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    • 3. 发明授权
    • Cache-based storage system architecture
    • 基于缓存的存储系统架构
    • US08549222B1
    • 2013-10-01
    • US12369502
    • 2009-02-11
    • Steven R. KleimanSteven C. MillerJeffrey S. Kimmel
    • Steven R. KleimanSteven C. MillerJeffrey S. Kimmel
    • G06F12/00
    • G06F12/0868G06F3/0613G06F3/0659G06F3/0685G06F3/0689G06F11/1076G06F12/126G06F2212/222G06F2212/262
    • A cache-based storage architecture has primary and secondary storage subsystems that are controlled by first and second data layout engines to provide a high-performance storage system. The primary storage subsystem illustratively comprises non-volatile electronic storage media configured as a cache, while the secondary storage subsystem comprises magnetic storage media configured as a disk array. The data layout engines illustratively implement data layout techniques that improve read and write performance to the primary and secondary storage subsystems. To that end, the data layout engines cooperate to optimize the use of the non-volatile cache as a primary storage stage that efficiently serves random data access operations prior to substantially transposing them into sequential data access operations for permanent (or archival) storage on the disk array.
    • 基于缓存的存储架构具有由第一和第二数据布局引擎控制以提供高性能存储系统的主存储子系统和辅助存储子系统。 主存储子系统示例性地包括配置为高速缓存的非易失性电子存储介质,而次存储子系统包括被配置为磁盘阵列的磁存储介质。 数据布局引擎说明性地实现了提高对主存储子系统和辅助存储子系统的读写性能的数据布局技术。 为此,数据布局引擎协同优化使用非易失性高速缓存作为主要存储阶段,其在将数据访问操作基本上转移到顺序数据访问操作之前有效地服务于随机数据访问操作,以便永久(或归档)存储在 磁盘阵列。
    • 9. 发明申请
    • SYSTEM AND METHOD FOR PRIORITIZATION OF CLOCK RATES IN A MULTI-CORE PROCESSOR
    • 用于在多核处理器中优化时钟速率的系统和方法
    • US20080263384A1
    • 2008-10-23
    • US11738841
    • 2007-04-23
    • Steven C. MillerNaresh Patel
    • Steven C. MillerNaresh Patel
    • G06F1/04
    • G06F1/3203G06F1/08G06F1/324G06F9/3869G06F9/3891Y02D10/126
    • A system and method for prioritization of clock rates in a multi-core processor is provided. Instruction arrival rates are measured during a time interval Ti−1 to Ti by a monitoring module either internal to the processor or operatively interconnected with the processor. Using the measured instruction arrival rates, the monitoring module calculates an optimal instruction arrival rate for each core of the processor. For processors that support continuous frequency changes for cores, each core is then set to an optimal service rate. For processors that only support a discrete set of arrival rates, the optimal rates are mapped to a closest supported rate and the cores are set to the closest supported rate. This procedure is then repeated for each time interval.
    • 提供了一种用于在多核处理器中优先化时钟速率的系统和方法。 指令到达速率在处理器内部或与处理器可操作地互连的监视模块在时间间隔T i-1至T i i中被测量。 使用测量的指令到达率,监视模块为处理器的每个核心计算最佳指令到达速率。 对于支持内核连续频率更改的处理器,每个核心然后设置为最佳服务速率。 对于仅支持离散到达率集合的处理器,最优速率被映射到最接近的支持速率,并且核心被设置为最接近的支持速率。 然后每个时间间隔重复该过程。
    • 10. 发明申请
    • Screening using polarization anisotropy in FRET emissions
    • 在FRET排放中使用偏振各向异性进行筛选
    • US20080206888A1
    • 2008-08-28
    • US12069724
    • 2008-02-11
    • Steven C. MillerPaul B. ComitaChristopher B. ShumateEvan F. Cromwell
    • Steven C. MillerPaul B. ComitaChristopher B. ShumateEvan F. Cromwell
    • G01N33/566G01N21/76
    • G01N33/542G01N2500/00
    • Methods and apparatus are described for detecting specific binding between first and second chemical entities. The first chemical entity in association with a first fluorophore is immobilized. The second chemical entity is allowed to bind with the immobilized first chemical entity. The second chemical entity is or becomes coupled to a second fluorophore, which forms a FRET pair with the first fluorophore. The bound chemical entities are exposed to radiation at an excitation frequency for either the first or the second fluorophore, and polarization anisotropy of a FRET fluorescent signal from the bound chemical entities is measured to detect specific binding between the first and second chemical entities. Techniques are also disclosed for detecting whether a FRET interaction is occurring between a first chemical entity including a donor fluorophore and a second chemical entity including an acceptor fluorophore, using simultaneous anisotropy measurements at the wavelengths of the donor and acceptor fluorophores.
    • 描述了用于检测第一和第二化学实体之间的特异性结合的方法和装置。 与第一荧光团相关联的第一化学实体被固定化。 允许第二化学实体与固定化的第一化学实体结合。 第二化学实体是或连接到与第一荧光团形成FRET对的第二荧光团。 结合的化学实体以第一或第二荧光团的激发频率暴露于辐射,并且测量来自结合的化学实体的FRET荧光信号的偏振各向异性以检测第一和第二化学实体之间的特异性结合。 还公开了用于检测在包括供体荧光团的第一化学实体和包括受体荧光团的第二化学实体之间是否发生FRET相互作用的技术,其使用在供体和受体荧光团的波长处的同时各向异性测量。