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    • 3. 发明申请
    • Method for making a porous polymeric material
    • 制造多孔聚合材料的方法
    • US20050075408A1
    • 2005-04-07
    • US10948486
    • 2004-09-23
    • Timothy RingeisenScott Goldman
    • Timothy RingeisenScott Goldman
    • C08J9/28
    • C08J9/0033A61L27/34A61L27/54B29C41/12B29C41/14B29C45/0001C08J9/0014C08J9/0023C08J9/0028C08J9/28C08J2201/054
    • Porous polymers having a plurality of openings or chambers that are highly convoluted, with each chamber being defined by multiple, thin, flat partitions are produced by a new gel enhanced phase separation technique. In a preferred embodiment, a second liquid is added to a polymer solution, the second liquid causing the solution to increase in viscosity. With sufficient polymer and second liquid present, the increase in viscosity can be up to that of a gel. The gel can then be shaped as needed. Subsequent solvent extraction leaves the porous polymeric body of defined shape. The porous polymers have utility as medical prostheses, the porosity permitting ingrowth of neighboring tissue. A second material may be incorporated into the chambers, thereby creating a microstructure filling the voids of the macrostructure. A porous polymeric body manufactured by this process may incorporate biologically active agents, and which agents may be delivered in a time-staged delivery manner, where differing drugs may be delivered over differing periods.
    • 通过新的凝胶增强相分离技术产生多孔聚合物,其具有高度卷曲的多个开口或室,每个室由多个薄的平坦隔板限定。 在优选的实施方案中,将第二液体加入到聚合物溶液中,使第二液体溶液增加粘度。 当存在足够的聚合物和第二液体时,粘度的增加可以达到凝胶的增加。 然后可以根据需要成型凝胶。 随后的溶剂萃取离开具有限定形状的多孔聚合物体。 多孔聚合物可用作医用假体,孔隙度允许相邻组织向内生长。 可以将第二材料并入室中,从而产生填充宏观结构的空隙的微结构。 通过该方法制造的多孔聚合体可以并入生物活性剂,并且哪些试剂可以按时间递送方式递送,其中不同的药物可以在不同的时期内递送。