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1. 发明授权

US09721776B2 Sample preparation method and sample preparation device for MALDI including depositing matrix substance on sample substrate in two steps 有权
公开(公告)号：US09721776B2
公开(公告)日：2017-08-01
申请号：US14781950
申请日：2014-04-04
申请人： SHIMADZU CORPORATION , KEIO UNIVERSITY
发明人： Koretsugu Ogata , Kazuteru Takahashi , Akiko Kubo , Makoto Suematsu , Takushi Yamamoto
IPC分类号： B05D1/02 , B05D3/10 , H01J49/04 , B05D1/00 , B05D7/00 , H01J49/00
CPC分类号： H01J49/0418 , B05D1/60 , B05D3/107 , B05D7/5483 , H01J49/0004
摘要： After a sample such as a biomedical tissue section is attached to an electrically-conductive slide glass (S1), the film layer of a matrix substance is appropriately formed by vapor deposition so as to cover the sample (S2). The crystal of the matrix substance in the film layer is very fine and uniform. Subsequently, the slide glass on which the matrix film layer is formed is placed in a vaporized solvent atmosphere, and the solvent infiltrates into the matrix film layer (S3). When the solvent sufficiently infiltrated is vaporized, a substance to be measured in the sample takes in the matrix and re-crystallized. Furthermore, the matrix film layer is formed again on the surface by the vapor deposition (S4). The added matrix film layer absorbs excessive energy of a laser beam during MALDI, which suppresses the denaturation of the substance to be measured and the like, so that high detection sensitivity can be achieved while high spatial resolution is maintained.

2. 发明授权

US10950423B2 Imaging mass spectrometry data processing device and imaging mass spectrometry data processing method 有权
公开(公告)号：US10950423B2
公开(公告)日：2021-03-16
申请号：US16328122
申请日：2016-08-26
申请人： SHIMADZU CORPORATION
发明人： Masahiro Ikegami , Koretsugu Ogata
IPC分类号： H01J49/00 , H01J49/02 , G01N27/62
摘要： The user specifies regions of interest (ROIs) such as a region where a large amount of compound to be identified is estimated to be included and a region where the compound is overlapped with another compound on one or more specific MS images, and specifies addition or subtraction of the ROIs. For each of the specified ROIs, an average MS/MS spectrum is calculated from MS/MS spectrum data at measurement points in the regions, and the average MS/MS spectra at the ROIs are subjected to addition or subtraction, to obtain an MS/MS spectrum. By addition between the ROIs, the intensity of peak derived from the target compound can be increased. By subtraction between the ROIs, a peak derived from the other compound overlapped with the target compound can be removed. When the MS/MS spectrum after addition or subtraction is subjected to library search for identification, a score indicating the similarity of the spectrum is higher than the conventional score, and the identification accuracy can be improved.

3. 发明申请

US20140288852A1 CELL IDENTIFICATION DEVICE AND PROGRAM 审中-公开
标题翻译：细胞鉴定设备和程序
公开(公告)号：US20140288852A1
公开(公告)日：2014-09-25
申请号：US14352496
申请日：2012-10-17
申请人： SHIMADZU CORPORATION
发明人： Noriyuki Ojima , Koretsugu Ogata , Keisuke Shima , Hiroto Tamura , Akifumi Hosoda , Yudai Hotta
IPC分类号： C12Q1/04 , H01J49/02 , G01N33/487
CPC分类号： C12Q1/04 , G01N15/10 , G01N33/48735 , G01N2015/1006 , G16C20/20 , H01J49/025
摘要： An apparatus that identifies the type of a test cell based on a result obtained by performing mass spectrometry on the test cell includes a higher-level database, which contains mass lists that each list ion mass values of constituent components of a known cell, and a lower-level database, which contains partial mass lists that each list only strain-specific ion mass values out of the ion mass values. The higher-level database is first searched for a test mass list which is created from the result of the mass spectrometry performed on the test cell, and based on a result of the search, an organism species to be searched in the following search operation is determined. Mass values common to the organism species are subsequently deleted from the mass list for the test cell, and the mass list having undergone the deletion operation is used to search the lower-level database.
摘要翻译：基于通过在测试单元上进行质谱法获得的结果来识别测试单元的类型的装置包括更高级别的数据库，其包含质量列表，每个质量列表列出了已知单元的构成组分的离子质量值和低级数据库包含部分质量列表，每个列表只列出离子质量值之外的应变特异性离子质量值。首先搜索高级数据库，根据在测试单元上执行的质谱测定结果创建的测试质量列表，并且根据搜索结果，在以下搜索操作中要搜索的生物种类是决心。生物物种共同的质量值随后从测试单元的质量列表中删除，并且已经进行了删除操作的质量列表用于搜索下级数据库。

4. 发明授权

US11232935B2 Mass spectrometry data processing device 有权
公开(公告)号：US11232935B2
公开(公告)日：2022-01-25
申请号：US16329925
申请日：2016-09-01
申请人： SHIMADZU CORPORATION
发明人： Masahiro Ikegami , Koretsugu Ogata
IPC分类号： H01J49/00 , G01N27/62 , H01J49/16
摘要： The compound list stored in identification information memory is populated with theoretical masses associated with a variety of compounds, as well as information such as the type of matrix capable of detecting said compound, potential neutral loss, etc. The adduct ion list, meanwhile, is populated with theoretical masses associated with a variety of adduct ions, as well as other information such as types of matrices capable of producing adducts, etc. When a user specifies a peak on the mass spectrum for a compound search, compound candidate search portion extracts combination candidates based on how well the measured m/z value of the specified peak matches the m/z value for combinations of compounds in the compound list and adduct ions in the adduct ion list, while the type of matrix used during measurement serves as a condition to narrow down the combinations. Display processing portion displays a list of the search results.

5. 发明授权

US11101125B2 Sample plate for PESI ion source and mass spectrometer using the same 有权
公开(公告)号：US11101125B2
公开(公告)日：2021-08-24
申请号：US16606382
申请日：2017-08-31
申请人： SHIMADZU CORPORATION
发明人： Tasuku Murata , Takeshi Uchida , Koretsugu Ogata
IPC分类号： H01J49/16 , H01J49/04 , H01J49/14
摘要： A sample plate for a solid sample includes a plate-shaped main body and lid. The main body has a concave portion, in which a sample placement platform shaped like a cylinder protrudes from the central area of the bottom surface of the concave portion. The lid has a funnel-shaped opening bored at a position immediately above the concave portion. The diameter of the opening on the lower side is approximately the same as that of the sample placement platform. After a sample, e.g. a biological tissue section, is placed in the concave portion, the lid is closed. Then, the lower wall surface of the lid surrounding the opening presses the sample downward. The sample is thereby sandwiched between the lower wall surface and the sample placement platform. A solvent for ionization is injected into the opening whose lower side is thus closed by the sample.

6. 发明授权

US11435370B2 Data analying device and program for data analysis 有权
公开(公告)号：US11435370B2
公开(公告)日：2022-09-06
申请号：US16477958
申请日：2017-11-09
申请人： Shimadzu Corporation
发明人： Yoshihiro Yamada , Koretsugu Ogata , Hiroto Tamura , Teruyo Kato
IPC分类号： G01N35/00 , H01J49/00
摘要： A sample group forming section 24 classifies samples derived from microorganisms into groups according to empirical information showing the species or strain of each sample. A differential analysis section 27 performs a differential analysis using a peak matrix created based on the result of the grouping. An operator enters group rearrangement conditions concerning the drug resistance of microorganisms. Under the entered conditions, a sample group rearranging/rearrangement-cancelling section 25 rearranges the already formed groups by selecting or merging groups using another kind of previously registered empirical information which shows the drug resistance of each group. The differential analysis section 27 performs a differential analysis using a peak matrix newly created based on the result of the rearrangement of the groups. Thus, differential analysis results concerning the resistance to different drugs can be sequentially acquired as the group rearrangement condition is successively changed.

7. 发明授权

US10550418B2 Cell identification device and program 有权
公开(公告)号：US10550418B2
公开(公告)日：2020-02-04
申请号：US16456971
申请日：2019-06-28
申请人： SHIMADZU CORPORATION
发明人： Noriyuki Ojima , Koretsugu Ogata , Keisuke Shima , Hiroto Tamura , Akifumi Hosoda , Yudai Hotta
IPC分类号： C12Q1/04 , G16C20/20 , G01N33/487 , H01J49/02 , G01N15/10
摘要： An apparatus that identifies the type of a test cell based on a result obtained by performing mass spectrometry on the test cell includes a higher-level database, which contains mass lists that each list ion mass values of constituent components of a known cell, and a lower-level database, which contains partial mass lists that each list only strain-specific ion mass values out of the ion mass values. The higher-level database is first searched for a test mass list which is created from the result of the mass spectrometry performed on the test cell, and based on a result of the search, an organism species to be searched in the following search operation is determined. Mass values common to the organism species are subsequently deleted from the mass list for the test cell, and the mass list having undergone the deletion operation is used to search the lower-level database.

8. 发明授权

US10385379B2 Cell identification device and program 有权
公开(公告)号：US10385379B2
公开(公告)日：2019-08-20
申请号：US14352496
申请日：2012-10-17
申请人： SHIMADZU CORPORATION
发明人： Noriyuki Ojima , Koretsugu Ogata , Keisuke Shima , Hiroto Tamura , Akifumi Hosoda , Yudai Hotta
IPC分类号： C12Q1/04 , G16C20/20 , H01J49/02 , G01N33/487 , G01N15/10
摘要： An apparatus that identifies the type of a test cell based on a result obtained by performing mass spectrometry on the test cell includes a higher-level database, which contains mass lists that each list ion mass values of constituent components of a known cell, and a lower-level database, which contains partial mass lists that each list only strain-specific ion mass values out of the ion mass values. The higher-level database is first searched for a test mass list which is created from the result of the mass spectrometry performed on the test cell, and based on a result of the search, an organism species to be searched in the following search operation is determined. Mass values common to the organism species are subsequently deleted from the mass list for the test cell, and the mass list having undergone the deletion operation is used to search the lower-level database.

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