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1. 发明授权

US07145148B2 Systems and methods for non-destructively detecting material abnormalities beneath a coated surface 有权
标题翻译：用于非破坏性地检测涂层表面下的材料异常的系统和方法
公开(公告)号：US07145148B2
公开(公告)日：2006-12-05
申请号：US10949571
申请日：2004-09-24
申请人： Robert R. Alfano , Baolong Yu
发明人： Robert R. Alfano , Baolong Yu
IPC分类号： G01J5/02 , G01N21/88 , G01N21/47
CPC分类号： G01N21/3581 , G01N21/3563 , G01N21/8422
摘要： The present invention provides systems and methods for non-destructively detecting material abnormalities beneath a coated surface. A terahertz (THz) illumination unit illuminates an area of the coated surface. A detection unit detects light reflected from the illuminated area of the coated surface, and a processing unit images the illuminated area of the coated surface from optical characteristics received from the detection unit.
摘要翻译：本发明提供用于非破坏性地检测涂覆表面下方的材料异常的系统和方法。太赫兹（THz）照明单元照亮涂层表面的一个区域。检测单元检测从涂覆表面的照射区域反射的光，并且处理单元从从检测单元接收的光学特性对涂覆表面的照射区域进行成像。

2. 发明申请

US20080014580A1 Detection of biological molecules using THz absorption spectroscopy 审中-公开
标题翻译：使用THz吸收光谱法检测生物分子
公开(公告)号：US20080014580A1
公开(公告)日：2008-01-17
申请号：US10827974
申请日：2004-04-19
申请人： Robert R. Alfano , Baolong Yu , Yuanlong Yang
发明人： Robert R. Alfano , Baolong Yu , Yuanlong Yang
IPC分类号： C12Q1/68 , G01N21/00
CPC分类号： G01N21/3586
摘要： A method and apparatus of detecting biological molecules, the method including the steps of: performing Terahertz (THz) absorption spectroscopy, performed in a first frequency range of 0.2 to 2.2 THz (10-79.2 cm−1), on at least one sample including a substance comprising the biological molecules, the substance being selected from at least one of tryptophan, albumin bovine, DNA, nucleotides, bacillus subtilis, spore, and DPA; calculating a frequency-dependent absorption value of biological molecules; performing THz absorption spectroscopy on at least one reference substance; detecting the substance through the frequency-dependent absorption value by comparison of absorption peaks; and outputting information proving existence of the substance in the sample. The method further creates a library of known THz frequency modes on spectra to identify the presence of unknown substance in biological and chemical composite media.
摘要翻译：一种检测生物分子的方法和装置，所述方法包括以下步骤：在至少一个样品上进行在0.2至2.2THz（10-79.2cm-1）的第一频率范围内执行的太赫兹（THz）吸收光谱，包括包含生物分子的物质，该物质选自色氨酸，白蛋白牛，DNA，核苷酸，枯草杆菌，孢子和DPA中的至少一种; 计算生物分子的频率依赖吸收值; 对至少一种参考物质进行太赫兹吸收光谱; 通过吸收峰的比较通过频率依赖吸收值检测物质; 并输出证明样品中物质存在的信息。该方法进一步在光谱上创建已知的THz频率模式的文库，以识别生物和化学复合介质中未知物质的存在。

3. 发明授权

US10433731B2 Continuous diode laser stimulated Raman gain/loss vibrational microscope 有权
公开(公告)号：US10433731B2
公开(公告)日：2019-10-08
申请号：US15243207
申请日：2016-08-22
申请人： Robert R. Alfano
发明人： Robert R. Alfano , Lingyan Shi , Yury Budansky
IPC分类号： A61B5/00 , G01N21/65
摘要： There is a need for a compact instrument and microscope that maps the vibration fingerprints of biomolecules and chemicals in a sample such as brain, breast, cervix, and arteries. One can use spontaneous Raman scattering to accomplish this; however, the problem is low scattering efficiency to 10−5. With the availability of continuous wave diode laser at numerous wavelengths from 375 nm-1800 nm for parametric nonlinear difference vibrational mixing to enhance Stimulated Raman process within materials. A seed beam at Raman frequency is used with pump laser beam. In this way one can map in 2D and 3D images of the vibrations associate with disease changes. Scanning a pair of laser beams can map the location of vibrations within cells, smears, membranes, arteries, and tissues of animal and human.

4. 发明授权

US09804088B2 Spatial frequency spectrometer for and method of detection of spatial structures in materials 有权
公开(公告)号：US09804088B2
公开(公告)日：2017-10-31
申请号：US14580892
申请日：2014-12-23
申请人： Robert R. Alfano , Yang Pu
发明人： Robert R. Alfano , Yang Pu
IPC分类号： G01B9/02 , G01N21/47
CPC分类号： G01N21/4788
摘要： Spatial frequency spectra from periodic, aperiodic and quasi-random structures in materials are shown and used to detect differences among objects via internal coding from the spatial frequencies. The method is applied to different grades of human tissues for a new form of histology and pathology, and to detect art forgeries and coding boxes, money and papers and gems. The randomness of material structures on surface and at depths near surface can be detected from the spatial spectrum. In tissue spectral features from normal to different stages of cancer in tissue for ex vivo and in vivo applications can be recognized by different spectral fingerprints content of the spatial frequency. Similarly, the painting for the strokes of artist is different. A new type of instrument is described to analyze materials as a Spatial Frequency Spectrometer.

5. 发明授权

US09620858B2 Compact electromagnetic-radiation antenna 有权
公开(公告)号：US09620858B2
公开(公告)日：2017-04-11
申请号：US14218864
申请日：2014-03-18
申请人： Robert R. Alfano
发明人： Robert R. Alfano , M. Yu Sharonov
IPC分类号： H01Q7/06 , H01Q7/08 , H01Q1/36
CPC分类号： H01Q7/08 , H01Q1/36 , H01Q7/06 , Y10T29/49016
摘要： A compact random media size antenna employing random magnetic and dielectrics nm to mm range size particles in polymer hosts is used to transfer E & M oscillations in 1 kHz to 900 Mhz range using a 1 cm to 1 meter length antenna. This is achieved by using small size particles and a random mean path length of E & M wavefront travel in and about a core tube of effective length matching Leff=L2/2ltr, equivalent to λ/2 for transmitting and receiving E & M radiation, where L is the physical size of the antenna, ltris the transport scattering random walk length between particles and λ is the frequency wavelength.

6. 发明申请

US20160128775A1 METHOD OF USING SUPERCONTINUUM LIGHT FOR MEDICAL AND BIOLOGICAL APPLICATIONS 审中-公开
标题翻译：超光连接用于医疗和生物应用的方法
公开(公告)号：US20160128775A1
公开(公告)日：2016-05-12
申请号：US14996449
申请日：2016-01-15
申请人： Robert R. Alfano
发明人： Robert R. Alfano
IPC分类号： A61B18/20
CPC分类号： G02B21/0064 , A61B5/0066 , A61B18/20 , A61B2017/00508 , A61B2018/1807 , A61B2018/2065 , A61N5/0622 , A61N2005/0659 , A61N2005/067 , G01N33/4833 , G02B21/0032 , G02B21/0084 , G02F1/3515 , G02F1/3536 , G02F1/355 , G02F1/3551 , G02F1/365 , G02F2001/3528 , G06N99/002
摘要： A method and an apparatus are provided for producing SuperContinuum (SC) light for medical and biological applications is provided. Pulses are focused from a laser system into at least one of a pressurized cell and one or more fibers. A pump pulse is converted into the SC light at a specified rate of repetition. The SC light is applied at the specified rate of repetition to tissue for medical and biological applications.
摘要翻译：提供了用于生产用于医疗和生物应用的超级连续（SC）光的方法和装置。脉冲从激光系统聚焦成加压电池和一个或多个光纤中的至少一个。泵浦脉冲以指定的重复速率转换成SC光。以指定的重复速率将SC光施加到用于医疗和生物应用的组织。

7. 发明授权

US08974444B2 Method for picosecond and femtosecond laser tissue welding 有权
标题翻译：皮秒和飞秒激光组织焊接方法
公开(公告)号：US08974444B2
公开(公告)日：2015-03-10
申请号：US13642746
申请日：2011-04-20
申请人： Robert R. Alfano , Vidyasagar Sriramoju
发明人： Robert R. Alfano , Vidyasagar Sriramoju
IPC分类号： A61B18/20 , A61B17/00 , A61B18/00
CPC分类号： A61B18/20 , A61B18/203 , A61B2017/00508 , A61B2018/00452
摘要： A method for welding tissue wounds in an animal. The method comprises joining edges of a tissue wound and irradiating the tissue wound and tissue surrounding the tissue wound with a pulsed laser. The pulsed laser has a laser wavelength in a range of an absorption band of water, elastin and/or collagen in the tissue wound and tissue surrounding the tissue wound. The pulsed laser has a pulse width of not more than picoseconds in order of magnitude to heat tissue surrounding the tissue wound and facilitate bonding of native tissue protein present in the tissue surrounding the tissue wound to achieve tissue repair. The laser wavelength is in a range of between about 800 nm to about 2,700 nm.
摘要翻译：一种用于焊接动物组织伤口的方法。该方法包括接合伤口组织的边缘并用脉冲激光照射卷绕的组织周围的组织。脉冲激光在组织伤口和围绕组织伤口的组织的水吸收带，弹性蛋白和/或胶原的范围内具有激光波长。脉冲激光器具有不超过皮秒的脉冲宽度，以加热组织周围的组织，并促进存在于围绕组织伤口的组织中的天然组织蛋白质的结合以实现组织修复。激光波长在约800nm至约2,700nm之间的范围内。

8. 发明授权

US07706862B2 Detecting human cancer through spectral optical imaging using key water absorption wavelengths 失效
标题翻译：通过使用关键吸水波长的光谱成像检测人类癌症
公开(公告)号：US07706862B2
公开(公告)日：2010-04-27
申请号：US10926556
申请日：2004-08-26
申请人： Robert R. Alfano , Jamal H. Ali , Wubao Wang , Manuel Zevallos
发明人： Robert R. Alfano , Jamal H. Ali , Wubao Wang , Manuel Zevallos
IPC分类号： A61B6/00 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/415 , A61B5/4381 , A61B5/7264
摘要： Spectral optical imaging at one or more key water absorption fingerprint wavelengths measures the difference in water content between a region of cancerous or precancerous tissue and a region of normal tissue. Water content is an important diagnostic parameter because cancerous and precancerous tissues have different water content than normal tissues. Key water absorption wavelengths include at least one of 980 nanometers (nm), 1195 nm, 1456 nm, 1944 nm, 2880 nm to 3360 nm, and 4720 nm. In the range of 400 nm to 6000 nm, one or more points of negligible water absorption are used as reference points for a comparison with one or more key neighboring water absorption wavelengths. Different images are generated using at least two wavelengths, including a water absorption wavelength and a negligible water absorption wavelength, to yield diagnostic information relevant for classifying a tissue region as cancerous, precancerous, or normal. The results of this comparison can be used to identify regions of cancerous tissue in organs such as the breast, cervix and prostate.
摘要翻译：一个或多个关键的吸水指纹波长的光谱成像测量癌变或癌前组织区域与正常组织区域之间的含水量差异。水含量是重要的诊断参数，因为癌和癌前组织的含水量比正常组织水分含量高。关键的吸水波长包括980纳米（nm），1195nm，1456nm，1944nm，2880nm至3360nm和4720nm中的至少一个。在400nm至6000nm的范围内，使用可忽略的吸水点的一个或多个点作为与一个或多个关键相邻吸水波长的比较的参考点。使用包括吸水波长和可忽略的吸水波长的至少两个波长产生不同的图像，以产生与将癌组织区域分类为癌，癌前或正常相关的诊断信息。该比较的结果可以用于识别器官如乳腺，子宫颈和前列腺中癌组织的区域。

9. 发明授权

US07106972B2 Methods of improving line of sight wireless optical communication through adverse environmental conditions 有权
公开(公告)号：US07106972B2
公开(公告)日：2006-09-12
申请号：US10116194
申请日：2002-04-04
申请人： Robert R. Alfano , Jin Pin Ying , Swapan K. Gayen , Wei Cai
发明人： Robert R. Alfano , Jin Pin Ying , Swapan K. Gayen , Wei Cai
IPC分类号： H04B10/00
CPC分类号： H04B10/1121
摘要： A method of improving a signal-to-noise (S/N) ratio for a light signal transmitted by wireless optical communication through adverse environmental conditions, the light signal including a snake component and a ballistic component for carrying coded information, and a diffusive component that adds to background noise, the method comprising the steps of: encoding information to be transmitted by the light signal, wherein the light signal is one of a serial train of code pulses or a modulated light beam; selecting an appropriate wavelength for the encoded light signal; transmitting the encoded light signal though the adverse environmental conditions; receiving the encoded light signal; sorting the received encoded light signal to preferentially select the information carrying components and reduce the diffusive component; and detecting the sorted encoded light signal with a photo-detector.

10. 发明授权

US06853926B2 Systems and methods for non-destructively detecting material abnormalities beneath a coated surface 失效
标题翻译：用于非破坏性地检测涂层表面下的材料异常的系统和方法
公开(公告)号：US06853926B2
公开(公告)日：2005-02-08
申请号：US10455662
申请日：2003-06-05
申请人： Robert R. Alfano , Iosif Zeylikovich , Wubao Wang , Jamal Ali , Vincent Benischek , Yury Budansky
发明人： Robert R. Alfano , Iosif Zeylikovich , Wubao Wang , Jamal Ali , Vincent Benischek , Yury Budansky
IPC分类号： G01N21/88 , G01N21/89 , G01B5/28
CPC分类号： G01N21/88 , G01N21/8422 , G01N2021/889 , G01N2021/8918
摘要： The present invention provides systems and methods for non-destructively detecting material abnormalities beneath a coated surface, comprising a mid-infrared (MIR) detection unit for illuminating an area of the coated surface and detecting light reflected from the illuminated area of the coated surface, and a processing unit for producing an image from optical characteristics received from the MIR detection unit. In addition, the system may further comprise a scanning unit for moving the MIR detection unit to a next area.
摘要翻译：本发明提供用于非破坏性地检测涂覆表面下方的材料异常的系统和方法，包括用于照射涂覆表面的区域并检测从涂覆表面的被照射区域反射的光的中红外（MIR）检测单元，以及处理单元，用于从从MIR检测单元接收的光学特性产生图像。另外，该系统还可以包括用于将MIR检测单元移动到下一个区域的扫描单元。

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