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1. 发明授权

US07514399B2 Bonding tissues and cross-linking proteins with naphthalimide compounds 有权
标题翻译：用萘二甲酰亚胺化合物结合组织和交联蛋白
公开(公告)号：US07514399B2
公开(公告)日：2009-04-07
申请号：US10982197
申请日：2004-11-05
申请人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
发明人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
IPC分类号： A01N37/18 , A01N43/04 , A61K38/00 , C07K1/00 , C07K14/00 , C07K16/00 , C07K17/00 , C08H1/00 , C07H5/04 , C07H5/06 , C08B37/00 , C08B37/08
CPC分类号： C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
摘要： Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.
摘要翻译：萘二甲酰亚胺化合物用于组织结合和蛋白质交联应用。当活化剂如400-500nm吸收范围的光激活时，萘酰亚胺化合物形成化学反应性物质，其将蛋白质交联，将结缔组织结合在一起，并将组织和其他生物材料结合在一起。萘二甲酰亚胺标记的生物分子，例如萘二甲酰亚胺标记的壳聚糖，也能够粘合组织而不随后直接照射接触的组织区域。萘二甲酰亚胺化合物可以用于组织或动脉修复，血管成形术后扩张的动脉壁的稳定化，将药剂束紧到组织表面以提供局部药物递送，以及将皮肤护理产品，防晒剂和化妆品化学粘合到皮肤上。

2. 发明授权

US08242114B2 Bonding tissues and cross-linking proteins with naphthalimide compounds 有权
标题翻译：用萘二甲酰亚胺化合物结合组织和交联蛋白
公开(公告)号：US08242114B2
公开(公告)日：2012-08-14
申请号：US12407481
申请日：2009-03-19
申请人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
发明人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
IPC分类号： A61K31/55
CPC分类号： C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
摘要： Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.
摘要翻译：萘二甲酰亚胺化合物用于组织结合和蛋白质交联应用。当活化剂如400-500nm吸收范围的光激活时，萘酰亚胺化合物形成化学反应性物质，其将蛋白质交联，将结缔组织结合在一起，并将组织和其他生物材料结合在一起。萘二甲酰亚胺标记的生物分子，例如萘二甲酰亚胺标记的壳聚糖，也能够粘合组织而不随后直接照射接触的组织区域。萘二甲酰亚胺化合物可以用于组织或动脉修复，血管成形术后扩张的动脉壁的稳定化，将药剂束紧到组织表面以提供局部药物递送，以及将皮肤护理产品，防晒剂和化妆品化学粘合到皮肤上。

3. 发明申请

US20130165970A1 BONDING TISSUES AND CROSS-LINKING PROTEINS WTH NAPHTHALIMIDE COMPOUNDS 有权
标题翻译：结合组织和交联蛋白质四萘酰胺化合物
公开(公告)号：US20130165970A1
公开(公告)日：2013-06-27
申请号：US13772543
申请日：2013-02-21
申请人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
发明人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
IPC分类号： A61L24/08 , A61B17/00
CPC分类号： C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
摘要： Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.
摘要翻译：萘二甲酰亚胺化合物用于组织结合和蛋白质交联应用。当活化剂如400-500nm吸收范围的光激活时，萘酰亚胺化合物形成化学反应性物质，其将蛋白质交联，将结缔组织结合在一起，并将组织和其他生物材料结合在一起。萘二甲酰亚胺标记的生物分子，例如萘二甲酰亚胺标记的壳聚糖，也能够粘合组织而不随后直接照射接触的组织区域。萘二甲酰亚胺化合物可以用于组织或动脉修复，血管成形术后扩张的动脉壁的稳定化，将药剂束紧到组织表面以提供局部药物递送，以及将皮肤护理产品，防晒剂和化妆品化学粘合到皮肤上。

4. 发明授权

US08546384B2 Bonding tissues and cross-linking proteins with naphthalimide compounds 有权
公开(公告)号：US08546384B2
公开(公告)日：2013-10-01
申请号：US13547196
申请日：2012-07-12
申请人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
发明人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
IPC分类号： A61K31/535
CPC分类号： C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
摘要： Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.

5. 发明申请

US20130230472A1 BONDING TISSUES AND CROSS-LINKING PROTEINS WITH NAPHTHALIMIDE COMPOUNDS 有权
公开(公告)号：US20130230472A1
公开(公告)日：2013-09-05
申请号：US13772510
申请日：2013-02-21
申请人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
发明人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
IPC分类号： A61K41/00 , A61K8/73 , A61Q17/04 , A61K31/722
CPC分类号： C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
摘要： Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.

6. 发明申请

US20130045171A1 BONDING TISSUES AND CROSS-LINKING PROTEINS WITH NAPHTHALIMIDE COMPOUNDS 有权
公开(公告)号：US20130045171A1
公开(公告)日：2013-02-21
申请号：US13547196
申请日：2012-07-12
申请人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
发明人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
IPC分类号： A61K31/722 , A61M37/00 , A61P17/02 , A61M25/10 , A61K8/73 , A61Q17/04
CPC分类号： C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
摘要： Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.

7. 发明授权

US08741270B2 Bonding tissues and cross-linking proteins with naphthalimide compounds 有权
标题翻译：用萘二甲酰亚胺化合物结合组织和交联蛋白
公开(公告)号：US08741270B2
公开(公告)日：2014-06-03
申请号：US13772510
申请日：2013-02-21
申请人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska
发明人： Ronald E. Utecht , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
IPC分类号： A61K8/00 , A61K8/18 , A61Q17/04 , A01N43/04
CPC分类号： C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
摘要： Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.
摘要翻译：萘二甲酰亚胺化合物用于组织结合和蛋白质交联应用。当活化剂如400-500nm吸收范围的光激活时，萘酰亚胺化合物形成化学反应性物质，其将蛋白质交联，将结缔组织结合在一起，并将组织和其他生物材料结合在一起。萘二甲酰亚胺标记的生物分子，例如萘二甲酰亚胺标记的壳聚糖，也能够粘合组织而不随后直接照射接触的组织区域。萘二甲酰亚胺化合物可以用于组织或动脉修复，血管成形术后扩张的动脉壁的稳定化，将药剂束紧到组织表面以提供局部药物递送，以及将皮肤护理产品，防晒剂和化妆品化学粘合到皮肤上。

8. 发明申请

US20090181927A1 BONDING TISSUES AND CROSS-LINKING PROTEINS WITH NAPHTHALIMIDE COMPOUNDS 有权
标题翻译：与硫辛酸酯化合物结合组织和交联蛋白
公开(公告)号：US20090181927A1
公开(公告)日：2009-07-16
申请号：US12407481
申请日：2009-03-19
申请人： Ronald E. Utech , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
发明人： Ronald E. Utech , Kaia L. Kloster , Millard M. Judy , Kevin J. Vaska , James L. Matthews
IPC分类号： A61K31/435 , A61K31/727 , A61K31/337 , A61K31/4355
CPC分类号： C08B37/003 , A61B17/00 , A61B17/08 , A61K8/736 , A61K31/722 , A61K41/00 , A61K41/0042 , A61K41/0057 , A61K47/61 , A61K2800/57 , A61K2800/81 , A61K2800/94 , A61L24/08 , A61N5/062 , A61N2005/0602 , A61N2005/0663 , A61Q17/04 , A61Q19/00
摘要： Naphthalimide compounds are used in tissue bonding and protein cross-linking applications. When activated by an activating agent, such as light in the 400-500 nm absorption range, the naphthalimide compounds form chemically-reactive species that cross-link proteins, bond connective tissues together, and bond tissues and other biomaterials together. A naphthalimide-labeled biomolecule, such as a naphthalimide-labeled chitosan, is also capable of bonding tissues without subsequent direct illumination of the contacted tissue area. The naphthalimide compounds may be used in tissue or arterial repair, stabilization of an expanded arterial wall after angioplasty, tethering pharmaceutical agents to tissue surfaces to provide local drug delivery, and for chemically bonding skin care products, sunscreens, and cosmetics to the skin.
摘要翻译：萘二甲酰亚胺化合物用于组织结合和蛋白质交联应用。当活化剂如400-500nm吸收范围的光激活时，萘酰亚胺化合物形成化学反应性物质，其将蛋白质交联，将结缔组织结合在一起，并将组织和其他生物材料结合在一起。萘二甲酰亚胺标记的生物分子，例如萘二甲酰亚胺标记的壳聚糖，也能够粘合组织而不随后直接照射接触的组织区域。萘二甲酰亚胺化合物可以用于组织或动脉修复，血管成形术后扩张的动脉壁的稳定化，将药剂束紧到组织表面以提供局部药物递送，以及将皮肤护理产品，防晒剂和化妆品化学粘合到皮肤上。

9. 发明授权

US5030200A Method for eradicating infectious biological contaminants in body tissues 失效
标题翻译：消除身体组织中感染性生物污染物的方法
公开(公告)号：US5030200A
公开(公告)日：1991-07-09
申请号：US433024
申请日：1989-11-06
申请人： Millard M. Judy , James L. Matthews , Joseph T. Newman , Franklin Sogandares-Bernal
发明人： Millard M. Judy , James L. Matthews , Joseph T. Newman , Franklin Sogandares-Bernal
IPC分类号： A61M1/00 , A61B17/00 , A61K35/14 , A61L2/00 , A61L2/08 , A61L2/10
CPC分类号： A61L2/0011 , A61L2/0082
摘要： A method for externally eradicating infectious pathogenic contaminants, such as enveloped viruses, bacteria, trypanosomal and malarial parasites, present in body tissues, such as blood, blood components, semen, skin, and cornea, before the treated body tissues are introduced into, or transplanted onto, the body of a human or an animal. Such method includes the steps of: (1) admixing an effective, non-toxic amount of photoactive compound, which has a selectively for binding to the infectious pathogenic biological contaminants present therein, with the body tissues outside the body to produce resulting body tissues; (2) maintaining the resulting body tissues in a suitable container in which there is no net mass transfer, and (3) irradiating the resulting body tissues in the container for an effective period of time with an effective level of radiation such that the radiation penetrates the resulting body tissues and eradicates the photoactive-compound-bound contaminants present in the resulting body tissues and produces a decontaminated body tissue suitable for introducing into, or transplanting onto, the body of a human or animal.
摘要翻译：在被处理的身体组织被引入之前，外部消除存在于身体组织如血液，血液成分，精液，皮肤和角膜中的感染性致病性污染物，例如包膜病毒，细菌，锥虫体和疟疾寄生虫的方法，或移植到人或动物的身体上。这种方法包括以下步骤：（1）将有效的无毒数量的光活性化合物与身体的身体组织选择性地结合存在于其中的感染性致病生物污染物以产生所得的身体组织; （2）将所得的身体组织保持在没有净质量转移的合适的容器中，和（3）以有效的辐射水平在有效的时间内照射容器中的所得体组织，使得辐射穿透所产生的身体组织并且消除存在于所得体组织中的光活化化合物结合的污染物，并产生适于引入或移植到人或动物体内的净化的身体组织。

10. 发明授权

US4878891A Method for eradicating infectious biological contaminants in body tissues 失效
标题翻译：消除身体组织中感染性生物污染物的方法
公开(公告)号：US4878891A
公开(公告)日：1989-11-07
申请号：US67237
申请日：1987-06-25
申请人： Millard M. Judy , James L. Matthews , Joseph T. Newman , Franklin Sogandares-Bernal
发明人： Millard M. Judy , James L. Matthews , Joseph T. Newman , Franklin Sogandares-Bernal
IPC分类号： A61M1/00 , A61B17/00 , A61K35/14 , A61L2/00 , A61L2/08 , A61L2/10
CPC分类号： A61L2/0011 , A61L2/0082
摘要： A method for externally eradicating infectious pathogenic contaminants, such as enveloped viruses, bacteria, trypanosomal and malarial parasites, present in body tissues, such as blood, blood components, semen, skin, and cornea, before the treated body tisues are introduced into, or transplanted onto, the body of a human or an animal. Such method includes the steps of: (1) admixing an effective, non-toxic amount of photoactive compound, whch has a selectivity for binding to the infectious pathogenic biological contaminants present therein, with the body tissues outside the body to produce a resulting body tissues; (2) passing the resulting body tissues through an irradiating cell assembly, and (3) irradiating the resulting body tissues in the irradiating path of the cell assembly for an effective period of time with an effective level of radiation such that the radiation penetrates the resulting body tissues and eradicates the photoactive-compound-bound contaminants present in the resulting body tissues and produces a decontaminated body tissue suitable for introducing into, or transplanting onto, the body of a human or animal.
摘要翻译：在治疗的身体部位之前，外部根除存在于身体组织（例如血液，血液成分，精液，皮肤和角膜）中的感染性病原体污染物，例如包膜病毒，细菌，锥虫体和疟疾寄生虫的方法被引入或移植到人或动物的身体上。这种方法包括以下步骤：（1）将有效的无毒量的光活性化合物与生物体内存在的感染性致病生物污染物结合起来，与体外的身体组织混合以产生所得的身体组织 ; （2）使所得到的身体组织通过照射细胞组件，和（3）以有效的辐射水平在有效的时间内照射细胞组件的照射路径中的所得体组织，使得辐射穿透所得到的身体组织并消除存在于所得体组织中的光敏化合物结合的污染物，并产生适于引入或移植到人或动物体内的净化身体组织。

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