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1. 发明申请

US20110245164A1 YL-BASED INSULIN-LIKE GROWTH FACTORS EXHIBITING HIGH ACTIVITY AT THE INSULIN RECEPTOR 审中-公开
标题翻译：基于YL的胰岛素样生长因子在胰岛素受体中展示高活性
公开(公告)号：US20110245164A1
公开(公告)日：2011-10-06
申请号：US13130960
申请日：2009-12-18
申请人： Richard D. DiMarchi , Shujiang Cheng , Binbin Kou , Jie Han
发明人： Richard D. DiMarchi , Shujiang Cheng , Binbin Kou , Jie Han
IPC分类号： A61K38/28 , C07K14/62 , A61K38/30 , A61P3/10 , C07K14/65
CPC分类号： C07K14/65 , A61K38/00
摘要： Insulin-like growth factor analogs are disclosed wherein substitution of the IGF native amino acids, at positions corresponding to positions B16 and B17 of native insulin, with tyrosine and leucine, respectively, increases potency of the resulting analog at the insulin receptor by tenfold. Also disclosed are prodrug and depot formulations of the IGF analogs, wherein the IGF analog has been modified by the linkage of a dipeptide to the analog through an amide bond linkage. The prodrug and depot formulations disclosed herein have extended half lives of at least 2 hours, 10 hours, and more typically greater than 2 are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability.
摘要翻译：公开了胰岛素样生长因子类似物，其中分别用酪氨酸和亮氨酸取代天然胰岛素的位置B16和B17处的IGF天然氨基酸将胰岛素受体上得到的类似物的效力增加十倍。还公开了IGF类似物的前药和贮库制剂，其中IGF类似物已经通过二肽与类似物通过酰胺键连接而被修饰。本文公开的前药和贮库制剂具有至少2小时，10小时，更典型地大于2的半衰期在生理条件下通过由化学不稳定性驱动的非酶反应而转化为活性形式。

2. 发明授权

US08481485B2 Insulin analogs 有权
标题翻译：胰岛素类似物
公开(公告)号：US08481485B2
公开(公告)日：2013-07-09
申请号：US13130976
申请日：2009-12-18
申请人： Richard D. DiMarchi , Jie Han
发明人： Richard D. DiMarchi , Jie Han
IPC分类号： A61K38/28 , A61K38/00 , A61K38/04 , A61P5/50 , A61P3/08 , A61P3/10 , A61P7/12 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00
CPC分类号： C07K14/62
摘要： Full potency analogs of insulin are provided wherein the analog comprises a modification of the tyrosine residue at position 19 of the A chain.
摘要翻译：提供胰岛素的全效能类似物，其中所述类似物包含A链第19位的酪氨酸残基的修饰。

3. 发明申请

US20110257091A1 INSULIN ANALOGS 有权
标题翻译：胰岛素类似物
公开(公告)号：US20110257091A1
公开(公告)日：2011-10-20
申请号：US13130976
申请日：2009-12-18
申请人： Richard D. DiMarchi , Jie Han
发明人： Richard D. DiMarchi , Jie Han
IPC分类号： A61K38/28 , C07K14/62 , A61P3/10 , C07K14/00
CPC分类号： C07K14/62
摘要： Full potency analogs of insulin are provided wherein the analog comprises a modification of the tyrosine residue at position 19 of the A chain.
摘要翻译：提供胰岛素的全效能类似物，其中所述类似物包含A链第19位的酪氨酸残基的修饰。

4. 发明申请

US20130271763A1 INSPECTION DEVICE AND METHOD THEREOF 有权
标题翻译：检查装置及其方法
公开(公告)号：US20130271763A1
公开(公告)日：2013-10-17
申请号：US13448691
申请日：2012-04-17
申请人： Tao Li , Guiju Song , Kevin George Harding , Dongmin Yang , Zirong Zhai , Jie Han , Gil Abramovich
发明人： Tao Li , Guiju Song , Kevin George Harding , Dongmin Yang , Zirong Zhai , Jie Han , Gil Abramovich
IPC分类号： G01J4/00
CPC分类号： G01N21/8806 , G01N21/21 , G01N21/8803 , G01N21/954 , G02B5/3083 , G02B23/243 , G02B26/00 , G02B27/0075 , G02B27/286
摘要： An optical system configured to visually inspect a target having a variable position with respect to the optical system is provided. The optical system includes a polarizer configured to convert an incident light reflected or diffused from the target into linearly polarized light; a light modulating element configured to modulate a polarization state of the linearly polarized light in response to control signals; and a lens group comprising at least one birefringent element, the birefringent element configured to refract or reflect the modulated linearly polarized light with a first polarization state under a first refraction index to enable inspection of the target at a first object position, and the birefringent element further configured to refract or reflect the modulated linearly polarized light with a second polarization state under a second refraction index to enable inspection of the target at a second object position.
摘要翻译：提供一种被配置为目视检查相对于光学系统具有可变位置的目标的光学系统。光学系统包括：偏振器，被配置为将从目标反射或扩散的入射光转换成线偏振光; 光调制元件，被配置为响应于控制信号调制所述线偏振光的偏振状态; 以及包括至少一个双折射元件的透镜组，所述双折射元件被配置为在第一折射率下折射或反射具有第一偏振态的调制线偏振光，以使得能够在第一物体位置检查所述目标，并且所述双折射元件还被配置为在第二折射率下折射或反射具有第二偏振状态的经调制的线性偏振光，以使得能够在第二物体位置检查目标。

5. 发明授权

US07820429B2 Method for dry fermentation and equipment for carrying out the same 失效
标题翻译：干发酵方法及其进行设备
公开(公告)号：US07820429B2
公开(公告)日：2010-10-26
申请号：US11571175
申请日：2005-07-14
申请人： Jie Han , Yuhua Zhang , Tong Chen , Xin Xiang
发明人： Jie Han , Yuhua Zhang , Tong Chen , Xin Xiang
IPC分类号： C12M1/00 , C12M3/00 , C12M1/02 , C12M1/10
CPC分类号： C05F17/0027 , C12M21/04 , C12M21/16 , C12M23/38 , Y02E50/343 , Y02P20/145 , Y02W30/43 , Y02W30/47
摘要： The present invention relates to a method for dry fermentation and equipment for carrying out the same. The invention equipment comprises a fermentation tank for dry fermentation which includes a tank body 5 for accommodating materials, a flexible sealing membrane 7 for covering said tank body 5, and a tight fixing means 3 for hermetically covering the tank body 5 with the flexible sealing membrane 7. This invention is characterized in that said tank body 5 is provided with a top opening 2 at its top part and at least one side opening 4 for loading and unloading materials at its side portions. When the tank body 5 is covered hermetically by the flexible sealing membrane 7, said tight fixing means 3 makes the contact area 6 between the tank body 5 and the flexible sealing membrane 7 form at least one sealing contacting strip or at least one sealing line which is continuous and close in three-dimensional space so that the flexible sealing membrane 7 covers hermetically both the top opening 2 and at least one side opening 4 for loading and unloading materials.
摘要翻译：本发明涉及一种干发酵方法及其设备。本发明的设备包括用于干发酵的发酵罐，其包括用于容纳材料的罐体5，用于覆盖所述罐体5的柔性密封膜7和用于通过柔性密封膜气密地覆盖罐体5的紧固固定装置3 本发明的特征在于，所述罐体5在其顶部设置有顶部开口2和至少一个用于在其侧部装载和卸载材料的侧面开口4。当罐体5被柔性密封膜7气密地覆盖时，所述紧固固定装置3使得罐体5和柔性密封膜7之间的接触区域6形成至少一个密封接触条或至少一条密封线，在三维空间中连续紧密，使得柔性密封膜7气密地覆盖顶部开口2和用于装载和卸载材料的至少一个侧面开口4。

6. 发明申请

US20080248541A1 Equipment and Method for Dry Ferment 失效
标题翻译：干发酵设备和方法
公开(公告)号：US20080248541A1
公开(公告)日：2008-10-09
申请号：US11571175
申请日：2005-07-14
申请人： Jie Han , Yuhua Zhang , Tong Chen , Xin Xiang
发明人： Jie Han , Yuhua Zhang , Tong Chen , Xin Xiang
IPC分类号： C12P1/00 , C12M1/00
CPC分类号： C05F17/0027 , C12M21/04 , C12M21/16 , C12M23/38 , Y02E50/343 , Y02P20/145 , Y02W30/43 , Y02W30/47
摘要： The present invention relates to a method for dry fermentation and equipment for carrying out the same. The invention equipment comprises a fermentation tank for dry fermentation which includes a tank body 5 for accommodating materials, a flexible sealing membrane 7 for covering said tank body 5, and a tight fixing means 3 for hermetically covering the tank body 5 with the flexible sealing membrane 7. This invention is characterized in that said tank body 5 is provided with a top opening 2 at its top part and at least one side opening 4 for loading and unloading materials at its side portions. When the tank body 5 is covered hermetically by the flexible sealing membrane 7, said tight fixing means 3 makes the contact area 6 between the tank body 5 and the flexible sealing membrane 7 form at least one sealing contacting strip or at least one sealing line which is continuous and close in three-dimensional space so that the flexible sealing membrane 7 covers hermetically both of the top opening 2 and at least one side opening 4 for loading and unloading materials.
摘要翻译：本发明涉及一种干发酵方法及其设备。本发明的设备包括用于干发酵的发酵罐，其包括用于容纳材料的罐体5，用于覆盖所述罐体5的柔性密封膜7和用于通过柔性密封膜气密地覆盖罐体5的紧固固定装置3 本发明的特征在于，所述罐体5在其顶部设置有顶部开口2和至少一个用于在其侧部装载和卸载材料的侧面开口4。当罐体5被柔性密封膜7气密地覆盖时，所述紧固固定装置3使得罐体5和柔性密封膜7之间的接触区域6形成至少一个密封接触条或至少一条密封线，在三维空间中连续紧密，使得柔性密封膜7气密地覆盖顶部开口2和用于装载和卸载材料的至少一个侧面开口4。

7. 发明申请

US20070284290A1 Method for Dismantling Capsules and an Apparatus Using Thereof 审中-公开
标题翻译：拆解胶囊的方法及其使用的装置
公开(公告)号：US20070284290A1
公开(公告)日：2007-12-13
申请号：US11630256
申请日：2005-05-16
申请人： Jie Han
发明人： Jie Han
IPC分类号： B07B7/00
CPC分类号： B65B69/00 , A61J3/074 , B67B7/00
摘要： This invention provides a method with an apparatus used during the steps of the method to dismantle capsules, the method comprising steps as firstly putting the capsules into a pressure vessel, secondly filling the pressure vessel with compressed air, to make the high-pressure air get into the capsules through the gap between the capsule body and the capsule cap, then quickly lowering the air pressure inside the pressure vessel, to generate a pressure difference between inside and outside of each capsule, making the compressed air inside each capsule expand, and at last the expansion force make the capsule body and the capsule cap be separated. Compared with the convention method of manually dismantling capsules, this method has many advantages such as more quickly dismantling, more efficiently separation of druggery and so on.
摘要翻译：本发明提供一种在胶囊拆卸方法的步骤中使用的装置的方法，所述方法包括首先将胶囊放入压力容器中，其次用压缩空气填充压力容器，以使高压空气得到通过胶囊主体和胶囊盖之间的间隙进入胶囊，然后快速降低压力容器内的空气压力，从而在每个胶囊的内部和外部之间产生压力差，使每个胶囊内的压缩空气膨胀，并且在最后的膨胀力使胶囊体和胶囊盖分开。与手动拆解胶囊的常规方法相比，该方法具有拆卸更快，药物分离更加有效等优点。

8. 发明申请

US20200291086A1 BIOREVERSABLE PROMOIETIES FOR NITROGEN-CONTAINING AND HYDROXYL-CONTAINING DRUGS 审中-公开
公开(公告)号：US20200291086A1
公开(公告)日：2020-09-17
申请号：US16822510
申请日：2020-03-18
申请人： Jie Han
发明人： Jie Han
IPC分类号： C07K14/62 , A61K47/60 , A61K47/54 , A61K47/64 , C07K14/575 , C07K19/00
摘要： Disclosed are promoieties of the following formula which can be used to form prodrugs of nitrogen-containing or hydroxyl-containing drug or a pharmaceutically active agent: and pharmaceutical compositions comprising the prodrugs.

9. 发明授权

US06831017B1 Catalyst patterning for nanowire devices 有权
标题翻译：用于纳米线器件的催化剂图案化
公开(公告)号：US06831017B1
公开(公告)日：2004-12-14
申请号：US10117866
申请日：2002-04-05
申请人： Jun Li , Alan M. Cassell , Jie Han
发明人： Jun Li , Alan M. Cassell , Jie Han
IPC分类号： H01L21311
CPC分类号： H01L21/2885 , B82Y10/00 , C30B11/12 , C30B29/605 , C30B29/62 , H01L21/02381 , H01L21/02576 , H01L21/02603 , H01L21/02639 , H01L21/02645 , H01L21/28562 , H01L21/76885 , H01L2221/1094 , Y10S977/75 , Y10S977/762 , Y10S977/887
摘要： Nanowire devices may be provided that are based on carbon nanotubes or single-crystal semiconductor nanowires. The nanowire devices may be formed on a substrate. Catalyst sites may be formed on the substrate. The catalyst sites may be formed using lithography, thin metal layers that form individual catalyst sites when heated, collapsible porous catalyst-filled microscopic spheres, microscopic spheres that serve as masks for catalyst deposition, electrochemical deposition techniques, and catalyst inks. Nanowires may be grown from the catalyst sites.
摘要翻译：可以提供基于碳纳米管或单晶半导体纳米线的纳米线器件。纳米线器件可以形成在衬底上。可以在衬底上形成催化剂位点。可以使用光刻法形成催化剂位点，当加热时形成单个催化剂位点的薄金属层，可折叠多孔催化剂填充的微球，用作催化剂沉积掩模的微观球体，电化学沉积技术和催化剂油墨。纳米线可以从催化剂部位生长。

10. 发明授权

US11285103B2 Degradable hydrogel under physiological conditions 有权
公开(公告)号：US11285103B2
公开(公告)日：2022-03-29
申请号：US16063687
申请日：2016-12-19
申请人： Jie Han
发明人： Jie Han
IPC分类号： A61K38/26 , A61K38/28 , A61K47/60 , A61K47/69 , A61K9/06
摘要： The present invention discloses a hydrogel that can be degraded under physiological conditions. The hydrogel includes at least one backbone moiety and an optional crosslinking moiety, and biodegradable linkers connecting backbone moieties and crosslinking moieties can be degraded by intramolecular cyclization.

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