专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08569287B2 Azepino[4,5-B]indoles and methods of use 失效
标题翻译： Azepino [4,5-B]吲哚和使用方法
公开(公告)号：US08569287B2
公开(公告)日：2013-10-29
申请号：US12610152
申请日：2009-10-30
申请人： David T. Hung , Andrew Asher Protter , Rajendra Parasmal Jain , Sarvajit Chakravarty
发明人： David T. Hung , Andrew Asher Protter , Rajendra Parasmal Jain , Sarvajit Chakravarty
IPC分类号： A61K31/55 , C07D401/06
CPC分类号： C07D487/04 , A61K31/55 , C07D471/04
摘要： This disclosure relates to new azepino[4,5-b]indole compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new 1,2,3,4,5,6-tetrahydroazepino[4,5-b]indoles. Pharmaceutical compositions are also provided.
摘要翻译：本公开涉及可用于调节个体中组胺受体的新的氮杂环[4,5-b]吲哚化合物。描述了新的化合物，包括新的1,2,3,4,5,6-四氮杂吖庚因[4,5-b]吲哚。还提供药物组合物。

2. 发明申请

US20130172366A1 BRIDGED HETEROCYCLIC COMPOUNDS AND METHODS OF USE 有权
公开(公告)号：US20130172366A1
公开(公告)日：2013-07-04
申请号：US13540472
申请日：2012-07-02
申请人： Rajendra Parasmal Jain , Sarvajit Chakravarty
发明人： Rajendra Parasmal Jain , Sarvajit Chakravarty
IPC分类号： C07D471/18
CPC分类号： C07D487/08 , C07D471/08 , C07D471/18
摘要： This disclosure relates to new compounds that may be used to modulate a histamine receptor in an individual. Novel compounds are described, including new bridged heterocyclic [4,3-b]indole compounds. Pharmaceutical compositions are also provided. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

3. 发明申请

US20100022580A1 NEW 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLE COMPOUNDS AND METHODS OF USE THEREOF 有权
标题翻译：新的2,3,4,5-四氢-1H-吡咯并[4,3-B]吲哚化合物及其使用方法
公开(公告)号：US20100022580A1
公开(公告)日：2010-01-28
申请号：US12360061
申请日：2009-01-26
申请人： David T. Hung , Andrew Asher Protter , Sarvajit Chakravarty , Rajendra Parasmal Jain
发明人： David T. Hung , Andrew Asher Protter , Sarvajit Chakravarty , Rajendra Parasmal Jain
IPC分类号： A61K31/437 , C07D471/04 , A61P25/28
CPC分类号： C07D487/14 , C07D471/04 , C07D471/14 , C07D487/04
摘要： This disclosure relates to new tricyclic compounds that may be used to modulate a histamine receptor in an individual. Compounds are described, including new 2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole compounds. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
摘要翻译：本公开涉及可用于调节个体中组胺受体的新型三环化合物。描述了化合物，包括新的2,3,4,5-四氢-1H-吡啶并[4,3-b]吲哚化合物。还提供了包含化合物的药物组合物，以及在多种治疗应用中使用化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或神经元病症。

4. 发明授权

US08907097B2 Pyrido[4,3-b]indoles containing rigid moieties 有权
标题翻译：含有刚性部分的吡啶并[4,3-b]吲哚
公开(公告)号：US08907097B2
公开(公告)日：2014-12-09
申请号：US12610217
申请日：2009-10-30
申请人： David T. Hung , Andrew Asher Protter , Rajendra Parasmal Jain , Sarvajit Chakravarty
发明人： David T. Hung , Andrew Asher Protter , Rajendra Parasmal Jain , Sarvajit Chakravarty
IPC分类号： C07D401/00 , A61K31/445 , C07D401/14 , C07D471/04
CPC分类号： C07D471/04 , C07D401/14
摘要： This disclosure is directed to pyrido[4,3-b]indoles having rigid moieties. The compounds in one embodiment are pyrido[4,3-b]indoles having an unsaturated hydrocarbon moiety. The compounds in another embodiment are pyrido[4,3-b]indoles having a cycloalkyl, cycloalkenyl or heterocyclyl moiety. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
摘要翻译：本公开涉及具有刚性部分的吡啶并[4,3-b]吲哚。一个实施方案中的化合物是具有不饱和烃部分的吡啶并[4,3-b]吲哚。另一个实施方案中的化合物是具有环烷基，环烯基或杂环基部分的吡啶并[4,3-b]吲哚。还提供了包含化合物的药物组合物，以及在多种治疗应用中使用化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或神经元病症。

5. 发明申请

US20130217675A1 PYRIDO [4,3-B] INDOLE AND PYRIDO [3,4-B] INDOLE DERIVATIVES AND METHODS OF USE 有权
公开(公告)号：US20130217675A1
公开(公告)日：2013-08-22
申请号：US13579904
申请日：2011-02-18
申请人： Sarvajit Chakravarty , Barry Patrick Hart , Rajendra Parasmal Jain
发明人： Sarvajit Chakravarty , Barry Patrick Hart , Rajendra Parasmal Jain
IPC分类号： C07D471/04 , C07D487/14 , C07D471/22 , C07D487/04 , C07D471/14 , C07D471/18
CPC分类号： A61K31/55 , A61K31/437 , A61K31/4375 , A61K31/439 , A61K31/444 , A61K31/497 , A61K31/506 , A61K31/519 , C07D471/04 , C07D471/14 , C07D471/18 , C07D471/22 , C07D487/04 , C07D487/14
摘要： This disclosure is directed to pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.

6. 发明申请

US20130053367A1 COMPOUNDS AND METHODS OF TREATING DIABETES 有权
标题翻译：化合物和治疗糖尿病的方法
公开(公告)号：US20130053367A1
公开(公告)日：2013-02-28
申请号：US13400032
申请日：2012-02-17
申请人： Andrew Asher Protter , Sarvajit Chakravarty , Rajendra Parasmal Jain , Michael John Green
发明人： Andrew Asher Protter , Sarvajit Chakravarty , Rajendra Parasmal Jain , Michael John Green
IPC分类号： A61K31/437 , A61K31/439 , A61K31/506 , A61K31/4375 , A61P3/00 , A61K31/519 , A61K31/4985 , A61P3/08 , A61P5/50 , A61P3/10 , A61K31/55 , A61K31/497
CPC分类号： C07D487/04 , A61K31/444 , A61K31/55 , A61K45/06 , C07D451/00 , C07D455/03 , C07D471/04 , C07D471/14 , C07D471/18 , C07D471/22
摘要： Hydrogenated pyrido[4,3-b]indoles, pyrido[3,4-b]indoles and azepino[4,5-b]indoles are described. The compounds may bind to and are antagonists of the adrenergic receptor α2A. The compounds may also bind to and are an antagonist of the adrenergic receptor α2B; or the compounds are not antagonists of the adrenergic receptor α2B and the compounds are administered in conjunction with a second agent that reduces, or is expected to reduce, blood pressure in an individual. The compounds may find use in therapy, e.g., to regulate blood glucose level, increase insulin secretion and treat diseases or conditions that are, or are expected to be, responsive to an increase in insulin production. Use of the compounds to treat type 2 diabetes is particularly described.
摘要翻译：描述了氢化吡啶并[4,3-b]吲哚，吡啶并[3,4-b]吲哚和氮杂环[4,5-b]吲哚。该化合物可以结合肾上腺素能受体α2A并且是拮抗剂。该化合物还可以结合并且是肾上腺素能受体α2B的拮抗剂; 或者化合物不是肾上腺素能受体α2B的拮抗剂，并且化合物与减少或预期降低个体血压的第二药剂一起施用。该化合物可用于治疗，例如调节血糖水平，增加胰岛素分泌并治疗对胰岛素产生增加或预期是响应的疾病或病症。特别描述了化合物治疗2型糖尿病的用途。

7. 发明申请

US20100216814A1 PYRIDO[4,3-B]INDOLES CONTAINING RIGID MOIETIES 有权
标题翻译： PYRIDO [4,3-B]包含刚果的动物
公开(公告)号：US20100216814A1
公开(公告)日：2010-08-26
申请号：US12610217
申请日：2009-10-30
申请人： David T. HUNG , Andrew Asher Protter , Rajendra Parasmal Jain , Sarvajit Chakravarty
发明人： David T. HUNG , Andrew Asher Protter , Rajendra Parasmal Jain , Sarvajit Chakravarty
IPC分类号： A61K31/497 , C07D471/04 , A61K31/437 , C07D401/14 , A61K31/506 , A61P25/00
CPC分类号： C07D471/04 , C07D401/14
摘要： This disclosure is directed to pyrido[4,3-b]indoles having rigid moieties. The compounds in one embodiment are pyrido[4,3-b]indoles having an unsaturated hydrocarbon moiety. The compounds in another embodiment are pyrido[4,3-b]indoles having a cycloalkyl, cycloalkenyl or heterocyclyl moiety. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
摘要翻译：本公开涉及具有刚性部分的吡啶并[4,3-b]吲哚。一个实施方案中的化合物是具有不饱和烃部分的吡啶并[4,3-b]吲哚。另一个实施方案中的化合物是具有环烷基，环烯基或杂环基部分的吡啶并[4,3-b]吲哚。还提供了包含化合物的药物组合物，以及在多种治疗应用中使用化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或神经元病症。

8. 发明授权

US09255094B2 Pyrido[4,3-B]indoles and methods of use 有权
标题翻译：吡啶并[4,3-B]吲哚和使用方法
公开(公告)号：US09255094B2
公开(公告)日：2016-02-09
申请号：US13318123
申请日：2010-04-29
申请人： Rajendra Parasmal Jain , Sarvajit Chakravarty
发明人： Rajendra Parasmal Jain , Sarvajit Chakravarty
IPC分类号： A61K31/437 , C07D417/04 , C07D471/04
CPC分类号： C07D471/04
摘要： Provided are new heterocyclic compounds that may be used to modulate a histamine receptor in an individual. Also provided are pyrido[4,3-b]indoles, as are pharmaceutical compositions comprising the compounds and methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
摘要翻译：提供了可用于调节个体中组胺受体的新的杂环化合物。还提供了吡啶并[4,3-b]吲哚，以及包含化合物的药物组合物以及在各种治疗应用中使用该化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/ 或神经元紊乱。

9. 发明授权

US09040519B2 Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use 有权
标题翻译：熔点四环吡啶并[4,3-B]吲哚和吡啶并[3,4-B]吲哚衍生物及其使用方法
公开(公告)号：US09040519B2
公开(公告)日：2015-05-26
申请号：US13579911
申请日：2011-02-18
申请人： Sarvajit Chakravarty , Barry Patrick Hart , Rajendra Parasmal Jain
发明人： Sarvajit Chakravarty , Barry Patrick Hart , Rajendra Parasmal Jain
IPC分类号： C07D471/14 , C07D471/18 , C07D471/16 , C07D471/22 , C07D498/16 , C07D498/22 , C07D471/20 , C07D487/14 , C07D498/14 , C07D513/14
CPC分类号： C07D471/14 , C07D471/16 , C07D471/20 , C07D471/22 , C07D487/14 , C07D498/14 , C07D498/16 , C07D498/22 , C07D513/14
摘要： This disclosure is directed to fused tetracyclic pyrido[4,3-b>]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder.
摘要翻译：本公开涉及稠合的四环吡啶并[4,3-b]吲哚和吡啶并[3,4-b]吲哚衍生物。还提供了包含化合物的药物组合物，以及在多种治疗应用中使用化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或神经元病症。

10. 发明申请

US20140206711A1 PYRIDO[4,3-b]INDOLE AND PYRIDO[3,4-b]INDOLE DERIVATIVES AND METHODS OF USE 有权
标题翻译：吡咯并[4,3-b]吲哚和吡咯并[3,4-b]吲哚衍生物及其使用方法
公开(公告)号：US20140206711A1
公开(公告)日：2014-07-24
申请号：US14000179
申请日：2012-02-17
申请人： Sarvajit Chakravarty , Barry Patrick Hart , Rajendra Parasmal Jain
发明人： Sarvajit Chakravarty , Barry Patrick Hart , Rajendra Parasmal Jain
IPC分类号： C07D471/04
CPC分类号： A61K31/437 , A61K31/4709 , A61K31/4745 , A61K31/55 , A61K45/06 , C07D471/04 , A61K2300/00
摘要： This disclosure is directed to pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives. Pharmaceutical compositions comprising the compounds are also provided, as are methods of using the compounds in a variety of therapeutic applications, including the treatment of a cognitive disorder, psychotic disorder, neurotransmitter-mediated disorder and/or a neuronal disorder. The compounds may bind to and antagonize receptor α2B, α1B or α2A. The compounds may find use in therapy, e.g., to (i) reduce blood pressure and/or (ii) promote renal blood flow and/or (iii) decrease or inhibit sodium reabsorption, or to regulate blood glucose level, increase insulin secretion and treat diseases or conditions that are, or are expected to be, responsive to an increase in insulin production. The compounds may also be used to treat diseases or conditions that are expected to be responsive to a decrease in blood pressure. Use of the compounds to treat cardiovascular, renal disorders or type 2 diabetes is particularly described.
摘要翻译：本公开涉及吡啶并[4,3-b]吲哚和吡啶并[3,4-b]吲哚衍生物。还提供了包含化合物的药物组合物，以及在多种治疗应用中使用化合物的方法，包括治疗认知障碍，精神病性障碍，神经递质介导的病症和/或神经元病症。该化合物可以结合并拮抗受体α2B，α1B或α2A。这些化合物可用于治疗，例如（i）降低血压和/或（ii）促进肾血流量和/或（iii）降低或抑制钠再吸收，或调节血糖水平，增加胰岛素分泌和治疗或预期对胰岛素生产增加有反应的疾病或病症。所述化合物也可用于治疗预期对血压降低有反应的疾病或病症。具体描述了使用该化合物治疗心血管，肾脏疾病或2型糖尿病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式