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1. 发明申请

US20080077179A1 Pretreatment method for enhancing tissue adhesion 审中-公开
标题翻译：增强组织粘连的预处理方法
公开(公告)号：US20080077179A1
公开(公告)日：2008-03-27
申请号：US11986470
申请日：2007-11-21
申请人： Stuart Edwards , Thomas Wehman , Theodore Parker , Eugene Skalnyi , Theodore Kucklick , John Evans
发明人： Stuart Edwards , Thomas Wehman , Theodore Parker , Eugene Skalnyi , Theodore Kucklick , John Evans
IPC分类号： A61B17/04
CPC分类号： A61B17/00491 , A61B17/0057 , A61B17/3415 , A61B18/148 , A61B18/1482 , A61B18/1485 , A61B18/1487 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00022 , A61B2017/00084 , A61B2017/00106 , A61B2017/003 , A61B2017/00495 , A61B2017/005 , A61B2017/00637 , A61B2017/0065 , A61B2017/00672 , A61B2017/22067 , A61B2017/3492 , A61B2017/4216 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00065 , A61B2018/00077 , A61B2018/00083 , A61B2018/00113 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00494 , A61B2018/00559 , A61B2018/00577 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00755 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00827 , A61B2018/00869 , A61B2018/00875 , A61B2018/00886 , A61B2018/00892 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/00982 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/1467 , A61B2018/1472 , A61B2090/064 , A61B2090/3614 , A61B2090/3782 , A61B2218/002 , A61M3/0279 , A61M16/0858 , A61M25/0662 , A61M25/1002 , A61M2016/0027 , A61M2025/1052 , A61M2025/1086
摘要： A closure device is provided for sealing a puncture in a body vessel. The closure device includes an energy delivery device for delivering energy to tissue adjacent the vessel puncture which enhances an adhesiveness of the tissue to a closure composition precursor. The closure device includes a sealer/dilator for dilating tissue adjacent a vessel puncture, at least one closure composition precursor lumen within the sealer/dilator having an entrance port adjacent the proximal end of the sealer/dilator through which one or more fluent closure composition precursors can be delivered into the closure composition precursor lumen and an exit port adjacent the distal end of the sealer/dilator through which the one or more fluent closure composition precursors can be delivered outside the vessel adjacent the vessel puncture, and a plugging catheter for positioning within the vessel puncture, the plugging catheter extending distally from the sealer/dilator and including at least one position sensing mechanism such that the exit port of the closure composition precursor lumen is outside the vessel when the at least one position sensing mechanism is detected outside the vessel.
摘要翻译：提供封闭装置用于密封身体容器中的穿刺。闭合装置包括能量递送装置，用于将能量递送到邻近容器穿刺的组织，这提高了组织与封闭组合物前体的粘附性。闭合装置包括用于扩张邻近容器穿刺的组织的封闭器/扩张器，密封器/扩张器内的至少一个闭合组合物前体管腔具有邻近密封器/扩张器的近端的入口端口，通过该封闭器/扩张器的一个或多个流体封闭组合物前体可以将其输送到闭合组合物前体管腔和邻近密封剂/扩张器远端的出口，一个或多个流体封闭组合物前体可通过该出口端口被输送到与血管穿刺相邻的血管外部，容器穿刺，插塞导管从密封剂/扩张器向远端延伸并且包括至少一个位置感测机构，使得当在容器外部检测到至少一个位置感测机构时，闭合组合物前体腔的出口在容器外部。

2. 发明申请

US20050149116A1 Systems and methods for sealing a vascular puncture 审中-公开
标题翻译：用于密封血管穿刺的系统和方法
公开(公告)号：US20050149116A1
公开(公告)日：2005-07-07
申请号：US11055440
申请日：2005-02-10
申请人： Stuart Edwards , Ronald Lax , Theodore Parker , Thomas Wehrman , Theodore Kucklick , Eugene Skalnyi
发明人： Stuart Edwards , Ronald Lax , Theodore Parker , Thomas Wehrman , Theodore Kucklick , Eugene Skalnyi
IPC分类号： A61B17/00 , A61B17/34 , A61B17/42 , A61B18/00 , A61B18/04 , A61B18/14 , A61B18/18 , A61F2/958 , A61M3/02 , A61M16/04 , A61M25/06 , A61B17/08
CPC分类号： A61B18/148 , A61B17/00491 , A61B17/0057 , A61B17/3415 , A61B18/1482 , A61B18/1485 , A61B18/1487 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00022 , A61B2017/00084 , A61B2017/00106 , A61B2017/003 , A61B2017/00495 , A61B2017/005 , A61B2017/00637 , A61B2017/0065 , A61B2017/22067 , A61B2017/3492 , A61B2017/4216 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00065 , A61B2018/00077 , A61B2018/00083 , A61B2018/00113 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00494 , A61B2018/00559 , A61B2018/00577 , A61B2018/00654 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00755 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00827 , A61B2018/00869 , A61B2018/00875 , A61B2018/00886 , A61B2018/00892 , A61B2018/00898 , A61B2018/0091 , A61B2018/00916 , A61B2018/00982 , A61B2018/046 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/1467 , A61B2018/1472 , A61B2090/064 , A61B2090/3614 , A61B2090/3782 , A61B2218/002 , A61M3/0279 , A61M16/0481 , A61M16/0858 , A61M25/0662 , A61M25/1002 , A61M2025/1052 , A61M2025/1086
摘要： Systems and methods introduce a closure material to seal a vessel puncture site. The system and methods provide a catheter adapted for passage through a tissue puncture and sized to occupy substantially all the tissue puncture. The catheter includes a lumen in fluid communication with a fluid delivery port adjacent the catheter distal end. One or more dispensers are in fluid communication with the catheter lumen for dispensing first and second fluid compositions in the catheter lumen. An actuator causes the first and second fluid compositions to be dispensed from the dispensers and mixed by flowing the first and second fluid compositions through a static mixer. The first and second fluid compositions are dispensed from the fluid delivery port as a fluid mixture that reacts in situ to form a nonfluent closure composition adjacent the vessel puncture site.
摘要翻译：系统和方法引入封闭材料以密封容器穿刺部位。该系统和方法提供适于通过组织穿刺的导管，并且尺寸适于占据基本上所有的组织穿刺。导管包括与邻近导管远端的流体输送端口流体连通的内腔。一个或多个分配器与导管内腔流体连通，用于分配导管内腔中的第一和第二流体组合物。致动器使得第一和第二流体组合物从分配器分配并通过使第一和第二流体组合物流过静态混合器而混合。第一和第二流体组合物作为流体混合物从流体输送端口分配，其在原位反应以在血管穿刺部位附近形成非流体封闭组合物。

3. 发明申请

US20060254603A1 Universal introducer 审中-公开
标题翻译：通用导引器
公开(公告)号：US20060254603A1
公开(公告)日：2006-11-16
申请号：US11491763
申请日：2006-07-24
申请人： Stuart Edwards , Ronald Lax , Theodore Parker , Thomas Wehman , Theodore Kucklick
发明人： Stuart Edwards , Ronald Lax , Theodore Parker , Thomas Wehman , Theodore Kucklick
IPC分类号： A61B18/18
CPC分类号： A61B17/00491 , A61B17/0057 , A61B17/3415 , A61B18/14 , A61B18/1482 , A61B18/1487 , A61B2017/00084 , A61B2017/00495 , A61B2017/005 , A61B2017/00637 , A61B2017/0065 , A61B2017/00672 , A61B2017/3441 , A61B2017/3492 , A61B2018/0063 , A61B2090/064 , A61M25/0662
摘要： A device for introducing a catheter into a vessel through a puncture in a vessel and for sealing the puncture. The device includes an elongated body having a proximal end and a distal end sized to be positioned within a tissue site which includes the puncture. The elongated body includes a utility lumen sized to allow a catheter to be delivered through the utility lumen. The utility lumen is positioned within the elongated body so positioning the elongated body within the tissue site allows a catheter delivered through the utility lumen to enter the vessel. The elongated body also includes a closure lumen having an entrance port. A closure composition can be delivered through the entrance port into the closure lumen. The closure lumen also includes an exit port adjacent the distal end of the elongated body. The closure composition delivered into the closure lumen can be delivered through the exit port to the tissue site adjacent the puncture.
摘要翻译：一种用于通过穿孔在容器中将导管引入容器并用于密封穿刺的装置。该装置包括细长体，其具有近端和远端，其尺寸设置成包括穿刺的组织部位内。细长主体包括大小适于允许导管通过效用管腔输送的应用腔。实用管腔定位在细长体内，从而将细长体定位在组织部位内，允许通过效用腔输送的导管进入血管。细长体还包括具有入口的封闭腔。封闭组合物可通过入口端口输送到封闭腔。闭合腔还包括邻近细长体的远端的出口。输送到闭合腔内的封闭组合物可以通过出口传送到穿刺附近的组织部位。

4. 发明申请

US20060178734A1 Methods of delivering anti-restenotic agents from a stent 审中-公开
标题翻译：从支架输送抗再狭窄剂的方法
公开(公告)号：US20060178734A1
公开(公告)日：2006-08-10
申请号：US11325223
申请日：2006-01-04
申请人： Theodore Parker , John Shanley , Brett Trauthen , Frank Litvack , Stephen Diaz
发明人： Theodore Parker , John Shanley , Brett Trauthen , Frank Litvack , Stephen Diaz
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61F2/91 , A61F2210/0004 , A61F2230/0054 , A61F2250/0068 , A61L2300/416 , A61L2300/602
摘要： A method for decreasing the level of restenosis following a stent placement medical intervention involves the continuous administration of a dose of an anti-restenotic agent, such as paclitaxel, from the stent to vascular tissue in need of treatment in a controlled, extended, and substantially linear drug release profile. The method of substantially linear extended release increases the therapeutic effectiveness of administration of a given dosage. In one example, a method of reducing restenosis includes delivering paclitaxel from a stent to an artery at a minimum release rate of 1 percent of the total dosage of paclitaxel on the stent per day throughout an entire administration period from the time of implantation of the stent until the time that substantially all the paclitaxel is released from the stent.
摘要翻译：用于降低支架置入医疗干预后再狭窄水平的方法包括将需要治疗的受支配物，延长和基本上的支架的支架到血管组织的持续施用一定剂量的抗再狭窄剂如紫杉醇线性药物释放曲线。基本线性延长释放的方法增加给药剂量的给药的治疗有效性。在一个实例中，减少再狭窄的方法包括将紫杉醇从支架输送到动脉，在从支架植入开始的整个施用期间，每天在支架上以最大释放速率将紫杉醇的总剂量的1％直到基本上所有的紫杉醇从支架释放出来。

5. 发明申请

US20050234538A1 Bioresorbable stent delivery system 审中-公开
标题翻译：生物可吸收支架输送系统
公开(公告)号：US20050234538A1
公开(公告)日：2005-10-20
申请号：US11096774
申请日：2005-03-31
申请人： Frank Litvack , Jonh Shanley , Theodore Parker , Stephen Diaz
发明人： Frank Litvack , Jonh Shanley , Theodore Parker , Stephen Diaz
IPC分类号： A61F2/00 , A61F2/02 , A61F2/06 , A61F2/84 , A61L31/16 , A61M25/10
CPC分类号： A61F2/958 , A61F2210/0004 , A61F2250/0068
摘要： A method and system for delivering a bioresorbable intravascular stent includes a delivery system or catheter having an expandable balloon. A guidewire lumen having a distal guidewire port and a proximal guidewire port spaced a relatively short distance from the distal end allows rapid exchange of the stent delivery system over a guidewire.
摘要翻译：用于递送生物可再吸收的血管内支架的方法和系统包括具有可膨胀气囊的输送系统或导管。具有远端导丝端口和与远端间隔相对较短距离的近端导丝端口的导丝管腔允许通过导丝线快速更换支架输送系统。

6. 发明申请

US20060222679A1 System and method for loading a beneficial agent into a medical device 有权
公开(公告)号：US20060222679A1
公开(公告)日：2006-10-05
申请号：US11392099
申请日：2006-03-28
申请人： John Shanley , Stephen Diaz , Theodore Parker
发明人： John Shanley , Stephen Diaz , Theodore Parker
IPC分类号： A61F2/00
CPC分类号： A61L31/16 , A61F2/91 , A61F2/915 , A61F2002/91575 , A61F2002/91583 , A61F2210/0076 , A61F2250/0068 , A61L2300/00
摘要： A system for delivery of a beneficial agent in the form of a viscous liquid or paste allows holes in a medical device to be loaded in a single step process. The loading of a beneficial agent in a paste form also provides the ability to deliver large and potentially sensitive molecules including proteins, enzymes, antibodies, antisense, ribozymes, gene/vector constructs, and cells including endothelial cells.

7. 发明申请

US20060204546A1 Methods and systems for delivering immunosuppressant and anti-inflammatory agents from a stent 审中-公开
标题翻译：从支架输送免疫抑制剂和抗炎剂的方法和系统
公开(公告)号：US20060204546A1
公开(公告)日：2006-09-14
申请号：US11375454
申请日：2006-03-14
申请人： Thai Nguyen , John Shanley , Frank Litvack , Theodore Parker
发明人： Thai Nguyen , John Shanley , Frank Litvack , Theodore Parker
IPC分类号： A61F2/06
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91541 , A61F2250/0068 , A61L31/10 , A61L31/16 , A61L2300/416
摘要： A method for decreasing the level of restenosis following a stent placement medical intervention involves the continuous administration of a dose of an immunosuppressant or anti-inflammatory agent from reservoirs in a stent to vascular tissue in need of treatment in a controlled, two phase drug release profile. It is envisioned that the vascular tissue in need of treatment is arterial tissue, specifically coronary arterial tissue. The agent or drug can be the calcineurin inhibitor Pimecrolimus. The drug can be held within reservoirs in the stent in a drug delivery matrix comprised of the drug and a bioresorbable polymeric material and optionally additives to regulate the drug release.
摘要翻译：用于降低支架置入医疗干预后再狭窄水平的方法包括将需要在受控的两相药物释放曲线中进行治疗的支架中的血管中的一个剂量的免疫抑制剂或抗炎药剂的剂量连续施用于血管组织。可以想象，需要治疗的血管组织是动脉组织，特别是冠状动脉组织。该药物或药物可以是钙调神经磷酸酶抑制剂Pimecrolimus。该药物可以在由药物和生物可再吸收的聚合物材料和任选的调节药物释放的添加剂的药物递送基质中的支架内的储存器中保持。

8. 发明申请

US20050100577A1 Expandable medical device with beneficial agent matrix formed by a multi solvent system 审中-公开
标题翻译：具有由多溶剂体系形成的有益剂基质的可扩展医疗器械
公开(公告)号：US20050100577A1
公开(公告)日：2005-05-12
申请号：US10830566
申请日：2004-04-22
申请人： Theodore Parker , John Shanley , Micheline Markey
发明人： Theodore Parker , John Shanley , Micheline Markey
IPC分类号： A61F2/00 , A61F2/06 , A61F2/90 , A61L31/10 , A61L31/14 , A61L31/16 , A61K38/28 , A61K9/22 , A61K31/445 , A61K31/7076
CPC分类号： A61L31/148 , A61F2/91 , A61F2/915 , A61F2002/91541 , A61F2210/0076 , A61F2250/0068 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2300/606 , A61L2300/61 , A61L2420/02 , A61L2420/08
摘要： A multi solvent drug delivery matrix formation method is used to place layers into a reservoir in a stent in a stepwise manner to achieve extended delivery of water soluble, sensitive, or difficult to deliver drugs. The multi solvent matrix formation method allows the formation of a drug reservoir with a layered morphology in which the mixing between layers is limited to allow the different layers to perform different functions in controlling drug delivery. A stent having a drug delivery matrix includes a first beneficial agent layer affixed to the stent by depositing a first solution of a first polymer and a first solvent, and a second beneficial agent layer affixed to the first beneficial agent layer by depositing a second solution of a second polymer and a second solvent. The second solvent is selected so that the first polymer is substantially insoluble in the second solvent to prevent degradation of the first polymer during deposition of the second polymer. A therapeutic agent is provided in the first beneficial agent layer or the second beneficial agent layer to form a drug delivery matrix.
摘要翻译：使用多溶剂药物递送基质形成方法以逐步方式将层放置在支架中的储存器中以实现水溶性，敏感或难以递送的药物的延长递送。多溶剂基质形成方法允许形成具有分层形态的药物储存器，其中层之间的混合被限制以允许不同的层在控制药物递送中执行不同的功能。具有药物递送基质的支架包括通过沉积第一聚合物和第一溶剂的第一溶液而固定到支架上的第一有益剂层和通过沉积第一有益剂层的第二溶液第二聚合物和第二溶剂。选择第二溶剂使得第一聚合物基本上不溶于第二溶剂以防止第二聚合物沉积期间第一聚合物的降解。在第一有益剂层或第二有益剂层中提供治疗剂以形成药物递送基质。

9. 发明申请

US20110282743A1 ASSOCIATIVE ONLINE ADVERTISEMENT 审中-公开
标题翻译：相关在线广告
公开(公告)号：US20110282743A1
公开(公告)日：2011-11-17
申请号：US12781665
申请日：2010-05-17
申请人： Roger Gerdes , Theodore Parker
发明人： Roger Gerdes , Theodore Parker
IPC分类号： G06Q30/00 , G06Q99/00
CPC分类号： G06Q30/02 , G06Q30/0257
摘要： Embodiments of methods and apparatuses for associative online advertisement are disclosed. In various embodiments, an online advertisement of a product or service provider may be selectively associated with a member of an online social network, under the selection control of the member. In various embodiments, the association enables at least another member of the online social network to select the online advertisement from a social media associated with the member to be likewise associated with the online advertisement, or purchase for the member, a product or service of the associated product or service provider. Other embodiments may be disclosed and/or claimed.
摘要翻译：公开了关联在线广告的方法和装置的实施例。在各种实施例中，在成员的选择控制下，产品或服务提供商的在线广告可以选择性地与在线社交网络的成员相关联。在各种实施例中，该关联使得在线社交网络的至少另一个成员能够从与该成员相关联的社交媒体中选择同样与在线广告相关联的在线广告，或者为该成员购买该产品或服务相关产品或服务提供商。可以公开和/或要求保护其他实施例。

10. 发明申请

US20070112414A1 System and method for local delivery of antithrombotics 审中-公开
标题翻译：用于局部递送抗血栓药物的系统和方法
公开(公告)号：US20070112414A1
公开(公告)日：2007-05-17
申请号：US11516054
申请日：2006-09-05
申请人： Theodore Parker , Frank Litvack , Micheline Lisa Markey
发明人： Theodore Parker , Frank Litvack , Micheline Lisa Markey
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61L31/146 , A61L2300/21 , A61L2300/402 , A61L2300/416 , A61L2300/42
摘要： Dipyridamole is an antithrombotic agent which also promotes the growth of endothelial cells. An endothelial cell lining within a stent is necessary for complete healing on the interior of the stent. A dual drug dipyridamole stent includes a first drug formulation of dipyridamole and polymer arranged in a first set of holes in the stent for primarily luminal delivery and a second drug formulation of an antirestenotic agent and polymer arranged in a second set of holes in the stent for primarily mural delivery. The delivery of dipyridamole luminally into the blood stream can involve a two phase release with the first phase being a burst to prevent initial clotting or thrombus formation followed by a second phase with a much slower and more sustained release to reduce thrombogenicity and promote the growth of the endothelial cell lining.
摘要翻译：双嘧达莫是一种还促进内皮细胞生长的抗血栓形成剂。支架内部的内皮细胞衬里对于在支架内部完全愈合是必需的。双药双嘧达莫支架包括双嘧达莫的第一药物制剂和布置在支架中的第一组孔中的聚合物，用于主要的腔内递送，以及布置在支架中的第二组孔中的抗再狭窄剂和聚合物的第二药物制剂，主要是壁画交付。将双嘧达莫光发射到血液中可涉及两相释放，第一阶段是爆发，以防止初始凝血或血栓形成，随后是具有更慢和更持续释放的第二相以降低血栓形成并促进生长内皮细胞内衬。

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