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    • 4. 发明申请
    • METHOD FOR PREDICTING ACTIVATION ENERGY USING ATOMIC FINGERPRINT DESCRIPTOR OR ATOMIC DESCRIPTOR
    • 使用原子指纹描述符或原子描述符预测激活能量的方法
    • US20120084012A1
    • 2012-04-05
    • US13277929
    • 2011-10-20
    • Ky Youb NamKyoung Tai NoDoo Nam KimWon Seok OhSung Kwang LeeJi Hoon JungKwang Hwi ChoChang Joon Lee
    • Ky Youb NamKyoung Tai NoDoo Nam KimWon Seok OhSung Kwang LeeJi Hoon JungKwang Hwi ChoChang Joon Lee
    • G06F19/10
    • G06F19/704G06F19/702G06F19/706G06F19/709
    • The present invention provides a method for constructing a database of atomic fingerprint descriptors. The invention provides a method for predicting activation energy using an atomic fingerprint descriptor and an atomic descriptor, the method comprising the steps of: (i) calculating the atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the constructed atomic fingerprint descriptor database to select an atomic position where cytochrome P450-mediated metabolism occurs; and (iii) predicting activation energy for the selected atomic position using an atomic descriptor. Also, the invention provides a method of predicting the activation energy of CYP450-mediated phase I metabolism using effective atomic descriptors. Specifically, the invention provides a method of predicting the activation energy either for cytochrome P450-mediated hydrogen abstraction or for tetrahedral intermediate formation in cytochrome P450-aromatic hydroxylation using equations including effective atomic descriptors.
    • 本发明提供了一种构建原子指纹描述符数据库的方法。 本发明提供一种使用原子指纹描述符和原子描述符来预测激活能的方法,该方法包括以下步骤:(i)计算衬底的原子指纹描述符; (ii)将计算的原子指纹描述符与构建的原子指纹描述符数据库进行比较,以选择细胞色素P450介导代谢发生的原子位置; 和(iii)使用原子描述符预测所选原子位置的活化能。 此外,本发明提供了使用有效原子描述符预测CYP450介导的I期代谢的活化能的方法。 具体地,本发明提供了一种使用包括有效原子描述符的方程式来预测细胞色素P450介导的氢提取或细胞色素P450-芳族羟基化中的四面体中间体形成的活化能的方法。
    • 5. 发明申请
    • ROTATING AIR DIRECTING APPARATUS FOR A HAIR DRYER
    • 旋转干燥器的空气导向装置
    • US20120260516A1
    • 2012-10-18
    • US13088005
    • 2011-04-15
    • Kyusang HANKyoung Hak LeeWon Seok Oh
    • Kyusang HANKyoung Hak LeeWon Seok Oh
    • A45D20/12
    • A45D20/124
    • A rotating air directing apparatus for a hair dryer is provided. The apparatus includes a tubular rotating member and a nozzle member disposed adjacent to an outlet opening of the tubular rotating member and adapted to rotate with the tubular rotating member. The nozzle member includes an angled tubular member having a nozzle opening disposed at an acute angle relative to the outlet opening. A plurality of curved vanes each have a fixed edge at a circumferential inner surface of the tubular rotating member, and an opposing free edge that defines a central open space of the tubular rotating member. Each of the plurality of curved vanes are spaced apart from each other, thereby defining a plurality of curved radial openings between adjacent curved vanes.
    • 提供一种用于吹风机的旋转空气引导装置。 该装置包括管状旋转构件和邻近管状旋转构件的出口设置并适于与管状旋转构件一起旋转的喷嘴构件。 喷嘴构件包括成角度的管状构件,其具有相对于出口开口设置成锐角的喷嘴开口。 多个弯曲叶片各自在管状旋转构件的周向内表面具有固定边缘,以及限定管状旋转构件的中心开放空间的相对的自由边缘。 多个弯曲叶片中的每一个彼此间隔开,从而在相邻的弯曲叶片之间限定多个弯曲的径向开口。
    • 7. 发明申请
    • METHOD FOR PREDICTING ACTIVATION ENERGY USING AN ATOMIC FINGERPRINT DESCRIPTOR OR AN ATOMIC DESCRIPTOR
    • US20110213558A1
    • 2011-09-01
    • US13001579
    • 2009-11-12
    • Ky Youb NamKyoung Tai NoDoo Nam KimWon Seok OhSung Kwang LeeJi Hoon JungKwang Hwi ChoChang Joon Lee
    • Ky Youb NamKyoung Tai NoDoo Nam KimWon Seok OhSung Kwang LeeJi Hoon JungKwang Hwi ChoChang Joon Lee
    • G06F19/00
    • G16C20/30G16C20/10G16C20/50G16C20/90
    • The present invention provides a method for constructing a database of atomic fingerprint descriptors. The invention provides a method for predicting activation energy using an atomic fingerprint descriptor and an atomic descriptor, the method comprising the steps of: (i) calculating the atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the constructed atomic fingerprint descriptor database to select an atomic position where cytochrome P450-mediated metabolism occurs; and (iii) predicting activation energy for the selected atomic position using an atomic descriptor. Also, the invention provides a method of predicting the activation energy of CYP450-mediated phase I metabolism using effective atomic descriptors. Specifically, the invention provides a method of predicting the activation energy either for cytochrome P450-mediated hydrogen abstraction or for tetrahedral intermediate formation in cytochrome P450-aromatic hydroxylation using equations including effective atomic descriptors. The method of the invention can rapidly predict activation energy for phase I metabolites at a practical level without having to perform a docking experiment between any additional CYP450 and the substrate, or a quantum mechanical calculation, thereby making it easier to develop new drugs using a computer. Also, the present invention may propose a strategy for increasing the bioavailability of drugs through the avoidance of metabolites based on the possibility of drug metabolism. Furthermore, the method of the present invention proposes new empirical approaches which can also be easily applied to activation energies for various chemical reactions, and makes it possible to explain physical and chemical factors that determine activation energy. In addition, through the prediction of activation energy according to the present invention, it is possible to predict i) metabolic products, ii) the relative rate of metabolism, iii) metabolic regioselectivity, iv) metabolic inhibition, v) drug-drug interactions, and vi) the toxicity of a metabolite.
    • 8. 发明授权
    • Rotating air directing apparatus for a hair dryer
    • 用于吹风机的旋转空气引导装置
    • US09072358B2
    • 2015-07-07
    • US13564267
    • 2012-08-01
    • Kyusang HanKyoung Hak LeeWon Seok Oh
    • Kyusang HanKyoung Hak LeeWon Seok Oh
    • A45D20/04A45D20/12
    • A45D20/124
    • A rotating air directing apparatus for a barrel of a hair dryer is provided. The apparatus includes a tubular adapter member having an inlet opening and an outlet opening. The inlet opening is adapted to be removably coupled to the barrel of the hair dryer. The apparatus also includes a propeller member rotatably coupled to the tubular adapter member. The propeller member includes a plurality of curved vanes extending from a central cylinder. The apparatus further includes a nozzle member disposed adjacent to the outlet opening of the tubular adapter member and adapted to rotate with the propeller member. The nozzle member includes an angled tubular member having a nozzle opening disposed at an acute angle relative to the outlet opening of the tubular adapter member.
    • 提供了一种用于吹风机的桶的旋转空气引导装置。 该装置包括具有入口开口和出口开口的管状适配器构件。 入口开口适于可拆卸地联接到吹风机的筒体上。 该装置还包括可旋转地联接到管状适配器构件的螺旋桨构件。 螺旋桨构件包括从中心圆筒延伸的多个弯曲叶片。 该装置还包括一个喷嘴构件,该喷嘴构件邻近管状适配器构件的出口开口设置并适于与螺旋桨构件一起旋转。 喷嘴构件包括成角度的管状构件,其具有相对于管状适配构件的出口开口以锐角设置的喷嘴开口。
    • 10. 发明申请
    • ROTATING AIR DIRECTING APPARATUS FOR A HAIR DRYER
    • 旋转干燥器的空气导向装置
    • US20130014402A1
    • 2013-01-17
    • US13564267
    • 2012-08-01
    • Kyusang HANKyoung Hak LeeWon Seok Oh
    • Kyusang HANKyoung Hak LeeWon Seok Oh
    • A45D20/04
    • A45D20/124
    • A rotating air directing apparatus for a barrel of a hair dryer is provided. The apparatus includes a tubular adapter member having an inlet opening and an outlet opening. The inlet opening is adapted to be removably coupled to the barrel of the hair dryer. The apparatus also includes a propeller member rotatably coupled to the tubular adapter member. The propeller member includes a plurality of curved vanes extending from a central cylinder. The apparatus further includes a nozzle member disposed adjacent to the outlet opening of the tubular adapter member and adapted to rotate with the propeller member. The nozzle member includes an angled tubular member having a nozzle opening disposed at an acute angle relative to the outlet opening of the tubular adapter member.
    • 提供了一种用于吹风机的桶的旋转空气引导装置。 该装置包括具有入口开口和出口开口的管状适配器构件。 入口开口适于可拆卸地联接到吹风机的筒体上。 该装置还包括可旋转地联接到管状适配器构件的螺旋桨构件。 螺旋桨构件包括从中心圆筒延伸的多个弯曲叶片。 该装置还包括一个与管状适配器构件的出口相邻设置并适于与螺旋桨构件一起转动的喷嘴构件。 喷嘴构件包括成角度的管状构件,其具有相对于管状适配器构件的出口开口以锐角设置的喷嘴开口。