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1. 发明申请

US20090105470A1 Tin Mediated Regioselective Synthesis of Sucrose-6-Esters 审中-公开
标题翻译：锡介导的区域选择性合成蔗糖-6-酯
公开(公告)号：US20090105470A1
公开(公告)日：2009-04-23
申请号：US11884678
申请日：2006-02-06
申请人： Rakesh Ratnam , Mohammed Mofizuddin , Sundeep Aurora
发明人： Rakesh Ratnam , Mohammed Mofizuddin , Sundeep Aurora
IPC分类号： C07H23/00
CPC分类号： C07H1/00 , C07H13/00
摘要： A method is disclosed for regioselective synthesis of sucrose-6-acetate via formation of a novel sucrose-tin adduct using sucrose and DBTO. The novel tin adduct can be represented by a formula (6-O-sucrose)-O—Snbutyl.sub.2-O-(6-O-sucrose) or as 1,3.(di O-sucrose) dibutyl stannylene. The adduct is acylated to yield sucrose-6-acetate or sucrose-6-benzoate as major product.
摘要翻译：公开了通过使用蔗糖和DBTO形成新的蔗糖 - 锡加合物来区域选择性合成蔗糖-6-乙酸酯的方法。新的锡加合物可以由式（6-O-蔗糖）-O- Snbutyl2-O-（6-O-蔗糖）或1,3（二O-蔗糖）二丁基亚锡来表示。将加合物酰化生成蔗糖-6-乙酸酯或蔗糖-6-苯甲酸酯作为主要产物。

2. 发明申请

US20100228020A1 Novel Chlorination Reagent and a Novel Process for Chlorination of Sugars Using Thionyl Chloride 审中-公开
标题翻译：新型氯化试剂和使用亚硫酰氯氯化氯的新方法
公开(公告)号：US20100228020A1
公开(公告)日：2010-09-09
申请号：US12224324
申请日：2007-02-28
申请人： Rakesh Ratnam , Sundeep Aurora , Mohammed Mofizuddin
发明人： Rakesh Ratnam , Sundeep Aurora , Mohammed Mofizuddin
IPC分类号： C07H13/02 , C07H1/00
CPC分类号： C07H1/00 , C07H5/02 , C07H13/02 , C07H15/00
摘要： Preparation of chlorinating reagent or chlorination reaction itself for use in a reaction such as production of high intensity sweetener trichlorogalactosucrose (TGS) from partially protected sucrose, comprising reaction of dimethylformamide (DMF) with thionyl chloride or another sulphur containing inorganic acid chlorides including sulphuryl chloride is faced with a problem of prolific release of gaseous by-products, that at times may lead to violent explosion also. This problem is solved by innovative addition of solid powder inert to the constituents of the chlorination reaction mixture to the reaction, or by adding DMF to acid chloride solution in that order. The invention also leads to use of isolated solid Vilsmeier reagent being used for chlorination in a solvent other than DMF making it possible to avoid altogether problems arising from use of DMF which include irrecoverable loss in alkaline as well as acid conditions, interference in crystallization of TGS and the like.
摘要翻译：制备氯化试剂或氯化反应本身用于反应，例如从部分保护的蔗糖生产高强度甜味剂三氯半乳糖（TGS），包括二甲基甲酰胺（DMF）与亚硫酰氯或另一种含硫的无机酰氯（包括磺酰氯）的反应，面临气体副产品多产释放的问题，有时也可能导致剧烈的爆炸。通过将氯化反应混合物的成分惰性的固体粉末添加到反应中，或者通过向该酰氯溶液中依次加入DMF来解决这个问题。本发明还导致使用分离的固体维尔斯迈尔试剂用于在DMF以外的溶剂中进行氯化，使得可以避免使用DMF引起的一切问题，其包括在碱性和酸性条件下不可恢复的损失，TGS的结晶干扰等等。

3. 发明申请

US20090131653A1 Generation of Phosphorus Oxychloride as by-Product from Phosphorus Pentachloride and DMF and its Use for Chlorination Reaction by Converting Into Vilsmeier-Haack Reagent 审中-公开
标题翻译：从五氯化磷和DMF中产生副产物作为副产物，并通过转化为维尔斯迈克试剂将其用于氯化反应
公开(公告)号：US20090131653A1
公开(公告)日：2009-05-21
申请号：US11919826
申请日：2006-04-28
申请人： Rakesh Ratnam , Aurora Sundeep , Mohammed Mofizuddin
发明人： Rakesh Ratnam , Aurora Sundeep , Mohammed Mofizuddin
IPC分类号： C07H1/00 , C07C251/30
CPC分类号： C01B25/10 , C07B39/00 , C07C249/02 , C07F9/1403 , C07H1/00 , C07H5/02 , C07H13/04 , C07H13/08 , C07C251/04
摘要： A process is described wherein after formation of first crop of Vilsmeier-Haack reagent by reacting Phosphorus Pentachloride with N,N-dimethylformamide to form a first crop of Vilsmeier reagent as insoluble crystals, a by-product of this reaction, the Phosphorus Oxy-Chloride, reacts with N,N-dimethylformamide to give a second crop of Vilsmeier reagent. This second crop of Vilsmeier reagent is soluble in DMF. This process makes it possible to double the yield of chlorinated substrate, such as sucrose-6-acetate or sucrose-6-benzoate, from the same quantity of Phosphorus Pentachloride.
摘要翻译：描述了一种方法，其中在通过使五氯化磷与N，N-二甲基甲酰胺反应形成第一批Vilsmeier-Haack试剂后，形成第一批Vilsmeier试剂作为不溶性晶体，该反应的副产物是氯氧化磷与N，N-二甲基甲酰胺反应，得到第二批Vilsmeier试剂。第二批Vilsmeier试剂可溶于DMF。该方法可以使来自相同量的五氯化磷的氯化底物如蔗糖-6-乙酸酯或蔗糖-6-苯甲酸酯的产率增加一倍。

4. 发明申请

US20080004439A1 Sucrose-6-Ester Chlorination by Co-Addition of Chlorination Reagent 审中-公开
标题翻译：通过共添加氯化试剂进行蔗糖-6-酯氯化
公开(公告)号：US20080004439A1
公开(公告)日：2008-01-03
申请号：US11794495
申请日：2005-12-23
申请人： Rakesh Ratnam , Sundeep Aurora
发明人： Rakesh Ratnam , Sundeep Aurora
IPC分类号： C07H1/00
CPC分类号： C07H1/00 , C07H1/06 , C07H5/02
摘要： An improved process for chlorination is described wherein a solution of chlorinating agent and solution of sucrose-6-ester are mixed together by co-addition to a reaction vessel, the addition of both the reactants starting and completing substantially at the same time. The product of chlorinated sucrose is further extracted in organic solvents and deacylated to produce the high intensity sweetener product 4, 1′, 6′ trichlorogalactosucrose.
摘要翻译：描述了一种改进的氯化方法，其中将氯化剂溶液和蔗糖-6-酯的溶液通过共添加到反应容器中混合在一起，两者的反应物的添加基本上同时进行。将氯代蔗糖的产物进一步在有机溶剂中萃取并脱酰基化以产生高强度甜味剂产物4'，6'三氯半乳糖。

5. 发明申请

US20110306102A1 IMPROVED METHODS FOR FERMENTATIVE PRODUCTION OF DOCOSAHEXAENOIC ACID 审中-公开
标题翻译：改善DOCOSAHEXAENOIC酸的生产方法
公开(公告)号：US20110306102A1
公开(公告)日：2011-12-15
申请号：US13203116
申请日：2010-02-24
申请人： Rakesh Ratnam , Sundeep Aurora , Surendra Talluri , Ellappan Ganesan , Vineetha Peter
发明人： Rakesh Ratnam , Sundeep Aurora , Surendra Talluri , Ellappan Ganesan , Vineetha Peter
IPC分类号： C12P7/64
CPC分类号： C12P7/6427
摘要： The invention comprises a process of producing polyunsaturated fatty acids from Thraustochytriales at high availability of oxygen by solid state fermentation or submerged fermentation in a batch, semi-continuous or continuous mode. Batch fermentation of more than 200 g/L and up to 450 g/L of dextrose added right in the beginning of fermentation was achieved with productivity of DHA achieved for higher than 10 g/Liter. The process comprises maintaining at least 20% to 30% dissolved oxygen and sometimes up to around 50% or more.
摘要翻译：本发明包括通过固态发酵或分批，半连续或连续模式的浸没发酵，从高可用性的氧气中从破囊壶菌产生多不饱和脂肪酸的方法。实现了在发酵开始时添加的超过200g / L和高达450g / L葡萄糖的分批发酵，其DHA的生产率达到高于10g / L。该方法包括保持至少20％至30％的溶解氧，有时高达约50％或更高。

6. 发明申请

US20100222568A1 Removal of pyridine and pyridine analogs from reaction mass containing sucrose esters 审中-公开
标题翻译：从含蔗糖酯的反应物中除去吡啶和吡啶类似物
公开(公告)号：US20100222568A1
公开(公告)日：2010-09-02
申请号：US11991169
申请日：2006-08-29
申请人： Rakesh Ratnam , Sundeep Aurora
发明人： Rakesh Ratnam , Sundeep Aurora
IPC分类号： C07H11/00 , C07H1/06
CPC分类号： C07H1/06
摘要： A process of removal of pyridine or a pyridine analogue from a composition or a Process Stream in a process of production of 4,1′, 6′ trichlorogalactosucrose is described comprising reacting pyridine with an acid, the said acid being used preferably in gaseous form, achieving complete precipitation of the salt of pyridine in higher alcoholic solvents and non-polar solvents, filtering off the precipitate of the said salt of pyridine to achieve removal of pyridine from the reaction system and optionally regenerating and recovering pyridine by reacting the said salt with alkali.
摘要翻译：描述了在制备4,1'，6'三氯半乳糖蔗糖的方法中从组合物或工艺流中除去吡啶或吡啶类似物的方法，其包括使吡啶与酸反应，所述酸优选以气态形式使用，使吡啶盐在较高的醇溶剂和非极性溶剂中完全沉淀，过滤掉所述吡啶盐的沉淀物，从反应体系中除去吡啶，任选地通过使所述盐与碱反应再生和回收吡啶。

7. 发明申请

US20100168412A1 Continuous Neutralizer Mixer Reactor and a Continuous Process for Quenching Chlorination Reaction Mixture in Production of Chlorinated Sucrose 审中-公开
标题翻译：连续中和器搅拌器和氯化蔗糖生产中淬灭氯化反应混合物的连续方法
公开(公告)号：US20100168412A1
公开(公告)日：2010-07-01
申请号：US12226566
申请日：2007-04-19
申请人： Rakesh Ratnam , Sundeep Aurora , Sanjiv Shankar Anand , Subramaniyam
发明人： Rakesh Ratnam , Sundeep Aurora , Sanjiv Shankar Anand , Subramaniyam
IPC分类号： C07H1/06 , C07H1/00 , B01J19/18
CPC分类号： C07B39/00 , B01J19/0013 , B01J19/0066 , B01J19/0086 , B01J19/1881 , B01J2219/00006 , B01J2219/00033 , B01J2219/00063 , B01J2219/00094 , B01J2219/0011 , B01J2219/00177 , B01J2219/002 , B01J2219/00238 , C07H1/00 , C07H1/06 , C07H5/02
摘要： An improved process of production of a chlorinated sugar is described comprising chlorination of a partially protected sugar, wherein quenching as well as neutralization of chlorinated reaction mass is carried out concurrently and continuously in a reactor which is a continuous mixer as well as quencher providing continuous mixing of chlorination reaction mixture and pH adjusting solution and also provides for continuous quenching and continuous removal of quenched chlorinated reaction mixture.
摘要翻译：描述了制备氯化糖的改进方法，其包括氯化部分保护的糖，其中在连续混合器的反应器中同时且连续地进行淬灭和氯化反应物质的中和，以及提供连续混合的猝灭剂的氯化反应混合物和pH调节溶液，并且还提供连续淬火和连续除去淬灭的氯化反应混合物。

8. 发明申请

US20080125584A1 Salts Assisted Selective Extraction Of 6-Acetyl- 4,1' , 6' Trichlorogalactosucrose And 4,1', 6' Trichlorogalactosucrosse From Aqueous Reaction Mixture 审中-公开
标题翻译：盐辅助选择性提取6-乙酰基-4,1'，6'三氯半乳糖和4,1'，6'三氯半乳糖苷从水性反应混合物
公开(公告)号：US20080125584A1
公开(公告)日：2008-05-29
申请号：US11792620
申请日：2005-12-09
申请人： Rakesh Ratnam , Sundeep Aurora
发明人： Rakesh Ratnam , Sundeep Aurora
IPC分类号： C07H1/06
CPC分类号： C07H5/02
摘要： A process is described to increase efficiency of extraction of 4,1′,6′ trichlorogalactosucrose (TGS) from aqueous solution by addition of salt. The invention helps in reducing the quantity of solvent needed for achieving substantial extraction. The invention also leads to extraction of TGS substantially free from polar impurities.
摘要翻译：描述了一种方法，以提高通过加入盐从水溶液中提取4,1'，6'三氯半乳糖蔗糖（TGS）的效率。本发明有助于减少实现大量萃取所需的溶剂量。本发明还导致提取基本上不含极性杂质的TGS。

9. 发明申请

US20100222570A1 Process for production of chlorinated sucrose based on hydrophobic affinity chromatography 审中-公开
标题翻译：基于疏水亲和色谱法生产氯化蔗糖的方法
公开(公告)号：US20100222570A1
公开(公告)日：2010-09-02
申请号：US11991135
申请日：2006-08-29
申请人： Rakesh Ratnam , Sundeep Aurora , Arvind Mallinath Lali , Sandeep Bhaskar Kale
发明人： Rakesh Ratnam , Sundeep Aurora , Arvind Mallinath Lali , Sandeep Bhaskar Kale
IPC分类号： C07H1/06
CPC分类号： C07H1/06 , C07H5/02
摘要： This invention relates to a process for selective capture, isolation and purification of chlorinated sucrose compounds, including chlorinated sucrose, their precursors and derivatives, including trichlorogalactosucrose (TGS), directly from chlorinated reaction mixture by column chromatography on adsorbents and under conditions which result in specific and selective affinity towards one or more of chlorinated sucrose compound. The process also integrates de-esterification of chlorinated sucrose esters adsorbed on the adsorbent while they are being treated with desorbent. The process also provides a novel approach to concentration and crystallization of TGS. The chlorinated sucrose derivatives, including TGS, thus isolated are substantially free from most impurities, salts and organic solvents. The process has high recovery of more than 95% in terms of desired chlorinated sucrose derivatives including TGS.
摘要翻译：本发明涉及一种选择性捕获，分离和纯化氯化蔗糖化合物的方法，包括氯化蔗糖，其前体和衍生物，包括三氯半乳糖（TGS），直接由氯化反应混合物通过柱色谱法在吸附剂上和在导致特定以及对一种或多种氯化蔗糖化合物的选择性亲和力。该方法还将吸附在吸附剂上的氯化蔗糖酯的脱酯化同时用解吸剂进行处理。该方法还提供了TGS的浓缩和结晶的新方法。由此分离的氯化蔗糖衍生物，包括TGS基本上不含大多数杂质，盐和有机溶剂。该方法在所需的氯代蔗糖衍生物（包括TGS）方面具有高于95％的高回收率。

10. 发明申请

US20080163867A1 Molecular Separation Process in Various Steps of Process for Production of Chlorinated Sugars, Their Precursors and Derivatives 审中-公开
标题翻译：氯化糖，其前体和衍生物的生产过程的各个步骤中的分子分离过程
公开(公告)号：US20080163867A1
公开(公告)日：2008-07-10
申请号：US11884679
申请日：2006-02-20
申请人： Subramanyam , Rakesh Ratnam , Sundeep Aurora
发明人： Subramanyam , Rakesh Ratnam , Sundeep Aurora
IPC分类号： C13D3/16
CPC分类号： C07H11/00
摘要： This invention comprises novel application of a molecular separation process, including one or more of a membrane separation/filtration process comprising reverse osmosis, micro filtration, nanofiltration ultrafiltration and perevaporation and the like to several process streams obtained in process of production of for synthesis, purification or isolation of 1-6-Dichloro-1-6-DIDEOXY-β-Fructofuranosyl-4-chloro-4-deoxy-galactopyranoside (TGS), its precursors or its derivatives for achieving a separation of molecules in combination with conventional unit processes of separation.
摘要翻译：本发明包括分子分离方法的新应用，包括一种或多种膜分离/过滤方法，包括反渗透，微过滤，纳滤超滤和蒸发等，用于合成，纯化生产过程中获得的几种工艺流程或分离1-6-二氯-1,6-二脱氧-β-呋喃果糖基-4-氯-4-脱氧 - 吡喃半乳糖苷（TGS），其前体或其衍生物，用于与常规的单元方法结合实现分子分离分离

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