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1. 发明申请

US20050124036A1 Method for producing recombinant proteins in micro-organisms 审中-公开
标题翻译：在微生物中生产重组蛋白的方法
公开(公告)号：US20050124036A1
公开(公告)日：2005-06-09
申请号：US10503910
申请日：2003-02-06
申请人： Rudy Susilo , Hans Korting , Hans Gassen , Martin Hils , Ralf Pasternack
发明人： Rudy Susilo , Hans Korting , Hans Gassen , Martin Hils , Ralf Pasternack
IPC分类号： C12N15/09 , A61K9/06 , A61K9/70 , A61K31/616 , A61K31/727 , A61K38/43 , A61K38/48 , A61K45/00 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P17/02 , A61P27/02 , C08B37/10 , C12N1/15 , C12N1/19 , C12N9/68 , C12N15/57 , C12N15/62 , C12Q1/37 , C07H21/04 , C12N1/18 , C12N9/48 , C12N15/74 , C12P21/04
CPC分类号： C12N9/6435 , C07K2319/02 , C12N15/62 , C12Y304/21007
摘要： The invention relates to a method for producing a recombinant functional plasminogen in micro-organisms, and to a method for identifying plasminogen activators. The nucleic acid sequence coding for the fuctional part of the plasminogen is fused with a nucleic acid molecule coding for at least one signal peptide. The nucleic acid molecule coding for the plasminogen and the nucleic acid molecule coding for the signal peptide are combined with codons for interfaces of proteases which ensure the separation of the signal peptide. The recombinant plasminogen or the corresponding plasmin is suitable for treating wounds which are slow to heal or not healing, by application of the enzyme in an appropriate formulation.
摘要翻译：本发明涉及一种用于在微生物中产生重组功能性纤溶酶原的方法和一种鉴定纤溶酶原激活物的方法。编码纤溶酶原功能部分的核酸序列与编码至少一个信号肽的核酸分子融合。编码纤溶酶原的核酸分子和编码信号肽的核酸分子与保证信号肽分离的蛋白酶界面的密码子组合。重组纤溶酶原或相应的纤溶酶适合于通过在合适的制剂中施用酶来治疗慢愈合或不愈合的伤口。

2. 发明授权

US07417034B2 Pharmaceutically active uridine esters 失效
标题翻译：药学活性尿苷酯
公开(公告)号：US07417034B2
公开(公告)日：2008-08-26
申请号：US10951776
申请日：2004-09-29
申请人： Rudy Susilo
发明人： Rudy Susilo
IPC分类号： A61K31/7072 , A61K31/70 , C07H19/00
CPC分类号： C07H19/06 , A61K31/20 , A61K31/385 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： The present invention relates to novel uridine esters of the general formula wherein R represents a carboxylic acid residue, preferably a fatty acid residue and R′ represents hydrogen or a hydroxy group, their use as pharmaceutically active agents against a variety of diseases, methods for the preparation of said uridine esters and pharmaceutical compositions containing at least one uridine ester as active ingredient. The present invention relates also to a drug combination comprising free fatty acids and/or fatty acid esters and uridine, deoxyuridine, uridine monophosphate and/or deoxyuridine monophosphate, and to the use of such a drug combination.
摘要翻译：本发明涉及以下通式的新型尿苷酯：其中R表示羧酸残基，优选脂肪酸残基，R'表示氢或羟基，它们作为药物活性剂用于各种疾病，用于所述尿苷酯和含有至少一种尿苷酯作为活性成分的药物组合物的制备。本发明还涉及包含游离脂肪酸和/或脂肪酸酯和尿苷，脱氧尿苷，单磷酸尿苷和/或脱氧尿苷单磷酸酯的药物组合，以及这种药物组合的用途。

3. 发明授权

US07244754B2 2-methylthiazolidine-2,4-dicarboxylic acid and salts thereof for treatment of neurodegenerative diseases 有权
标题翻译： 2-甲基噻唑烷-2,4-二羧酸及其盐，用于治疗神经变性疾病
公开(公告)号：US07244754B2
公开(公告)日：2007-07-17
申请号：US11408356
申请日：2006-04-21
申请人： Rudy Susilo
发明人： Rudy Susilo
IPC分类号： A61K31/426 , C07D277/06
CPC分类号： A61K31/425 , C07D277/06
摘要： The invention relates to the compounds (2R,4R), (2S,4R)-2-methylthiazolidine-2,4-dicarboxylic acid and (2RS,4R)-2-methylthiazolidine-2,4-dicarboxylic acid and salts of said compounds, the use thereof for the prophylaxis and/or treatment of neurodegenerative diseases, methods for the prophylaxis and/or treatment of neurodegenerative diseases, and pharmaceutical compositions containing said compounds together with physiologically compatible carriers, auxiliary agents, and/or solvents.
摘要翻译：本发明涉及化合物（2R，4R），（2S，4R）-2-甲基噻唑烷-2,4-二羧酸和（2RS，4R）-2-甲基噻唑烷-2,4-二羧酸和所述化合物的盐，其用于预防和/或治疗神经变性疾病的用途，用于预防和/或治疗神经变性疾病的方法，以及含有所述化合物以及与生理学相容的载体，辅助剂和/或溶剂的药物组合物。

4. 发明申请

US20050148641A1 2-Methylthiazolidine-2,4-dicarboxylic acid and salts thereof for the treatment of neurodegenerative diseases 失效
标题翻译： 2-甲基噻唑烷-2,4-二羧酸及其盐，用于治疗神经变性疾病
公开(公告)号：US20050148641A1
公开(公告)日：2005-07-07
申请号：US10504069
申请日：2003-02-24
申请人： Rudy Susilo
发明人： Rudy Susilo
IPC分类号： C07D263/04 , A61K31/425 , A61P9/10 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/28 , C07D277/06 , A61K31/426 , A61K31/198
CPC分类号： A61K31/425 , C07D277/06
摘要： The invention relates to the compounds (2R,4R), (2S,4R)-2-methylthiazolidine-2,4-dicarboxylic acid and (2RS,4R)-2-methylthiazolidine-2,4-dicarboxylic acid and salts of said compounds, the use thereof for the prophylaxis and/or treatment of neurodegenerative diseases, methods for the prophylaxis and/or treatment of neurodegenerative diseases, and pharmaceutical compositions containing said compounds together with physiologically compatible carriers, auxiliary agents, and/or solvents.
摘要翻译：本发明涉及化合物（2R，4R），（2S，4R）-2-甲基噻唑烷-2,4-二羧酸和（2RS，4R）-2-甲基噻唑烷-2,4-二羧酸和所述化合物的盐，其用于预防和/或治疗神经变性疾病的用途，用于预防和/或治疗神经变性疾病的方法，以及含有所述化合物以及与生理学相容的载体，辅助剂和/或溶剂的药物组合物。

5. 发明申请

US20050043269A1 Pharmaceutically active uridine esters 失效
标题翻译：药学活性尿苷酯
公开(公告)号：US20050043269A1
公开(公告)日：2005-02-24
申请号：US10951764
申请日：2004-09-29
申请人： Rudy Susilo
发明人： Rudy Susilo
IPC分类号： C07H19/067 , A61K20060101 , A61K31/20 , A61K31/385 , A61K31/7072 , A61K45/00 , A61K45/06 , A61P20060101 , A61P1/04 , A61P1/16 , A61P3/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P25/00 , A61P25/02 , A61P25/04 , A61P25/16 , A61P25/24 , A61P25/28 , A61P29/00 , A61P31/04 , A61P31/18 , A61P35/00 , A61P37/08 , A61P39/02 , C07H20060101 , C07H19/06 , C07H19/073
CPC分类号： C07H19/06 , A61K31/20 , A61K31/385 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： The present invention relates to novel uridine esters of the general formula wherein R represents a carboxylic acid residue, preferably a fatty acid residue and R′ represents hydrogen or a hydroxy group, their use as pharmaceutically active agents against a variety of diseases, methods for the preparation of said uridine esters and pharmaceutical compositions containing at least one uridine ester as active ingredient. The present invention relates also to a drug combination comprising free fatty acids and/or fatty acid esters and uridine, deoxyuridine, uridine monophosphate and/or deoxyuridine monophosphate, and to the use of such a drug combination.
摘要翻译：本发明涉及以下通式的新型尿苷酯：其中R表示羧酸残基，优选脂肪酸残基，R'表示氢或羟基，它们作为药物活性剂用于各种疾病，用于所述尿苷酯和含有至少一种尿苷酯作为活性成分的药物组合物的制备。本发明还涉及包含游离脂肪酸和/或脂肪酸酯和尿苷，脱氧尿苷，单磷酸尿苷和/或脱氧尿苷单磷酸酯的药物组合，以及这种药物组合的用途。

6. 发明授权

US07915234B2 Pharmaceutically active uridine esters 失效
标题翻译：药学活性尿苷酯
公开(公告)号：US07915234B2
公开(公告)日：2011-03-29
申请号：US10951724
申请日：2004-09-29
申请人： Rudy Susilo
发明人： Rudy Susilo
IPC分类号： A61K31/7072 , A61K31/70 , C07H19/00
CPC分类号： C07H19/06 , A61K31/20 , A61K31/385 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： The present invention relates to novel uridine esters of the general formula wherein R represents a carboxylic acid residue, preferably a fatty acid residue and R′ represents hydrogen or a hydroxy group, their use as pharmaceutically active agents against a variety of diseases, methods for the preparation of said uridine esters and pharmaceutical compositions containing at least one uridine ester as active ingredient. The present invention relates also to a drug combination comprising free fatty acids and/or fatty acid esters and uridine, deoxyuridine, uridine monophosphate and/or deoxyuridine monophosphate, and to the use of such a drug combination.
摘要翻译：本发明涉及以下通式的新型尿苷酯：其中R表示羧酸残基，优选脂肪酸残基，R'表示氢或羟基，它们作为药物活性剂用于各种疾病，用于所述尿苷酯和含有至少一种尿苷酯作为活性成分的药物组合物的制备。本发明还涉及包含游离脂肪酸和/或脂肪酸酯和尿苷，脱氧尿苷，单磷酸尿苷和/或脱氧尿苷单磷酸酯的药物组合，以及这种药物组合的用途。

7. 发明授权

US07560442B2 Pharmaceutically active uridine esters 失效
标题翻译：药学活性尿苷酯
公开(公告)号：US07560442B2
公开(公告)日：2009-07-14
申请号：US10476287
申请日：2002-04-29
申请人： Rudy Susilo
发明人： Rudy Susilo
IPC分类号： A61K31/7072 , A61K31/70 , C07H19/00
CPC分类号： C07H19/06 , A61K31/20 , A61K31/385 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： The present invention relates to novel uridine esters of the general formula (I) wherein R represents a carboxylic acid residue, preferably a fatty acid residue and R′ represents hydrogen or a hydroxy group, their use as pharmaceutically active agents against a variety of diseases, methods for the preparation of said uridine esters and pharmaceutical compositions containing at least one uridine ester as active ingredient. The present invention relates also to a drug combination comprising free fatty acids and/or fatty acid esters and uridine, deoxyuridine, uridine monophosphate and/or deoxyuridine monophosphate, and to the use of such a drug combination.
摘要翻译：本发明涉及通式（I）的新型尿苷酯，其中R代表羧酸残基，优选脂肪酸残基，R'代表氢或羟基，它们作为药物活性剂用于各种疾病，用于制备所述尿苷酯的方法和含有至少一种尿苷酯作为活性成分的药物组合物。本发明还涉及包含游离脂肪酸和/或脂肪酸酯和尿苷，脱氧尿苷，单磷酸尿苷和/或脱氧尿苷单磷酸酯的药物组合，以及这种药物组合的用途。

8. 发明授权

US06441011B1 Combined preparation consisting of 2-methylthiazolidine-2,4-dicarboxylic acid and paracetamol 失效
标题翻译：由2-甲基噻唑烷-2,4-二羧酸和对乙酰氨基酚组成的组合制剂
公开(公告)号：US06441011B1
公开(公告)日：2002-08-27
申请号：US09380472
申请日：1999-11-08
申请人： Rudy Susilo , Hans Rommelspacher , Lidia Wlodek
发明人： Rudy Susilo , Hans Rommelspacher , Lidia Wlodek
IPC分类号： A61K31135
CPC分类号： A61K31/425 , A61K31/165 , A61K2300/00
摘要： This invention relates to a pharmaceutical containing a combination of 2-methyl-thiazolidine-2,4-dicarboxylic acid and paracetamol, and to the use of a combination of 2-methyl-thiazolidine-2,4-dicarboxylic acid and paracetamol as an analgesic and/or antipyretic.
摘要翻译：本发明涉及含有2-甲基 - 噻唑烷-2,4-二羧酸与对乙酰氨基酚的组合的药物，以及2-甲基 - 噻唑烷-2,4-二羧酸与对乙酰氨基酚的组合作为止痛剂和/或解热药。

9. 发明授权

US07615238B2 Plaster for the treatment of dysfunctions and disorders of nails, comprising sertaconazole 失效
标题翻译：用于治疗功能障碍和指甲疾病的石膏，其包含塞曲康唑
公开(公告)号：US07615238B2
公开(公告)日：2009-11-10
申请号：US10488905
申请日：2002-09-04
申请人： Rudy Susilo
发明人： Rudy Susilo
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61K31/4178
摘要： The present invention relates to plasters for prophylaxis and/or treatment of a dysfunction or disorder of nails, especially onychomycosis, onychocryptosis, nail psoriasis, melanonychia striata, and onychodystrophy, the use of said plasters and methods for prophylaxis and/or treatment of a dysfunction or disorder of nails using said plasters. Said dysfunction or disorder of nails may be induced or caused by drugs, systemic diseases, chemical compounds, physical influences, fungal, yeast, or bacterial infection of the nails and/or the nail beds, or in the context of skin diseases. The plasters show good therapeutically effects on said dysfunction or disorder of nails without the need of drilling a hole into the nail and/or daily scraping of the nail. Preferred embodiments of the plasters consist of an occlusive backing layer and a layer attached to said backing layer. The layer comes in close contact with the nail and optionally with the surrounding skin. The layer is made of a adhesive, a skin and/or nail permeation enhancer, a therapeutically effective amount of sertaconazole, and suitable additives, and/or further pharmaceutically active agents.
摘要翻译：本发明涉及用于预防和/或治疗指甲功能障碍或病症的膏药，特别是甲真菌病，精神分裂症，指甲牛皮癣，黑斑病和发育不良症，所述膏药的使用以及预防和/或治疗功能障碍的方法或使用所述膏药的指甲紊乱。所述功能障碍或指甲紊乱可能由指甲和/或甲床的药物，系统性疾病，化学化合物，物理影响，真菌，酵母或细菌感染或皮肤疾病的背景引起或引起。膏药对指甲的功能障碍或无序症状具有良好的治疗作用，而不需要在钉子上钻孔和/或每日刮擦指甲。膏药的优选实施方案由闭塞背衬层和附着到所述背衬层的层组成。该层与指甲紧密接触并可选择与周围的皮肤接触。该层由粘合剂，皮肤和/或指甲渗透增强剂，治疗有效量的依托他康和合适的添加剂和/或其它药物活性剂制成。

10. 发明授权

US07396826B2 Pharmaceutically active uridine esters 失效
公开(公告)号：US07396826B2
公开(公告)日：2008-07-08
申请号：US10951764
申请日：2004-09-29
申请人： Rudy Susilo
发明人： Rudy Susilo
IPC分类号： A61K31/7072 , A61K31/70 , C07H19/00
CPC分类号： C07H19/06 , A61K31/20 , A61K31/385 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： The present invention relates to novel uridine esters of the general formula wherein R represents a carboxylic acid residue, preferably a fatty acid residue and R′ represents hydrogen or a hydroxy group, their use as pharmaceutically active agents against a variety of diseases, methods for the preparation of said uridine esters and pharmaceutical compositions containing at least one uridine ester as active ingredient. The present invention relates also to a drug combination comprising free fatty acids and/or fatty acid esters and uridine, deoxyuridine, uridine monophosphate and/or deoxyuridine monophosphate, and to the use of such a drug combination.

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