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    • 9. 发明授权
    • Enhanced moisture barrier immediate release film coating systems and substrates coated therewith
    • 增强的防潮快速脱膜膜涂层系统和涂覆的基材
    • US08647645B2
    • 2014-02-11
    • US12769188
    • 2010-04-28
    • Thomas P. FarrellJason Teckoe
    • Thomas P. FarrellJason Teckoe
    • A61K47/10
    • A61K9/2866A61K9/284A61K9/2846A61K47/02
    • The present invention is directed to immediate release film coating systems for use on oral dosage forms such as compressed tablets and other orally-ingestible substrates which have improved moisture barrier properties. The film coating systems can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the moisture barrier film coating is prepared as a dry powder mixture containing polyvinyl alcohol, a polymer with pH dependent solubility, a plasticizer, a glidant, and, optionally, a detackifier, an alkalizing agent and a pigment. Film coating compositions containing an aqueous suspension of the powder mixtures, methods of applying the coatings to substrates and the coated substrates are also disclosed.
    • 本发明涉及用于口服剂型例如压缩片剂和具有改善的防潮性能的其它可口服摄取的底物的立即释放膜包衣系统。 膜涂层系统可以直接施加到基底上,或者在基底涂覆有底涂层之后。 在优选的方面,防潮膜涂层被制备为含有聚乙烯醇,具有pH依赖性溶解度的聚合物,增塑剂,助流剂和任选的防粘剂,碱化剂和颜料的干粉混合物。 还公开了含有粉末混合物的水性悬浮液的薄膜包衣组合物,将涂料施加到基材和涂布的基材上的方法。