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1. 发明申请

US20070231858A1 ENZYMATIC PREPARATION OF (S) AMINO ACID FROM (R,S) AMINO ACID OR FROM KETO ACID 审中-公开
标题翻译：（R，S）氨基酸或酮酸的（S）氨基酸的酶促制备
公开(公告)号：US20070231858A1
公开(公告)日：2007-10-04
申请号：US11690159
申请日：2007-03-23
申请人： Ramesh Patel , Yijun Chen , Steven Goldberg , Iqbal Gill , Animesh Goswami , Thomas Tully , William Parker , Ronald Hanson
发明人： Ramesh Patel , Yijun Chen , Steven Goldberg , Iqbal Gill , Animesh Goswami , Thomas Tully , William Parker , Ronald Hanson
IPC分类号： C12P21/06 , C12P13/04 , C12N9/90 , C07D213/55
CPC分类号： C12N9/1096 , C07D213/55 , C12N9/0016 , C12P13/04 , C12P17/12 , C12P41/002
摘要： Disclosed and claimed herein are novel biocatalysts for converting racemic mixtures of amino acids to an enantiomerically pure (S) form of the amino acid, methods for their use, and the enantiomerically enriched products of such biocatalytic processes.
摘要翻译：本文公开和要求保护的是用于将氨基酸的外消旋混合物转化为对映体纯的（S）形式的氨基酸的新型生物催化剂，其使用方法以及这些生物催化方法的对映异构体富集的产物。

2. 发明申请

US20060292678A1 Gluconobacter oxydans 2-ketoreductase enzyme and applications thereof 审中-公开
标题翻译：氧化葡糖杆菌2-酮还原酶及其应用
公开(公告)号：US20060292678A1
公开(公告)日：2006-12-28
申请号：US11159690
申请日：2005-06-23
申请人： Venkata Nanduri , Robert Johnston , Steven Goldberg , Paul Cino , Ramesh Patel
发明人： Venkata Nanduri , Robert Johnston , Steven Goldberg , Paul Cino , Ramesh Patel
IPC分类号： C12P7/02 , C12P21/06 , C07H21/04 , C12N1/21 , C12N15/74
CPC分类号： C12N9/0004 , C12Q1/26 , C12Q1/32 , G01N2333/04
摘要： This invention relates to an novel Gluconobacter oxydans 2-ketoreductase useful for the synthesis of chiral alcohols. Also related are isolated nucleic acids encoding G. oxydans 2-ketoreductase enzymes, and enzyme fragments and variants thereof, as well as vectors and host cells comprising these nucleic acids. Further related are isolated G. oxydans 2-ketoreductase polypeptides, and fragments and variants thereof, and antibodies that specifically bind to G. oxydans 2-ketoreductase polypeptides, fragments, or variants. The invention also relates to methods of obtaining isolated G. oxydans 2-ketoreductase nucleic acids, polypeptides, and antibodies, and methods of using G. oxydans 2-ketoreductase in various reactions for industrial or pharmaceutical applications.
摘要翻译：本发明涉及可用于合成手性醇的新型氧化葡糖杆菌2-酮还原酶。还涉及编码G.oxydans 2-酮还原酶的分离的核酸及其酶片段及其变体，以及包含这些核酸的载体和宿主细胞。进一步相关的是分离的G.oxydans 2-酮还原酶多肽及其片段和变体，以及特异性结合G.oxydans 2-酮还原酶多肽，片段或变体的抗体。本发明还涉及获得分离的G.oxydans 2-酮还原酶核酸，多肽和抗体的方法，以及在工业或药物应用的各种反应中使用G.oxydans 2-酮还原酶的方法。

3. 发明授权

US07845223B2 Condensing chamber design 有权
标题翻译：冷凝室设计
公开(公告)号：US07845223B2
公开(公告)日：2010-12-07
申请号：US11220672
申请日：2005-09-08
申请人： Ramesh Patel , Albert Tsang , James Sawabe , Hwang Choe
发明人： Ramesh Patel , Albert Tsang , James Sawabe , Hwang Choe
IPC分类号： G01F23/00
CPC分类号： G01F23/14 , G01F23/162 , G21C17/035
摘要： The disclosed apparatus includes a condensing chamber (CC) that maintains a volume of a condensate obtained from vapor emitting from a vessel, for example a reactor pressure vessel (RPV). The condensing chamber is connected to a reference leg (RL), a variable leg (VL) and a vapor or steam leg (SL). RL connection provides a flow path for the CRD drive water system backfill to flow into the CC and overflow into the VL. The excess backfill and/or condensate will be returned to the vessel, typically at a point below the liquid level within the vessel. Non-condensable gases will thereby be returned from the CC to the RPV in a substantially continuous manner, thereby tending to prevent the introduction of non-condensable gas enriched liquid from the CC into the RL and improving the tolerance and reliability of the level measurements and/or reducing thermal stresses on the various CC connections.
摘要翻译：所公开的设备包括冷凝室（CC），其保持从容器（例如反应堆压力容器（RPV））发射的蒸汽获得的冷凝物的体积。冷凝室连接到参考腿（RL），可变腿（VL）和蒸汽或蒸汽腿（SL）。 RL连接提供了CRD驱动水系统回填流入CC并溢出到VL中的流路。多余的回填物和/或冷凝物将返回到容器中，通常在容器内的液面以下。因此，不可冷凝的气体将以基本上连续的方式从CC返回到RPV，从而倾向于防止将不可冷凝的富含气体的液体从CC引入RL并提高液位测量的公差和可靠性， /或降低各种CC连接上的热应力。

4. 发明申请

US20060286646A1 STEREOSELECTIVE REDUCTION PROCESS FOR THE PREPARATION OF PYRROLOTRIAZINE COMPOUNDS 有权
标题翻译：用于制备吡咯啉化合物的选择性缩合方法
公开(公告)号：US20060286646A1
公开(公告)日：2006-12-21
申请号：US11421112
申请日：2006-05-31
申请人： Ramesh Patel , Linda Chu , Robert Johnson , Zhiwei Guo , Yijun Chen , Steven Goldberg , Ronald Hanson , Animesh Goswami , Kishta Katipally
发明人： Ramesh Patel , Linda Chu , Robert Johnson , Zhiwei Guo , Yijun Chen , Steven Goldberg , Ronald Hanson , Animesh Goswami , Kishta Katipally
IPC分类号： C12P17/16 , C07D487/04
CPC分类号： C12N9/0006 , C07D487/04 , C12P17/165
摘要： The invention relates to a process for the enzymatic, stereoselective reduction of ketone compounds to provide chiral alcohols, for example the compound of formula Ib:
摘要翻译：本发明涉及一种用于酶促立构选择性还原酮化合物以提供手性醇的方法，例如式Ib化合物：

5. 发明申请

US20060275878A1 N-carbobenzyloxy (N-CBZ)-deprotecting enzyme and uses therefor 失效
标题翻译： N-苄氧羰基（N-CBZ） - 保护酶，并用于此
公开(公告)号：US20060275878A1
公开(公告)日：2006-12-07
申请号：US11502704
申请日：2006-08-10
申请人： Venkata Nanduri , Ramesh Patel , Steven Goldberg , Robert Johnston
发明人： Venkata Nanduri , Ramesh Patel , Steven Goldberg , Robert Johnston
IPC分类号： C12P13/00 , C12P7/16 , C07H21/04 , C12P21/06 , C12N9/20 , C12N9/80
CPC分类号： C12N9/78
摘要： This invention relates to isolated or recombinant N—CBZ-deprotecting enzyme polypeptides that catalyze the removal of CBZ from CBZ-protected amino acids and alcohols, and variants, modifications, and fragments thereof. Also related are isolated nucleic acids encoding N—CBZ-deprotecting enzyme polypeptides, and variants, modifications, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using polypeptides in various reactions for industrial or pharmaceutical applications.
摘要翻译：本发明涉及分离或重组的N-CBZ脱保护酶多肽，其催化从CBZ保护的氨基酸和醇及其变体，修饰和片段中除去CBZ。还涉及编码N-CBZ-脱保护酶多肽的分离的核酸及其变体，修饰和片段，以及包含这些核酸的载体和宿主细胞。本发明还涉及获得分离的核酸，多肽和抗体的方法，以及在工业或药物应用的各种反应中使用多肽的方法。

6. 发明申请

US20050090539A1 Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof 有权
标题翻译：二肽基肽酶IV抑制剂的生产方法和化合物及其中间体
公开(公告)号：US20050090539A1
公开(公告)日：2005-04-28
申请号：US10716012
申请日：2003-11-18
申请人： Truc Vu , David Brzozowski , Rita Fox , Jollie Godfrey , Ronald Hanson , Sergei Kolotuchin , John Mazzullo , Ramesh Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason Zhu , David Magnin , David Augeri , Lawrence Hamann
发明人： Truc Vu , David Brzozowski , Rita Fox , Jollie Godfrey , Ronald Hanson , Sergei Kolotuchin , John Mazzullo , Ramesh Patel , Jianji Wang , Kwok Wong , Jurong Yu , Jason Zhu , David Magnin , David Augeri , Lawrence Hamann
IPC分类号： A61K31/403 , A61K31/435 , C07C62/06 , C07C69/00 , C07C69/716 , C07C229/28 , C07C271/22 , C07D20060101 , C07D201/00 , C07D207/22 , C07D207/277 , C07D209/02 , C07D209/52 , C07D221/02
CPC分类号： C07C69/757 , C07C62/06 , C07C69/635 , C07C69/675 , C07C229/28 , C07C271/22 , C07C2603/74 , C07D207/22 , C07D209/52
摘要： Methods and compounds for production of cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV are provided.
摘要翻译：提供了用于制备二肽基肽酶IV的环丙基稠合吡咯烷基抑制剂的方法和化合物。

7. 发明授权

US06828119B2 Enzymatic deprotection of amines and hydroxides 失效
标题翻译：胺和氢氧化物的酶解脱保护
公开(公告)号：US06828119B2
公开(公告)日：2004-12-07
申请号：US10017711
申请日：2001-12-14
申请人： Ramesh Patel , David Brzozowski , Venkata Nanduri
发明人： Ramesh Patel , David Brzozowski , Venkata Nanduri
IPC分类号： C12P100
CPC分类号： C12P41/007 , C12P17/00 , C12P17/10 , C12P41/004
摘要： Provided is a method of deprotecting a hydroxide or amine protected with a group of formula ArC*(R)H—(CH2)n—O—C(═O)— where the substituents are as described below, the method comprising: contacting the protected hydroxide or amine with an enzyme effective to remove the protecting group; and recovering the amine. Also provided is a method of isolating a bacteria producing an enzyme effective to remove a protecting group comprising: growing prospective bacteria on a medium having a growth selective amount of an amine compound that is protected as above; and isolating bacteria that grow on said medium.
摘要翻译：本发明提供了一种使由一组取代基保护的氢氧化物或胺脱保护的方法，所述取代基如下所述，所述方法包括：使被保护的氢氧化物或胺与有效除去保护基团的酶接触; 并回收胺。还提供了分离产生有效去除保护基团的酶的细菌的方法，包括：在具有生长选择量的如上所述保护的胺化合物的培养基上生长未来的细菌; 并分离在所述培养基上生长的细菌。

8. 发明申请

US20060223832A1 Fused heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function 有权
公开(公告)号：US20060223832A1
公开(公告)日：2006-10-05
申请号：US10917031
申请日：2004-08-12
申请人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
发明人： Mark Salvati , James Balog , Dacia Pickering , Soren Giese , Aberra Fura , Wenying Li , Ramesh Patel , Ronald Hanson , Toomas Mitt , Jacques Roberge , James Corte , Steven Spergel , Richard Rampulla , Raj Misra , Hai-Yun Xiao
IPC分类号： A61K31/497 , C07D487/14
CPC分类号： C07D487/18 , A61K31/00 , A61K31/403 , A61K31/407 , A61K31/655 , A61K31/675 , A61K45/06 , C07B2200/11 , C07D401/08 , C07D471/08 , C07D487/08 , C07D491/08 , C07D491/18 , C07D491/22 , C07D495/08 , C07D495/18 , C07D519/00 , C40B40/00 , A61K2300/00
摘要： Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

9. 发明申请

US20060149047A1 N-CARBOBENZYLOXY (N-CBZ)-DEPROTECTING ENZYME AND USES THEREFOR 失效
标题翻译： N-CARBOBENZYLOXY（N-CBZ）-EPROTECTING ENZYME AND USES THEREFOR
公开(公告)号：US20060149047A1
公开(公告)日：2006-07-06
申请号：US10453418
申请日：2003-06-03
申请人： Venkata Nanduri , Ramesh Patel , Steven Goldberg , Robert Johnston
发明人： Venkata Nanduri , Ramesh Patel , Steven Goldberg , Robert Johnston
IPC分类号： C07H21/04
CPC分类号： C12N9/78
摘要： This invention relates to isolated or recombinant N-CBZ-deprotecting enzyme polypeptides that catalyze the removal of CBZ from CBZ-protected amino acids and alcohols, and variants, modifications, and fragments thereof. Also related are isolated nucleic acids encoding N-CBZ-deprotecting enzyme polypeptides, and variants, modifications, and fragments thereof, as well as vectors and host cells comprising these nucleic acids. The invention also relates to methods of obtaining isolated nucleic acids, polypeptides, and antibodies, and methods of using polypeptides in various reactions for industrial or pharmaceutical applications.
摘要翻译：本发明涉及分离或重组的N-CBZ脱保护酶多肽，其催化从CBZ保护的氨基酸和醇及其变体，修饰和片段中除去CBZ。还涉及编码N-CBZ-脱保护酶多肽的分离的核酸及其变体，修饰和片段，以及包含这些核酸的载体和宿主细胞。本发明还涉及获得分离的核酸，多肽和抗体的方法，以及在工业或药物应用的各种反应中使用多肽的方法。

10. 发明申请

US20050256019A1 Enzymatic ammonolysis process for the preparation of intermediates for DPP IV inhibitors 有权
标题翻译：用于制备DPP IV抑制剂中间体的酶促氨解过程
公开(公告)号：US20050256019A1
公开(公告)日：2005-11-17
申请号：US11119552
申请日：2005-05-02
申请人： Ramesh Patel , Ronald Hanson , Iqbal Gill , David Brzozowski , Paul Skonezny , Michael Politino , Jason Chen , Francisco Moris-Varas , Brenda White
发明人： Ramesh Patel , Ronald Hanson , Iqbal Gill , David Brzozowski , Paul Skonezny , Michael Politino , Jason Chen , Francisco Moris-Varas , Brenda White
IPC分类号： C07D207/22 , C07D209/52 , C07K5/065 , C11D3/00 , C12P17/10
CPC分类号： C07D207/22 , C07D209/52 , C07K5/06078 , C12P13/04 , C12P17/10 , C12P17/12
摘要： An enzymatic ammonolysis process is provided for the preparation of intermediates used in preparing dipeptidyl peptidase IV inhibitors wherein the enzyme Candida antarctica lipase-B is used to catalyze the ammonolysis process.
摘要翻译：提供酶促氨解方法用于制备用于制备二肽基肽酶IV抑制剂的中间体，其中使用南极假丝酵母脂肪酶-B来催化氨解过程。

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