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1. 发明授权

US09448238B2 Monoclonal antibody for detecting exosomes 有权
标题翻译：用于检测外来体的单克隆抗体
公开(公告)号：US09448238B2
公开(公告)日：2016-09-20
申请号：US14368706
申请日：2012-12-26
申请人： SHIONOGI & CO., LTD.
发明人： Hideki Ohta , Chihiro Okada , Tomi Murakami , Hiroyuki Okamoto , Hikaru Sonoda
IPC分类号： C07K16/28 , G01N33/574 , C07K16/18 , G01N33/577 , C12Q1/68
CPC分类号： G01N33/574 , C07K16/18 , C07K16/2896 , C12Q1/6804 , C12Q1/6886 , G01N33/577 , G01N2333/70596 , G01N2500/04 , C12Q2563/161
摘要： A monoclonal antibody for detecting or capturing an exosome, selected from the group consisting of a monoclonal antibody or antibody fragments thereof that recognize amino acid numbers 113 to 195 of the amino acid sequence as shown in SEQ ID NO: 1, a monoclonal antibody or antibody fragments thereof that recognize amino acid numbers 104 to 202 of the amino acid sequence as shown in SEQ ID NO: 2, a monoclonal antibody or antibody fragments thereof that recognize amino acid numbers 36 to 54 of the amino acid sequence as shown in SEQ ID NO: 3, and a monoclonal antibody or antibody fragments thereof that recognize amino acid numbers 113 to 201 of the amino acid sequence as shown in SEQ ID NO: 3, each capable of detecting or capturing an exosome. The monoclonal antibody for detecting an exosome of the present invention is capable of detecting CD9, CD63 or CD81 on the exosome in a living body with an excellent sensitivity and specificity.
摘要翻译：用于检测或捕获外来体的单克隆抗体，其选自SEQ ID NO：1所示的氨基酸序列的氨基酸编号113〜195的单克隆抗体或其抗体片段，单克隆抗体或抗体如SEQ ID NO：2所示的识别氨基酸序列的氨基酸编号104至202的其片段，识别SEQ ID NO所示的氨基酸序列的36至54位氨基酸的单克隆抗体或其抗体片段 3，以及识别SEQ ID NO：3所示氨基酸序列的氨基酸编号113〜201的单克隆抗体或其抗体片段，其各自能够检测或捕获外来体。用于检测本发明的外来体的单克隆抗体能够以极好的灵敏度和特异性检测活体中的外来体上的CD9，CD63或CD81。

2. 发明申请

US20150010913A1 MONOCLONAL ANTIBODY FOR DETECTING EXOSOMES 有权
标题翻译：用于检测EXOSOMES的单克隆抗体
公开(公告)号：US20150010913A1
公开(公告)日：2015-01-08
申请号：US14368706
申请日：2012-12-26
申请人： SHIONOGI & CO., LTD.
发明人： Hideki Ohta , Chihiro Okada , Tomi Murakami , Hiroyuki Okamoto , Hikaru Sonoda
IPC分类号： G01N33/574 , C12Q1/68 , C07K16/28
CPC分类号： G01N33/574 , C07K16/18 , C07K16/2896 , C12Q1/6804 , C12Q1/6886 , G01N33/577 , G01N2333/70596 , G01N2500/04 , C12Q2563/161
摘要： A monoclonal antibody for detecting or capturing an exosome, selected from the group consisting of a monoclonal antibody or antibody fragments thereof that recognize amino acid numbers 113 to 195 of the amino acid sequence as shown in SEQ ID NO: 1, a monoclonal antibody or antibody fragments thereof that recognize amino acid numbers 104 to 202 of the amino acid sequence as shown in SEQ ID NO: 2, a monoclonal antibody or antibody fragments thereof that recognize amino acid numbers 36 to 54 of the amino acid sequence as shown in SEQ ID NO: 3, and a monoclonal antibody or antibody fragments thereof that recognize amino acid numbers 113 to 201 of the amino acid sequence as shown in SEQ ID NO: 3, each capable of detecting or capturing an exosome. The monoclonal antibody for detecting an exosome of the present invention is capable of detecting CD9, CD63 or CD81 on the exosome in a living body with an excellent sensitivity and specificity.
摘要翻译：用于检测或捕获外来体的单克隆抗体，其选自SEQ ID NO：1所示的氨基酸序列的氨基酸编号113〜195的单克隆抗体或其抗体片段，单克隆抗体或抗体如SEQ ID NO：2所示的识别氨基酸序列的氨基酸编号104至202的其片段，识别SEQ ID NO所示的氨基酸序列的36至54位氨基酸的单克隆抗体或其抗体片段 3，以及识别SEQ ID NO：3所示氨基酸序列的氨基酸编号113〜201的单克隆抗体或其抗体片段，其各自能够检测或捕获外来体。用于检测本发明的外来体的单克隆抗体能够以极好的灵敏度和特异性检测活体中的外来体上的CD9，CD63或CD81。

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