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1. 发明申请

US20050107829A1 Methods for treating the cardia of the stomach 审中-公开
标题翻译：治疗胃贲门的方法
公开(公告)号：US20050107829A1
公开(公告)日：2005-05-19
申请号：US10963025
申请日：2004-10-12
申请人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Qin
发明人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Qin
IPC分类号： A61B18/00 , A61B18/04 , A61B18/12 , A61B18/14 , A61N1/00
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Methods treat a tissue region. In one arrangement, the methods deploy an electrode on a support structure in a tissue region at or near the cardia of the stomach. In one embodiment, the support structure has a proximal region and a distal region. The proximal region is enlarged in comparison to the distal region, and the electrode is carried by the enlarged proximal surface. The methods advance the electrode in a path to penetrate the tissue region and couple the electrode to a source of radio frequency energy to ohmically heat tissue and create a lesion in the tissue region.
摘要翻译：方法治疗组织区域。在一种布置中，所述方法将电极部署在胃贲门处或附近的组织区域中的支撑结构上。在一个实施例中，支撑结构具有近端区域和远侧区域。近端区域与远侧区域相比放大，并且电极由扩大的近侧表面承载。所述方法使电极在路径中前进以穿透组织区域并将电极耦合到射频能量源以欧姆加热组织并在组织区域中产生损伤。

2. 发明申请

US20060259029A1 Method for Cryogenic Tissue Ablation 有权
标题翻译：低温组织消融方法
公开(公告)号：US20060259029A1
公开(公告)日：2006-11-16
申请号：US11420714
申请日：2006-05-26
申请人： David Utley , John Gaiser , Stuart Edwards , Scott West , Jay Qin
发明人： David Utley , John Gaiser , Stuart Edwards , Scott West , Jay Qin
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Methods of accessing and ablating abnormal epithelium tissue in an alimentary canal are provided. The methods can include steps of (i) inserting an operative element into an alimentary canal such that the proximate to a portion of the alimentary canal having tissue to be ablated; and (ii) using the operative element to apply cryogenic ablation to a site of abnormal tissue.
摘要翻译：提供了在消化道中获取和消融异常上皮组织的方法。所述方法可以包括以下步骤：（i）将操作元件插入消化道，使得靠近消化道的一部分具有要消融的组织; 和（ii）使用手术元件将低温消融应用于异常组织的部位。

3. 发明申请

US20080097422A1 Graphical user interface for association with an electrode structure deployed in contact with a tissue region 有权
标题翻译：图形用户界面，用于与部署为与组织区域接触的电极结构相关联
公开(公告)号：US20080097422A1
公开(公告)日：2008-04-24
申请号：US12001091
申请日：2007-12-10
申请人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Qin , Peter Muller
发明人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Qin , Peter Muller
IPC分类号： A61B18/12
CPC分类号： A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Systems and methods deploy an electrode structure in contact with the tissue region. The electrode structure carries a sensor at a known location on the electrode structure to monitor an operating condition. The systems and methods provide an interface, which generate an idealized image of the electrode structure and an indicator image to represent the monitored operating condition in a spatial position on the idealized image corresponding to the location of the sensor on the electrode structure. The interface displays a view image comprising the idealized image and indicator image. The systems and methods cause the electrode structure to apply energy to heat the tissue region while the view image is displayed on the display screen.
摘要翻译：系统和方法部署与组织区域接触的电极结构。电极结构在电极结构上的已知位置处携带传感器以监测操作状态。系统和方法提供了一种接口，其产生电极结构的理想化图像和指示图像，以在对应于电极结构上的传感器的位置的理想化图像上的空间位置中表示监视的操作条件。界面显示包含理想图像和指示图像的视图。当视觉图像显示在显示屏上时，系统和方法使电极结构施加能量来加热组织区域。

4. 发明申请

US20070032788A1 Sphincter treatment apparatus 审中-公开
标题翻译：括约肌治疗仪
公开(公告)号：US20070032788A1
公开(公告)日：2007-02-08
申请号：US11580543
申请日：2006-10-13
申请人： Stuart Edwards , John Gaiser , David Utley , Jay Qin
发明人： Stuart Edwards , John Gaiser , David Utley , Jay Qin
IPC分类号： A61B18/14
摘要： An apparatus treats tissue at or near a sphincter. The apparatus has an elongated member having at least one lumen including an inflation lumen, and a basket assembly including a first and a second arm. An inflatable member is coupled to the inflation lumen and has a deployed and a non-deployed state. In the deployed state, the inflatable member expands the basket assembly into contact with tissue. At least one of the first and second arms of the basket assembly has a fluid lumen having an aperture for conveying a fluid from the basket assembly. A source of fluid is coupled to the fluid lumen for conveyance of fluid through the aperture. The fluid can be, e.g., an electrolytic solution, and/or an anti-infection agent, and/or an echogenic media, and/or a steroid, and/or an anesthetic, and/or a medicament, and/or a tissue cooling agent. The source can be a drug delivery device.
摘要翻译：装置处理括约肌处或附近的组织。该装置具有细长构件，其具有包括充气腔的至少一个腔，以及包括第一臂和第二臂的篮组件。可膨胀构件联接到膨胀腔并具有展开和非展开状态。在展开状态下，可膨胀构件将篮组件膨胀成与组织接触。篮组件的第一和第二臂中的至少一个具有流体腔，其具有用于从篮组件输送流体的孔。流体源耦合到流体腔，用于输送流体通过该孔。流体可以是例如电解溶液和/或抗感染剂和/或回声介质，和/或类固醇，和/或麻醉剂，和/或药物，和/或组织冷却剂。来源可以是药物递送装置。

5. 发明申请

US20060282071A1 Method for Tissue Ablation 失效
标题翻译：组织消融方法
公开(公告)号：US20060282071A1
公开(公告)日：2006-12-14
申请号：US11420722
申请日：2006-05-26
申请人： David Utley , John Gaiser , Stuart Edwards , Scott West , Jay Qin
发明人： David Utley , John Gaiser , Stuart Edwards , Scott West , Jay Qin
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Methods of ablating mucosal tissue in an alimentary canal are provided. The methods can include the steps of (i) providing an ablation device comprising a tissue ablation source; (ii) positioning at least a portion of the ablation device at a mucosal tissue surface of the alimentary canal; (iii) delivering a sufficient amount of the source for tissue ablation to the mucosal tissue surface to create a lesion in the mucosal tissue. In one implementation the methods include a step of providing a radiofrequency (RF) energy delivery device.
摘要翻译：提供消化道中消融粘膜组织的方法。所述方法可以包括以下步骤：（i）提供包括组织消融源的消融装置; （ii）将消融装置的至少一部分定位在消化道的粘膜组织表面; （iii）将足够量的用于组织消融的来源输送到粘膜组织表面以在粘膜组织中产生损伤。在一个实现中，所述方法包括提供射频（RF）能量传递装置的步骤。

6. 发明申请

US20060259030A1 Method for Vacuum-Assisted Tissue Ablation 失效
标题翻译：真空辅助组织消融方法
公开(公告)号：US20060259030A1
公开(公告)日：2006-11-16
申请号：US11420719
申请日：2006-05-26
申请人： David Utley , John Gaiser , Stuart Edwards , Scott West , Jay Qin
发明人： David Utley , John Gaiser , Stuart Edwards , Scott West , Jay Qin
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Methods of accessing and ablating abnormal epithelium tissue in an alimentary canal are provided. The methods can include steps of (i) inserting a vacuum source comprising one or more suction ports into an alimentary canal; (ii) inserting an operative element comprising a conduit for a tissue ablation source into the alimentary canal; (iii) positioning the vacuum source and the operative element proximate a portion of the alimentary canal having a site of abnormal tissue to be ablated; (iv) applying a vacuum to at least one of each suction port to draw the tissue against the operative element; and (v) applying the tissue ablation source to the tissue through the conduit to effect tissue ablation.
摘要翻译：提供了在消化道中获取和消融异常上皮组织的方法。所述方法可以包括以下步骤：（i）将包括一个或多个吸入口的真空源插入消化道; （ii）将包括用于组织消融源的导管的操作元件插入消化道中; （iii）将真空源和操作元件定位在具有要消融的异常组织部位的消化道的一部分附近; （iv）向每个抽吸口中的至少一个施加真空以将组织拉向操作元件; 和（v）通过导管将组织消融源施加到组织以实现组织消融。

7. 发明申请

US20060259028A1 System for Tissue Ablation 失效
标题翻译：组织消融系统
公开(公告)号：US20060259028A1
公开(公告)日：2006-11-16
申请号：US11420712
申请日：2006-05-26
申请人： David Utley , John Gaiser , Stuart Edwards , Scott West , Jay Qin
发明人： David Utley , John Gaiser , Stuart Edwards , Scott West , Jay Qin
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/1477 , A61B18/1485 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Systems for treating a mucosal surface of an alimentary canal tissue region are provided. The systems can include an elongate support structure, an expandable member positionable at a distal portion of the support structure and one or more radio frequency (RF) ablation electrodes carried by the expandable member. The elongate support structure and the expandable member can be adapted to place the one or more electrodes in contact with a mucosal surface of an alimentary canal tissue region. The system can further include an RF energy source connected to the one or more electrodes.
摘要翻译：提供了用于治疗消化道组织区域的粘膜表面的系统。该系统可以包括细长的支撑结构，可定位在支撑结构的远端部分处的可扩张构件以及由可扩张构件承载的一个或多个射频（RF）消融电极。细长支撑结构和可扩张构件可适于将一个或多个电极与消化道组织区域的粘膜表面接触。该系统还可以包括连接到一个或多个电极的RF能量源。

8. 发明授权

US06440128B1 Actively cooled electrode assemblies for forming lesions to treat dysfunction in sphincters and adjoining tissue regions 有权
标题翻译：用于形成损伤以治疗括约肌和邻近组织区域功能障碍的主动冷却电极组件
公开(公告)号：US06440128B1
公开(公告)日：2002-08-27
申请号：US09304784
申请日：1999-05-04
申请人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin
发明人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin
IPC分类号： A61B1818
CPC分类号： A61B18/1485 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B2018/00029 , A61B2018/00035 , A61B2018/00065 , A61B2018/00214 , A61B2018/00238 , A61B2018/00267 , A61B2018/00553 , A61B2018/046 , A61B2018/1425 , A61B2018/1472 , A61B2218/002 , A61B2218/007
摘要： An assembly for treating tissue at or near the sphincter includes a support structure for deployment in a tissue region, and a an electrode carried by the support structure. The support structure includes a spine with a lumen having an exit port, the electrode being deployable from the exit port. The spine also includes a cooling lumen and as aspiration lumen to provide and remove fluids, respectively.
摘要翻译：用于在括约肌处或附近处理组织的组件包括用于展开在组织区域中的支撑结构和由支撑结构承载的电极。支撑结构包括具有出口的内腔的脊柱，电极可从出口端部分展开。脊柱还包括冷却腔和分别用于提供和移除流体的抽吸腔。

9. 发明授权

US06355031B1 Control systems for multiple electrode arrays to create lesions in tissue regions at or near a sphincter 有权
标题翻译：用于多个电极阵列的控制系统以在括约肌处或附近的组织区域中产生损伤
公开(公告)号：US06355031B1
公开(公告)日：2002-03-12
申请号：US09304733
申请日：1999-05-04
申请人： Stuart Edwards , John Gaiser , David S Utley , Scott West , Jay Qin
发明人： Stuart Edwards , John Gaiser , David S Utley , Scott West , Jay Qin
IPC分类号： A61B1818
CPC分类号： A61B18/1206 , A61B18/12 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00494 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1475 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Multiple electrodes are coupled together in monopolar or bipolar arrays to form lesion patterns in tissue regions at or near a sphincter. A controller couples the electrodes to a generator so that a single power channel serves more than a single electrode.
摘要翻译：多个电极以单极或双极阵列耦合在一起，以在括约肌处或附近的组织区域中形成病变图案。控制器将电极耦合到发生器，使得单个功率通道服务于单个电极。

10. 发明申请

US20050159743A1 Method for treating a sphincter 有权
标题翻译：治疗括约肌的方法
公开(公告)号：US20050159743A1
公开(公告)日：2005-07-21
申请号：US11079697
申请日：2005-03-14
申请人： Stuart Edwards , David Utley , Ronald Lax , John Gaiser
发明人： Stuart Edwards , David Utley , Ronald Lax , John Gaiser
IPC分类号： A61B18/00 , A61B18/12 , A61B18/14 , A61B18/18 , A61F7/00 , A61F7/12
CPC分类号： A61B18/1492 , A61B18/1206 , A61B18/1477 , A61B18/18 , A61B2018/00011 , A61B2018/00029 , A61B2018/00047 , A61B2018/00214 , A61B2018/0022 , A61B2018/00494 , A61B2018/00553 , A61B2018/00666 , A61B2018/00678 , A61B2018/00684 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2218/002
摘要： A method for treating a sphincter provides a polymer material having a liquid state. The method also provides a catheter having a distal end, a tissue piercing device carried by the distal end, and an energy delivery device coupled to the tissue piercing device. The tissue piercing device has a lumen. The method introduces the catheter into an esophagus and pierces an exterior sphincter tissue surface within with the tissue piercing device. The method advances the tissue piercing device into an interior sphincter tissue site and conveys the polymer material while in a liquid state through the lumen into the interior sphincter tissue site. The method delivers energy to the tissue piercing device to transform the polymer material into a less liquid state within the interior sphincter tissue site, to thereby remodel the sphincter.
摘要翻译：用于治疗括约肌的方法提供具有液体状态的聚合物材料。该方法还提供了具有远端的导管，由远端承载的组织刺穿装置，以及耦合到组织刺穿装置的能量输送装置。组织穿刺装置具有内腔。该方法将导管引入食道并刺穿组织穿刺装置内的外括约肌组织表面。该方法使组织穿刺装置进入内部括约肌组织部位，并将液体状态下的聚合物材料通过内腔输送到内括约肌组织部位。该方法将能量传递到组织刺穿装置，以将聚合物材料转变成内部括约肌组织部位内的较少液体状态，从而改变括约肌。

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