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1. 发明授权

US10345314B2 Lateral flow membrane arrangement and lateral flow immunoassay device comprising the same 有权
公开(公告)号：US10345314B2
公开(公告)日：2019-07-09
申请号：US14910711
申请日：2014-04-29
申请人： SARTORIUS STEDIM BIOTECH GMBH
发明人： Dieter Melzner , Denise Van Rossum
IPC分类号： G01N1/00 , G01N33/68 , G01N33/52 , G01N33/558 , B05D1/02 , B05D3/00 , B05D3/06 , G01N33/76
摘要： The present invention relates to a lateral flow membrane arrangement (1), comprising a microporous membrane layer (2) and a liquid-impermeable support layer (3), for lateral flow of a liquid through the microporous membrane layer (2), wherein the microporous membrane layer (2) is supported on the liquid-impermeable support layer (3) and has at least one detection zone (5) and at least one non-detection zone, wherein binding agents are immobilized in the at least one detection zone (5), the liquid-impermeable support layer (3) has at least one zone having a large thickness and at least one zone having a small thickness, the microporous membrane layer (2) is supported on the liquid-impermeable support layer (3) such that said at least one detection zone is provided above said at least one zone of the support layer having a large thickness and said at least one non-detection zone is provided above said at least one zone of the support layer having a small thickness, the zones are oriented in a direction orthogonally to the lateral flow direction (a) of said liquid, the detection zone (5) has a thickness (7) of 100 to 150 μm over the entire width of the membrane, the non-detection zone has a thickness (8) of at most 300 μm over the entire width of the membrane, and the lateral flow membrane arrangement (1) has a constant thickness (9), as well as to a lateral flow immunoassay device comprising said membrane arrangement (1).

2. 发明授权

US11913949B2 Lateral flow membrane designed for multiparameter readouts and compact multiparameter lateral flow immunoassay device comprising the same 有权
公开(公告)号：US11913949B2
公开(公告)日：2024-02-27
申请号：US15315553
申请日：2015-04-28
申请人： Sartorius Stedim Biotech GmbH
发明人： Denise Van Rossum , Eric Jallérat , Susanne Drebing , Dieter Melzner
IPC分类号： G01N33/543 , G01N33/76
CPC分类号： G01N33/54388 , G01N33/76 , B01L2300/0883 , G01N2333/59
摘要： The present invention relates to a multiparameter lateral flow strip (1), comprising a microporous membrane layer (2) supported on a liquid-impermeable support layer (3), for lateral flow of a liquid through the microporous membrane layer (2), wherein the microporous membrane layer (2) has two or more flow lanes (4) in the direction of lateral flow, wherein said two or more flow lanes (4) are separated by hydrophobic separation channels (5), and wherein each of said two or more flow lanes (4) comprises a detection spot (6) including a binding agent, wherein said two or more flow lanes (4) are isomorphic lanes. Furthermore, the present invention relates to a multiparameter lateral flow immunoassay device comprising said multiparameter lateral flow membrane (1), the use of said multiparameter configured lateral flow membrane (1) in an immunological test, as well as to a method for the manufacture of said multiparameter configured lateral flow membrane (1).

3. 发明申请

US20200230557A1 CROSSLINKED UNREINFORCED CELLULOSE HYDRATE MEMBRANE, METHOD FOR THE PRODUCTION THEREOF, AND USE THEREOF 审中-公开
公开(公告)号：US20200230557A1
公开(公告)日：2020-07-23
申请号：US16482974
申请日：2017-12-01
申请人： Sartorius Stedim Biotech GmbH
发明人： Sandra Van Der Kruijs , Annette Reiche , Gabriel Nino-Amézquita , Louis Villain , Hans-Heinrich Hörl , Dieter Melzner , Franziska Bäthe
IPC分类号： B01D67/00 , B01D71/10 , B01D61/14 , B01D69/02 , C02F1/44
摘要： The present invention relates to a crosslinked unreinforced cellulose hydrate membrane crosslinked using at least two different crosslinking agents, to a method for the production thereof and to the use of the crosslinked unreinforced cellulose hydrate membrane according to the invention.

4. 发明申请

US20180143191A1 Lateral flow membrane designed for multiparameter readouts and compact multiparameter lateral flow immunoassay device comprising the same 审中-公开
公开(公告)号：US20180143191A1
公开(公告)日：2018-05-24
申请号：US15315553
申请日：2015-04-28
申请人： Sartorius Stedim Biotech GmbH
发明人： Denise Van Rossum , Eric Jallérat , Susanne Drebing , Dieter Melzner
IPC分类号： G01N33/558 , G01N33/543 , G01N33/76 , G01N33/548 , B01L3/00 , G01N21/84
CPC分类号： G01N33/558 , B01L3/5023 , B01L3/502707 , B01L2200/12 , B01L2300/069 , B01L2300/0825 , B01L2300/0861 , B01L2300/0883 , B01L2400/0406 , G01N21/8483 , G01N33/50 , G01N33/538 , G01N33/54386 , G01N33/548 , G01N33/76 , G01N2333/59
摘要： The present invention relates to a multiparameter lateral flow strip (1), comprising a microporous membrane layer (2) supported on a liquid-impermeable support layer (3), for lateral flow of a liquid through the microporous membrane layer (2), wherein the microporous membrane layer (2) has two or more flow lanes (4) in the direction of lateral flow, wherein said two or more flow lanes (4) are separated by hydrophobic separation channels (5), and wherein each of said two or more flow lanes (4) comprises a detection spot (6) including a binding agent, wherein said two or more flow lanes (4) are isomorphic lanes. Furthermore, the present invention relates to a multiparameter lateral flow immunoassay device comprising said multiparameter lateral flow membrane (1), the use of said multiparameter configured lateral flow membrane (1) in an immunological test, as well as to a method for the manufacture of said multiparameter configured lateral flow membrane (1).

5. 发明授权

US11313854B2 Patterned membrane structure 有权
公开(公告)号：US11313854B2
公开(公告)日：2022-04-26
申请号：US15774143
申请日：2016-07-19
申请人： SARTORIUS STEDIM BIOTECH GMBH
发明人： Susanne Drebing , Alfons Kesting , Dieter Melzner , Denise Van Rossum
IPC分类号： G01N33/52 , G01N33/543 , B01D61/18 , B01D69/12
摘要： The present invention relates to a patterned membrane structure comprising a microporous membrane layer, wherein the microporous membrane layer includes a plurality of flow lanes, the flow lanes are separated by hydrophobic separation channels, and the flow lanes and hydrophobic separation channels form a repetitive pattern; and a method for manufacture of the patterned membrane structure. The patterned membrane structure according to the present invention represents an industrial scale precursor of membranes such as a multiparameter lateral flow membrane comprising separated flow lanes.

6. 发明授权

US11224843B2 Crosslinked unreinforced cellulose hydrate membrane, method for the production thereof, and use thereof 有权
公开(公告)号：US11224843B2
公开(公告)日：2022-01-18
申请号：US16482974
申请日：2017-12-01
申请人： Sartorius Stedim Biotech GmbH
发明人： Sandra Van Der Kruijs , Annette Reiche , Gabriel Nino-Amézquita , Louis Villain , Hans-Heinrich Hörl , Dieter Melzner , Franziska Bäthe
IPC分类号： B01D67/00 , B01D61/14 , B01D69/02 , B01D71/10 , C02F1/44
摘要： The present invention relates to a crosslinked unreinforced cellulose hydrate membrane crosslinked using at least two different crosslinking agents, to a method for the production thereof and to the use of the crosslinked unreinforced cellulose hydrate membrane according to the invention.

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