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1. 发明申请

US20140004196A1 POLYAMIDE-AMINE DENDRIMER OR DERIVATIVE THEREOF-MATH1 GENE NANO PARTICLE AND USE THEREOF IN TREATMENT OF HEARING LOSS 审中-公开
标题翻译：聚酰胺胺衍生物或其衍生物 - 数学1基因纳米颗粒及其用于治疗听力损失的用途
公开(公告)号：US20140004196A1
公开(公告)日：2014-01-02
申请号：US13978060
申请日：2012-01-04
申请人： Shi-Ming Yang , Nan Wu , Yan Wu , Dong Han , Wei-Wei Guo , Li-Dong Zhao , Suo-Quiang Zhai , Wei-Quiang Gao , Wei-Yen Young
发明人： Shi-Ming Yang , Nan Wu , Yan Wu , Dong Han , Wei-Wei Guo , Li-Dong Zhao , Suo-Quiang Zhai , Wei-Quiang Gao , Wei-Yen Young
IPC分类号： A61K48/00 , C12N15/85 , A61K38/17 , A61K9/14
CPC分类号： A61K48/0041 , A61K9/146 , A61K9/5146 , A61K9/5161 , A61K38/1709 , A61K48/005 , B82Y5/00 , C12N15/85
摘要： Polyamidoamine, its partially degraded products or its complexes-Math1 gene nanoparticles, method for preparing the same and use thereof, the gene nanoparticles can be produced through complex coacervating of polyamidoamine, or polyamidoamine complexes and a Math1 gene-containing plasmid. The gene nanoparticles are controllable in particle size, uniform in size, favorable for surface modification, can enhance the ability of expression and delivery of the Math1 gene, and is useful in a sensorineural hearing loss caused by hair cells loss due to noise, drug toxicity etc.
摘要翻译：聚酰胺胺，其部分降解产物或其复合物-Math1基因纳米颗粒，其制备方法及其用途，可以通过聚酰胺胺或聚酰胺胺配合物和含有Math1基因的质粒的复合凝聚来制备基因纳米颗粒。基因纳米粒子粒径可控，粒径均匀，有利于表面修饰，可提高Math1基因的表达和递送能力，可用于由于噪音，药物毒性引起的毛细胞损失引起的感觉神经性听力损失等等

2. 发明申请

US20160173993A1 Circuit Module For Silicon Condenser Microphone 有权
标题翻译：硅电容麦克风电路模块
公开(公告)号：US20160173993A1
公开(公告)日：2016-06-16
申请号：US14832535
申请日：2015-08-21
申请人： Dong Han , Chua TiongKee , Roger Tay , Tan Siew Seong
发明人： Dong Han , Chua TiongKee , Roger Tay , Tan Siew Seong
IPC分类号： H04R19/04 , H04R3/02
CPC分类号： H04R19/04 , H04R3/00 , H04R3/02 , H04R19/005 , H04R2410/03
摘要： A circuit module for a silicon condenser microphone of the present disclosure includes a transducer, a charge pump, an isolator, a first amplifier, a second amplifier, a reaction circuit, a first bias circuit, and a second bias circuit. The charge pump electrically connects to an input port of the transducer, and an output port of the transducer electrically connects to an input port of the first amplifier via the isolator. An output port of the first amplifier electrically connects to an input port of the second amplifier. The reaction circuit is arranged between the output port of the first amplifier and the input port of the transducer. The isolator isolates the direct-current components of the first electrical signal, and therefore, the oscillations of the direct-current components will not affect the performance of the first amplifier.
摘要翻译：本公开的用于硅电容式麦克风的电路模块包括换能器，电荷泵，隔离器，第一放大器，第二放大器，反应电路，第一偏置电路和第二偏置电路。电荷泵电连接到换能器的输入端口，并且换能器的输出端口通过隔离器电连接到第一放大器的输入端口。第一放大器的输出端口电连接到第二放大器的输入端口。反应电路设置在第一放大器的输出端口和换能器的输入端口之间。隔离器隔离第一电信号的直流分量，因此直流分量的振荡不会影响第一放大器的性能。

3. 发明授权

US08507491B2 Compounds and compositions as hedgehog pathway inhibitors 有权
标题翻译：化合物和组合物作为刺猬蛋白通路抑制剂
公开(公告)号：US08507491B2
公开(公告)日：2013-08-13
申请号：US13060426
申请日：2009-08-24
申请人： Dai Cheng , Dong Han , Guobao Zhang , Yongqin Wan , Yun Feng Xie , Jiqing Jiang , Wenqi Gao , Shifeng Pan
发明人： Dai Cheng , Dong Han , Guobao Zhang , Yongqin Wan , Yun Feng Xie , Jiqing Jiang , Wenqi Gao , Shifeng Pan
IPC分类号： A61K31/501 , A61K31/4725 , A61K31/4439 , A61K31/497 , A61K31/472 , A61K31/4427 , A61P35/00
CPC分类号： C07D401/12 , A61K31/47 , C07D217/04 , C07D217/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07D513/04
摘要： The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).
摘要翻译：本发明提供了调节刺猬蛋白信号通路活性的方法，化合物和组合物。特别地，本发明提供了一种抑制由诸如Ptc丧失功能，刺猬获得功能，平滑增益功能或GIi功能增益等表型引起的异常生长状态的方法，包括使细胞接触与足量的式（I）化合物反应。

4. 发明申请

US20130079328A1 COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY 有权
标题翻译：用于调制WNT信号通路的组合物和方法
公开(公告)号：US20130079328A1
公开(公告)日：2013-03-28
申请号：US13701982
申请日：2011-06-28
申请人： Dai Cheng , Guobao Zhang , Dong Han , Wenqi Gao , Shifeng Pan , Lichun Shen , Rajender Reddy Leleti
发明人： Dai Cheng , Guobao Zhang , Dong Han , Wenqi Gao , Shifeng Pan , Lichun Shen , Rajender Reddy Leleti
IPC分类号： C07D417/14 , A61K45/06 , A61K31/541 , C07D237/08 , A61K31/50
CPC分类号： C07D417/14 , A61K31/50 , A61K31/541 , A61K45/06 , C07D213/56 , C07D237/08 , C07D279/12 , C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to compositions and methods for modulating the Wnt signaling pathway, using compounds having Formula (1) and (3): wherein A, B, Y and Z all represent rings, and R1, R2, R3 are as defined herein.
摘要翻译：本发明涉及使用具有式（1）和（3）的化合物调节Wnt信号通路的组合物和方法：其中A，B，Y和Z均表示环，并且R 1，R 2，R 3如本文所定义。

5. 发明申请

US20120196849A1 COMPOUNDS AND COMPOSITIONS AS HEDGEHOG PATHWAY MODULATORS 审中-公开
标题翻译：化合物和组合物作为HEDGEHOG PATHWAY调制器
公开(公告)号：US20120196849A1
公开(公告)日：2012-08-02
申请号：US13443631
申请日：2012-04-10
申请人： Wenqi Gao , Jiqing Jiang , Yongqin Wan , Dai Cheng , Dong Han , Xu Wu , Shifeng Pan
发明人： Wenqi Gao , Jiqing Jiang , Yongqin Wan , Dai Cheng , Dong Han , Xu Wu , Shifeng Pan
IPC分类号： A61K31/553 , C07D295/26 , C07D295/155 , C07D401/14 , C07D401/04 , A61K31/5375 , A61K31/5377 , A61K31/551 , A61K31/55 , A61K31/496 , A61P1/18 , A61P13/08 , A61P35/00 , C12N5/09 , C07D413/04
CPC分类号： C07C255/57 , C07C235/56 , C07C237/40 , C07C2601/14 , C07D413/04
摘要： The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
摘要翻译：本发明提供了一种调节刺猬蛋白信号通路活性的方法。特别地，本发明提供了一种抑制由诸如Ptc功能丧失，hedgehog功能增益，平滑增益功能或Gli功能增益等表现形成的异常生长状态的方法，包括使细胞接触与足量的式I化合物反应。

6. 发明申请

US20110237573A1 N- (HETERO)ARYL, 2- (HETERO)ARYL-SUBSTITUTED ACETAMIDES FOR USE AS WNT SIGNALING MODULATORS 有权
标题翻译：用作WNT信号调节剂的N-（异氟烷基）亚甲基，2-（异丁基）亚芳基取代的乙酰胺
公开(公告)号：US20110237573A1
公开(公告)日：2011-09-29
申请号：US13132294
申请日：2010-03-01
申请人： Dai Cheng , Guobao Zhang , Dong Han , Wenqi Gao , Shifeng Pan
发明人： Dai Cheng , Guobao Zhang , Dong Han , Wenqi Gao , Shifeng Pan
IPC分类号： A61K31/541 , C07D417/12 , C07D401/12 , C07D401/14 , C07D413/14 , C07D417/14 , A61K31/4439 , A61K31/444 , A61K31/501 , A61K31/5377 , A61K31/497 , C12N5/071 , A61P19/02 , A61P25/16 , A61P27/02 , A61P7/10 , A61P35/00 , A61P17/02 , A61P3/00 , A61P35/02
CPC分类号： A61K31/541 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , C07D213/75 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to compounds of formulae 1 and 2 and methods for modulating the Wnt signaling pathway using these compounds, wherein A1, A2, B, Y and Z all represent rings.
摘要翻译：本发明涉及式1和化合物2以及使用这些化合物调节Wnt信号通路的方法，其中A1，A2，B，Y和Z都代表环。

7. 发明申请

US20110152282A1 HEDGEHOG PATHWAY MODULATORS 有权
标题翻译： HEDGEHOG路径调制器
公开(公告)号：US20110152282A1
公开(公告)日：2011-06-23
申请号：US13060426
申请日：2009-08-24
申请人： Dai Cheng , Dong Han , Guobao Zhang , Yongqin Wan , Yun Feng Xie , Jiqing Jiang , Wenqi Gao , Shifeng Pan
发明人： Dai Cheng , Dong Han , Guobao Zhang , Yongqin Wan , Yun Feng Xie , Jiqing Jiang , Wenqi Gao , Shifeng Pan
IPC分类号： A61K31/501 , C07D401/12 , C07D409/14 , C07D471/04 , C07D401/14 , C07D473/00 , A61K31/4725 , A61K31/519 , A61K31/4375 , A61K31/52 , A61P35/00 , A61P17/06
CPC分类号： C07D401/12 , A61K31/47 , C07D217/04 , C07D217/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07D513/04
摘要： The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).
摘要翻译：本发明提供了调节刺猬蛋白信号通路活性的方法，化合物和组合物。特别地，本发明提供了一种抑制由诸如Ptc丧失功能，刺猬获得功能，平滑增益功能或GIi功能增益等表型引起的异常生长状态的方法，包括使细胞接触与足量的式（I）化合物反应。

8. 发明申请

US20070185215A1 Pharmaceutical composition containing obovatol as an active ingredient for the prevention and treatment of neurodegenerative diseases 审中-公开
标题翻译：含有挥发酚作为预防和治疗神经变性疾病的有效成分的药物组合物
公开(公告)号：US20070185215A1
公开(公告)日：2007-08-09
申请号：US11401341
申请日：2006-04-10
申请人： Byoung-Mog Kwon , Kwang-Hee Son , Dong Han , Ji-Min Lee , Kyoungho Suk , Su Hong , Jiyeon Ock
发明人： Byoung-Mog Kwon , Kwang-Hee Son , Dong Han , Ji-Min Lee , Kyoungho Suk , Su Hong , Jiyeon Ock
IPC分类号： A61K31/075
CPC分类号： A61K31/075 , A61K36/57
摘要： Disclosed herein a pharmaceutical composition, comprising obovatol as an active ingredient, for the prevention and treatment of neurodegenerative diseases. Having superior inhibitory activity against the production of neurotoxic nitric oxides, the obovatol isolated and purified from Magnoliaceae can be used as active ingredient for a pharmaceutical composition or a neuroprotective agent for the prevention and treatment of neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
摘要翻译：本文公开了一种药物组合物，其包含用作预防和治疗神经退行性疾病的作为活性成分的高效醇。对于神经毒性一氧化氮的生产具有优异的抑制活性，从木兰科分离和纯化的浮游动物可以用作药物组合物或神经保护剂的有效成分，用于预防和治疗神经变性疾病，例如阿尔茨海默病，帕金森氏病，和多发性硬化症。

9. 发明公开

US20240250766A1 METHOD OF PERFORMANCE MONITORING FOR CSI PREDICTION 审中-公开
公开(公告)号：US20240250766A1
公开(公告)日：2024-07-25
申请号：US18628042
申请日：2024-04-05
申请人： Viktor Sergeev , Bishwarup Mondal , Avik Sengupta , Utthara Shankar , Dong Han
发明人： Viktor Sergeev , Bishwarup Mondal , Avik Sengupta , Utthara Shankar , Dong Han
IPC分类号： H04B17/391 , H04W24/10
CPC分类号： H04B17/3913 , H04W24/10
摘要： An apparatus and system are described for measurement and reporting of Channel State Information (CSI) prediction performance. A user equipment (UE) receives Channel State Information (CSI) Reference Signals (CSI-RS) from a 5th generation NodeB (gNB) at different time instances and performs perform channel measurements on the CSI-RS. The UE calculates a predicted CSI for a later time instance based on the CSI-RS and subsequently performs a channel measurement based on a CSI-RS received in the later time instance. The UE calculates an actual CSI based on the CSI-RS received in the later time instance. determines metrics based on a comparison between the predicted CSI and the actual CSI, and transmits the metrics to the gNB.

10. 外观设计

USD844262S1 Disposable pet waste collector 有权
公开(公告)号：USD844262S1
公开(公告)日：2019-03-26
申请号：US29609597
申请日：2017-07-02
申请人： Dong Han
设计人： Dong Han
摘要： FIG. 1 is a first perspective view of a disposable pet waste collector showing my new design;
FIG. 2 is a second perspective view thereof;
FIG. 3 is a front elevational view thereof;
FIG. 4 is a rear elevational view thereof;
FIG. 5 is a left side view thereof;
FIG. 6 is a right side view thereof;
FIG. 7 is a top plan view thereof;
FIG. 8 is a bottom plan view thereof;
FIG. 9 shows the disposable pet waste collector in an in-use configuration; and,
FIG. 10 is an exploded perspective view of the disposable pet waste collector in which the disposable pet waste collector is in a disassembled condition.

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