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1. 发明授权

US11052051B2 Coating composition, drug-containing particle, solid preparation and method for preparing drug-containing particle 有权
公开(公告)号：US11052051B2
公开(公告)日：2021-07-06
申请号：US14151205
申请日：2014-01-09
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Takuya Yokosawa , Yuichi Nishiyama , Naosuke Maruyama
IPC分类号： A61K9/50 , A61K9/00 , A61K9/20 , C09D101/32
摘要： Provided are a drug-containing particle capable of suppressing dissolution of a drug in the oral cavity to suppress an unpleasant taste thereof and having excellent dissolution of the drug in the digestive tract after passing through the oral cavity; a method for preparing the drug-containing particle; a coating composition used for preparing the drug-containing particle; and a solid preparation having the drug-containing particle. More specifically, provided are a coating composition having 100 parts by weight of a cellulose-based enteric base and 50 parts by weight or less of a water-soluble cellulose ether; a drug-containing particle having a drug-containing core and a coat portion obtained by coating the core with the coating composition; a solid preparation having the drug-containing particle; and a method for preparing a drug-containing particle having a step of coating the drug-containing core with the coating composition.

2. 发明授权

US09382336B2 Method for preparing cellulose ether having low degree of polymerization and cellulose ether prepared thereby 有权
标题翻译：制备低聚合度的纤维素醚的方法和由此制备的纤维素醚
公开(公告)号：US09382336B2
公开(公告)日：2016-07-05
申请号：US14150793
申请日：2014-01-09
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Mitsuo Narita , Yuichi Nishiyama
IPC分类号： C08B1/08 , C08B1/06 , C08B11/00 , C08B11/08 , C08B11/20 , C08B11/02
CPC分类号： C08B11/08 , C08B1/06 , C08B1/08 , C08B11/02 , C08B11/20
摘要： Provided is a method for preparing a cellulose ether having a low degree of polymerization and undergoing less yellowing and a cellulose ether prepared thereby. Specifically, provided is a method for preparing a cellulose ether having a low degree of polymerization, the method including a step of bringing pulp and an alkali metal hydroxide solution into contact with each other or mixing them to obtain a corresponding alkali cellulose, a first depolymerization step of reacting the alkali cellulose with oxygen to adjust a viscosity reduction percentage of the alkali cellulose to from 10 to 95%, a step of reacting the depolymerized alkali cellulose with an etherifying agent, a step of washing and drying the reaction product to obtain a cellulose ether, and a second depolymerization step of bringing the cellulose ether into contact with hydrochloric acid to adjust a viscosity reduction percentage of the cellulose ether from 40 to 99.9%.
摘要翻译：本发明提供一种制备聚合度低，发黄不足的纤维素醚的方法以及由此制备的纤维素醚。具体地说，提供一种低聚合度的纤维素醚的制造方法，其特征在于，包括使纸浆和碱金属氢氧化物溶液相互接触或混合以获得相应的碱纤维素的步骤，首先解聚将碱纤维素与氧反应以将碱纤维素的粘度降低百分比调节为10〜95％的步骤，使解聚的碱纤维素与醚化剂反应的步骤，将反应产物洗涤和干燥的步骤，纤维素醚和使纤维素醚与盐酸接触的第二解聚步骤，将纤维素醚的粘度降低百分比调节至40〜99.9％。

3. 发明申请

US20150040798A1 Method For Producing Water-Soluble Cellulose Ether Having Low Degree of Polymerization and Method for Producing Film Coating Composition Comprising Same 有权
标题翻译：具有低聚合度的水溶性纤维素醚的制造方法及其制造方法
公开(公告)号：US20150040798A1
公开(公告)日：2015-02-12
申请号：US14447846
申请日：2014-07-31
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Akira Kitamura , Mitsuo Narita , Takuya Yokosawa , Yuichi Nishiyama
IPC分类号： C08B11/20 , C09D101/28
CPC分类号： C08B11/20 , C08B1/06 , C08B1/08 , C08B11/00 , C08B15/00 , C09D101/26 , C09D101/284 , D21C9/004 , D21C9/007 , D21H15/02 , D21H19/34 , D21H19/52
摘要： Provided are a method for producing a water-soluble cellulose ether having a low degree of polymerization and enhanced whiteness, and the like. The method includes the steps of: bringing a pulp powder having a multiplication product of less than 0.004 mm2 which is obtained by multiplying a number-average fiber length by a number-average fiber width, each measured with a Kajaani fiber length analyzer, into contact with an alkali metal hydroxide to obtain an alkali cellulose; reacting the alkali cellulose with an etherifying agent to obtain a crude water-soluble cellulose ether having a high degree of polymerization; purifying the crude water-soluble cellulose ether; drying the purified water-soluble cellulose ether; grinding the dried water-soluble cellulose ether into a water-soluble cellulose ether powder; and depolymerizing the water-soluble cellulose ether powder to obtain the water-soluble cellulose ether having a low degree of polymerization.
摘要翻译：提供具有低聚合度和白度提高的水溶性纤维素醚的制造方法等。该方法包括以下步骤：使用Kajaani纤维长度分析仪测定的数均纤维宽度乘以数均纤维长度乘以小于0.004mm 2的纸浆粉末，形成接触与碱金属氢氧化物反应得到碱纤维素; 使碱纤维素与醚化剂反应，得到聚合度高的粗水溶性纤维素醚; 净化粗水溶性纤维素醚; 干燥纯化的水溶性纤维素醚; 将干燥的水溶性纤维素醚研磨成水溶性纤维素醚粉末; 并使水溶性纤维素醚粉末解聚，得到低聚合度的水溶性纤维素醚。

4. 发明申请

US20140199406A1 Coating Composition, Drug-Containing Particle, Solid Preparation and Method for Preparing Drug-Containing Particle 审中-公开
标题翻译：涂料组合物，含药颗粒，固体制剂和制备含药颗粒的方法
公开(公告)号：US20140199406A1
公开(公告)日：2014-07-17
申请号：US14151205
申请日：2014-01-09
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Takuya Yokosawa , Yuichi Nishiyama , Naosuke Maruyama
IPC分类号： A61K9/14
CPC分类号： A61K9/5047 , A61K9/0056 , A61K9/2081 , A61K9/5042 , A61K9/5078 , C09D101/32 , C08L1/26 , C08L1/28 , C08L1/284
摘要： Provided are a drug-containing particle capable of suppressing dissolution of a drug in the oral cavity to suppress an unpleasant taste thereof and having excellent dissolution of the drug in the digestive tract after passing through the oral cavity; a method for preparing the drug-containing particle; a coating composition used for preparing the drug-containing particle; and a solid preparation having the drug-containing particle. More specifically, provided are a coating composition having 100 parts by weight of a cellulose-based enteric base and 50 parts by weight or less of a water-soluble cellulose ether; a drug-containing particle having a drug-containing core and a coat portion obtained by coating the core with the coating composition; a solid preparation having the drug-containing particle; and a method for preparing a drug-containing particle having a step of coating the drug-containing core with the coating composition.
摘要翻译：提供能够抑制药物在口腔中溶解的药物含量粒子，以抑制其口感不适，并且在通过口腔后药物在消化道中的溶解性优异; 制备含药颗粒的方法; 用于制备含药颗粒的涂料组合物; 和含有药物的颗粒的固体制剂。更具体地说，提供了一种涂料组合物，其具有100重量份的基于纤维素的肠溶基质和50重量份或更少的水溶性纤维素醚; 含有药物的核心的药物粒子和通过用所述涂料组合物涂覆所述核得到的涂层部分; 具有含药物颗粒的固体制剂; 以及制备含有药物的颗粒的方法，所述药物含有颗粒具有用所述涂料组合物涂覆含药芯的步骤。

5. 发明授权

US09926385B2 Method for producing water-soluble cellulose ether having low degree of polymerization and method for producing film coating composition comprising same 有权
公开(公告)号：US09926385B2
公开(公告)日：2018-03-27
申请号：US14447846
申请日：2014-07-31
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Akira Kitamura , Mitsuo Narita , Takuya Yokosawa , Yuichi Nishiyama
IPC分类号： C08B11/20 , C09D101/28 , C08B1/06 , C08B1/08 , C08B11/00 , C08B15/00 , C09D101/26 , D21C9/00 , D21H15/02 , D21H19/34 , D21H19/52
CPC分类号： C08B11/20 , C08B1/06 , C08B1/08 , C08B11/00 , C08B15/00 , C09D101/26 , C09D101/284 , D21C9/004 , D21C9/007 , D21H15/02 , D21H19/34 , D21H19/52
摘要： Provided are a method for producing a water-soluble cellulose ether having a low degree of polymerization and enhanced whiteness, and the like. The method includes the steps of: bringing a pulp powder having a multiplication product of less than 0.004 mm2 which is obtained by multiplying a number-average fiber length by a number-average fiber width, each measured with a Kajaani fiber length analyzer, into contact with an alkali metal hydroxide to obtain an alkali cellulose; reacting the alkali cellulose with an etherifying agent to obtain a crude water-soluble cellulose ether having a high degree of polymerization; purifying the crude water-soluble cellulose ether; drying the purified water-soluble cellulose ether; grinding the dried water-soluble cellulose ether into a water-soluble cellulose ether powder; and depolymerizing the water-soluble cellulose ether powder to obtain the water-soluble cellulose ether having a low degree of polymerization.

6. 发明申请

US20140370091A1 Method for Producing Aqueous Enteric Coating Liquid, Solid Preparation, and Method for Producing Same 审中-公开
标题翻译：生产水性肠溶衣液的方法，固体制剂及其制备方法
公开(公告)号：US20140370091A1
公开(公告)日：2014-12-18
申请号：US14288836
申请日：2014-05-28
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Shingo Kikuchi , Takafumi Hoshino , Yuichi Nishiyama
IPC分类号： A61K9/28 , A61K31/525
CPC分类号： A61K9/2866 , A61K31/525
摘要： An enteric preparation having a film-forming property and acid resistance is provided by using a simple and efficient method without using a special cooling apparatus. More specifically, provided is a method for producing an aqueous enteric coating liquid including the steps of: partially neutralizing an aqueous suspension including a cellulosic enteric material with an aqueous alkali solution, and mixing the partially-neutralized aqueous suspension with a plasticizer. Also provided is a solid preparation including a core including a drug and a coating portion obtained by coating the core with the produced aqueous enteric coating liquid. Further, provided is a method for producing a solid preparation, including respective steps in the method for producing an aqueous enteric coating liquid and a step of coating a core including a drug with the produced aqueous enteric coating liquid.
摘要翻译：具有成膜性和耐酸性的肠溶制剂通过使用简单有效的方法而不使用特殊的冷却装置来提供。更具体地说，提供了一种生产水性肠溶液的方法，包括以下步骤：用碱性水溶液部分中和包含纤维素肠溶性物质的水性悬浮液，并将部分中和的水性悬浮液与增塑剂混合。还提供了一种固体制剂，其包括包含药物的核心和通过用所制备的水性肠溶衣来涂覆核心获得的涂覆部分。此外，提供了一种制备固体制剂的方法，包括在肠溶液制剂的制备方法中的各个步骤，以及用所制备的水性肠溶衣液涂覆包含药物的核心的步骤。

7. 发明申请

US20140194618A1 Method For Preparing Cellulose Ether Having Low Degree Of Polymerization And Cellulose Ether Prepared Thereby 有权
标题翻译：制备具有低聚合度和纤维素醚的纤维素醚的方法
公开(公告)号：US20140194618A1
公开(公告)日：2014-07-10
申请号：US14150793
申请日：2014-01-09
申请人： Shin-Etsu Chemical Co., Ltd.
发明人： Mitsuo NARITA , Yuichi Nishiyama
IPC分类号： C08B11/08
CPC分类号： C08B11/08 , C08B1/06 , C08B1/08 , C08B11/02 , C08B11/20
摘要： Provided is a method for preparing a cellulose ether having a low degree of polymerization and undergoing less yellowing and a cellulose ether prepared thereby. Specifically, provided is a method for preparing a cellulose ether having a low degree of polymerization, the method including a step of bringing pulp and an alkali metal hydroxide solution into contact with each other or mixing them to obtain a corresponding alkali cellulose, a first depolymerization step of reacting the alkali cellulose with oxygen to adjust a viscosity reduction percentage of the alkali cellulose to from 10 to 95%, a step of reacting the depolymerized alkali cellulose with an etherifying agent, a step of washing and drying the reaction product to obtain a cellulose ether, and a second depolymerization step of bringing the cellulose ether into contact with hydrochloric acid to adjust a viscosity reduction percentage of the cellulose ether from 40 to 99.9%.
摘要翻译：本发明提供一种制备聚合度低，发黄不足的纤维素醚的方法以及由此制备的纤维素醚。具体地说，提供一种低聚合度的纤维素醚的制造方法，其特征在于，包括使纸浆和碱金属氢氧化物溶液相互接触或混合以获得相应的碱纤维素的步骤，首先解聚将碱纤维素与氧反应以将碱纤维素的粘度降低百分比调节为10〜95％的步骤，使解聚的碱纤维素与醚化剂反应的步骤，洗涤并干燥反应产物的步骤，得到纤维素醚和使纤维素醚与盐酸接触的第二解聚步骤，将纤维素醚的粘度降低百分比调节至40〜99.9％。

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