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1. 发明授权

US4805622A Direction-finding system for localization of reflection-causing nterfaces in the human body 失效
标题翻译：人体内反射引起的表面定位的测向系统
公开(公告)号：US4805622A
公开(公告)日：1989-02-21
申请号：US25510
申请日：1987-03-13
申请人： Rainer Riedlinger , Friedrich Ueberle
发明人： Rainer Riedlinger , Friedrich Ueberle
IPC分类号： A61B8/00 , A61B8/08 , A61B17/22 , G01S15/06 , A61B10/00
CPC分类号： G01S15/06 , A61B8/0833 , Y10S977/929
摘要： A direction-finding system for localization of reflection-causing interfaces in the human body, in particular those of concretions, consists of at least one transmitter (18) emitting pulsed ultrasound and at least two ultrasound receivers (2, 3), of gate circuits (25) associated with each receiver, with variable amplifiers (26), and respective storage media (6) for ultrasonic echo signals (22, 21), and of a following device for sweep magnification (7) consisting of signal memories for readout at an adjustable clock frequency, there being provided variations of the delay differences ML and of the amplitude frequency spectra MF adjustable independently of each other. Connected downstream are devices for auditory direction finding (8, 9, 10, 15).
摘要翻译：用于定位人体内的反射界面的方向调查系统，特别是结构的定向系统由至少一个发射脉冲超声波发射器（18）和至少两个超声波接收器（2,3）组成，门极电路（25），具有可变放大器（26）和用于超声波回波信号（22,21）的相应存储介质（6），以及用于扫描放大率（7）的随后装置，其由信号存储器组成，用于在提供了可调节的时钟频率，提供了彼此独立调节的延迟差ML和振幅频谱MF的变化。下游连接是用于听觉方向发现的装置（8,9,10,15）。

2. 发明授权

US4819621A Method for detection of cavitations during medical application of high sonic energy 失效
标题翻译：在高声波能量医疗应用过程中检测空穴的方法
公开(公告)号：US4819621A
公开(公告)日：1989-04-11
申请号：US17752
申请日：1987-02-24
申请人： Friedrich Ueberle , Rainer Riedlinger
发明人： Friedrich Ueberle , Rainer Riedlinger
IPC分类号： A61B17/22 , A61B17/225 , G01S7/52 , A61H1/00 , A61B10/00
CPC分类号： G01S7/5205 , A61B17/22004 , A61B17/2256 , A61B2017/22008
摘要： A method and apparatus are described for the detection of possible tissue injuries caused by cavitation during the medical application to a patient's body of high sonic energy which is generated extraneously by means of a sonic transducer for destruction of an element--for example a concretion--which is present in a target area. To detect the possible occurrence of cavitation the target area is acted upon by an acoustic test signal and a reception signal is generated from at least an initial reflection of the test signal. This signal is then examined by comparison with the test signal to detect the presence of an impedance jump leading to an attenuated reflection, so that a control signal may be generated upon detection of an impedance jump of this nature. Audible or visible warning signals may be engendered among others, and the sonic transducer may be deactivated if need be, by means of this control signal.
摘要翻译：描述了一种方法和装置，用于检测在医疗应用期间由空气引起的可能的组织损伤，所述组织损伤是通过用于破坏元件的声音换能器（例如凝结物）而外部产生的高声能的身体存在于目标区域。为了检测气蚀的可能发生，目标区域由声学测试信号作用，并且从测试信号的至少初始反射产生接收信号。然后通过与测试信号进行比较来检查该信号，以检测导致衰减反射的阻抗跳跃的存在，使得可以在检测到这种性质的阻抗跳跃时产生控制信号。可能会产生声音或可见的警告信号，如果需要，声音换能器可以通过该控制信号来停用。

3. 发明授权

US4639904A Sonic transmitters 失效
标题翻译：声波发射机
公开(公告)号：US4639904A
公开(公告)日：1987-01-27
申请号：US823642
申请日：1986-01-29
申请人： Rainer Riedlinger
发明人： Rainer Riedlinger
IPC分类号： A61B17/225 , G01V1/387 , G10K11/32 , H04R1/34
CPC分类号： G10K11/32 , G01V1/387
摘要： A sound transmitter for generation of transient acoustic pulses, comprising a spatially curved focussing emitter surface which is represented by the area of a single active or passive emitter or by the areas of several emitters matched in respect of their period of operation and amplitude. The pulses occurring in the region of the focus are generated by a substantially unipolar and chronologically limited pressure and/or velocity evolution at the emitter surface. So that a substantially unipolar pressure pulse may equally be generated at the focus of an emitter surface of this nature, the emitter surface deviates in a specified manner from an ideally focussing emitter surface so that as a result of the differences in period of operation caused by a real deviation in the region of the focus, the chronological increase and decrease of the velocity potential in the focal region calculable by means of the Rayleigh integral differ in speed, so that the pressure evolution determined from the substantially unipolar evolution of the velocity potential by derivation based on time has a brief pulse of high amplitude at the beginning or end, which is followed or preceded by a longer pulse of lesser amplitude.
摘要翻译：一种用于产生瞬时声脉冲的声发射器，包括空间弯曲的聚焦发射器表面，其由单个有源或无源发射器的面积或由它们的操作周期和振幅相匹配的几个发射器的面积表示。在焦点区域中出现的脉冲是由发射极表面的基本单极和时间限制的压力和/或速度演变产生的。因此，在这种性质的发射体表面的焦点处可以同样产生基本上单极的压力脉冲，发射体表面以指定的方式从理想的聚焦发射器表面偏离，从而由于由焦点区域的实际偏差，通过瑞利积分计算的聚焦区域中的速度势能的时间递增和减少速度不同，从而通过速度势能的基本单极演化确定压力演变基于时间的推导在开始或结束时具有高幅度的短暂脉冲，其后跟或较小幅度较长的脉冲。

4. 发明授权

US4858597A Piezoelectric transducer for the destruction of concretions within an animal body 失效
标题翻译：用于破坏动物体内结实的压电换能器
公开(公告)号：US4858597A
公开(公告)日：1989-08-22
申请号：US253884
申请日：1988-10-05
申请人： Gunther Kurtze , Rainer Riedlinger
发明人： Gunther Kurtze , Rainer Riedlinger
IPC分类号： B06B1/06 , G10K11/32
CPC分类号： B06B1/0637 , G10K11/32
摘要： A piezoelectric transducer in the form of a spheroidal cap comprises a mosaic of individual piezoceramic elements having a height of 3 to 10 mms and a lateral extension that does not substantially exceed the height there being gaps between the piezoceramic elements which are filled with an electrically insulating material having a modulus of elasticity which is smaller by at least one order of magnitude than that of the ceramic material, with the rise of the spheroidal cap amounting to at least 5 cms and the apex angle of the corresponding spherical sector amounting to at least 60.degree..
摘要翻译：呈球形帽形式的压电传感器包括具有3至10mms高度的单独的压电陶瓷元件的镶嵌，并且横向延伸部基本上不超过其上的高度，其中填充有电绝缘的压电陶瓷元件之间的间隙具有小于陶瓷材料的至少一个数量级的弹性模量的材料，球形帽的上升至少为5厘米，并且相应球形部分的顶角为至少60度 DEG。

5. 发明申请

US20060173388A1 Method for effecting local increases in temperature inside materials, particularly body tissue 有权
标题翻译：影响材料，特别是身体组织内局部温度升高的方法
公开(公告)号：US20060173388A1
公开(公告)日：2006-08-03
申请号：US10523334
申请日：2003-07-29
申请人： Siegfried Ginter , Marko Liebler , Thomas Dreyer , Rainer Riedlinger
发明人： Siegfried Ginter , Marko Liebler , Thomas Dreyer , Rainer Riedlinger
IPC分类号： A61H1/00
CPC分类号： A61N7/02
摘要： Local tissue areas should be thermally destroyed when using ultrasound thermotherapy. Traditionally, mono-frequency continuous wave ultrasound signals are used to this end. These lead to a non-optimal distribution of heat or to a non-optimal localization of the heating inside the tissue. In practice, the following dosage problem arises: the prevention of unwanted tissue damage in the tissue located in front of the target area while simultaneously having a sufficiently high damaging effect in the target area The aim of the invention is to optimize the distribution of heat or to increase the localization of the heating. To these ends, modified transmitted signals (e.g. multi-frequency signals) are used that are adapted to a specific utilization of the non-linear ultrasound propagation and attenuation properties inside the tissue. This enables, while limited to the target area, a non-linear heating yield caused by non-linear ultrasound effects to be achieved that drastically improves the localization of the heating. Due to this optimization, the problem of dosage is substantially eased, and it is possible to thermally destroy even deep-lying tumors without unwanted burning of the tissue located in front of the tumors. This results in both improving the practical usability of ultrasound thermotherapy and in further reducing the side effects thereof.
摘要翻译：当使用超声波热疗时，局部组织区域应该被热破坏。传统上，为此，使用单频连续波超声信号。这些导致热量的非最佳分布或组织内的加热的非最佳定位。在实践中，出现以下剂量问题：防止位于目标区域前方的组织中的不想要的组织损伤，同时在目标区域中具有足够高的破坏作用本发明的目的是优化热分布或以增加加热的本地化。为了这些目的，使用修改的发射信号（例如，多频信号），其适于特定利用组织内的非线性超声波传播和衰减特性。这使得能够在限于目标区域的情况下获得由非线性超声效应引起的非线性加热产生，从而大大提高了加热的定位。由于这种优化，剂量的问题基本上是缓解的，并且可能热破坏甚至深层的肿瘤，而不需要在肿瘤前面组织的不必要的燃烧。这可以提高超声热疗的实用性，进一步降低其副作用。

6. 发明授权

US5209221A Ultrasonic treatment of pathological tissue 失效
标题翻译：超声波治疗病理组织
公开(公告)号：US5209221A
公开(公告)日：1993-05-11
申请号：US763475
申请日：1991-09-20
申请人： Rainer Riedlinger
发明人： Rainer Riedlinger
IPC分类号： A61B17/00 , A61B17/22 , A61N7/00 , G10K11/28
CPC分类号： A61N7/00 , A61B17/22004 , G10K11/28 , A61B2017/0015 , A61B2017/00172 , A61B2017/22008
摘要： A device for generating sonic signal forms for limiting, preventing or regressing the growth of pathological tissue comprises an ultrasonic transmission system for transmitting sound waves, focussed on the tissue to be treated, by way of a coupling medium. An ultrasonic signal produced at the focus of the system comprises brief pulses having at least one rarefaction phase with a negative sonic pressure amplitude with a value greater than 2.times.10.sup.5 Pa. The ultrasonic signal is radiated with a carrier frequency exceeding 20 kHz, a sonic pulse duration T of less than 100 .mu.s and a pulse recurrence rate of less than 1/(5T). The device produces controlled cavitation in the tissue to be treated.
摘要翻译：用于产生用于限制，预防或消退病理组织生长的声音信号形式的装置包括用于通过耦合介质传播聚焦在待治疗组织上的声波的超声波传输系统。在系统焦点处产生的超声信号包括具有至少一个稀释相的短脉冲，具有大于2×105Pa的值的负声压级振幅，超声信号以超过20kHz的载波频率辐射，声波脉冲持续时间 T小于100μs，脉搏复发率小于1 /（5T）。该装置在待治疗的组织中产生受控的气蚀。

7. 发明授权

US4618796A Acoustic diode 失效
标题翻译：声二极管
公开(公告)号：US4618796A
公开(公告)日：1986-10-21
申请号：US783143
申请日：1985-10-02
申请人： Rainer Riedlinger
发明人： Rainer Riedlinger
IPC分类号： G10K11/04 , H01L41/08
CPC分类号： G10K11/04 , Y10S310/80
摘要： A sonic transmitter has placed in front of it or in its acoustic beam path, an acoustic diode comprising at least two peripherally secured foils in mutual contact, the foils having opposed surfaces with a degree of adhesion and/or cohesion such that they may be pulled apart beyond a threshold value which may be acted upon--of negative sound pressure thus suppressing negative sound pulses, whereas positive sound pressures may be transmitted at almost unaltered levels in view of the existing mechanical contact of the foils.
摘要翻译：声音发射器已经放置在其前面或在其声束路径中，声二极管包括相互接触的至少两个外围固定的箔，箔具有相对的表面，具有一定程度的粘附和/或内聚，使得它们可以被拉除了可以通过负声压作用的阈值之外，从而抑制负声音脉冲，而正面声压可以以几乎未改变的水平传播，因为箔的现有机械接触。

8. 发明授权

US07645235B2 Method for effecting local increases in temperature inside materials, particularly body tissue 有权
标题翻译：影响材料，特别是身体组织内局部温度升高的方法
公开(公告)号：US07645235B2
公开(公告)日：2010-01-12
申请号：US10523334
申请日：2003-07-29
申请人： Siegfried Ginter , Marko Liebler , Thomas Dreyer , Rainer Riedlinger
发明人： Siegfried Ginter , Marko Liebler , Thomas Dreyer , Rainer Riedlinger
IPC分类号： A61B10/00
CPC分类号： A61N7/02
摘要： Local tissue areas should be thermally destroyed when using ultrasound thermotherapy. Traditionally, mono-frequency continuous wave ultrasound signals are used to this end. These lead to a non-optimal distribution of heat or to a non-optimal localization of the heating inside the tissue. In practice, the following dosage problem arises: the prevention of unwanted tissue damage in the tissue located in front of the target area while simultaneously having a sufficiently high damaging effect in the target area. The aim of the invention is to optimize the distribution of heat or to increase the localization of the heating. To these ends, modified transmitted signals (e.g. multi-frequency signals) are used that are adapted to a specific utilization of the non-linear ultrasound propagation and attenuation properties inside the tissue. This enables, while limited to the target area, a non-linear heating yield caused by non-linear ultrasound effects to be achieved that drastically improves the localization of the heating. Due to this optimization, the problem of dosage is substantially eased, and it is possible to thermally destroy even deep-lying tumors without unwanted burning of the tissue located in front of the tumors. This results in both improving the practical usability of ultrasound thermotherapy and in further reducing the side effects thereof.
摘要翻译：当使用超声波热疗时，局部组织区域应该被热破坏。传统上，为此，使用单频连续波超声信号。这些导致热量的非最佳分布或组织内的加热的非最佳定位。实际上，出现以下剂量问题：防止位于目标区域前方的组织中有害的组织损伤，同时在目标区域具有足够高的破坏作用。本发明的目的是优化热分布或增加加热的定位。为了这些目的，使用修改的发射信号（例如，多频信号），其适于特定利用组织内的非线性超声波传播和衰减特性。这使得能够在限于目标区域的情况下获得由非线性超声效应引起的非线性加热产生，从而大大提高了加热的定位。由于这种优化，剂量的问题基本上是缓解的，并且可能热破坏甚至深层的肿瘤，而不需要在肿瘤前面组织的不必要的燃烧。这可以提高超声热疗的实用性，进一步降低其副作用。

9. 发明授权

US4721106A Piezoelectric transducer for destruction of concretions inside the body 失效
标题翻译：用于破坏体内结实的压电换能器
公开(公告)号：US4721106A
公开(公告)日：1988-01-26
申请号：US63693
申请日：1987-06-15
申请人： Gunther Kurtze , Rainer Riedlinger
发明人： Gunther Kurtze , Rainer Riedlinger
IPC分类号： G10K11/00 , A61B17/00 , A61H23/02
CPC分类号： G10K11/002
摘要： A piezoelectric transducer for destruction of concretions inside the body. The transducer essentially comprises a spheroidal cap having piezoelectric ceramic elements situated at its radially inner front side. To prevent overpressure pulses radiated at the front side of the transducer being followed by underpressure pulse reflected from the rear side of the cap, the cap is produced from metal, preferably from a copper alloy. The impact wave resistances of the cap metal and of the ceramic material should largely correspond. Furthermore, the rear-side surface of the rear wall of the cap is so shaped geometrically and/or provided with a coating, that the sonic waves reflected therefrom are no longer focussed.
摘要翻译：用于破坏体内结实的压电换能器。换能器基本上包括球形帽，其具有位于其径向内侧的压电陶瓷元件。为了防止在换能器的前侧辐射的过压脉冲紧随着从盖的后侧反射的负压脉冲，帽由金属制成，优选由铜合金制成。盖金属和陶瓷材料的冲击波电阻应该在很大程度上对应。此外，帽的后壁的后侧表面是几何形状的和/或设置有涂层，使得从其反射的声波不再聚焦。

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