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1. 发明授权

US4336251A Medicaments containing an organosilicon compound 失效
标题翻译：含有机硅化合物的药物
公开(公告)号：US4336251A
公开(公告)日：1982-06-22
申请号：US178359
申请日：1980-08-15
申请人： Shigeshi Toyoshima , Ryuichi Sato , Koichi Ito , Toshio Shinohara , Yasushi Yamamoto , Shoji Ichinohe
发明人： Shigeshi Toyoshima , Ryuichi Sato , Koichi Ito , Toshio Shinohara , Yasushi Yamamoto , Shoji Ichinohe
IPC分类号： A61K31/695 , A61P9/12 , A61P35/00 , C07F7/08
CPC分类号： A61K31/695 , C07F7/0818
摘要： A novel medicament which is effective as an antihypertensive agent is proposed which contains, as its effective ingredient, an organosilicon compound represented by the general formulaR.sub.3 Si(CH.sub.2).sub.n COOH,where R denotes an alkyl group having from 1 to 6 carbon atoms and n is an integer from 1 to 5 inclusive, or a therapeutically acceptable salt thereof such as a salt with an alkali metal, e.g. sodium or potassium. The effectiveness of the compound, for example, 3-trimethylsilyl butyric acid as well as the sodium and potassium salts thereof is established by the animal test undertaken with hypertensive rats.
摘要翻译：提出作为抗高血压药有效的新型药物，其含有作为其有效成分的由通式R 3 Si（CH 2）n COOH表示的有机硅化合物，其中R表示具有1至6个碳原子的烷基，n为 1〜5的整数，或其治疗上可接受的盐，例如与碱金属的盐，例如，钠或钾。化合物，例如3-三甲基甲硅烷基丁酸及其钠盐和钾盐的有效性是通过用高血压大鼠进行的动物试验建立的。

2. 发明授权

US4328216A Novel organosilicon compounds and anti-tumor agents containing the same 失效
标题翻译：新型有机硅化合物和含有相同的抗肿瘤剂
公开(公告)号：US4328216A
公开(公告)日：1982-05-04
申请号：US102225
申请日：1979-12-10
申请人： Shigeshi Toyoshima , Ryuichi Sato , Koichi Ito , Toshio Shinohara , Yasushi Yamamoto , Shoji Ichinohe
发明人： Shigeshi Toyoshima , Ryuichi Sato , Koichi Ito , Toshio Shinohara , Yasushi Yamamoto , Shoji Ichinohe
IPC分类号： A61K31/695 , A61P35/00 , C07F7/08 , C07F7/10
CPC分类号： C07F7/0818
摘要： The invention provides a novel anti-tumor agent highly effective for inhibiting growth of several tumor or cancer cells with low toxicity. The active ingredient contained in the anti-tumor agent is an .omega.-triorganosilyl-substituted linear alkanoic acid anilide which is a hitherto unknown novel compound prepared by the reaction of corresponding acid chloride and aniline.
摘要翻译：本发明提供了用于抑制几种具有低毒性的肿瘤或癌细胞生长的新型抗肿瘤剂。包含在抗肿瘤剂中的活性成分是ω-三有机甲硅烷基取代的直链烷酸酰苯胺，它是迄今未知的通过相应的酰氯和苯胺反应制备的新化合物。

3. 发明授权

US4349682A 2-(3-Trimethylsilylpropyl)benzothiazole 失效
标题翻译： 2-（3-三甲基甲硅烷基丙基）苯并噻唑
公开(公告)号：US4349682A
公开(公告)日：1982-09-14
申请号：US186211
申请日：1980-09-11
申请人： Shigeshi Toyoshima , Ryuichi Sato , Koichi Ito , Toshio Shinohara , Yasushi Yamamoto
发明人： Shigeshi Toyoshima , Ryuichi Sato , Koichi Ito , Toshio Shinohara , Yasushi Yamamoto
IPC分类号： A61K31/695 , A61P35/00 , C07F7/08 , C07F7/10 , A61K31/425
CPC分类号： C07F7/0812
摘要： The invention provides a novel compound 2-(3-trimethylsilylpropyl)benzothiazole having remarkable anti-tumor effects or, in particular, inhibiting growth of melanoma cells in test animals. The compound is synthesized by the ring-closing intramolecular dehydration condensation of 2-mercapto-(.gamma.-trimethylsilyl)butyroanilide which in turn is obtained by the dehydrochlorination condensation of 2-aminothiophenol and .gamma.-trimethylsilylbutyryl chloride in a polar solvent in the presence of an acid acceptor.
摘要翻译：本发明提供了具有显着的抗肿瘤作用或特别是抑制试验动物中黑素瘤细胞生长的新型化合物2-（3-三甲基甲硅烷基丙基）苯并噻唑。通过2-巯基 - （γ-三甲基甲硅烷基）丁酰苯胺的闭环分子内脱水缩合合成化合物，其通过2-苯基硫酚和γ-三甲基甲硅烷基丁酰氯在极性溶剂中的脱氯化氢缩合获得，酸受体。

4. 发明授权

US4278666A Novel organosilicon compounds and anti-transplanted tumor agents containing the same 失效
标题翻译：新型有机硅化合物和含有其的抗移植肿瘤剂
公开(公告)号：US4278666A
公开(公告)日：1981-07-14
申请号：US124957
申请日：1980-02-26
申请人： Shigeshi Toyoshima , Ryuichi Sato , Koichi Ito , Toshio Shinohara , Yasushi Yamamoto
发明人： Shigeshi Toyoshima , Ryuichi Sato , Koichi Ito , Toshio Shinohara , Yasushi Yamamoto
IPC分类号： A61K31/695 , A61P35/00 , C07F7/08 , C07F7/10 , A61K31/725 , A01N55/00
CPC分类号： C07F7/0818
摘要： The invention provides a novel class of organosilicon compounds and a method for the preparation thereof as well as an anti-tumor agent containing the compound having very remarkable anti-tumor activity but with very low toxicity. The inventive compound is a (trihydrocarbylsilylmethyloxyimino)alkane, which is a silicon-containing oxime compound hitherto not described in any prior art literatures, represented by the general formula R.sup.1.sub.3 Si--CH.sub.2 --O--N.dbd.Y, R.sup.1 is a substituted or unsubstituted monovalent hydrocarbon group having from 1 to 10 carbon atoms and Y is a divalent hydrocarbon group denoted by .dbd.CR.sup.2 R.sup.3 or .dbd.CR.sup.4, R.sup.2 and R.sup.3, which may be identical or different, having the same meaning as R.sup.1 defined above and R.sup.4 being an alkylene group to form a ring structure jointly with the carbon atom directly bonded to the nitrogen atom. Typical examples of the compounds are: 2-(trimethylsilylmethyloxyimino) butane, 2-(trimethylsilylmethyloxyimino)propane, 2-(dimethylphenylsilylmethyloxyimino) butane and trimethylsilylmethyloxyiminocyclohexane.
摘要翻译：本发明提供了一类新颖的有机硅化合物及其制备方法以及含有非常显着的抗肿瘤活性但毒性非常低的化合物的抗肿瘤剂。本发明化合物是一种（三烃基甲硅烷基甲氧基亚氨基）烷烃，其是迄今尚未在任何现有技术文献中描述的含硅肟化合物，由通式R 13 Si-CH 2 -ON A = Y表示，R 1是取代或未取代的单价烃基， 1至10个碳原子，Y是由= CR 2 R 3或= CR 4，R 2和R 3表示的二价烃基，其可以相同或不同，具有与上述R 1相同的含义，R 4为形成环的亚烷基与与氮原子直接键合的碳原子结合。化合物的典型实例是：2-（三甲基甲硅烷基甲氧基亚氨基）丁烷，2-（三甲基甲硅烷基甲氧基亚氨基）丙烷，2-（二甲基苯基甲硅烷基甲氧基亚氨基）丁烷和三甲基甲硅烷基甲氧基亚氨基环己烷。

5. 发明授权

US4267172A Bis(triorganosilylalkyl) phosphites 失效
标题翻译：双（三有机甲硅烷基烷基）亚磷酸酯
公开(公告)号：US4267172A
公开(公告)日：1981-05-12
申请号：US78772
申请日：1979-09-25
申请人： Shigeshi Toyoshima , Ryuichi Sato , Koichi Ito , Toshio Shinohara , Masatoshi Arai
发明人： Shigeshi Toyoshima , Ryuichi Sato , Koichi Ito , Toshio Shinohara , Masatoshi Arai
IPC分类号： C08K5/00 , A01N55/10 , A61K31/695 , A61P9/12 , A61P35/00 , C07F9/02 , C07F9/141 , C08K5/5419 , A01N55/00 , C07F7/08
CPC分类号： A61K31/695 , C07F9/1415
摘要： The present invention presents a novel class of compounds bis(triorganosilylalkyl) phosphites, e.g. bis(trimethylsilylmethyl) phosphite. The compound is readily prepared by the reaction of a corresponding triorganosilyl alkanol with phosphorus trichloride or by the partial hydrolysis of a corresponding tris(triorganosilylalkyl) phosphite with an equimolar amount of water followed by distillation of the reaction mixture.The compound has a remarkable anti-transplanted tumor effectiveness as established by the test with mice as the test animals for preventing the growth of Ehrlich's cancer cells and Sarcoma 180 cells. The compound has very low toxicity when orally administrated.
摘要翻译：本发明提供了一类新颖的化合物双（三有机甲硅烷基）亚磷酸酯，例如双（三甲基甲硅烷基甲基）亚磷酸酯。通过相应的三有机甲硅烷基链烷醇与三氯化磷的反应或通过相应的三（三有机甲硅烷基烷基）亚磷酸酯与等摩尔量的水部分水解然后蒸馏反应混合物来容易地制备该化合物。该化合物具有显着的抗移植肿瘤效力，其通过用小鼠作为用于预防Ehrlich癌细胞和肉瘤180细胞生长的试验动物的试验建立。该化合物在口服时具有非常低的毒性。

6. 发明授权

US4096161A Process for the preparation of halogenosilanes 失效
标题翻译：卤代硅烷的制备方法
公开(公告)号：US4096161A
公开(公告)日：1978-06-20
申请号：US742845
申请日：1976-11-18
申请人： Toshio Shinohara , Masatoshi Arai , Shoji Ichinohe
发明人： Toshio Shinohara , Masatoshi Arai , Shoji Ichinohe
IPC分类号： C01B33/107 , C07F7/12 , C07F7/08
CPC分类号： C07F7/125
摘要： Halogenosilanes are prepared from an organohalogenosilane and an organopolysiloxane as the starting materials by subjecting them to an intermolecular redistribution reaction in the presence of a monohydrochloride of a hexaalkylphosphotriamide. The thus prepared halogenosilanes, which are different from the starting halogenosilane reactant, are very useful in the silicone industry.
摘要翻译：卤代硅烷由有机基卤硅烷和有机聚硅氧烷作为原料，通过在六烷基磷酰三胺的一盐酸盐存在下进行分子间再分布反应。如此制备的与起始卤代硅烷反应物不同的卤代硅烷在硅氧烷工业中是非常有用的。

7. 发明授权

US4320172A Organopolysiloxane resin compositions for release papers 失效
标题翻译：用于剥离纸的有机聚硅氧烷树脂组合物
公开(公告)号：US4320172A
公开(公告)日：1982-03-16
申请号：US165148
申请日：1980-07-01
申请人： Minoru Takamizawa , Toshio Shinohara , Yasushi Yamamoto , Tasuku Tanino , Kiyoyuki Takano , Fumiaki Mori
发明人： Minoru Takamizawa , Toshio Shinohara , Yasushi Yamamoto , Tasuku Tanino , Kiyoyuki Takano , Fumiaki Mori
IPC分类号： C08L33/06 , D21H27/00 , C08L31/02 , C08L67/06 , C08L83/10
CPC分类号： D21H27/001 , C08L33/06 , Y10T428/31663
摘要： The invention provides a novel in-process release paper, i.e. a release paper used as a backing paper in the manufacturing of, e.g. a synthetic leather with a polyurethane resin. The releasing resin composition with which the release paper is coated is novel as comprising (a) a base resin selected from the group consisting of alkyd resins and acrylic resins modified with an organopolysiloxane, of which from 15 to 50% by moles of the organic groups directly bonded to the silicon atoms in a molecule are phenyl groups, having at least one hydroxy-substituted organic group directly bonded to the silicon atom in a molecule, (b) an alkanol-modified amino resin and (c) an acidic catalyst. The inventive in-process release paper is very superior to the conventional ones in the very much reduced peeling resistance, increased surface gloss and durability in repeated use.
摘要翻译：本发明提供了一种新颖的过程中的脱模纸，即在例如制造中用作背纸的剥离纸。具有聚氨酯树脂的合成革。包含剥离纸的释放树脂组合物是新颖的，包括（a）选自醇酸树脂和用有机聚硅氧烷改性的丙烯酸树脂的基础树脂，其中15至50摩尔％的有机基团与分子中的硅原子直接键合的苯基具有至少一个羟基取代的有机基团，其分子中直接与硅原子键合，（b）链烷醇改性的氨基树脂和（c）酸性催化剂。本发明的在制脱模纸非常优于常规剥离纸，在非常降低的抗剥离性，增加的表面光泽度和重复使用中的耐久性。

8. 发明授权

US06686312B1 Metallic copper catalyst and process for making organohalosilanes 有权
标题翻译：金属铜催化剂和制备有机卤代硅烷的方法
公开(公告)号：US06686312B1
公开(公告)日：2004-02-03
申请号：US09522690
申请日：2000-03-10
申请人： Mikio Aramata , Masaaki Furuya , Yoshihiro Shirota , Akio Muraida , Susumu Ueno , Toshio Shinohara
发明人： Mikio Aramata , Masaaki Furuya , Yoshihiro Shirota , Akio Muraida , Susumu Ueno , Toshio Shinohara
IPC分类号： B01J2370
CPC分类号： C07F7/16 , B01J23/72
摘要： In the synthesis of organohalosilanes by the direct process of reacting an organic halogen with metallic silicon powder, a metallic copper catalyst in the form of a thermally active metallic copper powder having large strain energy is used.
摘要翻译：在通过使有机卤素与金属硅粉反应的直接方法合成有机卤代硅烷中，使用具有大应变能的热活性金属铜粉形式的金属铜催化剂。

9. 发明授权

US06218562B1 Process for preparing organohalosilanes 有权
标题翻译：制备有机卤代硅烷的方法
公开(公告)号：US06218562B1
公开(公告)日：2001-04-17
申请号：US09548053
申请日：2000-04-12
申请人： Mikio Aramata , Akio Ohori , Masaaki Furuya , Susumu Ueno , Toshio Shinohara , Tetsuya Inukai
发明人： Mikio Aramata , Akio Ohori , Masaaki Furuya , Susumu Ueno , Toshio Shinohara , Tetsuya Inukai
IPC分类号： C07F716
CPC分类号： C07F7/16
摘要： Organohalosilanes are prepared by the Rochow process of reacting metallic silicon particles with an organohalide in the presence of a copper catalyst. The metallic silicon particles, which are prepared by comminuting fragments of metallic silicon raw material, have a mean particle size of 10 &mgr;m to 10 mm and a surface oxygen quantity of up to 0.3 wt % which is given as the difference between the oxygen concentrations determined by in-metal oxygen analysis of the metallic silicon particles and the fragments, respectively.
摘要翻译：有机卤代硅烷通过在铜催化剂存在下使金属硅颗粒与有机卤化物反应的Rochow方法制备。通过粉碎金属硅原料碎片制备的金属硅颗粒的平均粒径为10〜10μm，表面氧量为0.3重量％，其作为测定的氧浓度之差分别通过金属硅颗粒和碎片的金属间氧分析。

10. 发明授权

US5783647A 1,1,2,2-tetramethylpropylperoxy esters and method for preparing vinyl polymers 失效
标题翻译： 1,1,2,2-四甲基丙基过氧酯和乙烯基聚合物的制备方法
公开(公告)号：US5783647A
公开(公告)日：1998-07-21
申请号：US566509
申请日：1995-12-04
申请人： Takashi Kobayashi , Tadashi Amano , Hideshi Kurihara , Toshio Shinohara , Yoshitaka Okuno , Tohru Nishikawa
发明人： Takashi Kobayashi , Tadashi Amano , Hideshi Kurihara , Toshio Shinohara , Yoshitaka Okuno , Tohru Nishikawa
IPC分类号： C07C409/38 , C08F2/00 , C08F4/34 , C08F14/06 , C08F14/08 , C08F18/08
CPC分类号： C08F4/34 , C07C409/38 , C08F14/06
摘要： Novel 1,1,2,2-tetramethylpropylperoxy esters are provided. They are useful as a polymerization initiator in polymerizing vinyl chloride, vinylidene chloride and vinyl acetate monomers, with the advantage of completing polymerization within a short time.
摘要翻译：提供了新的1,1,2,2-四甲基丙基过氧酯。它们可用作聚合氯乙烯，偏二氯乙烯和乙酸乙烯酯单体中的聚合引发剂，其优点是在短时间内完成聚合。

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