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1. 发明授权

US08447412B2 Apparatus and methods for wireless communication via electrical pulses conducted by the interstitial tissues of the body for an active implantable medical device 有权
标题翻译：用于通过用于主动植入式医疗装置的身体的间质组织传导的电脉冲进行无线通信的装置和方法
公开(公告)号：US08447412B2
公开(公告)日：2013-05-21
申请号：US13245155
申请日：2011-09-26
申请人： Renzo Dal Molin , Ashutosh Ghildiyal
发明人： Renzo Dal Molin , Ashutosh Ghildiyal
IPC分类号： A61N1/18
CPC分类号： A61N1/37217 , A61B5/0028 , A61B5/0031 , A61B5/0215 , A61B5/042 , A61B5/1118 , A61B5/14542 , A61B2562/162 , A61N1/37205 , A61N1/3727 , A61N1/37288 , H04B13/005
摘要： An active implantable medical device having wireless communication of data via electrical pulses conducted by the interstitial tissues of the body. This device (12, 14) includes a pair of electrodes (22, 24) and generates pulse trains consisting of a series of electrical pulses applied to the electrodes. The pulse train is modulated by digital information (data) that is produced by the device. A regulated current or voltage source (42) is used to generate (44, 48) current or voltage pulses to form the pulse train. Each current or voltage pulse is a biphasic pulse comprising a positive and negative alternation. The biphasic current or voltage modulated by the digital information, is injected between the electrodes (22, 24) and wirelessly communicated.
摘要翻译：一种主动植入式医疗装置，其通过由身体的间质组织传导的电脉冲进行数据的无线通信。该装置（12,14）包括一对电极（22,24），并且产生由施加到电极的一系列电脉冲组成的脉冲串。脉冲串由设备产生的数字信息（数据）进行调制。使用调节电流或电压源（42）产生（44,48）电流或电压脉冲以形成脉冲串。每个电流或电压脉冲是包括正和负交变的双相脉冲。由数字信息调制的双相电流或电压被注入到电极（22,24）之间并进行无线通信。

2. 发明申请

US20120263218A1 APPARATUS AND METHOD FOR QUANTIFICATION OF THE DESYNCHRONIZATION BETWEEN THE CLOCKS OF TWO HBC ACTIVE IMPLANTS 有权
标题翻译：用于定量两个HBC活动植入物的时钟之间的分离的装置和方法
公开(公告)号：US20120263218A1
公开(公告)日：2012-10-18
申请号：US13370200
申请日：2012-02-09
申请人： Renzo Dal Molin , Ashutosh Ghildiyal
发明人： Renzo Dal Molin , Ashutosh Ghildiyal
IPC分类号： H04B17/00
CPC分类号： A61N1/37288 , A61N1/37205 , A61N1/3962 , G06F1/06 , G06F1/12 , H04B3/46 , H04B17/00 , H04J3/06 , H04Q1/20
摘要： A method for quantification of the desynchronization between the clocks of two medical devices communicating wirelessly, for example, by HBC signals. The devices are separately clocked by slow clocks (CLK1/32k, CLK2/32k) and include selectively activated fast clocks (CLK1/10M, CLK2/10M). The method comprises: a) on a predetermined transition (T1) of a slow clock, transmission by one device of a synchronization query signal (SYNC) to the other device, b) counting of the pulses of the activated fast clock to detect a predetermined transition (T3) of the first slow clock, then c) transmitting from the other device to the first device a response signal (D1) and d) upon reception of the response signal, computing a temporal shift (OFFSET) according to the result (D1, D2) of the counting of the pulses of the fast clock. Two fast clocks, one on each device, also can be used.
摘要翻译：用于定量通过HBC信号无线通信的两个医疗设备的时钟之间的去同步化的方法。器件分别由慢时钟（CLK1 / 32k，CLK2 / 32k）提供时钟，并包括有选择地激活的快速时钟（CLK1 / 10M，CLK2 / 10M）。该方法包括：a）在慢时钟的预定转换（T1）上，由一个设备向另一个设备发送同步查询信号（SYNC）; b）计数激活的快速时钟的脉冲，以检测预定的转换（T3），然后c）在接收到响应信号时从另一个设备向第一设备发送响应信号（D1）和d），d）根据结果计算时间偏移（OFFSET） D1，D2）对快时钟脉冲的计数。每个设备上有两个快速时钟，也可以使用。

3. 发明授权

US08705599B2 Apparatus and method for quantification of the desynchronization between the clocks of two HBC active implants 有权
标题翻译：用于量化两个HBC活性植入物的时钟之间的失步的装置和方法
公开(公告)号：US08705599B2
公开(公告)日：2014-04-22
申请号：US13370200
申请日：2012-02-09
申请人： Renzo dal Molin , Ashutosh Ghildiyal
发明人： Renzo dal Molin , Ashutosh Ghildiyal
IPC分类号： H04B3/46 , H04B17/00 , H04Q1/20
CPC分类号： A61N1/37288 , A61N1/37205 , A61N1/3962 , G06F1/06 , G06F1/12 , H04B3/46 , H04B17/00 , H04J3/06 , H04Q1/20
摘要： A method for quantification of the desynchronization between the clocks of two medical devices communicating wirelessly, for example, by HBC signals. The devices are separately clocked by slow clocks (CLK1/32k, CLK2/32k) and include selectively activated fast clocks (CLK1/10M, CLK2/10M). The method comprises: a) on a predetermined transition (T1) of a slow clock, transmission by one device of a synchronization query signal (SYNC) to the other device, b) counting of the pulses of the activated fast clock to detect a predetermined transition (T3) of the first slow clock, then c) transmitting from the other device to the first device a response signal (D1) and d) upon reception of the response signal, computing a temporal shift (OFFSET) according to the result (D1, D2) of the counting of the pulses of the fast clock. Two fast clocks, one on each device, also can be used.
摘要翻译：用于定量通过HBC信号无线通信的两个医疗设备的时钟之间的去同步化的方法。器件分别由慢时钟（CLK1 / 32k，CLK2 / 32k）提供时钟，并包括有选择地激活的快速时钟（CLK1 / 10M，CLK2 / 10M）。该方法包括：a）在慢时钟的预定转换（T1）上，由一个设备向另一个设备发送同步查询信号（SYNC）; b）计数激活的快速时钟的脉冲，以检测预定的转换（T3），然后c）在接收到响应信号时从另一个设备向第一设备发送响应信号（D1）和d），d）根据结果计算时间偏移（OFFSET） D1，D2）对快时钟脉冲的计数。每个设备上有两个快速时钟，也可以使用。

4. 发明授权

US08577327B2 System, methods and apparatus for waking an autonomous active implantable medical device communicating by pulses transmitted through the interstitial tissues of the body 有权
标题翻译：用于通过穿过身体的间质组织的脉冲通信的用于唤醒自主有源可植入医疗装置的系统，方法和装置
公开(公告)号：US08577327B2
公开(公告)日：2013-11-05
申请号：US13276198
申请日：2011-10-18
申请人： Alaa Makdissi , Karima Amara , Ashutosh Ghildiyal
发明人： Alaa Makdissi , Karima Amara , Ashutosh Ghildiyal
IPC分类号： H04B1/16 , H04K3/00
CPC分类号： A61B5/0028 , A61N1/37217 , A61N1/37276 , A61N1/37288
摘要： An autonomous active medical implantable device, with a power supply and a wake-up circuit that responds to receipt of specific pulses transmitted through the interstitial tissues of the body. A transmitter device (40) generates trains of modulated pulses applied to electrodes (22, 24), and a receiver (50) processes (e.g., filter, amplify and demodulate) pulses collected on electrodes (22′, 24′). The receiver circuits (50) are selectively activated from a dormant (sleep) state in which they are not powered by a power source (34), to an operational (active) state in which they are powered and able to process (e.g., filter, amplify and demodulate) the collected pulses. A specific wake-up pulse train, configured in a predetermined characteristic pulse pattern, triggers passive wake-up circuits (66) in the receiver (50) to switch the receiver circuits from the sleep state to the operational state.
摘要翻译：一种具有电源和唤醒电路的自主主动医用可植入装置，其响应于通过身体的间隙组织传输的特定脉冲的接收。发射机设备（40）产生施加到电极（22,24）的调制脉冲串，并且接收器（50）处理（例如，滤波，放大和解调）在电极（22'，24'）上收集的脉冲。接收器电路（50）被选择性地从休眠（休眠）状态激活，其中它们不由电源（34）供电到处于它们被供电并能够处理的操作（活动）状态（例如，滤波器，放大和解调）收集的脉冲。以预定特征脉冲模式配置的特定唤醒脉冲串触发接收器（50）中的被动唤醒电路（66），以将接收器电路从睡眠状态切换到操作状态。

5. 发明申请

US20120093245A1 System, Methods And Apparatus For Waking An Autonomous Active Implantable Medical Device Communicating By Pulses Transmitted Through The Interstitial Tissues Of The Body 有权
标题翻译：用于通过身体间质组织传播的脉冲进行通信的自动有源植入式医疗装置的系统，方法和装置
公开(公告)号：US20120093245A1
公开(公告)日：2012-04-19
申请号：US13276198
申请日：2011-10-18
申请人： Alaa Makdissi , Karima Amara , Ashutosh Ghildiyal
发明人： Alaa Makdissi , Karima Amara , Ashutosh Ghildiyal
IPC分类号： H04L27/00
CPC分类号： A61B5/0028 , A61N1/37217 , A61N1/37276 , A61N1/37288
摘要： An autonomous active medical implantable device, with a power supply and a wake-up circuit that responds to receipt of specific pulses transmitted through the interstitial tissues of the body transmitter device (40) generates trains of modulated pulses applied to electrodes (22, 24), and a receiver (50) processes (e.g., filter, amplify and demodulate) pulses collected on electrodes (22′, 24′). The receiver circuits (50) are selectively activated from a dormant (sleep) state in which they are not powered by a power source (34), to an operational (active) state in which they are powered and able to process (e.g., filter, amplify and demodulate) the collected pulses specific wake-up pulse train, configured in a predetermined characteristic pulse pattern triggers passive wake-up circuits (66) in the receiver (50) to switch the receiver circuits from the sleep state to the operational state.
摘要翻译：具有电源和唤醒电路的自主主动医疗可植入装置响应于通过身体发射器装置（40）的间隙组织传输的特定脉冲的响应，产生施加到电极（22,24）的调制脉冲的列，，并且接收器（50）处理（例如，滤波，放大和解调）在电极（22'，24'）上收集的脉冲。接收器电路（50）被选择性地从休眠（休眠）状态激活，其中它们不由电源（34）供电到处于它们被供电并能够处理的操作（活动）状态（例如，滤波器，放大和解调）以预定特征脉冲模式配置的收集的脉冲特定的唤醒脉冲串触发接收器（50）中的被动唤醒电路（66），以将接收器电路从睡眠状态切换到操作状态。

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