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1. 发明申请

US20100048570A1 THIAZOLIDINE DERIVATIVES AND METHODS FOR THE PREPARATION THEREOF 审中-公开
标题翻译：噻唑烷衍生物及其制备方法
公开(公告)号：US20100048570A1
公开(公告)日：2010-02-25
申请号：US12523285
申请日：2008-01-16
申请人： Sung Soo Kim , Jin Hee Ahn , Hyae Gyeong Cheon , Sang Dal Rhee , Nam Sook Kang , Ki Young Kim , Seung Kyu Kang , Won Hoon Jung , Sung Gyu Kim , Sun Young Kim , Jae Hong Kweon , Sang Kwon Sohn , Min Ki Shin , Ni Na Ha
发明人： Sung Soo Kim , Jin Hee Ahn , Hyae Gyeong Cheon , Sang Dal Rhee , Nam Sook Kang , Ki Young Kim , Seung Kyu Kang , Won Hoon Jung , Sung Gyu Kim , Sun Young Kim , Jae Hong Kweon , Sang Kwon Sohn , Min Ki Shin , Ni Na Ha
IPC分类号： A61K31/5377 , C07D277/00 , C07D415/00 , A61K31/426
CPC分类号： C07D277/06 , C07D417/12 , Y02P20/55
摘要： The present invention relates to novel 2-carbonyl-3-acyl-1,3-thiazolidines having a β-amino group on the acyl chain, in free, prodrug form or pharmaceutically acceptable salt thereof, including their enantiomers, diastereomers and racemates, as efficient inhibitors against DPP-IV. The invention further relates to the pharmaceutical compositions comprising the disclosed compounds. The present invention also relates to methods for preparing the disclosed compounds and for treating DPP-IV-mediated diseases.
摘要翻译：本发明涉及在酰基链上具有游离的前药形式或其药学上可接受的盐，包括它们的对映异构体，非对映异构体和外消旋体的具有“ - ” - 氨基的新的2-羰基-3-酰基-1,3-噻唑烷，作为DPP-IV的有效抑制剂。本发明还涉及包含所公开的化合物的药物组合物。本发明还涉及制备所公开的化合物和用于治疗DPP-IV介导的疾病的方法。

2. 发明授权

US07745439B2 Indene derivatives and process for the preparation thereof 失效
标题翻译：茚衍生物及其制备方法
公开(公告)号：US07745439B2
公开(公告)日：2010-06-29
申请号：US10599913
申请日：2005-04-12
申请人： Hyae Gyeong Cheon , Sung-Eun Yoo , Sung Soo Kim , Sung-Don Yang , Kwang-Rok Kim , Sang Dal Rhee , Jin Hee Ahn , Seung Kyu Kang , Won Hoon Jung , Sung Dae Park , Nam Gee Kim , Sun Mee Kim , Kil Woong Mo , Jae Mok Lee , Hye Jung Kang , Koun Ho Lee , Jong Hoon Kim , Jeong-Hyung Lee , Seung Jun Kim
发明人： Hyae Gyeong Cheon , Sung-Eun Yoo , Sung Soo Kim , Sung-Don Yang , Kwang-Rok Kim , Sang Dal Rhee , Jin Hee Ahn , Seung Kyu Kang , Won Hoon Jung , Sung Dae Park , Nam Gee Kim , Sun Mee Kim , Kil Woong Mo , Jae Mok Lee , Hye Jung Kang , Koun Ho Lee , Jong Hoon Kim , Jeong-Hyung Lee , Seung Jun Kim
IPC分类号： A61K31/216 , A61K31/4402 , A61K31/5375 , C07C69/753 , C07D211/70 , C07D265/32
CPC分类号： C07D295/088 , C07C65/26 , C07C69/757 , C07C229/50 , C07C233/52 , C07C255/47 , C07C2601/14 , C07C2602/08 , C07D295/155
摘要： The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.
摘要翻译：式（I）的本发明的茚衍生物能够选择性调节过氧化物酶体增殖物激活受体（PPAR）的活性，不引起副作用，因此它们可用于治疗和预防由PPARs调节的病症，糖尿病，肥胖，动脉硬化，高脂血症，高胰岛素血症和高血压等代谢综合征，骨质疏松症，肝硬化和哮喘等炎性疾病和癌症。

3. 发明授权

US07741323B2 Indene derivatives and process for the preparation thereof 有权
标题翻译：茚衍生物及其制备方法
公开(公告)号：US07741323B2
公开(公告)日：2010-06-22
申请号：US10599911
申请日：2005-04-13
申请人： Hyae Gyeong Cheon , Sung-Eun Yoo , Sung Soo Kim , Sung-Don Yang , Kwang-Rok Kim , Sang Dal Rhee , Jin Hee Ahn , Seung Kyu Kang , Won Hoon Jung , Sung Dae Park , Nam Gee Kim , Jang Hyuk Lee , Sun Chul Huh , Jae Mok Lee , Seog Beom Song , Soon Ji Kwon , Jong Hoon Kim , Jeong-Hyung Lee , Seung Jun Kim
发明人： Hyae Gyeong Cheon , Sung-Eun Yoo , Sung Soo Kim , Sung-Don Yang , Kwang-Rok Kim , Sang Dal Rhee , Jin Hee Ahn , Seung Kyu Kang , Won Hoon Jung , Sung Dae Park , Nam Gee Kim , Jang Hyuk Lee , Sun Chul Huh , Jae Mok Lee , Seog Beom Song , Soon Ji Kwon , Jong Hoon Kim , Jeong-Hyung Lee , Seung Jun Kim
IPC分类号： C07C255/47 , C07C251/32 , C07C237/24 , C07C69/74 , C07D413/12 , C07D333/28 , C07D333/22 , C07D333/24 , C07D333/60 , C07D317/60 , C07D317/70 , C07D307/54 , C07D277/30 , C07D265/30 , C07D295/135 , C07D233/64 , C07D213/53 , C07D213/64 , A61K31/5377 , A61K31/495 , A61K31/4402 , A61K31/44 , A61K31/426 , A61K31/4164 , A61K31/381 , A61K31/36 , A61K31/277 , A61K31/216 , A61K31/165
CPC分类号： C07D213/30 , C07C291/02 , C07C309/66 , C07C2601/02 , C07C2601/14 , C07C2602/08 , C07C2603/74 , C07D213/53 , C07D233/64 , C07D277/24 , C07D295/088 , C07D295/185 , C07D307/54 , C07D317/60 , C07D317/70 , C07D333/24 , C07D333/28 , C07D417/12
摘要： An indene derivative for selectively modulating the activities of peroxisome proliferator activated receptors (PPARs) having the following formula (I): wherein, R1 is C1-6 alkyl, C1-6 alkenyl, or C3-6 cycloalkyl, each of which is unsubstituted or substituted with one or more phenyl groups; R2 is H, CN, CO2Ra, CH2CO2Ra, CONRbRc, or phenyl; R3 is C1-6 alkyl, C3-6 cycloalkyl, naphthyl, phenyl, being each unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, CN, NH2, NO2, ORa, phenyloxy, C1-6 alkyl, and C3-6 cycloalkyl; and R4, R5, R6, and R7 are each independently H, OH, OSO2CH3, O(CH2)mRe, CH2Rf, OCOCH2ORg, OCH2CH2ORg, OCH2CH═CHRg, or pyridine-2-yloxy, or R5 and R6 together form OCH2O.
摘要翻译：用于选择性调节具有下式（I）的过氧化物酶体增殖物激活受体（PPAR）的活性的茚衍生物：其中，R 1为C 1-6烷基，C 1-6链烯基或C 3-6环烷基，其各自为未取代或未取代的被一个或多个苯基取代; R2是H，CN，CO2Ra，CH2CO2Ra，CONRbRc或苯基; R 3是C 1-6烷基，C 3-6环烷基，萘基，苯基，各自未被取代或被一个或多个选自卤素，CN，NH 2，NO 2，OR a，苯氧基，C 1-6烷基和 C3-6环烷基; 和R 4，R 5，R 6和R 7各自独立地为H，OH，OSO 2 CH 3，O（CH 2）m RE，CH 2 R f，OCOCH 2 OR g，OCH 2 CH 2 OR g，OCH 2 CH = CHR g或吡啶-2-基氧基，或者R 5和R 6一起形成OCH 2 O。

4. 发明申请

US20070225288A1 Indene Derivatives and Process for the Preparation Thereof 失效
标题翻译：茚衍生物及其制备方法
公开(公告)号：US20070225288A1
公开(公告)日：2007-09-27
申请号：US10599913
申请日：2005-04-12
申请人： Hyae Gyeong Cheon , Sung-Eun Yoo , Sung Soo Kim , Sung-Don Yang , Kwang-Rok Kim , Sang Dal Rhee , Jin Hee Ahn , Seung Kyu Kang , Won Hoon Jung , Sung Dae Park , Nam Gee Kim , Sun Mee Kim , Kil Woong Mo , Jae Mok Lee , Hye Jung Kang , Koun Ho Lee , Jong Hoon Kim , Jeong-Hyung Lee , Seung Jun Kim
发明人： Hyae Gyeong Cheon , Sung-Eun Yoo , Sung Soo Kim , Sung-Don Yang , Kwang-Rok Kim , Sang Dal Rhee , Jin Hee Ahn , Seung Kyu Kang , Won Hoon Jung , Sung Dae Park , Nam Gee Kim , Sun Mee Kim , Kil Woong Mo , Jae Mok Lee , Hye Jung Kang , Koun Ho Lee , Jong Hoon Kim , Jeong-Hyung Lee , Seung Jun Kim
IPC分类号： A61K31/216 , A61K31/4402 , A61K31/5375 , C07C69/753 , C07D211/70 , C07D265/32
CPC分类号： C07D295/088 , C07C65/26 , C07C69/757 , C07C229/50 , C07C233/52 , C07C255/47 , C07C2601/14 , C07C2602/08 , C07D295/155
摘要： The inventive indene derivatives of formula (I) are capable of selectively modulating the activities of peroxisome proliferator activated receptors (PPARs), causing no adverse side effects, and thus, they are useful for the treatment and prevention of disorders modulated by PPARs, i.e., metabolic syndromes such as diabetes, obesity, arteriosclerosis, hyperlipidemia, hyperinsulinism and hypertension, inflammatory diseases such as osteoporosis, liver cirrhosis and asthma, and cancer.
摘要翻译：式（I）的本发明的茚衍生物能够选择性调节过氧化物酶体增殖物激活受体（PPAR）的活性，不引起副作用，因此它们可用于治疗和预防由PPARs调节的病症，糖尿病，肥胖，动脉硬化，高脂血症，高胰岛素血症和高血压等代谢综合征，骨质疏松症，肝硬化和哮喘等炎性疾病和癌症。

5. 发明授权

US09073906B2 Sulfamide derivative having an adamantyl group and its pharmaceutically acceptable salt 有权
标题翻译：具有金刚烷基的磺酰胺衍生物及其药学上可接受的盐
公开(公告)号：US09073906B2
公开(公告)日：2015-07-07
申请号：US14008899
申请日：2012-03-30
申请人： Ki Young Kim , Jin Hee Ahn , Seung Kyu Kang , Sang Dal Rhee , Myung Ae Bae , Sung Hoon Ahn , Hee Youn Kim , Won Hoon Jung , Nam Sook Kang
发明人： Ki Young Kim , Jin Hee Ahn , Seung Kyu Kang , Sang Dal Rhee , Myung Ae Bae , Sung Hoon Ahn , Hee Youn Kim , Won Hoon Jung , Nam Sook Kang
IPC分类号： C07D285/16 , C07D285/36 , A61K31/541 , C07D417/04 , A61K31/18 , C07C307/10 , C07D417/10 , C07D417/12 , C07D285/10 , C07D285/14 , C07D285/15
CPC分类号： C07D417/04 , A61K31/18 , C07C307/10 , C07C2603/74 , C07D285/10 , C07D285/14 , C07D285/15 , C07D285/16 , C07D285/36 , C07D417/10 , C07D417/12
摘要： Provided is a sulfamide derivative having an adamantyl group represented by the following Formula 1, or a pharmaceutically acceptable salt thereof. The sulfamide derivative suppresses the activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), and is useful in the treatment of various diseases that are mediated by 11β-HSD1.
摘要翻译：提供具有由下式1表示的金刚烷基的磺酰胺衍生物或其药学上可接受的盐。磺酰胺衍生物抑制11型β-羟基类固醇脱氢酶1（11＆bgr-HSD1）的活性，可用于治疗由11＆bgr-HSD1介导的各种疾病。

6. 发明申请

US20140024636A1 SULFAMIDE DERIVATIVE HAVING AN ADAMANTYL GROUP AND ITS PHARMACEUTICALLY ACCEPTABLE SALT 有权
标题翻译：具有营养素组的磺胺衍生物及其药学上可接受的盐
公开(公告)号：US20140024636A1
公开(公告)日：2014-01-23
申请号：US14008899
申请日：2012-03-30
申请人： Ki Young Kim , Jin Hee Ahn , Seung Kyu Kang , Sang Dal Rhee , Myung Ae Bae , Sung Hoon Ahn , Hee Youn Kim , Won Hoon Jung , Nam Sook Kang
发明人： Ki Young Kim , Jin Hee Ahn , Seung Kyu Kang , Sang Dal Rhee , Myung Ae Bae , Sung Hoon Ahn , Hee Youn Kim , Won Hoon Jung , Nam Sook Kang
IPC分类号： C07C307/10 , C07D285/10 , C07D417/04 , C07D417/10 , C07D417/12 , C07D285/15 , C07D285/14 , C07D285/16 , C07D285/36
CPC分类号： C07D417/04 , A61K31/18 , C07C307/10 , C07C2603/74 , C07D285/10 , C07D285/14 , C07D285/15 , C07D285/16 , C07D285/36 , C07D417/10 , C07D417/12
摘要： Provided is a sulfamide derivative having an adamantyl group represented by the following Formula 1, or a pharmaceutically acceptable salt thereof. The sulfamide derivative suppresses the activity of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), and is useful in the treatment of various diseases that are mediated by 11β-HSD1.
摘要翻译：提供具有由下式1表示的金刚烷基的磺酰胺衍生物或其药学上可接受的盐。该磺酰胺衍生物抑制1型11β-羟类固醇脱氢酶（11beta-HSD1）的活性，可用于治疗由11beta-HSD1介导的各种疾病。

7. 发明申请

US20130097947A1 STEEL STRUCTURE INCLUDING PRE-STRESSING BRACKETS FOR IMPROVING LOAD-CARRYING CAPACITY AND SERVICEABILITY 有权
标题翻译：钢结构包括用于提高承载能力和维修能力的预应力支架
公开(公告)号：US20130097947A1
公开(公告)日：2013-04-25
申请号：US13807823
申请日：2011-05-04
申请人： Sang Hyo Kim , Jin Hee Ahn , Jung Ho Yoo , Seung Soo Han , Chang Keon Cho , Kyu Tae Choi
发明人： Sang Hyo Kim , Jin Hee Ahn , Jung Ho Yoo , Seung Soo Han , Chang Keon Cho , Kyu Tae Choi
IPC分类号： E04C5/16 , E04C5/08
CPC分类号： E04C5/162 , E01D2/00 , E01D2/02 , E01D2101/32 , E04C3/04 , E04C5/08 , E04C2003/0417 , E04C2003/0434 , E04C2003/0452
摘要： A steel structure including pre-stressing brackets for improving load-carrying capacity and serviceability comprises: a steel girder; a plurality of connecting brackets connected to the bottom surface of the steel girder spaced and apart from one; and a cover plate connected to the bottom surfaces of the connecting brackets. Since the cover plate is installed regardless of the connecting portion of the steel girder, pre-stressing section can be consecutively formed therefore pre-stress effect is improved. Moreover, since the connecting brackets space the cover plate a constant distance from the steel girder, the moment of inertia is increased so the span of a bridge might be increased.
摘要翻译：包括用于提高承载能力和可使用性的预应力支架的钢结构包括：钢梁; 多个连接托架连接到钢梁的底表面上，间隔开并分开; 以及连接到连接支架的底表面的盖板。由于无论钢梁的连接部分如何安装盖板，因此可以连续地形成预应力部，因此提高了预应力效果。此外，由于连接支架将盖板与钢梁隔开一定距离，因此惯性矩增大，从而可能增加桥的跨度。

8. 发明授权

US08621797B2 Steel structure including pre-stressing brackets for improving load-carrying capacity and serviceability 有权
标题翻译：钢结构包括预应力支架，用于提高承载能力和适用性
公开(公告)号：US08621797B2
公开(公告)日：2014-01-07
申请号：US13807823
申请日：2011-05-04
申请人： Sang Hyo Kim , Jin Hee Ahn , Jung Ho Yoo , Seung Soo Han , Chang Keon Cho , Kyu Tae Choi
发明人： Sang Hyo Kim , Jin Hee Ahn , Jung Ho Yoo , Seung Soo Han , Chang Keon Cho , Kyu Tae Choi
IPC分类号： E04C3/10
CPC分类号： E04C5/162 , E01D2/00 , E01D2/02 , E01D2101/32 , E04C3/04 , E04C5/08 , E04C2003/0417 , E04C2003/0434 , E04C2003/0452
摘要： A steel structure including pre-stressing brackets for improving load-carrying capacity and serviceability comprises: a steel girder; a plurality of connecting brackets connected to the bottom surface of the steel girder spaced and apart from one; and a cover plate connected to the bottom surfaces of the connecting brackets. Since the cover plate is installed regardless of the connecting portion of the steel girder, pre-stressing section can be consecutively formed therefore pre-stress effect is improved. Moreover, since the connecting brackets space the cover plate a constant distance from the steel girder, the moment of inertia is increased so the span of a bridge might be increased.
摘要翻译：包括用于提高承载能力和可使用性的预应力支架的钢结构包括：钢梁; 多个连接托架连接到钢梁的底表面上，间隔开并分开; 以及连接到连接支架的底表面的盖板。由于无论钢梁的连接部分如何安装盖板，因此可以连续地形成预应力部，因此提高了预应力效果。此外，由于连接支架将盖板与钢梁隔开一定距离，因此惯性矩增大，从而可能增加桥的跨度。

9. 发明申请

US20090042872A1 Rhodanine Derivatives, a Process for the Preparation Thereof and Pharmaceutical Composition Containing the Same 有权
标题翻译：罗丹明衍生物，其制备方法和含有其的药物组合物
公开(公告)号：US20090042872A1
公开(公告)日：2009-02-12
申请号：US12087474
申请日：2006-12-08
申请人： Seong Eon Ryu , Seung Jun Kim , Dae Gwin Jeong , Sang Hyeup Lee , Suk Kyeong Jung , Hwan Mook Kim , Song Kyu Park , Ki Ho Lee , Chang Woo Lee , Joong-Kwon Choi , Jin Hee Ahn
发明人： Seong Eon Ryu , Seung Jun Kim , Dae Gwin Jeong , Sang Hyeup Lee , Suk Kyeong Jung , Hwan Mook Kim , Song Kyu Park , Ki Ho Lee , Chang Woo Lee , Joong-Kwon Choi , Jin Hee Ahn
IPC分类号： A61K31/426 , C07D277/04 , C07D413/12 , A61K31/538 , A61P3/10 , A61P35/00 , A61P3/04 , A61K31/5377 , C07D265/34
CPC分类号： C07D277/20 , C07D417/12
摘要： Disclosed herein are rhodanine derivatives, a method for the preparation thereof, and a pharmaceutical composition containing the same. The rhodanine derivatives have inhibitory activity against protein phosphatases (PPase) such as PTP1B, Prl-3, LAR, CD45, Cdc25A, Cdc25B, Cdc25C, Yop, PP1 and VHR, and can be applied for the prevention and treatment of PPase-caused diseases, including autoimmune diseases, diabetes, impaired glucose intolerance, insulin resistance, obesity, cancers, etc. when the inhibitory activity thereof is modulated.
摘要翻译：本文公开了绕丹宁衍生物，其制备方法和含有它们的药物组合物。罗丹明衍生物对PTP1B，Prl-3，LAR，CD45，Cdc25A，Cdc25B，Cdc25C，Yop，PP1和VHR等蛋白磷酸酶（PPase）具有抑制活性，可用于预防和治疗PPase引起的疾病包括自身免疫性疾病，糖尿病，葡萄糖耐受不良，胰岛素抵抗，肥胖，癌症等。

10. 发明申请

US20080128418A1 Vessel Cap Having Straw 审中-公开
标题翻译：船帽有秸秆
公开(公告)号：US20080128418A1
公开(公告)日：2008-06-05
申请号：US11720295
申请日：2005-11-28
申请人： Jin Hee Ahn
发明人： Jin Hee Ahn
IPC分类号： B65D51/16 , B65D41/04 , A47G19/22
CPC分类号： B65D5/748 , B65D47/066 , B65D51/226 , B65D2251/0025 , B65D2251/0056 , B65D2251/0093
摘要： A vessel cap having a straw comprises a body mounted at a vessel inlet through which liquid material stored in a vessel is discharged outward, having a straw receiving portion at an upper surface thereof, and having a through hole at one side of the straw receiving portion; a straw horizontally disposed in the straw receiving portion of the body, and passing through the through hole thereby penetrating a sealing member formed at a vessel inlet when vertically positioned; and a connection film connected between an inner circumferential surface of the through hole of the body and an outer circumferential surface of the straw for guiding the straw to be vertically positioned. Once the straw is uprighted, the straw penetrates the sealing member. A user can drink the liquid material stored in the vessel by only one operation to open the cover thereby to enhance the user's convenience.
摘要翻译：具有吸管的容器盖包括安装在容器入口的主体，储存在容器中的液体材料通过该主体向外排出，在其上表面具有吸管接收部分，并且在吸管接收部分的一侧具有通孔 ; 秸杆水平地设置在主体的吸管接收部分中，并且穿过通孔，从而当垂直定位时穿过形成在容器入口处的密封构件; 以及连接膜，其连接在所述主体的通孔的内周面和所述吸管的外周面之间，用于引导所述吸管被垂直定位。一旦秸秆竖立，秸秆就会渗透密封件。使用者只需一次操作即可饮用储存在容器中的液体材料，从而提高使用者的便利性。

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