专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5668256A Chimeric interleukin 5-receptor/immunoglobulin polypeptides 失效
标题翻译：嵌合白介素5受体/免疫球蛋白多肽
公开(公告)号：US5668256A
公开(公告)日：1997-09-16
申请号：US421822
申请日：1995-04-13
申请人： Rene Devos , Walter Fiers , Jose van der Heyden , Geert Plaetinck , Jan Tavernier
发明人： Rene Devos , Walter Fiers , Jose van der Heyden , Geert Plaetinck , Jan Tavernier
IPC分类号： A61K38/00 , A61P11/00 , C07K14/715 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C07K16/46
CPC分类号： C07K14/7155 , C07K16/2866 , C07K19/00 , A61K38/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C07K2319/32
摘要： Chimeric polypeptides encoded by a DNA sequence having a first DNA subsequence coding for a fragment of at least one of the .alpha.- and/or .beta.-chain of the human interleukin-5 receptor, and a second DNA subsequence coding for the constant domains of a heavy- or a light-chain of a human immunoglobulin, or a fragment thereof are useful in treating illnesses with demonstrated eosinophilia.
摘要翻译：由具有编码人白细胞介素-5受体的α和/或β链中的至少一个的片段的第一DNA亚序列的DNA序列编码的嵌合多肽和编码人白细胞介素-5受体的恒定结构域的第二DNA亚序列人免疫球蛋白的重链或轻链或其片段可用于治疗伴有嗜酸性粒细胞增多症的疾病。

2. 发明授权

US5455337A DNA encoding chimeric polypeptides comprising the interleukin-5 receptor .alpha.-chain fused to immunoglobulin heavy chain constant regions 失效
标题翻译：编码包含与免疫球蛋白重链恒定区融合的白细胞介素-5受体α-链的嵌合多肽的DNA
公开(公告)号：US5455337A
公开(公告)日：1995-10-03
申请号：US947130
申请日：1992-09-16
申请人： Rene Devos , Walter Fiers , Jose van der Heyden , Geert Plaetinck , Jan Tavernier
发明人： Rene Devos , Walter Fiers , Jose van der Heyden , Geert Plaetinck , Jan Tavernier
IPC分类号： A61K38/00 , A61P11/00 , C07K14/715 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C07H21/04 , C12N1/21 , C12N15/11
CPC分类号： C07K14/7155 , C07K16/2866 , C07K19/00 , A61K38/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C07K2319/32
摘要： Chimeric polypeptides encoded by a DNA sequence having a first DNA subsequence coding for a fragment of at least one of the .alpha.- and/or .beta.-chain of the human interleukin-5 receptor, and a second DNA subsequence coding for the constant domains of a heavy- or a light-chain of a human immunoglobulin, or a fragment thereof are useful in treating illnesses with demonstrated eosinophilia.
摘要翻译：由具有编码人白细胞介素-5受体的α和/或β链中的至少一个的片段的第一DNA亚序列的DNA序列编码的嵌合多肽和编码人白细胞介素-5受体的恒定结构域的第二DNA亚序列人免疫球蛋白的重链或轻链或其片段可用于治疗伴有嗜酸性粒细胞增多症的疾病。

3. 发明授权

US5712121A Chimeric interleukin 5-receptor/immunoglobulin polypeptides 失效
标题翻译：嵌合白介素5受体/免疫球蛋白多肽
公开(公告)号：US5712121A
公开(公告)日：1998-01-27
申请号：US421823
申请日：1995-04-13
申请人： Rene Devos , Walter Fiers , Jose van der Heyden , Geert Plaetinck , Jan Tavernier
发明人： Rene Devos , Walter Fiers , Jose van der Heyden , Geert Plaetinck , Jan Tavernier
IPC分类号： A61K38/00 , A61P11/00 , C07K14/715 , C07K16/28 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C07K14/00 , C12N15/11 , C12N15/64
CPC分类号： C07K14/7155 , C07K16/2866 , C07K19/00 , A61K38/00 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C07K2319/32
摘要： Chimeric polypeptides encoded by a DNA sequence having a first DNA subsequence coding for a fragment of at least one of the .alpha.-and/or .beta.-chain of the human interleukin-5 receptor, and a second DNA subsequence coding for the constant domains of a heavy--or a light-chain of a human immunoglobulin, or a fragment thereof are useful in treating illnesses with demonstrated eosinophilia.
摘要翻译：由具有编码人白细胞介素-5受体的α-和/或β-链中的至少一个的片段的第一DNA亚序列的DNA序列编码的嵌合多肽和编码人白细胞介素-5受体的恒定结构域的第二DNA亚序列人免疫球蛋白的重链或轻链或其片段可用于治疗伴有嗜酸性粒细胞增多症的疾病。

4. 发明授权

US5422104A TNF-muteins 失效
标题翻译： TNF-突变蛋白
公开(公告)号：US5422104A
公开(公告)日：1995-06-06
申请号：US794400
申请日：1991-11-20
申请人： Walter Fiers , Jan Tavernier , Xaveer Van Ostade
发明人： Walter Fiers , Jan Tavernier , Xaveer Van Ostade
IPC分类号： A61K38/00 , A61P35/00 , C07K14/52 , C07K14/525 , C12N1/21 , C12N15/09 , C12N15/28 , C12P21/02 , C12R1/19 , A61K45/05 , C12P21/06
CPC分类号： C07K14/525 , A61K38/00
摘要： It is an object of this invention to provide a human Tumor Necrosis Factor mutein or a pharmaceutically acceptable salt thereof characterized in that the TNF sequence is changed by a deletion, insertion, substitution or combinations thereof, of one or more amino acids so that the mutein shows a significant difference between its binding affinity to the human p75-Tumor-Necrosis-Factor-Receptor and to the human p55-Tumor-Necrosis-Factor-Receptor. The invention also includes DNA sequences coding for such muteins, vectors comprising such DNA sequences, host cells transformed with such vectors and a process for the production of such muteins employing such transformed host cells and pharmaceutical compositions containing such muteins and their use for the treatment of illnesses, for example cancer.
摘要翻译：本发明的目的是提供一种人肿瘤坏死因子突变蛋白或其药学上可接受的盐，其特征在于通过其一个或多个氨基酸的缺失，插入，取代或组合改变TNF序列，使得突变蛋白显示其与人p75-肿瘤坏死因子受体和人p55-肿瘤坏死因子受体的结合亲和力之间的显着差异。本发明还包括编码这种突变蛋白的DNA序列，包含这种DNA序列的载体，用这种载体转化的宿主细胞和使用这种转化的宿主细胞产生这种突变蛋白的方法和含有这种突变蛋白的药物组合物及其用于治疗疾病，例如癌症。

5. 发明授权

US5652353A DNAs encoding tumor necrosis factor-.alpha. muteins 失效
标题翻译：编码肿瘤坏死因子-α突变蛋白的DNA
公开(公告)号：US5652353A
公开(公告)日：1997-07-29
申请号：US397470
申请日：1995-03-01
申请人： Walter Fiers , Jan Tavernier , Xaveer Van Ostade
发明人： Walter Fiers , Jan Tavernier , Xaveer Van Ostade
IPC分类号： A61K38/00 , A61P35/00 , C07K14/52 , C07K14/525 , C12N1/21 , C12N15/09 , C12N15/28 , C12P21/02 , C12R1/19
CPC分类号： C07K14/525 , A61K38/00
摘要： It is an object of this invention to provide a human Tumor Necrosis Factor mutein or a pharmaceutically acceptable salt thereof characterized in that the TNF sequence is changed by a deletion, insertion, substitution or combinations thereof, of one or more amino acids so that the mutein shows a significant difference between its binding affinity to the human p75-Tumor-Necrosis-Factor-Receptor and to the human p55-Tumor-Necrosis-Factor-Receptor. The invention also includes DNA sequences coding for such muteins, vectors comprising such DNA sequences, host cells transformed with such vectors and a process for the production of such muteins employing such transformed host cells and pharmaceutical compositions containing such muteins and their use for the treatment of illnesses, for example cancer.
摘要翻译：本发明的目的是提供一种人肿瘤坏死因子突变蛋白或其药学上可接受的盐，其特征在于通过其一个或多个氨基酸的缺失，插入，取代或组合改变TNF序列，使得突变蛋白显示其与人p75-肿瘤坏死因子受体和人p55-肿瘤坏死因子受体的结合亲和力之间的显着差异。本发明还包括编码这种突变蛋白的DNA序列，包含这种DNA序列的载体，用这种载体转化的宿主细胞和使用这种转化的宿主细胞产生这种突变蛋白的方法和含有这种突变蛋白的药物组合物及其用于治疗疾病，例如癌症。

6. 发明申请

US20070036826A1 Influenza immunogen and vaccine 失效
标题翻译：流感免疫原和疫苗
公开(公告)号：US20070036826A1
公开(公告)日：2007-02-15
申请号：US11509382
申请日：2006-08-24
申请人： Ashley Birkett , Walter Fiers
发明人： Ashley Birkett , Walter Fiers
IPC分类号： A61K39/395 , A61K39/12
CPC分类号： A61K39/145 , A61K39/12 , A61K39/292 , A61K2039/5256 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55572 , A61K2039/70 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , C12N2760/16122 , C12N2760/16134 , Y02A50/484
摘要： A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An immunogenic influenza sequence in two to four copies is preferably expressed at or near the N-terminus or in the HBc immunogenic loop sequence. The HBc chimer preferably contains an influenza-specific T cell epitope and is preferably engineered for both enhanced stability of self-assembled particles and enhanced yield of those chimeric particles. Methods of making and using the chimers are also disclosed.
摘要翻译：公开了一种嵌合的羧基末端截短的乙型肝炎病毒核衣壳蛋白（HBc），其包含用于诱导产生针对流感M2蛋白的抗体的免疫原。 2至4个拷贝中的免疫原性流感病毒序列优选在N末端或HBc免疫原性环序列中或附近表达。 HBc嵌合体优选含有流感特异性T细胞表位，并且优选地被设计用于增强自组装颗粒的稳定性和提高那些嵌合颗粒的产量。还公开了制造和使用这种开发者的方法。

7. 发明申请

US20060115489A1 Influenza immunogen and vaccine 失效
标题翻译：流感免疫原和疫苗
公开(公告)号：US20060115489A1
公开(公告)日：2006-06-01
申请号：US10787734
申请日：2004-02-26
申请人： Ashley Birkett , Walter Fiers
发明人： Ashley Birkett , Walter Fiers
IPC分类号： A61K39/29 , C12N7/00 , C07K14/02 , C12N7/01
CPC分类号： A61K39/145 , A61K39/12 , A61K39/292 , A61K2039/5256 , A61K2039/5258 , A61K2039/543 , A61K2039/55505 , A61K2039/55572 , A61K2039/70 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2730/10122 , C12N2730/10123 , C12N2730/10134 , C12N2760/16122 , C12N2760/16134 , Y02A50/484
摘要： A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid (HBc) protein is disclosed that contains an immunogen for inducing the production of antibodies to the influenza M2 protein. An immunogenic influenza sequence in two to four copies is preferably expressed at or near the N-terminus or in the HBc immunogenic loop sequence. The HBc chimer preferably contains an influenza-specific T cell epitope and is preferably engineered for both enhanced stability of self-assembled particles and enhanced yield of those chimeric particles. Methods of making and using the chimers are also disclosed.
摘要翻译：公开了一种嵌合的羧基末端截短的乙型肝炎病毒核衣壳蛋白（HBc），其包含用于诱导产生针对流感M2蛋白的抗体的免疫原。 2至4个拷贝中的免疫原性流感病毒序列优选在N末端或HBc免疫原性环序列中或附近表达。 HBc嵌合体优选含有流感特异性T细胞表位，并且优选地被设计用于增强自组装颗粒的稳定性和提高那些嵌合颗粒的产量。还公开了制造和使用这种开发者的方法。

8. 发明授权

US6093554A Genetics manipulations with recombinant DNA virus comprising sequences derived from RNA virus 失效
标题翻译：用包含源自RNA病毒的序列的重组DNA病毒的遗传操作
公开(公告)号：US6093554A
公开(公告)日：2000-07-25
申请号：US234163
申请日：1999-01-21
申请人： Eddie Van Haute , Paul Ameloot , Jean De Lafonteyne , Walter Fiers
发明人： Eddie Van Haute , Paul Ameloot , Jean De Lafonteyne , Walter Fiers
IPC分类号： C07K14/08 , C07K14/48 , C12N9/12 , C12N15/82 , C12P21/06 , C07G17/00 , C12N5/02 , C12N5/04 , C12P21/04
CPC分类号： C07K14/005 , C07K14/48 , C12N15/8203 , C12N15/8216 , C12N15/8257 , C12N15/8283 , C12N9/127 , C12N2770/38022
摘要： The invention relates to genetic manipulations of eukaryotic organisms, with recombinant DNA comprising RNA virus derived sequences for protecting such organisms against RNA viruses or enabling inducible or tissue-specific production of foreign proteins/peptides or RNAs. One embodiment of the recombinant DNA according to the invention comprises recombinant DNA, comprising two, 12-250 base pair long, inverted repeat nucleotide sequences with therebetween at least one nucleotide sequence which is derived from RNA virus which for its replication is dependent upon a viral RNA/RNA polymerase, said RNA virus derived sequence comprising at least cis elements for replication but no gene that codes for viral RNA/RNA polymerase and no gene that codes for viral coat protein. The invention also relates to eukaryotic or prokaryotic cells or organisms which incorporate the recombinant DNA according to the invention. Further, the invention relates to a method of protecting such cells or organisms by genetically incorporating recombinant DNA according to the invention.
摘要翻译：本发明涉及真核生物的遗传操作，其中重组DNA包含RNA病毒衍生的序列，用于保护这些生物体免受RNA病毒的侵袭或使得诱导或组织特异性产生外源蛋白/肽或RNA。根据本发明的重组DNA的一个实施方案包含重组DNA，其包含两个12-250碱基对长的反向重复核苷酸序列，其间具有至少一个核苷酸序列，其衍生自RNA病毒，其复制依赖于病毒 RNA / RNA聚合酶，所述RNA病毒衍生序列至少包含用于复制的顺式元件，但没有编码病毒RNA / RNA聚合酶的基因，并且没有编码病毒外壳蛋白的基因。本发明还涉及掺入根据本发明的重组DNA的真核或原核细胞或生物体。此外，本发明涉及通过遗传掺入根据本发明的重组DNA来保护这些细胞或生物体的方法。

9. 发明授权

US07993652B2 Immunoprotective influenza antigen and its use in vaccination 有权
标题翻译：免疫保护性流感抗原及其在疫苗接种中的应用
公开(公告)号：US07993652B2
公开(公告)日：2011-08-09
申请号：US12795506
申请日：2010-06-07
申请人： Sabine Neirynck , Willy Min Jou , Walter Fiers
发明人： Sabine Neirynck , Willy Min Jou , Walter Fiers
IPC分类号： A61K39/00 , A61K39/145
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/523 , A61K2039/53 , A61K2039/543 , A61K2039/55566 , A61K2039/55572 , C07K2319/00 , C12N2710/14143 , C12N2730/10122 , C12N2760/16122
摘要： The present invention relates to an influenza antigen, comprising a fusion product of at least the extracellular part of a conserved influenza membrane protein or a functional fragment thereof and a presenting carrier, which may be a presenting (poly)peptide or a non-peptidic structure, such as glycans, peptide mimetics, synthetic polymers. The invention further relates to a vaccine against influenza, comprising at least an antigen of the invention, optionally in the presence of one or more excipients. The invention also relates to use of the antigen, a method for preparing the antigen and acceptor cells expressing the antigen.
摘要翻译：本发明涉及流感抗原，其包含至少保守的流感病毒膜蛋白的细胞外部分或其功能片段和呈递载体的融合产物，其可以是呈递（多）肽或非肽结构，如聚糖，肽模拟物，合成聚合物。本发明进一步涉及抗流感疫苗，其中至少包含本发明的抗原，任选地在一种或多种赋形剂的存在下。本发明还涉及抗原的用途，制备抗原的方法和表达抗原的受体细胞。

10. 发明申请

US20070134718A1 Use of interleukin-15 审中-公开
标题翻译：使用白细胞介素-15
公开(公告)号：US20070134718A1
公开(公告)日：2007-06-14
申请号：US11703974
申请日：2007-02-08
申请人： Johan Adriaan Grooten , Hans Peter Dooms , Walter Fiers
发明人： Johan Adriaan Grooten , Hans Peter Dooms , Walter Fiers
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： A61K38/2086 , A61K38/1793 , Y10S930/14 , Y10S930/141
摘要： The invention relates to the use of IL-15 or active variants thereof and/or IL-15 activity enhancing compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of the immune system, such as manipulating viability and/or responsiveness of said memory cells. The IL-15 activity enhancing compound is for example lipopolysaccharide (LPS). The invention further relates to the use of IL-15 inhibiting or eliminating compounds for the manufacture of a pharmaceutical composition for manipulating memory cells of the immune system. Such inhibiting or eliminating compounds are for example anti-IL-15 antibodies, anti-IL-15Rα antibodies, fragments of these antibodies, e.g. the Fab or F(ab′)2 fragment, soluble IL-15Rα, fusion proteins consisting of soluble IL-15Rα, and Fc fragment, compounds, e.g. peptides, binding and/or inhibiting functional IL-15 receptor, IL-15 antisense oligonucleotides.
摘要翻译：本发明涉及IL-15或其活性变体和/或IL-15活性增强化合物在制备用于操纵免疫系统的记忆细胞的药物组合物中的用途，例如操纵所述存储器的存活力和/或响应性细胞。 IL-15活性增强化合物是例如脂多糖（LPS）。本发明还涉及IL-15抑制或消除化合物用于制造用于操纵免疫系统的记忆细胞的药物组合物的用途。这样的抑制或消除化合物是例如抗IL-15抗体，抗IL-15Rα抗体，这些抗体的片段，例如， Fab或F（ab'）2片段，可溶性IL-15Rα，由可溶性IL-15Rα和Fc片段组成的融合蛋白，例如化合物。肽，结合和/或抑制功能性IL-15受体，IL-15反义寡核苷酸。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式