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1. 发明申请

US20100320377A1 LOW VOLTAGE, HIGH MASS RANGE ION TRAP SPECTROMETER AND ANALYZING METHODS USING SUCH A DEVICE 审中-公开
标题翻译：低电压，高质量离子阱测量仪和使用这种器件的分析方法
公开(公告)号：US20100320377A1
公开(公告)日：2010-12-23
申请号：US12742252
申请日：2008-11-10
申请人： Robert J. Cotter , Luann Becker , William B. Brinckerhoff
发明人： Robert J. Cotter , Luann Becker , William B. Brinckerhoff
IPC分类号： H01J49/42 , B01D59/44
CPC分类号： H01J49/424
摘要： Featured is a quadrupole ion trap mass spectrometer having a compact configuration with a low voltage fundamental RF and using supplemental RF to a very low qejec value so as to yield a device characterized as having a high mass range. In more particular embodiments, such a quadrupole ion trap mass spectrometer is configured and arranged so as to a mass range on the order of 1,000 to 2,500 Da. Also featured are methods embodying the use of such a quadrupole ion trap mass spectrometer.
摘要翻译：特色是四极离子阱质谱仪，其具有紧凑配置，具有低电压基波RF，并且使用补充RF至非常低的qejec值，以便产生具有高质量范围的器件。在更具体的实施方案中，这种四极离子阱质谱仪被配置和布置成质量范围为1,000-2,500Da。还特征在于使用这种四极离子阱质谱仪的方法。

2. 发明授权

US06365892B1 Method and apparatus for correction of initial ion velocity in a reflectron time-of-flight mass spectrometer 有权
标题翻译：用于校正反射器飞行时间质谱仪中初始离子速度的方法和装置
公开(公告)号：US06365892B1
公开(公告)日：2002-04-02
申请号：US09199108
申请日：1998-11-24
申请人： Robert J. Cotter , Vladimir M. Doroshenko
发明人： Robert J. Cotter , Vladimir M. Doroshenko
IPC分类号： B01D5944
CPC分类号： H01J49/405 , H01J49/06 , H01J49/40
摘要： The present invention provides for a reflectron time-of-flight mass spectrometer in which there exists a curved field in a portion of the reflectron that takes into account acceleration and deceleration fields in upstream (from the ion source down to the reflectron) and downstream (from the reflectron down to the ion detector) regions, which are always present in any TOF-MS. The reflectron includes a decelerating section and a correcting section, with curved electric fields in the correcting and/or decelerating sections of the reflectron being considered. Moreover, analytic expressions are provided for calculating the profiles of the curved electric field in the second (correcting) section of the reflectron, which expressions are valid for arbitrary electric field distributions in the upstream and downstream regions as well as in the first (deceleration) section of the reflectron. These profiles will depend on the electric field distributions in the upstream and downstream regions and in the first (deceleration) section of the reflectron.
摘要翻译：本发明提供了一种反射器飞行时间质谱仪，其中在反射器的一部分中存在弯曲场，其考虑上游（从离子源到反射器）和下游的加速和减速场（从反射器到离子检测器）区域，其总是存在于任何TOF-MS中。反射镜包括减速部分和校正部分，在反射镜的校正和/或减速部分中考虑弯曲的电场。此外，提供分析表达式用于计算反射器的第二（校正）部分中的弯曲电场的轮廓，该表达式对于上游和下游区域以及第一（减速）区域中的任意电场分布是有效的，反射镜的一部分。这些轮廓将取决于上游和下游区域以及反射镜的第一（减速）部分中的电场分布。

3. 发明授权

US5696376A Method and apparatus for isolating ions in an ion trap with increased resolving power 失效
标题翻译：用于以更高的分辨能力分离离子阱中的离子的方法和装置
公开(公告)号：US5696376A
公开(公告)日：1997-12-09
申请号：US650411
申请日：1996-05-20
申请人： Vladimir M. Doroshenko , Robert J. Cotter
发明人： Vladimir M. Doroshenko , Robert J. Cotter
IPC分类号： H01J49/42 , B01D59/44 , H01J49/00
CPC分类号： H01J49/424 , H01J49/427
摘要： A method of operation of an ion trap mass spectrometer which isolates a first group of ions having a mass-to-charge ratio range is disclosed. The method includes producing ions from a plurality of atoms or molecules; trapping the ions in an ion trap by applying a trapping voltage to a ring electrode; applying an excitation voltage to a pair of end-cap electrodes; employing as the excitation voltage a first broadband excitation waveform and a second broadband excitation waveform, with the first waveform exciting the ions excluding substantially all of the first group and also excluding substantially all of a second group of ions having a range of mass-to-charge ratios about the first group's mass-to-charge ratio range, and the second waveform exciting the second group; applying the first waveform in order to eject the ions excluding substantially all of the first and second groups; and applying the second waveform in order to successively eject the second group of ions, according to the mass-to-charge ratios thereof, excluding substantially all of the first group of ions, thereby isolating the first group of ions. In another embodiment, the excitation voltage is a broadband excitation waveform having first, second, and third excitation portions, with the first and third portions exciting the ions excluding substantially all of the first group and also excluding substantially all of the second group, and the second portion exciting the second group. Associated apparatus is also disclosed.
摘要翻译：公开了分离具有质荷比范围的第一组离子的离子阱质谱仪的操作方法。该方法包括从多个原子或分子产生离子; 通过向环形电极施加捕获电压将离子捕获在离子阱中; 向一对端帽电极施加激励电压; 使用第一宽带激励波形和第二宽带激励波形作为激励电压，其中第一波形激励除了基本上所有第一组之外的离子，并且还排除基本上全部具有质量 - 电荷比关于第一组的质荷比范围，第二波形激励第二组; 施加第一波形以排出除了基本上所有第一和第二组之外的离子; 以及施加所述第二波形，以便根据其质荷比，连续地排出所述第二组离子，所述第二组离子基本上不包括所述第一组离子，从而隔离所述第一组离子。在另一个实施例中，激励电压是具有第一，第二和第三激励部分的宽带激励波形，其中第一和第三部分激励除了基本上所有第一组之外的离子，并且还排除了基本上所有的第二组，激励第二组的第二部分。还公开了相关装置。

4. 发明授权

US5464985A Non-linear field reflectron 失效
标题翻译：非线性场反射镜
公开(公告)号：US5464985A
公开(公告)日：1995-11-07
申请号：US130530
申请日：1993-10-01
申请人： Timothy J. Cornish , Robert J. Cotter
发明人： Timothy J. Cornish , Robert J. Cotter
IPC分类号： H01J49/40
CPC分类号： H01J49/405
摘要： A reflectron capable of focusing an entire mass range of product ions at substantially the same focal point, comprising a plurality of lens plates, each having an opening therein, for generating a non-linear electric field in the reflectron. To generate the non-linear electric field, the voltage applied to each successive lens plate increases non-linearly with respect to its adjacent lens plate. The voltage of the first lens plate having the opening through which the ions first enter the reflectron is set to a low potential and the voltage being applied to each successive lens plate increases in a non-linear manner with the largest voltage being applied to the lens plate furthest from the first lens plate. This non-linear voltage application, to generate the non-linear electric field, can be achieved by coupling a potentiometer between each lens plate and adjusting each potentiometer accordingly. Alternatively, to generate the non-linear electric field, the lens plates may be unequally spaced and an equal voltage may be applied to each lens plate.
摘要翻译：一种反射镜，其能够将基本上相同的焦点处的整个质量范围的产物离子聚焦，包括多个透镜板，每个透镜板在其中具有开口，用于在反射器中产生非线性电场。为了产生非线性电场，施加到每个连续透镜板的电压相对于其相邻的透镜板非线性增加。具有离子首先进入反射器的开口的第一透镜板的电压被设定为低电位，并且施加到每个连续透镜板的电压以非线性方式增加，其中施加到透镜的最大电压板最远离第一透镜板。用于产生非线性电场的非线性电压应用可以通过在每个透镜板之间耦合电位器并相应地调节每个电位器来实现。或者，为了产生非线性电场，透镜板可以不等间隔，并且可以向每个透镜板施加相等的电压。

5. 发明申请

US20110143453A1 ALBUMIN-BOUND PROTEIN/PEPTIDE COMPLEX AS A BIOMARKER FOR DISEASE 有权
标题翻译： ALBUMIN-BOUND蛋白/肽复合物作为疾病的生物标志物
公开(公告)号：US20110143453A1
公开(公告)日：2011-06-16
申请号：US12304895
申请日：2007-06-14
申请人： Jennifer E. Van Eyk , Rebekah Lynn Gundry , Robert J. Cotter
发明人： Jennifer E. Van Eyk , Rebekah Lynn Gundry , Robert J. Cotter
IPC分类号： G01N33/68 , G01N33/72 , G01N33/92 , B01D59/44 , G01N30/02
CPC分类号： G01N33/6893 , G01N33/6848 , G01N2333/76 , G01N2800/00 , G01N2800/324
摘要： Methods and kits for diagnosis and prognosis using biomarkers comprising albumin-bound protein/peptide complex (ABPPC).
摘要翻译：使用包含白蛋白结合蛋白/肽复合物（ABPPC）的生物标志物进行诊断和预后的方法和试剂盒。

6. 发明授权

US5624332A Golf ball core patching method 失效
标题翻译：高尔夫球核心修补方法
公开(公告)号：US5624332A
公开(公告)日：1997-04-29
申请号：US482523
申请日：1995-06-07
申请人： Jeffrey L. Dalton , Robert J. Cotter
发明人： Jeffrey L. Dalton , Robert J. Cotter
IPC分类号： A63B37/00 , A63B45/00 , B05D3/06 , B29C35/02 , B29C35/08 , A63B37/08
CPC分类号： B05D3/067 , A63B37/0052 , A63B37/0074 , A63B45/00 , B29C35/0266 , A63B37/0003 , B29C2035/0827 , B29C2035/0877 , B29L2031/54 , Y10T29/49712
摘要： A method of producing a sealed, liquid filled spherical object for use in a golf ball core comprising the steps of;(a) providing a hollow spherical object;(b) injecting a flowable material into said spherical object wherein said injecting produces an aperture in said spherical object;(c) sealing said aperture with a radiation curable polymer; and(d) exposing said radiation curable polymer to radiation in an amount and for a time sufficient to cure said polymer.
摘要翻译：一种制造用于高尔夫球芯的密封的充满液体的球形物体的方法，包括以下步骤：（a）提供中空的球形物体; （b）将可流动材料注射到所述球形物体中，其中所述注射在所述球形物体中产生孔; （c）用可辐射固化聚合物密封所述孔; 和（d）将所述可辐射固化聚合物暴露于足以固化所述聚合物的量和一段时间内的辐射。

7. 发明授权

US5596050A High modulus epoxy resin systems 失效
标题翻译：高模量环氧树脂体系
公开(公告)号：US5596050A
公开(公告)日：1997-01-21
申请号：US583358
申请日：1984-03-01
申请人： Hugh C. Gardner , Michael J. Michno, Jr. , Robert J. Cotter
发明人： Hugh C. Gardner , Michael J. Michno, Jr. , Robert J. Cotter
IPC分类号： C08G59/06 , C08G59/10 , C08G59/22 , C08G59/24 , C08G59/38 , C08L63/00
CPC分类号： C08G59/226 , C08G59/066 , C08G59/10 , C08G59/24 , C08G59/38 , C08L63/00
摘要： Described herein are resinous compositions comprising a particular cycloaliphatic epoxy resin and the adduct of these epoxy resins with an aromatic active hydrogen-containing compound. These compositions afford unreinforced castings with higher heat deflection temperatures, faster cure rates, and reduced water uptake than similar compositions containing epoxy adducts made from aliphatic polyols.
摘要翻译：本文描述了包含特定脂环族环氧树脂和这些环氧树脂与芳族含活性氢的化合物的加合物的树脂组合物。与含有由脂族多元醇制成的环氧加合物的组合物相比，这些组合物提供具有较高热变形温度，较快固化速率和降低吸水率的未增强铸件。

8. 发明授权

US4939199A Novel poly(aryl ethers) useful for molding into a circuit board substrate 失效
标题翻译：用于模塑成电路板基底的新型聚（芳基醚）
公开(公告)号：US4939199A
公开(公告)日：1990-07-03
申请号：US286519
申请日：1988-12-19
申请人： Robert J. Cotter , Stephen B. Rimsa , Robert Barclay, Jr.
发明人： Robert J. Cotter , Stephen B. Rimsa , Robert Barclay, Jr.
IPC分类号： C08G75/23 , H05K1/03
CPC分类号： C08G75/23 , H05K1/0333
摘要： Described herein are circuit board substrates prepared from certain poly(aryl ethers) based on 4,4'-dichlorodiphenyl sulfone.
摘要翻译：这里描述的是由基于4,4'-二氯二苯砜的某些聚（芳基醚）制备的电路板基底。

9. 发明授权

US4594404A Polycarbonates having improved hydrolytic stability 失效
标题翻译：聚碳酸酯具有改善的水解稳定性
公开(公告)号：US4594404A
公开(公告)日：1986-06-10
申请号：US591539
申请日：1984-03-20
申请人： James H. Kawakami , James E. Harris , Louis M. Maresca , Lloyd M. Robeson , Robert J. Cotter
发明人： James H. Kawakami , James E. Harris , Louis M. Maresca , Lloyd M. Robeson , Robert J. Cotter
IPC分类号： C08G64/08 , C08G63/62
CPC分类号： C08G64/081
摘要： This invention relates to moldable polycarbonate compositions and in particular to moldable polycarbonates which have ordered alternating repeating units derived from bis-(3,5-dimethyl-4-hydroxyphenyl)sulfone (TMBS) and 2,2-bis-(4-hydroxyphenyl)propane (Bisphenol A) dihaloformate, or ordered, alternating repeating units derived from bis-(3,5-dimethyl-4-hydroxyphenyl) sulfone (TMBS) dihaloformate and a bisphenol compound such as 2,2-bis-(4-hydroxyphenyl)propane (Bisphenol A). Such polycarbonates exhibit improved hydrolytic stability and also excellent processability in molding applications.
摘要翻译：本发明涉及可模制的聚碳酸酯组合物，特别涉及可衍生的聚碳酸酯，其具有衍生自双 - （3,5-二甲基-4-羟基苯基）砜（TMBS）和2,2-双 - （4-羟基苯基）丙二醇（双酚A）二卤代甲酸酯，或有序的衍生自二 - （3,5-二甲基-4-羟基苯基）砜（TMBS）二卤代甲酸酯和双酚化合物如2,2-双 - （4-羟基苯基）丙烷（双酚A）。这种聚碳酸酯表现出改善的水解稳定性和在成型应用中的优异加工性能。

10. 发明授权

US07271397B2 Combined chemical/biological agent detection system and method utilizing mass spectrometry 有权
标题翻译：组合化学/生物试剂检测系统和利用质谱法的方法
公开(公告)号：US07271397B2
公开(公告)日：2007-09-18
申请号：US10515300
申请日：2003-07-17
申请人： Wayne A. Bryden , Robert J. Cotter , Scott A. Ecelberger
发明人： Wayne A. Bryden , Robert J. Cotter , Scott A. Ecelberger
IPC分类号： H01J49/44
CPC分类号： H01J49/147 , H01J49/107
摘要： A mass spectrometer is provided herein and is configured to have two ionization sources, in which a first ionization source, such as MALDI, ESI and the like, which is capable of providing in addition to ions a set of normally intractable desorbed neutrals that are ionized by a second EI source coupled with the first source.
摘要翻译：本文提供了一种质谱仪，并且被配置为具有两个电离源，其中第一电离源如MALDI，ESI等能够提供除离子之外的一组正常难溶的解吸的中性粒子，其被离子化通过与第一源耦合的第二EI源。

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