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1. 发明申请

US20100219084A1 METHOD FOR DETERMINING HEMATOCRIT CORRECTED ANALYTE CONCENTRATIONS 有权
标题翻译：用于确定HEMATOCRIT校正分析物浓度的方法
公开(公告)号：US20100219084A1
公开(公告)日：2010-09-02
申请号：US12305363
申请日：2007-10-05
申请人： Stephen Patrick Blythe , Marco F. Cardosi , Andrew Gill , Leanne Mills , Christopher Philip Leach
发明人： Stephen Patrick Blythe , Marco F. Cardosi , Andrew Gill , Leanne Mills , Christopher Philip Leach
IPC分类号： G01N27/26 , C12Q1/00
CPC分类号： C12Q1/006 , G01N27/3271
摘要： Description is provided herein for an embodiment of a method determining a hematocrit-corrected glucose concentration. The exemplary method includes providing a test strip having a reference electrode and a working electrode, wherein the working electrode includes a plurality of microelectrodes and is coated with at least an enzyme and a mediator. The method can be achieved by: providing a test strip comprising a reference electrode and a working electrode formed with a plurality of microelectrodes and coated with a reagent layer; applying a fluid sample to the test strip for a reaction period; applying a test voltage between the reference electrode and the working electrode; measuring a test current as a function of time; measuring a steady state current value when the test current has reached an equilibrium; calculating a ratio of the test current to the steady state current value; plotting the ratio of the test current to the steady state current value as a function of the inverse square root of time; calculating an effective diffusion coefficient from the slope of the linearly regressed plot of the ratio of the test current to the steady state current value as a function of the inverse square root of time; and calculating a hematocrit-corrected concentration of analyte.
摘要翻译：本文提供了确定血细胞比容校正葡萄糖浓度的方法的实施方案的描述。该示例性方法包括提供具有参考电极和工作电极的测试条，其中工作电极包括多个微电极并且至少涂覆有酶和介体。该方法可以通过以下方式实现：提供包括参考电极和形成有多个微电极并涂覆有试剂层的工作电极的测试条; 将流体样品施加到测试条上一段反应期; 在参考电极和工作电极之间施加测试电压; 测量作为时间的函数的测试电流; 当测试电流达到平衡时测量稳态电流值; 计算测试电流与稳态电流值的比值; 将测试电流与稳态电流值的比率绘制为时间的逆平方根的函数; 根据测试电流与稳态电流值的比值的线性回归曲线的斜率计算有效扩散系数作为时间的平方根的函数; 并计算分析物的血细胞比容校正浓度。

2. 发明授权

US08388821B2 Method for determining hematocrit corrected analyte concentrations 有权
标题翻译：确定血细胞比容校正分析物浓度的方法
公开(公告)号：US08388821B2
公开(公告)日：2013-03-05
申请号：US12305363
申请日：2007-10-05
申请人： Stephen Patrick Blythe , Marco F. Cardosi , Andrew Gill , Leanne Mills , Christopher Philip Leach
发明人： Stephen Patrick Blythe , Marco F. Cardosi , Andrew Gill , Leanne Mills , Christopher Philip Leach
IPC分类号： G01N27/327
CPC分类号： C12Q1/006 , G01N27/3271
摘要： Description is provided herein for an embodiment of a method determining a hematocrit-corrected glucose concentration. The exemplary method includes providing a test strip having a reference electrode and a working electrode, wherein the working electrode includes a plurality of microelectrodes and is coated with at least an enzyme and a mediator. The method can be achieved by: providing a test strip comprising a reference electrode and a working electrode formed with a plurality of microelectrodes and coated with a reagent layer; applying a fluid sample to the test strip for a reaction period; applying a test voltage between the reference electrode and the working electrode; measuring a test current as a function of time; measuring a steady state current value when the test current has reached an equilibrium; calculating a ratio of the test current to the steady state current value; plotting the ratio of the test current to the steady state current value as a function of the inverse square root of time; calculating an effective diffusion coefficient from the slope of the linearly regressed plot of the ratio of the test current to the steady state current value as a function of the inverse square root of time; and calculating a hematocrit-corrected concentration of analyte.
摘要翻译：本文提供了确定血细胞比容校正葡萄糖浓度的方法的实施方案的描述。该示例性方法包括提供具有参考电极和工作电极的测试条，其中工作电极包括多个微电极并且至少涂覆有酶和介体。该方法可以通过以下方式实现：提供包括参考电极和形成有多个微电极并涂覆有试剂层的工作电极的测试条; 将流体样品施加到测试条上一段反应期; 在参考电极和工作电极之间施加测试电压; 测量作为时间的函数的测试电流; 当测试电流达到平衡时测量稳态电流值; 计算测试电流与稳态电流值的比值; 将测试电流与稳态电流值的比率绘制为时间的逆平方根的函数; 根据测试电流与稳态电流值的比值的线性回归曲线的斜率计算有效扩散系数作为时间的平方根的函数; 并计算分析物的血细胞比容校正浓度。

3. 发明授权

US08460537B2 Methods for determining an analyte concentration using signal processing algorithms 有权
标题翻译：使用信号处理算法确定分析物浓度的方法
公开(公告)号：US08460537B2
公开(公告)日：2013-06-11
申请号：US12553976
申请日：2009-09-03
申请人： Stephen Patrick Blythe , Marco F Cardosi , Leanne Mills , Manuel Alvarez-Icaza , Emma Vanessa Jayne Day , Richard Michael Day , Christopher Philip Leach
发明人： Stephen Patrick Blythe , Marco F Cardosi , Leanne Mills , Manuel Alvarez-Icaza , Emma Vanessa Jayne Day , Richard Michael Day , Christopher Philip Leach
IPC分类号： G01F1/64 , G01N17/00 , G01N27/26
CPC分类号： G01N27/3273
摘要： A method for determining an analyte concentration in blood is described that reduces the effects of hematocrit using a test strip attached to a test meter. The test strip includes a working electrode and a reference electrode. The test meter applies a test voltage between the working electrode and the reference electrode. After a user applies a blood sample containing an analyte onto the test strip, the test meter measures a plurality of test currents for a test time interval.
摘要翻译：描述了用于测定血液中分析物浓度的方法，其使用连接到测试仪的测试条减少了血细胞比容的影响。测试条包括工作电极和参考电极。测试仪在工作电极和参比电极之间施加测试电压。在用户将含有分析物的血液样本应用到测试条上之后，测试仪测量测试时间间隔的多个测试电流。

4. 发明授权

US08293096B2 Systems and methods for determining a substantially hematocrit independent analyte concentration 有权
标题翻译：用于确定基本上血细胞比容的独立分析物浓度的系统和方法
公开(公告)号：US08293096B2
公开(公告)日：2012-10-23
申请号：US12692120
申请日：2010-01-22
申请人： Marco F. Cardosi , Stephen Patrick Blythe , Matthew Finch , Arlene Thompson , Nina Antonia Naylor , Eric Jason Bailey , Michael Patrick Dolan , Gretchen Anderson , Lorraine Comstock , Mary McEvoy , Thomas Sutton , Richard Michael Day , Leanne Mills , Emma Vanessa Jayne Day , Christopher Philip Leach
发明人： Marco F. Cardosi , Stephen Patrick Blythe , Matthew Finch , Arlene Thompson , Nina Antonia Naylor , Eric Jason Bailey , Michael Patrick Dolan , Gretchen Anderson , Lorraine Comstock , Mary McEvoy , Thomas Sutton , Richard Michael Day , Leanne Mills , Emma Vanessa Jayne Day , Christopher Philip Leach
IPC分类号： G01N27/327
CPC分类号： G01N27/3274
摘要： A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.
摘要翻译：提供了一种方法和系统，用于确定基本上血细胞比容的独立分析物浓度。在一个示例中，提供了包括测试条和测试仪的分析物测量系统。测试条包括参考电极和工作电极，其中工作电极涂覆有试剂层。测试仪包括电子电路和信号处理器。电子电路在相应的持续时间内对参考电极和工作电极施加多个电压。所述信号处理器被配置成确定来自多个电流值的分析物的基本上与血细胞比容无关的浓度，所述多个电流值在由静止电压施加多个测试电压至参考电极和工作电极的多个持续时间时由处理器测量低于施加到电极的测试电压。

5. 发明申请

US20110162978A1 SYSTEMS AND METHODS FOR DETERMINING A SUBSTANTIALLY HEMATOCRIT INDEPENDENT ANALYTE CONCENTRATION 有权
标题翻译：用于确定重大分析纯化分析物浓度的系统和方法
公开(公告)号：US20110162978A1
公开(公告)日：2011-07-07
申请号：US12692120
申请日：2010-01-22
申请人： Marco F. CARDOSI , Stephen Patrick Blythe , Matthew Finch , Arlene Thompson , Nina Antonia Naylor , Eric Jason Bailey , Michael Patrick Dolan , Gretchen Anderson , Lorraine Comstock , Mary Mcevoy , Thomas Sutton , Richard Michael Day , Leanne Mills , Emma Vanessa Jayne Day , Christopher Philip Leach
发明人： Marco F. CARDOSI , Stephen Patrick Blythe , Matthew Finch , Arlene Thompson , Nina Antonia Naylor , Eric Jason Bailey , Michael Patrick Dolan , Gretchen Anderson , Lorraine Comstock , Mary Mcevoy , Thomas Sutton , Richard Michael Day , Leanne Mills , Emma Vanessa Jayne Day , Christopher Philip Leach
IPC分类号： C12Q1/26 , G01N27/416 , C12Q1/54
CPC分类号： G01N27/3274
摘要： A method and system is provided to allow for determination of substantially Hematocrit independent analyte concentration. In one example, an analyte measurement system is provided that includes a test strip and a test meter. The test strip includes a reference electrode and a working electrode, in which the working electrode is coated with a reagent layer. The test meter includes an electronic circuit and a signal processor. The electronic circuit applies a plurality of voltages to the reference electrode and the working electrode over respective durations. The signal processor is configured to determine a substantially hematocrit-independent concentration of the analyte from a plurality of current values as measured by the processor upon application of a plurality of test voltages to the reference and working electrodes over a plurality of durations interspersed with rest voltages lower than the test voltages being applied to the electrodes.
摘要翻译：提供了一种方法和系统，用于确定基本上血细胞比容的独立分析物浓度。在一个示例中，提供了包括测试条和测试仪的分析物测量系统。测试条包括参考电极和工作电极，其中工作电极涂覆有试剂层。测试仪包括电子电路和信号处理器。电子电路在相应的持续时间内对参考电极和工作电极施加多个电压。所述信号处理器被配置成确定来自多个电流值的分析物的基本上与血细胞比容无关的浓度，所述多个电流值在由静止电压施加多个测试电压至参考电极和工作电极的多个持续时间时由处理器测量低于施加到电极的测试电压。

6. 发明授权

US07740801B2 System for determination of an analyte in a bodily fluid sample that includes an electroluminescent component 有权
标题翻译：用于测定包含电致发光组分的体液样品中的分析物的系统
公开(公告)号：US07740801B2
公开(公告)日：2010-06-22
申请号：US11591138
申请日：2006-10-31
申请人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
发明人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
IPC分类号： G01N21/76
CPC分类号： G01N21/69 , G01N21/76 , G01N2021/6439
摘要： A system for the determination of an analyte in a bodily fluid sample includes an analytical test strip and an analytical meter. The analytical test strip has a substrate layer, an electroluminescent component (either an electroluminescent module and/or an electroluminescent lamp) disposed on the substrate layer, and a sample chamber configured for receiving a bodily fluid sample disposed above the substrate layer. Moreover, the analytical meter is configured for insertion of the analytical test strip therein and subsequent determination of the analyte.
摘要翻译：用于测定体液样品中的分析物的系统包括分析测试条和分析计。分析测试条具有设置在基底层上的基底层，电致发光元件（电致发光模块和/或电致发光灯），以及被配置为接收设置在基底层上方的体液样品的样本室。此外，分析仪被配置用于在其中插入分析测试条并随后确定分析物。

7. 发明申请

US20080100689A1 Method for manufacturing an analytical test strip with an electroluminescent component 审中-公开
标题翻译：用于制造具有电致发光元件的分析测试条的方法
公开(公告)号：US20080100689A1
公开(公告)日：2008-05-01
申请号：US11591366
申请日：2006-10-31
申请人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
发明人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
IPC分类号： B41J2/435
CPC分类号： C12Q1/001 , G01N21/66 , G01N21/8483
摘要： A method for manufacturing an analytical test strip with an electroluminescent component (either an electroluminescent module and/or an electroluminescent lamp) includes sequentially applying to a substrate layer, a rear electrode layer disposed on the substrate layer, an electrically-insulating layer disposed over the rear electrode layer, a phosphor layer disposed over the electrically insulating layer, and a front electrode layer (at least a portion of which is translucent) disposed over the phosphor layer. The sequential application is accomplished such that it forms an electroluminescent component of the analytical test strip.
摘要翻译：制造具有电致发光元件（电致发光模块和/或电致发光灯）的分析测试条的方法包括：顺序地施加到基底层，设置在基底层上的背面电极层，设置在基底层上的电绝缘层背面电极层，设置在电绝缘层上的荧光体层和设置在荧光体层上的前电极层（其至少一部分是半透明的）。顺序应用完成，使得其形成分析测试条的电致发光部件。

8. 发明申请

US20080101986A1 Analytical test strip with electroluminescent module 审中-公开
标题翻译：带电致发光模块的分析测试条
公开(公告)号：US20080101986A1
公开(公告)日：2008-05-01
申请号：US11591313
申请日：2006-10-31
申请人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
发明人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
IPC分类号： G01N21/00
CPC分类号： G01N21/76 , G01N21/69 , G01N2021/6439
摘要： An analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes a substrate layer, an electroluminescent module disposed on the substrate layer, a sample chamber configured for receiving the bodily fluid sample disposed above the substrate layer; and a fluorophore-containing photometric enzymatic reagent disposed within the sample chamber. Moreover, the electroluminescent module is in optical communication with the sample chamber and is configured to emit light that facilitates a fluorescent chemical reaction sequence involving the fluorophore-containing photometric enzymatic reagent and the analyte.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的分析测试条包括基底层，设置在基底层上的电致发光模块，被配置为接收设置在基底层上方的体液样品; 和设置在样品室内的含荧光团的光度测定酶试剂。此外，电致发光模块与样品室光学连通，并且被配置为发射促进涉及含荧光团的光度测定酶试剂和分析物的荧光化学反应序列的光。

9. 发明申请

US20080101984A1 Method for determining an analyte in a bodily fluid sample 审中-公开
标题翻译：用于测定体液样品中分析物的方法
公开(公告)号：US20080101984A1
公开(公告)日：2008-05-01
申请号：US11591316
申请日：2006-10-31
申请人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
发明人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
IPC分类号： G01N21/76
CPC分类号： G01N21/69 , G01N21/76 , G01N2021/6439
摘要： A method for the determination of an analyte in a bodily fluid sample includes transferring a bodily fluid sample (such as a whole blood sample) to a sample chamber of an analytical test strip. The analytical test strip to which the bodily fluid sample is transferred has a substrate layer, an electroluminescent module disposed on the substrate layer and in optical communication with the sample chamber, and a fluorophore-containing photometric enzymatic reagent disposed within the sample chamber. In addition, the electroluminescent module is configured to emit light that facilitates a fluorescent chemical reaction sequence involving the fluorophore-containing photometric enzymatic reagent and the analyte. The method also includes exposing the fluorophore-containing photometric enzymatic reagent to the bodily fluid sample and to light emitted from the electroluminescent module such that photons are emitted from the fluorophore-containing photometric enzymatic reagent via a fluorescent chemical reaction sequence. Moreover, the method includes detecting the photons with a photodetector.
摘要翻译：用于测定体液样品中的分析物的方法包括将体液样品（例如全血样品）转移到分析测试条的样品室。体液样本被转移到的分析测试条具有衬底层，设置在衬底层上并与样品室光学连通的电致发光模块，以及置于样品室内的含荧光团的光度测定试剂。此外，电致发光模块被配置为发射促进包含含荧光团的光度测定酶试剂和分析物的荧光化学反应序列的光。该方法还包括将含荧光团的光度测试酶试剂暴露于体液样品和从电致发光模块发射的光，使得通过荧光化学反应顺序从含荧光团的光度测定酶试剂发射光子。此外，该方法包括用光电检测器检测光子。

10. 发明申请

US20080101985A1 System for determination of an analyte in a bodily fluid sample that includes an electroluminescent component 有权
标题翻译：用于测定包含电致发光组分的体液样品中的分析物的系统
公开(公告)号：US20080101985A1
公开(公告)日：2008-05-01
申请号：US11591138
申请日：2006-10-31
申请人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
发明人： Selwayan Saini , Marco Fabio Cardosi , Leanne Mills , Stephen Patrick Blythe
IPC分类号： G01N21/00
CPC分类号： G01N21/69 , G01N21/76 , G01N2021/6439
摘要： A system for the determination of an analyte in a bodily fluid sample includes an analytical test strip and an analytical meter. The analytical test strip has a substrate layer, an electroluminescent component (either an electroluminescent module and/or an electroluminescent lamp) disposed on the substrate layer, and a sample chamber configured for receiving a bodily fluid sample disposed above the substrate layer. Moreover, the analytical meter is configured for insertion of the analytical test strip therein and subsequent determination of the analyte.
摘要翻译：用于测定体液样品中的分析物的系统包括分析测试条和分析计。分析测试条具有设置在基底层上的基底层，电致发光元件（电致发光模块和/或电致发光灯），以及被配置为接收设置在基底层上方的体液样品的样本室。此外，分析仪被配置用于在其中插入分析测试条并随后确定分析物。

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