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1. 发明申请

US20160089037A1 METHOD AND DEVICE FOR ESTIMATING A MYOCARDIAL PERFORMANCE PARAMETER 审中-公开
标题翻译：估计心肌性能参数的方法和装置
公开(公告)号：US20160089037A1
公开(公告)日：2016-03-31
申请号：US14963120
申请日：2015-12-08
申请人： ST. JUDE MEDICAL AB
发明人： Michael Broome , Andreas Blomqvist
IPC分类号： A61B5/02 , A61N1/368 , A61N1/365 , A61B5/053 , A61B5/00
CPC分类号： A61B5/02028 , A61B5/053 , A61B5/0538 , A61B5/6846 , A61B5/686 , A61B5/7235 , A61B5/7239 , A61N1/36521 , A61N1/3682
摘要： An implantable medical device applies an electric signal to at least a portion of a heart in a subject. A resulting electric signal is collected from the heart and is used together with the applied signal for determining a cardiogenic impedance signal. The impedance signal is processed in order to estimate an isovolumetric contraction time, an isovolumetric relaxation time and an ejection time for a heart cycle. These three time parameters are employed for calculating a Tei-index of the heart. The Tei-index can be used as myocardial performance parameter in heart diagnosis and/or cardiac therapy adjustment.
摘要翻译：可植入医疗装置将电信号施加到受试者的心脏的至少一部分。所得到的电信号从心脏收集并与所应用的信号一起用于确定心源性阻抗信号。处理阻抗信号以估计等体积收缩时间，等体积弛豫时间和心脏周期的排出时间。这三个时间参数用于计算心脏的Tei指数。 Tei指数可用作心脏诊断和/或心脏治疗调整中的心肌性能参数。

2. 发明申请

US20130345582A1 IMPLANTABLE HEART MONITORING DEVICE AND METHOD 有权
标题翻译：可注入的心脏监测装置和方法
公开(公告)号：US20130345582A1
公开(公告)日：2013-12-26
申请号：US13971722
申请日：2013-08-20
申请人： ST. JUDE MEDICAL AB
发明人： Andreas Blomqvist , Michael Broome
IPC分类号： A61B5/042 , A61B5/0245 , A61B5/029
CPC分类号： A61B5/026 , A61B5/0245 , A61B5/029 , A61B5/042 , A61B5/0452 , A61B5/053 , A61B5/6846 , A61N1/3627 , A61N1/36585
摘要： In an implantable heart monitoring device and method, particularly for monitoring diastolic dysfunction, a control circuit (a) detects the heart rate, (b) derives information correlated to the stroke volume of the heart at the detected heart rate, and (c) stores the detected heart rate and the derived information correlated to the stroke volume in a memory. The control circuit automatically implements (a), (b) and (c) at a number of different occasions for a number of different, naturally varying heart rates, so that the memory contains information indicating the stroke volume as a function of the heart rate.
摘要翻译：在可植入心脏监测装置和方法中，特别是用于监测舒张功能障碍，控制电路（a）检测心率，（b）以检测到的心率导出与心脏的搏动体积相关的信息，以及（c）检测到的心率和导出的信息与存储器中的笔画体积相关。控制电路在许多不同的，自然变化的心率的多个不同场合自动实现（a），（b）和（c），使得存储器包含指示作为心率的函数的行程体积的信息。

3. 发明申请

US20130289642A1 PACING SEQUENCE OPTIMIZATION 有权
标题翻译： PACING序列优化
公开(公告)号：US20130289642A1
公开(公告)日：2013-10-31
申请号：US13648984
申请日：2012-10-10
申请人： St. Jude Medical AB
发明人： Sven-Erik Hedberg , Malin Hollmark , Stefan Hjelm , Michael Broome
IPC分类号： A61N1/365
CPC分类号： A61N1/365 , A61N1/3627 , A61N1/36507 , A61N1/36514 , A61N1/36585
摘要： An implantable medical device is connected to a multipolar LV lead and an implantable sensor. The sensor signal from the sensor is used to identify a time point of mitral valve closure for a cardiac cycle when a ventricular pulse generator generates pacing pulses that are applied to the electrodes of the multipolar LV lead according to a pacing sequence. A time interval processor determines the time interval from onset of LV activation to the time point of mitral valve closure. This procedure is repeated for multiple different pacing sequences of a sequence set. The pacing sequence that resulted in shortest time interval is then selected by a selector as the currently optimal pacing sequence for the patient.
摘要翻译：可植入医疗装置连接到多极LV引线和可植入传感器。来自传感器的传感器信号用于当心室脉搏发生器根据起搏序列产生施加到多极LV引线的电极的起搏脉冲时，识别心动周期二尖瓣关闭的时间点。时间间隔处理器确定从LV启动开始到二尖瓣闭合时间点的时间间隔。对于序列集的多个不同的起搏序列重复该过程。导致最短时间间隔的起搏序列然后由选择器选择作为患者的当前最佳起搏序列。

4. 发明授权

US08929982B2 Ischemia detection 有权
标题翻译：缺血检测
公开(公告)号：US08929982B2
公开(公告)日：2015-01-06
申请号：US13653276
申请日：2012-10-16
申请人： St. Jude Medical AB
发明人： Nils Holmstrom , Michael Broome
IPC分类号： A61N1/365 , A61B5/145 , A61N1/37 , A61B5/1459 , A61B5/1473
CPC分类号： A61B5/14542 , A61B5/1459 , A61B5/1473 , A61N1/36557 , A61N1/3702
摘要： An implantable medical device comprises a connector connectable to an implantable oxygen sensor configured to generate a sensor signal representative of oxygen concentration in coronary sinus blood in a subject's heart. An ischemia detector is connected to the connector and configured to detect an ischemic event in the heart if the sensor signal indicates a temporary decrease in oxygen concentration in the coronary sinus blood below a normal level followed by a temporary increase in oxygen concentration in the coronary sinus blood above the normal level.
摘要翻译：可植入医疗装置包括可连接到可植入氧传感器的连接器，其被配置为产生代表受试者心脏中冠状窦血液中氧浓度的传感器信号。如果传感器信号表示冠状窦血液中的氧浓度暂时降低到正常水平以下，然后临时增加冠状窦中的氧浓度，则缺血检测器连接到连接器并被配置为检测心脏中的缺血事件血液高于正常水平。

5. 发明授权

US08781580B2 Pacing sequence optimization 有权
标题翻译：起搏序列优化
公开(公告)号：US08781580B2
公开(公告)日：2014-07-15
申请号：US13648984
申请日：2012-10-10
申请人： St. Jude Medical AB
发明人： Sven-Erik Hedberg , Malin Hollmark , Stefan Hjelm , Michael Broome
IPC分类号： A61N1/18 , A61N1/362 , A61N1/365
CPC分类号： A61N1/365 , A61N1/3627 , A61N1/36507 , A61N1/36514 , A61N1/36585
摘要： An implantable medical device is connected to a multipolar LV lead and an implantable sensor. The sensor signal from the sensor is used to identify a time point of mitral valve closure for a cardiac cycle when a ventricular pulse generator generates pacing pulses that are applied to the electrodes of the multipolar LV lead according to a pacing sequence. A time interval processor determines the time interval from onset of LV activation to the time point of mitral valve closure. This procedure is repeated for multiple different pacing sequences of a sequence set. The pacing sequence that resulted in shortest time interval is then selected by a selector as the currently optimal pacing sequence for the patient.
摘要翻译：可植入医疗装置连接到多极LV引线和可植入传感器。来自传感器的传感器信号用于当心室脉搏发生器根据起搏序列产生施加到多极LV引线的电极的起搏脉冲时，识别心动周期二尖瓣关闭的时间点。时间间隔处理器确定从LV启动开始到二尖瓣闭合时间点的时间间隔。对于序列集的多个不同的起搏序列重复该过程。导致最短时间间隔的起搏序列然后由选择器选择作为患者的当前最佳起搏序列。

6. 发明授权

US09549674B2 Method and device for estimating a myocardial performance parameter 有权
标题翻译：用于估计心肌性能参数的方法和装置
公开(公告)号：US09549674B2
公开(公告)日：2017-01-24
申请号：US14963120
申请日：2015-12-08
申请人： ST. JUDE MEDICAL AB
发明人： Michael Broome , Andreas Blomqvist
IPC分类号： A61N1/365 , A61B5/02 , A61B5/053 , A61B5/00 , A61N1/368
CPC分类号： A61B5/02028 , A61B5/053 , A61B5/0538 , A61B5/6846 , A61B5/686 , A61B5/7235 , A61B5/7239 , A61N1/36521 , A61N1/3682
摘要： An implantable medical device applies an electric signal to at least a portion of a heart in a subject. A resulting electric signal is collected from the heart and is used together with the applied signal for determining a cardiogenic impedance signal. The impedance signal is processed in order to estimate an isovolumetric contraction time, an isovolumetric relaxation time and an ejection time for a heart cycle. These three time parameters are employed for calculating a Tei-index of the heart. The Tei-index can be used as myocardial performance parameter in heart diagnosis and/or cardiac therapy adjustment.
摘要翻译：可植入医疗装置将电信号施加到受试者的心脏的至少一部分。所得到的电信号从心脏收集并与所应用的信号一起用于确定心源性阻抗信号。处理阻抗信号以估计等体积收缩时间，等体积弛豫时间和心脏周期的排出时间。这三个时间参数用于计算心脏的Tei指数。 Tei指数可用作心脏诊断和/或心脏治疗调整中的心肌性能参数。

7. 发明授权

US08750975B2 Implantable heart monitoring device and method 有权
标题翻译：可植入心脏监测装置及方法
公开(公告)号：US08750975B2
公开(公告)日：2014-06-10
申请号：US13971722
申请日：2013-08-20
申请人： St. Jude Medical AB
发明人： Andreas Blomqvist , Michael Broome
IPC分类号： A61B5/026 , A61B5/029
CPC分类号： A61B5/026 , A61B5/0245 , A61B5/029 , A61B5/042 , A61B5/0452 , A61B5/053 , A61B5/6846 , A61N1/3627 , A61N1/36585
摘要： In an implantable heart monitoring device and method, particularly for monitoring diastolic dysfunction, a control circuit (a) detects the heart rate, (b) derives information correlated to the stroke volume of the heart at the detected heart rate, and (c) stores the detected heart rate and the derived information correlated to the stroke volume in a memory. The control circuit automatically implements (a), (b) and (c) at a number of different occasions for a number of different, naturally varying heart rates, so that the memory contains information indicating the stroke volume as a function of the heart rate.
摘要翻译：在可植入心脏监测装置和方法中，特别是用于监测舒张功能障碍，控制电路（a）检测心率，（b）以检测到的心率导出与心脏的搏动体积相关的信息，以及（c）检测到的心率和导出的信息与存储器中的笔画体积相关。控制电路在许多不同的，自然变化的心率的多个不同场合自动实现（a），（b）和（c），使得存储器包含指示作为心率的函数的行程体积的信息。

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