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1. 发明申请

US20100197906A1 Method for purification of chlorinated sucrose derivatives from reaction mixture by chromatography 审中-公开
标题翻译：通过色谱法从反应混合物中纯化氯化蔗糖衍生物的方法
公开(公告)号：US20100197906A1
公开(公告)日：2010-08-05
申请号：US11921564
申请日：2006-06-02
申请人： Subramaniyam , Chethana , Rakesh Ratnam , Sundeep Aurora
发明人： Subramaniyam , Chethana , Rakesh Ratnam , Sundeep Aurora
IPC分类号： B01D15/08 , C07H5/02
CPC分类号： C07H1/00 , B01J20/261 , B01J20/265 , B01J20/283 , B01J20/285 , B01J20/287 , B01J20/3217 , C07H1/06 , C07H5/02
摘要： A chromatographic process of DMF removal from an aqueous composition is described comprising its loading on a column of hydrophobic fixed bed adsorbent and eluting out DMF with an aqueous alkaline buffer. This method is useful to remove DMF as a process of general application wherever simultaneous removal and isolation of DMF is desired from an organic molecule which is not an organic solvent, is soluble in DMF. This method can be used for simultaneous removal of DMF from reaction mixtures and isolation of Trichlorogalactose (TGS) or TGS-6-acetate in a process of production of TGS.
摘要翻译：描述了从水性组合物中除去DMF的层析方法，其包括其在疏水性固定床吸附剂柱上的负载并用碱性缓冲液水溶液洗脱出来。该方法作为一般应用的方法是有用的，只要从不是有机溶剂的有机分子中同时除去和分离DMF，可溶于DMF。该方法可用于在反应混合物中同时除去DMF，并在生产TGS的过程中分离三氯半乳糖（TGS）或TGS-6-乙酸酯。

2. 发明申请

US20100168412A1 Continuous Neutralizer Mixer Reactor and a Continuous Process for Quenching Chlorination Reaction Mixture in Production of Chlorinated Sucrose 审中-公开
标题翻译：连续中和器搅拌器和氯化蔗糖生产中淬灭氯化反应混合物的连续方法
公开(公告)号：US20100168412A1
公开(公告)日：2010-07-01
申请号：US12226566
申请日：2007-04-19
申请人： Rakesh Ratnam , Sundeep Aurora , Sanjiv Shankar Anand , Subramaniyam
发明人： Rakesh Ratnam , Sundeep Aurora , Sanjiv Shankar Anand , Subramaniyam
IPC分类号： C07H1/06 , C07H1/00 , B01J19/18
CPC分类号： C07B39/00 , B01J19/0013 , B01J19/0066 , B01J19/0086 , B01J19/1881 , B01J2219/00006 , B01J2219/00033 , B01J2219/00063 , B01J2219/00094 , B01J2219/0011 , B01J2219/00177 , B01J2219/002 , B01J2219/00238 , C07H1/00 , C07H1/06 , C07H5/02
摘要： An improved process of production of a chlorinated sugar is described comprising chlorination of a partially protected sugar, wherein quenching as well as neutralization of chlorinated reaction mass is carried out concurrently and continuously in a reactor which is a continuous mixer as well as quencher providing continuous mixing of chlorination reaction mixture and pH adjusting solution and also provides for continuous quenching and continuous removal of quenched chlorinated reaction mixture.
摘要翻译：描述了制备氯化糖的改进方法，其包括氯化部分保护的糖，其中在连续混合器的反应器中同时且连续地进行淬灭和氯化反应物质的中和，以及提供连续混合的猝灭剂的氯化反应混合物和pH调节溶液，并且还提供连续淬火和连续除去淬灭的氯化反应混合物。

3. 发明申请

US20100151526A1 Method of Producing Sucrose-6-Acetate by Whole-Cell Biocatalysis 审中-公开
标题翻译：通过全细胞生物催化法生产蔗糖-6-乙酸酯的方法
公开(公告)号：US20100151526A1
公开(公告)日：2010-06-17
申请号：US11992235
申请日：2006-09-21
申请人： Rakesh Ratnam , Sundeep Aurora , P. Subramaniyam
发明人： Rakesh Ratnam , Sundeep Aurora , P. Subramaniyam
IPC分类号： C12P19/02 , C07H1/06
CPC分类号： C07H1/00 , C12P19/18 , C12P19/44
摘要： A process is described which uses whole cell preparations, immobilized or without immobilization, of a microorganism, including Aureobasidium pullulans, capable of forming enzymes of the group of fructosyltransferases, for catalyzing a reaction between sucrose and 6-O-protected glucose for formation of 6-O-protected sucrose, an intermediate in synthesis of trichlorogalactosucrose. 6-O-protected Sucrose is separated from high molecular weight by-products of the reaction having molecular weight of 500 daltons and more by reverse osmosis, and further purified by column chromatography.
摘要翻译：描述了一种使用能够形成果糖基转移酶基团的酶的微生物的全细胞制备物（固定化或不固定）的方法，其包括能产生蔗糖和6-O-保护的葡萄糖的反应的微生物，例如可以形成6 -O保护的蔗糖，三氯半乳糖蔗糖合成中间体。通过反渗透将6-O-保护的蔗糖与分子量为500道尔顿的反应的高分子量副产物分离，并通过柱色谱进一步纯化。

4. 发明申请

US20080004439A1 Sucrose-6-Ester Chlorination by Co-Addition of Chlorination Reagent 审中-公开
标题翻译：通过共添加氯化试剂进行蔗糖-6-酯氯化
公开(公告)号：US20080004439A1
公开(公告)日：2008-01-03
申请号：US11794495
申请日：2005-12-23
申请人： Rakesh Ratnam , Sundeep Aurora
发明人： Rakesh Ratnam , Sundeep Aurora
IPC分类号： C07H1/00
CPC分类号： C07H1/00 , C07H1/06 , C07H5/02
摘要： An improved process for chlorination is described wherein a solution of chlorinating agent and solution of sucrose-6-ester are mixed together by co-addition to a reaction vessel, the addition of both the reactants starting and completing substantially at the same time. The product of chlorinated sucrose is further extracted in organic solvents and deacylated to produce the high intensity sweetener product 4, 1′, 6′ trichlorogalactosucrose.
摘要翻译：描述了一种改进的氯化方法，其中将氯化剂溶液和蔗糖-6-酯的溶液通过共添加到反应容器中混合在一起，两者的反应物的添加基本上同时进行。将氯代蔗糖的产物进一步在有机溶剂中萃取并脱酰基化以产生高强度甜味剂产物4'，6'三氯半乳糖。

5. 发明申请

US20100222570A1 Process for production of chlorinated sucrose based on hydrophobic affinity chromatography 审中-公开
标题翻译：基于疏水亲和色谱法生产氯化蔗糖的方法
公开(公告)号：US20100222570A1
公开(公告)日：2010-09-02
申请号：US11991135
申请日：2006-08-29
申请人： Rakesh Ratnam , Sundeep Aurora , Arvind Mallinath Lali , Sandeep Bhaskar Kale
发明人： Rakesh Ratnam , Sundeep Aurora , Arvind Mallinath Lali , Sandeep Bhaskar Kale
IPC分类号： C07H1/06
CPC分类号： C07H1/06 , C07H5/02
摘要： This invention relates to a process for selective capture, isolation and purification of chlorinated sucrose compounds, including chlorinated sucrose, their precursors and derivatives, including trichlorogalactosucrose (TGS), directly from chlorinated reaction mixture by column chromatography on adsorbents and under conditions which result in specific and selective affinity towards one or more of chlorinated sucrose compound. The process also integrates de-esterification of chlorinated sucrose esters adsorbed on the adsorbent while they are being treated with desorbent. The process also provides a novel approach to concentration and crystallization of TGS. The chlorinated sucrose derivatives, including TGS, thus isolated are substantially free from most impurities, salts and organic solvents. The process has high recovery of more than 95% in terms of desired chlorinated sucrose derivatives including TGS.
摘要翻译：本发明涉及一种选择性捕获，分离和纯化氯化蔗糖化合物的方法，包括氯化蔗糖，其前体和衍生物，包括三氯半乳糖（TGS），直接由氯化反应混合物通过柱色谱法在吸附剂上和在导致特定以及对一种或多种氯化蔗糖化合物的选择性亲和力。该方法还将吸附在吸附剂上的氯化蔗糖酯的脱酯化同时用解吸剂进行处理。该方法还提供了TGS的浓缩和结晶的新方法。由此分离的氯化蔗糖衍生物，包括TGS基本上不含大多数杂质，盐和有机溶剂。该方法在所需的氯代蔗糖衍生物（包括TGS）方面具有高于95％的高回收率。

6. 发明申请

US20080163867A1 Molecular Separation Process in Various Steps of Process for Production of Chlorinated Sugars, Their Precursors and Derivatives 审中-公开
标题翻译：氯化糖，其前体和衍生物的生产过程的各个步骤中的分子分离过程
公开(公告)号：US20080163867A1
公开(公告)日：2008-07-10
申请号：US11884679
申请日：2006-02-20
申请人： Subramanyam , Rakesh Ratnam , Sundeep Aurora
发明人： Subramanyam , Rakesh Ratnam , Sundeep Aurora
IPC分类号： C13D3/16
CPC分类号： C07H11/00
摘要： This invention comprises novel application of a molecular separation process, including one or more of a membrane separation/filtration process comprising reverse osmosis, micro filtration, nanofiltration ultrafiltration and perevaporation and the like to several process streams obtained in process of production of for synthesis, purification or isolation of 1-6-Dichloro-1-6-DIDEOXY-β-Fructofuranosyl-4-chloro-4-deoxy-galactopyranoside (TGS), its precursors or its derivatives for achieving a separation of molecules in combination with conventional unit processes of separation.
摘要翻译：本发明包括分子分离方法的新应用，包括一种或多种膜分离/过滤方法，包括反渗透，微过滤，纳滤超滤和蒸发等，用于合成，纯化生产过程中获得的几种工艺流程或分离1-6-二氯-1,6-二脱氧-β-呋喃果糖基-4-氯-4-脱氧 - 吡喃半乳糖苷（TGS），其前体或其衍生物，用于与常规的单元方法结合实现分子分离分离

7. 发明申请

US20070270583A1 Process for Purification of 6 Acetyl 4,1', 6' Trichlorogalactosucrose and 4,1', 6' Trichlorogalactosucrose by Chromatography on Silanized Silica Gel 审中-公开
标题翻译：通过层析在硅烷化硅胶上纯化6个乙酰基4,1'，6'三氯半乳糖和4,1'，6'三氯半乳糖蔗糖的方法
公开(公告)号：US20070270583A1
公开(公告)日：2007-11-22
申请号：US11792621
申请日：2005-12-09
申请人： Rakesh Ratnam , Sundeep Aurora
发明人： Rakesh Ratnam , Sundeep Aurora
IPC分类号： C07H1/06
CPC分类号： C13B20/14 , C13B20/12
摘要： A reverse phase column chromatographic process of purification of 6-acetyl-4,1′,6′trichlorogalactose and 4,1′,6′trichlorogalactose is described which uses silanized silica as stationary phase and water or predominatly aqeous mixture derived from water and small proportion of organic solvents as a mobile phase.
摘要翻译：描述了纯化6-乙酰基-4,1'，6'-三氯半乳糖和4,1'，6'-三氯半乳糖的反相柱层析方法，其使用硅烷化二氧化硅作为固定相和水或主要来自水和小的水混合物有机溶剂作为流动相的比例。

8. 发明申请

US20110306102A1 IMPROVED METHODS FOR FERMENTATIVE PRODUCTION OF DOCOSAHEXAENOIC ACID 审中-公开
标题翻译：改善DOCOSAHEXAENOIC酸的生产方法
公开(公告)号：US20110306102A1
公开(公告)日：2011-12-15
申请号：US13203116
申请日：2010-02-24
申请人： Rakesh Ratnam , Sundeep Aurora , Surendra Talluri , Ellappan Ganesan , Vineetha Peter
发明人： Rakesh Ratnam , Sundeep Aurora , Surendra Talluri , Ellappan Ganesan , Vineetha Peter
IPC分类号： C12P7/64
CPC分类号： C12P7/6427
摘要： The invention comprises a process of producing polyunsaturated fatty acids from Thraustochytriales at high availability of oxygen by solid state fermentation or submerged fermentation in a batch, semi-continuous or continuous mode. Batch fermentation of more than 200 g/L and up to 450 g/L of dextrose added right in the beginning of fermentation was achieved with productivity of DHA achieved for higher than 10 g/Liter. The process comprises maintaining at least 20% to 30% dissolved oxygen and sometimes up to around 50% or more.
摘要翻译：本发明包括通过固态发酵或分批，半连续或连续模式的浸没发酵，从高可用性的氧气中从破囊壶菌产生多不饱和脂肪酸的方法。实现了在发酵开始时添加的超过200g / L和高达450g / L葡萄糖的分批发酵，其DHA的生产率达到高于10g / L。该方法包括保持至少20％至30％的溶解氧，有时高达约50％或更高。

9. 发明申请

US20100222568A1 Removal of pyridine and pyridine analogs from reaction mass containing sucrose esters 审中-公开
标题翻译：从含蔗糖酯的反应物中除去吡啶和吡啶类似物
公开(公告)号：US20100222568A1
公开(公告)日：2010-09-02
申请号：US11991169
申请日：2006-08-29
申请人： Rakesh Ratnam , Sundeep Aurora
发明人： Rakesh Ratnam , Sundeep Aurora
IPC分类号： C07H11/00 , C07H1/06
CPC分类号： C07H1/06
摘要： A process of removal of pyridine or a pyridine analogue from a composition or a Process Stream in a process of production of 4,1′, 6′ trichlorogalactosucrose is described comprising reacting pyridine with an acid, the said acid being used preferably in gaseous form, achieving complete precipitation of the salt of pyridine in higher alcoholic solvents and non-polar solvents, filtering off the precipitate of the said salt of pyridine to achieve removal of pyridine from the reaction system and optionally regenerating and recovering pyridine by reacting the said salt with alkali.
摘要翻译：描述了在制备4,1'，6'三氯半乳糖蔗糖的方法中从组合物或工艺流中除去吡啶或吡啶类似物的方法，其包括使吡啶与酸反应，所述酸优选以气态形式使用，使吡啶盐在较高的醇溶剂和非极性溶剂中完全沉淀，过滤掉所述吡啶盐的沉淀物，从反应体系中除去吡啶，任选地通过使所述盐与碱反应再生和回收吡啶。

10. 发明申请

US20080125584A1 Salts Assisted Selective Extraction Of 6-Acetyl- 4,1' , 6' Trichlorogalactosucrose And 4,1', 6' Trichlorogalactosucrosse From Aqueous Reaction Mixture 审中-公开
标题翻译：盐辅助选择性提取6-乙酰基-4,1'，6'三氯半乳糖和4,1'，6'三氯半乳糖苷从水性反应混合物
公开(公告)号：US20080125584A1
公开(公告)日：2008-05-29
申请号：US11792620
申请日：2005-12-09
申请人： Rakesh Ratnam , Sundeep Aurora
发明人： Rakesh Ratnam , Sundeep Aurora
IPC分类号： C07H1/06
CPC分类号： C07H5/02
摘要： A process is described to increase efficiency of extraction of 4,1′,6′ trichlorogalactosucrose (TGS) from aqueous solution by addition of salt. The invention helps in reducing the quantity of solvent needed for achieving substantial extraction. The invention also leads to extraction of TGS substantially free from polar impurities.
摘要翻译：描述了一种方法，以提高通过加入盐从水溶液中提取4,1'，6'三氯半乳糖蔗糖（TGS）的效率。本发明有助于减少实现大量萃取所需的溶剂量。本发明还导致提取基本上不含极性杂质的TGS。

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