DURING RADIATION TREATMENT 有权
公开(公告)号：US20210001153A1
公开(公告)日：2021-01-07
申请号：US16975301
申请日：2019-02-22
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE
发明人： Brian W. Pogue , Petr Bruza , David Gladstone , Lesley A. Jarvis , Irwin Tendler
IPC分类号： A61N5/10 , G01T1/20 , G01T1/15 , G01T7/00
摘要： A system for dosimetry includes a radiation source that provides a pulsed radiation beam to a treatment zone, and a thin sheet of scintillator disposed between the radiation source and skin of a subject in the treatment zone. A gated camera images the scintillator integrating light from the scintillator during multiple pulses of the radiation beam while excluding light received between pulses of the pulsed radiation beam; and an image capture and processing machine that receives images from the gated camera and performs additional corrections to provide a map of dose received by the subject.

6. 发明申请

US20150374308A1 Method And Apparatus For Medical Imaging Using Differencing Of Multiple Fluorophores 审中-公开
标题翻译：使用多个荧光团差异的医学成像方法和装置
公开(公告)号：US20150374308A1
公开(公告)日：2015-12-31
申请号：US14767836
申请日：2014-02-13
申请人： THE TRUSTEES OF DARTMOUTH COLLEGE
发明人： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
IPC分类号： A61B5/00 , A61K49/00
摘要： A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.
摘要翻译：产生受试者组织中靶向荧光团浓度的校正荧光数据的方法包括向受试者施用第一和第二荧光造影剂，靶向目的组织的第一造影剂，第二剂未被靶向。用第一刺激波长的光照射组织，并以适当的发射波长获取第一数据; 在第二刺激波长照射组织，并且以与第二试剂相关联的第二发射波长获取第二数据，第一和第二发射波长不同。通过从第一数据中减去第二数据来产生差分数据。系统提供多个波长的刺激和捕获，具有图像存储和减法代码，以执行该方法。校正的数据可以形成荧光图像，或用于产生荧光断层图像。

7. 发明授权

US11564639B2 Method and apparatus for medical imaging using differencing of multiple fluorophores 有权
公开(公告)号：US11564639B2
公开(公告)日：2023-01-31
申请号：US14767836
申请日：2014-02-13
申请人： The Trustees of Dartmouth College
发明人： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
IPC分类号： A61B5/00 , A61K49/00
摘要： A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.

8. 发明授权

US10485425B2 Apparatus and methods for structured light scatteroscopy 有权
公开(公告)号：US10485425B2
公开(公告)日：2019-11-26
申请号：US15116808
申请日：2015-02-04
申请人： The Trustees of Dartmouth College
发明人： Venkataramanan Krishnaswamy , Brian W. Pogue , Keith D. Paulsen , Jonathan T. Elliott , David M. McClatchy, III
IPC分类号： A61B5/00 , G01B11/25
CPC分类号： A61B5/0059 , A61B5/4869 , G01B11/2513 , A61B2505/05
摘要： A structured-light imaging system includes a structured light projector for illuminating a surface and an electronic camera configured to image the surface. An image processor receives the images and has structured light scatteroscopy (SLS) firmware with machine readable instructions that illuminate the surface with structured light having a spatial frequency of at least 0.5 mm″1, and process the images to determine a map of scattering parameters at the surface independent of absorption properties. In an embodiment, the system also has cameras configured to obtain a stereo pair of images of the surface, the image processor having 3D firmware for extracting a three dimensional model of the surface from the stereo pair of images and compensating the map for non-flat surfaces.

9. 发明授权

US11937951B2 Method and apparatus for medical imaging using differencing of multiple fluorophores 有权
公开(公告)号：US11937951B2
公开(公告)日：2024-03-26
申请号：US18159495
申请日：2023-01-25
申请人： The Trustees of Dartmouth College
发明人： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
IPC分类号： A61B5/00 , A61K49/00
CPC分类号： A61B5/7278 , A61B5/0071 , A61K49/0058 , A61B5/0035 , A61B5/0062 , A61B2576/00
摘要： A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.

10. 发明公开

US20230233157A1 METHOD AND APPARATUS FOR MEDICAL IMAGING USING DIFFERENCING OF MULTIPLE FLUOROPHORES 审中-公开
公开(公告)号：US20230233157A1
公开(公告)日：2023-07-27
申请号：US18159495
申请日：2023-01-25
申请人： The Trustees of Dartmouth College
发明人： Kenneth Tichauer , Robert W. Holt , Frederic Leblond , Pablo Valdes , Brian W. Pogue , Keith D. Paulsen , David W. Roberts
IPC分类号： A61B5/00 , A61K49/00
CPC分类号： A61B5/7278 , A61B5/0071 , A61K49/0058 , A61B5/0062 , A61B5/0035 , A61B2576/00
摘要： A method of generating corrected fluorescence data of concentrations of a targeted fluorophore in tissue of a subject includes administering first and second fluorescent contrast agents to the subject, the first contrast agent targeted to tissue of interest, the second agent untargeted. The tissue is illuminated with light of a first stimulus wavelength and first data is acquired at an appropriate emissions wavelength; the tissue is illuminated at a second stimulus wavelength and second data is acquired at a second emissions wavelength associated with the second agent, the first and second emissions wavelength differ. Difference data is generated by subtracting the second data from the first data. A system provides for stimulus and capture at multiple wavelengths, with image storage memory and subtraction code, to perform the method. Corrected data may form an fluorescence image, or is used to generate fluorescence tomographic images.

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