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1. 发明授权

US4559304A Substratum for cell culture and a method for culturing and isolating cells using same 失效
标题翻译：用于细胞培养的底物和使用其培养和分离细胞的方法
公开(公告)号：US4559304A
公开(公告)日：1985-12-17
申请号：US521083
申请日：1983-08-08
申请人： Shunji Kasai , Toshihiro Akaike , Teruo Miyata
发明人： Shunji Kasai , Toshihiro Akaike , Teruo Miyata
IPC分类号： C12N5/06 , C12N5/00 , C12R1/91
CPC分类号： C12N5/0068 , C12N2533/54 , Y10S435/948
摘要： A substratum for cell culture which comprises a chemically modified collagen rich in either positive or negative charges when under culture conditions. The substratum is prepared by modifying the amino groups or carboxyl groups of collagen. The chemically modified collagen enhances the adherence and proliferation of animal cells much more actively than unmodified collagen in the presence or absence of bovine fetus serum. The cultured animal cells can be detached efficiently from the chemically modified collagen. This allows for highly selective isolation and recovery of the cultured animal cells which can be accomplished without incurring any injury from the chemically modified collagen.
摘要翻译：用于细胞培养的基质，其包含在培养条件下富含正电荷或负电荷的化学修饰的胶原。通过改变胶原蛋白的氨基或羧基来制备底物。在牛胎儿血清存在或不存在下，化学修饰的胶原蛋白比未修饰的胶原蛋白更积极地增强动物细胞的粘附和增殖。培养的动物细胞可以从化学改性的胶原中有效分离。这允许高度选择性地分离和回收培养的动物细胞，其可以在不引起化学改性的胶原蛋白的任何损伤的情况下完成。

2. 发明授权

US4883487A Method of producing an artifical skin 失效
标题翻译：生产人造皮肤的方法
公开(公告)号：US4883487A
公开(公告)日：1989-11-28
申请号：US34958
申请日：1987-04-06
申请人： Katsutoshi Yoshizato , Toshio Taira , Teruo Miyata
发明人： Katsutoshi Yoshizato , Toshio Taira , Teruo Miyata
IPC分类号： A61L27/00 , A61F2/00 , A61F2/10 , A61L27/24 , A61L27/60
CPC分类号： A61L27/24 , A61F2/105 , A61L27/60 , A61F2310/00365 , Y10S623/901
摘要： An artifical skin comprising an insoluble atelocollagen sheet and an epidermal cell layer cultured only on one surface of the sheet, and a method of producing the same are disclosed, which method includes the steps of: forming an insoluble atelocollagen sheet; inoculating epidermal cells only on one surface of the atelocollagen sheet; and suspending the atelocollagen sheet in a liquid culture medium to culture the epidermal cells, thereby forming an epidermal cell layer.
摘要翻译：公开了包含不溶性胶原蛋白片和仅在片材的一个表面上培养的表皮细胞层的人造皮肤及其制造方法，该方法包括以下步骤：形成不溶性胶原蛋白片; 仅在表皮细胞上接种atelocollagen片的一个表面; 并将所述胶原蛋白片悬浮在液体培养基中以培养表皮细胞，由此形成表皮细胞层。

3. 发明授权

US4690973A Production process of an antithrombogenic and antiadhesive material for medical use 失效
标题翻译：用于医疗用途的抗血栓形成和抗粘附材料的生产工艺
公开(公告)号：US4690973A
公开(公告)日：1987-09-01
申请号：US885782
申请日：1986-07-15
申请人： Yasuharu Noishiki , Kazuhiko Kodaira , Masayasu Furuse , Teruo Miyata , Takeaki Miyamoto , Hiraku Ito
发明人： Yasuharu Noishiki , Kazuhiko Kodaira , Masayasu Furuse , Teruo Miyata , Takeaki Miyamoto , Hiraku Ito
IPC分类号： A61L33/10 , A61L33/00 , A61M25/00 , C08H1/06 , C08L89/04 , C08L89/06
CPC分类号： A61L33/0023 , Y10S128/08
摘要： This invention concerns a production process of an antithrombogenic and antiadhesive material which can favorably be used as artificial blood vessels, artificial valves, grafting patches for cardiovascular organs, artificial heart catheters and so on. The gist of this invention is constructed substantially of subjecting glycidyltrialkylammonium halide such as glycidyltrimethylammonium chloride to the reaction with a material comprising pure collagen or collagen and other components like mucopolysaccharide in order to introduce a cationic quaternary functional group in collagen molecules of the material and then subjecting heparin to the ionic combination with the cationic functional group introduced. Meanwhile, in advance of the above chemical treatment, the material is prepared from dog's blood vessel by removing proteins except collagen, from cow's Achilles tendon by crushing into powder, from human amnion by rinsing in distilled water or from polyester knit tube by coating its inside with powdered collagen, for example.
摘要翻译：本发明涉及可有利地用作人造血管，人造瓣膜，心血管器官接枝片，人造心导管等的抗血栓形成和抗粘附材料的生产方法。本发明的要点基本上是将缩水甘油三烷基铵卤化物如缩水甘油基三甲基氯化铵与含有纯胶原或胶原和其他组分如粘多糖的材料进行反应，以便在材料的胶原分子中引入阳离子季铵官能团，肝素与阳离子官能团的离子组合引入。同时，在上述化学处理之前，通过从牛的跟腱中除去胶原蛋白之外的蛋白质从狗的血管中制备，通过粉碎，从人羊膜中通过在蒸馏水中冲洗或从聚酯针织管中涂覆其内部制备材料以胶原蛋白粉为例。

4. 发明授权

US4642118A Man-made skin composed of two layers: collagen and a poly-alpha-amino acid 失效
标题翻译：人造皮肤由两层组成：胶原蛋白和聚-α-氨基酸
公开(公告)号：US4642118A
公开(公告)日：1987-02-10
申请号：US741835
申请日：1985-06-06
申请人： Yoshimitsu Kuroyanagi , Teruo Miyata , Manabu Seno
发明人： Yoshimitsu Kuroyanagi , Teruo Miyata , Manabu Seno
IPC分类号： A61L27/00 , A61F2/10 , A61L27/34 , A61L27/60
CPC分类号： A61L27/60 , A61L27/34
摘要： This invention concerns a double-layered man-made skin which is prepared by laminating a collagen sponge sheet and a poly-.alpha.-amino acid membrane that has a good affinity with tissue cells and an appropriate permeability for moisture. When the man-made skin is applied on burns, cuts or wounds, the fibroblasts proliferate in the collagen sponge sheet forming a three-dimensional structure, while the epidermal cells proliferate in the region between the poly-.alpha.-amino acid membrane and a collagen sponge sheet. The poly-.alpha.-amino acid membrane plays a role in protecting affected part and in providing an optimum condition for the proliferation of fibroblasts and epidermal cells, and then it falls off as the epidermis completely regenerates. On the other hand, the collagen sponge sheet assimilates in the living tissue after having played a general role of the dermis.
摘要翻译：本发明涉及一种双层人造皮肤，其通过层叠胶原海绵片和与组织细胞具有良好亲和性并具有适当的渗透性的聚-α-氨基酸膜制备。当人造皮肤应用于烧伤，切口或伤口时，成纤维细胞在形成三维结构的胶原海绵片中增殖，而表皮细胞在聚-α-氨基酸膜和胶原之间的区域中增殖海绵片。聚-α-氨基酸膜在保护受影响部位和为成纤维细胞和表皮细胞增殖提供最佳条件方面发挥作用，随着表皮完全再生，其脱落。另一方面，在发挥真皮的一般作用后，胶原蛋白海绵片在活组织中被吸收。

5. 发明授权

US4349026A Regenerated fiber collagen condom and method of preparation 失效
标题翻译：再生纤维胶原避孕套及其制备方法
公开(公告)号：US4349026A
公开(公告)日：1982-09-14
申请号：US125538
申请日：1980-02-28
申请人： Teruo Miyata
发明人： Teruo Miyata
IPC分类号： A61F6/04 , A61F5/42
CPC分类号： A61F6/04 , Y10S128/08
摘要： A novel collagen condom consists of isotropically-strong, crosslinked, regenerated fiber collagen. A method of preparation involves the steps of at least twice dipping a mandrel into an acidic collagen dispersion; slowly removing the mandrel under spinning conditions; neutralizing and drying the membrane between dippings; crosslinking the finally dried membrane while on the mandrel and removing the membrane from the mandrel.
摘要翻译：一种新型胶原蛋白避孕套由各向同性，交联，再生的纤维胶原组成。制备方法包括将心轴至少两次浸入酸性胶原分散体中的步骤; 在纺丝条件下慢慢取出心轴; 蘸液中和干燥膜; 在芯棒上交联最终干燥的膜，并从心轴上除去膜。

6. 发明授权

US5164139A Method for drying wetted molded product 失效
标题翻译：用于干燥湿成型产品的方法
公开(公告)号：US5164139A
公开(公告)日：1992-11-17
申请号：US690385
申请日：1991-04-24
申请人： Keiji Fujioka , Shigeji Sato , Yoshio Sasaki , Hiromi Naito , Teruo Miyata , Masayasu Furuse
发明人： Keiji Fujioka , Shigeji Sato , Yoshio Sasaki , Hiromi Naito , Teruo Miyata , Masayasu Furuse
IPC分类号： A61J3/00 , A61K9/70 , F26B5/16
CPC分类号： F26B5/16
摘要： A method for drying a wetted molded product of pasty high viscous composition which comprises subjecting the molded product to a dehydration process while wholly or partially contacting the product with an open-cell foamed hydrophobic porous membrane.

7. 发明授权

US5080670A Bioprosthetic valve 失效
标题翻译：生物阀
公开(公告)号：US5080670A
公开(公告)日：1992-01-14
申请号：US238233
申请日：1988-08-30
申请人： Eisaburo Imamura , Yasuharu Noishiki , Hitoshi Koyanagi , Teruo Miyata , Masayasu Furuse
发明人： Eisaburo Imamura , Yasuharu Noishiki , Hitoshi Koyanagi , Teruo Miyata , Masayasu Furuse
IPC分类号： A61L27/00 , A61F2/24 , A61L2/00 , A61L27/36
CPC分类号： A61L27/3687 , A61F2/2412 , A61L2/0088 , A61L27/3625 , A61L27/507 , A61L2400/02 , Y10S623/915
摘要： A bioprosthetic valve made from a biological tissue containing collagen which has been cross-linked with a polyepoxy compound is disclosed. The valve has excellent biocompatibility and is durable and is free from calcification.

8. 发明授权

US4840937A Surfactant composed of acylated collagen or acylated gelatine and a production process thereof 失效
标题翻译：由酰化胶原或酰化明胶组成的表面活性剂及其制备方法
公开(公告)号：US4840937A
公开(公告)日：1989-06-20
申请号：US97400
申请日：1987-09-16
申请人： Tetsuro Namiki , Masayasu Furuse , Yoshimitsu Kuroyanagi , Teruo Miyata , Takashi Suzuki
发明人： Tetsuro Namiki , Masayasu Furuse , Yoshimitsu Kuroyanagi , Teruo Miyata , Takashi Suzuki
IPC分类号： A23L29/10 , A61K8/06 , A61K8/65 , A61K8/96 , A61K47/42 , A61Q19/10 , B01F17/00 , B01F17/30 , C08H1/06 , C08L89/04
CPC分类号： B01F17/005 , A23L29/10 , A61K47/42 , A61K8/06 , A61K8/65 , A61Q19/10 , A61K2800/75 , Y10S516/06
摘要： This invention relates to a surfactant with less toxicity and irritation against the human body and a production process thereof. The surfactant is produced by the acylation of the side chain amino radicals of collagen or gelatine with an aliphatic acid having 2 to 26 carbon atoms; it is used as an emulsifier and an antiseptic for cosmetics.
摘要翻译：本发明涉及对人体毒性和刺激性低的表面活性剂及其制造方法。表面活性剂是通过用具有2至26个碳原子的脂肪酸酰化胶原或明胶的侧链氨基来产生的; 它被用作化妆品的乳化剂和防腐剂。

9. 发明授权

US4714758A Surfactant composed of acylated collagen or acylated gelatine and a production process thereof 失效
标题翻译：由酰化胶原或酰化明胶组成的表面活性剂及其制备方法
公开(公告)号：US4714758A
公开(公告)日：1987-12-22
申请号：US845441
申请日：1986-03-28
申请人： Tetsuro Namiki , Masayasu Furuse , Yoshimitsu Kuroyanagi , Teruo Miyata
发明人： Tetsuro Namiki , Masayasu Furuse , Yoshimitsu Kuroyanagi , Teruo Miyata
IPC分类号： A23L29/00 , A23L29/10 , A61K8/36 , A61K8/65 , A61K8/96 , A61K47/42 , A61Q19/00 , B01F17/00 , B01F17/30 , C07K1/113 , C07K14/78 , C08H1/06 , C11D1/32 , C09H7/00
CPC分类号： A61K8/36 , A23L29/10 , A61K47/42 , A61K8/361 , A61K8/65 , A61Q19/00 , B01F17/005 , A61K2800/75 , Y10S516/06
摘要： This invention relates to a surfactant composed of acylated collagen or acylated gelatine produced by the acylation of the side chain amino radicals of collagen or gelatine with an aliphatic acid having 2-26 carbon atoms and a dicarboxylic acid having 2-8 carbon atoms and a production process thereof. Since it has less toxicity and irritation against the human body and can dissolve in a neutral solution of pH 6-8 in the form of molecular dispersion, the surfactant is especially suitable for use in the field of cosmetic and foodstuff industries.
摘要翻译：本发明涉及由酰化胶原或酰化明胶组成的表面活性剂，其通过用2-26个碳原子的脂族酸和2-8个碳原子的二羧酸酰化胶原或明胶的侧链氨基，过程。由于其对人体具有较小的毒性和刺激性，并且可以以分子分散体的形式溶于pH6-8的中性溶液中，所以表面活性剂特别适用于化妆品和食品工业领域。

10. 发明授权

US4687518A Method for manufacturing pyrogen-free collagen gels useful as contact lenses 失效
标题翻译：用于制造不用作隐形眼镜的无热原胶原凝胶的方法
公开(公告)号：US4687518A
公开(公告)日：1987-08-18
申请号：US795633
申请日：1985-11-06
申请人： Teruo Miyata , Albert L. Rubin
发明人： Teruo Miyata , Albert L. Rubin
IPC分类号： A61L2/20 , B29D11/00 , C08L89/06 , G02B1/04 , G02C7/04 , C08L89/00
CPC分类号： C08L89/06 , G02B1/043
摘要： Pyrogen-free collagen useful for manufacturing soft contact lenses is made by performing all manufacturing process steps under aseptic conditions.

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