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    • 4. 发明授权
    • Process for recovering organic acids
    • 回收有机酸的方法
    • US5426219A
    • 1995-06-20
    • US96939
    • 1993-07-26
    • William F. LehnhardtRobert V. SchanefeltLori L. Napier
    • William F. LehnhardtRobert V. SchanefeltLori L. Napier
    • C07B63/00C07C51/48C07C59/06C12P7/56C07C51/42
    • C12P7/56C07C51/48
    • An organic acid can be recovered from a fermentation broth by clarifying the broth to remove at least a substantial portion of the impurities therein, producing a clarified feed; acidulating the clarified feed by adding a quantity of a mineral acid effective to lower the pH of the feed to between about 1.0 and about 4.5, producing an acidulated feed which is substantially saturated with respect to at least one electrolyte selected from the group consisting of MHSO.sub.4, M.sub.2 SO.sub.4, M.sub.3 PO.sub.4, M.sub.2 HPO.sub.4, MH.sub.2 PO.sub.4, and MNO.sub.3, where M is selected from the group consisting of Na, NH.sub.4, and K; extracting the acidulated feed with an extraction mixture which includes (a) water, (b) a mineral acid, in a quantity effective to maintain the pH of the feed between about 1.0 and about 4.5, and (c) an oxygenated solvent which has limited miscibility with water and the acidulated feed, the oxygenated solvent having from 4 to 12 carbon atoms and having at least one functional group selected from the group consisting of hydroxyl, ester, keto, ether, carbonyl, and amido, with the extraction producing a solvent extract and a first raffinate; and back extracting the solvent extract with an aqueous liquid, thereby producing an organic acid-rich aqueous extract and an organic acid-depleted solvent raffinate.
    • 通过澄清肉汤以除去其中至少大部分杂质,从发酵液中回收有机酸,产生澄清的饲料; 通过添加一定量的无机酸来将澄清的进料酸化,将无机酸的有效量降低到约1.0至约4.5之间,产生酸化的进料,其相对于选自MHSO 4中的至少一种电解质基本饱和 ,M2SO4,M3PO4,M2HPO4,MH2PO4和MNO3,其中M选自Na,NH4和K; 用提取混合物萃取酸化的进料,该提取混合物包括(a)水,(b)无机酸,其量为有效地将进料的pH保持在约1.0至约4.5之间,和(c)含有限制的含氧溶剂 与水和酸化的原料的混溶性,含氧的溶剂具有4至12个碳原子并具有至少一个选自羟基,酯,酮,醚,羰基和酰氨基的官能团,萃取产生溶剂 提取物和第一残液; 并用水性液体反萃取溶剂提取物,从而产生富含有机酸的水提取物和有机酸贫溶剂残液。