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1. 发明授权

US4805622A Direction-finding system for localization of reflection-causing nterfaces in the human body 失效
标题翻译：人体内反射引起的表面定位的测向系统
公开(公告)号：US4805622A
公开(公告)日：1989-02-21
申请号：US25510
申请日：1987-03-13
申请人： Rainer Riedlinger , Friedrich Ueberle
发明人： Rainer Riedlinger , Friedrich Ueberle
IPC分类号： A61B8/00 , A61B8/08 , A61B17/22 , G01S15/06 , A61B10/00
CPC分类号： G01S15/06 , A61B8/0833 , Y10S977/929
摘要： A direction-finding system for localization of reflection-causing interfaces in the human body, in particular those of concretions, consists of at least one transmitter (18) emitting pulsed ultrasound and at least two ultrasound receivers (2, 3), of gate circuits (25) associated with each receiver, with variable amplifiers (26), and respective storage media (6) for ultrasonic echo signals (22, 21), and of a following device for sweep magnification (7) consisting of signal memories for readout at an adjustable clock frequency, there being provided variations of the delay differences ML and of the amplitude frequency spectra MF adjustable independently of each other. Connected downstream are devices for auditory direction finding (8, 9, 10, 15).
摘要翻译：用于定位人体内的反射界面的方向调查系统，特别是结构的定向系统由至少一个发射脉冲超声波发射器（18）和至少两个超声波接收器（2,3）组成，门极电路（25），具有可变放大器（26）和用于超声波回波信号（22,21）的相应存储介质（6），以及用于扫描放大率（7）的随后装置，其由信号存储器组成，用于在提供了可调节的时钟频率，提供了彼此独立调节的延迟差ML和振幅频谱MF的变化。下游连接是用于听觉方向发现的装置（8,9,10,15）。

2. 发明授权

US4819621A Method for detection of cavitations during medical application of high sonic energy 失效
标题翻译：在高声波能量医疗应用过程中检测空穴的方法
公开(公告)号：US4819621A
公开(公告)日：1989-04-11
申请号：US17752
申请日：1987-02-24
申请人： Friedrich Ueberle , Rainer Riedlinger
发明人： Friedrich Ueberle , Rainer Riedlinger
IPC分类号： A61B17/22 , A61B17/225 , G01S7/52 , A61H1/00 , A61B10/00
CPC分类号： G01S7/5205 , A61B17/22004 , A61B17/2256 , A61B2017/22008
摘要： A method and apparatus are described for the detection of possible tissue injuries caused by cavitation during the medical application to a patient's body of high sonic energy which is generated extraneously by means of a sonic transducer for destruction of an element--for example a concretion--which is present in a target area. To detect the possible occurrence of cavitation the target area is acted upon by an acoustic test signal and a reception signal is generated from at least an initial reflection of the test signal. This signal is then examined by comparison with the test signal to detect the presence of an impedance jump leading to an attenuated reflection, so that a control signal may be generated upon detection of an impedance jump of this nature. Audible or visible warning signals may be engendered among others, and the sonic transducer may be deactivated if need be, by means of this control signal.
摘要翻译：描述了一种方法和装置，用于检测在医疗应用期间由空气引起的可能的组织损伤，所述组织损伤是通过用于破坏元件的声音换能器（例如凝结物）而外部产生的高声能的身体存在于目标区域。为了检测气蚀的可能发生，目标区域由声学测试信号作用，并且从测试信号的至少初始反射产生接收信号。然后通过与测试信号进行比较来检查该信号，以检测导致衰减反射的阻抗跳跃的存在，使得可以在检测到这种性质的阻抗跳跃时产生控制信号。可能会产生声音或可见的警告信号，如果需要，声音换能器可以通过该控制信号来停用。

3. 发明授权

US5195508A Spark gap unit for lithotripsy 失效
标题翻译：用于石灰石的SPARK GAP单元
公开(公告)号：US5195508A
公开(公告)日：1993-03-23
申请号：US701817
申请日：1991-05-17
申请人： Michael Muller , Peter Buchbauer , Harald Eizenhofer , Friedrich Ueberle , Herbert Weiler , Reiner Schultheiss
发明人： Michael Muller , Peter Buchbauer , Harald Eizenhofer , Friedrich Ueberle , Herbert Weiler , Reiner Schultheiss
IPC分类号： A61B17/22 , G10K15/06
CPC分类号： G10K15/06
摘要： A spark gap unit that is easy to manufacture and significantly lighter than previously used spark gap units for generating underwater shock waves, particularly for non-invasive lithotrispy, has an internal conductor with an inner electrode, an insulation which at least partially envelops the internal conductor, and an external conductor with a bow and an outer electrode. The internal conductor is significantly shorter than the external conductor, and the external conductor at the rearward end of the spark gap unit projects beyond the internal conductor. The internal conductor, the insulation, and the external conductor are coaxially arranged. An outside diameter of the internal conductor is relatively small in comparison to an inside diameter of the external conductor. The spark gap unit has a hollow space inside the insulation, this hollow space being open in the direction of a rearward end of the spark gap unit. In the opposite direction from the rearward end, the hollow space is bounded by the internal conductor itself and the envelopment of the internal conductor by the insulation.
摘要翻译：易于制造和比以前使用的用于产生水下冲击波的火花隙单元明显更轻的火花隙单元，特别是用于非侵入性碎石的火花隙单元具有内部导体，其具有内部电极，至少部分地包围内部导体的绝缘体，以及具有弓形和外部电极的外部导体。内部导体明显短于外部导体，并且火花隙单元后端的外部导体超出内部导体。内部导体，绝缘体和外部导体同轴布置。与外部导体的内径相比，内部导体的外径相对较小。火花隙单元在绝缘体内部具有中空空间，该中空空间在火花隙单元的后端方向上敞开。在与后端相反的方向上，中空空间由内部导体本身和内部导体的绝缘体包围。

4. 发明授权

US5224468A Combination shock wave source 失效
标题翻译：组合冲击波源
公开(公告)号：US5224468A
公开(公告)日：1993-07-06
申请号：US680072
申请日：1991-04-03
申请人： Michael Grunewald , Hans Lobentanzer , Harald Eizenhofer , Friedrich Ueberle , Heribert Koch
发明人： Michael Grunewald , Hans Lobentanzer , Harald Eizenhofer , Friedrich Ueberle , Heribert Koch
IPC分类号： A61B17/22 , A61B17/225 , A61B18/00 , G10K9/12 , G10K15/04
CPC分类号： G10K9/12 , G10K15/043
摘要： An arrangement for generating focussed shock waves having two two-dimensional shock wave sources. The sources are of different types. In particular, an electromagnetic shock wave source is used in combination with a piezoelectric shock wave source. The arrangement has applications in no-contact lithotrity.
摘要翻译：用于产生具有两个二维冲击波源的聚焦冲击波的装置。来源是不同的类型。特别地，电磁冲击波源与压电冲击波源组合使用。该安排具有无接触式的应用。

5. 发明授权

US06640139B1 Thermal therapy with tissue protection 失效
标题翻译：热疗与组织保护
公开(公告)号：US06640139B1
公开(公告)日：2003-10-28
申请号：US09786805
申请日：2001-03-07
申请人： Friedrich Ueberle
发明人： Friedrich Ueberle
IPC分类号： A61F200
CPC分类号： A61B18/18 , A61B18/1815 , A61B2017/00084 , A61B2017/00132 , A61B2017/00274 , A61B2017/22072 , A61B2018/00547 , A61B2018/1861 , A61F7/12 , A61N5/06 , A61N7/02
摘要： A thermotherapy device for treatment of diseased biological tissues includes an outer lumen and at least one inner lumen. Preheating of non-target tissue is carried out during a desensitizing mode of the thermotherapy process at a temperature that is sublethal to cells of the non-target tissue structure but is high enough to provoke the building of heat shock proteins for protecting non-target tissue structures during the thermotherapy process. Then during a destructive mode of the thermotherapy process, an energy source is insertable into one of the lumens in carry out a heating protocol to treat the enlarged tissue while the non-target tissue is protected by shock proteins produced during the desensitizing mode of the process. The energy source can be microwave, ultrasound or other energy source, and a temperature sensing device can be used in controlling the energy source for effective treatment.
摘要翻译：用于治疗患病生物组织的热疗装置包括外腔和至少一个内腔。非目标组织的预热在热疗过程的脱敏模式期间在与非靶组织结构的细胞亚致死的温度下进行，但是足够高以引发用于保护非靶组织的热休克蛋白的构建结构在热疗过程中。然后在热疗过程的破坏性模式期间，能量源可插入其中一个内腔，以执行加热方案来治疗扩大的组织，同时非靶组织受到在该过程的脱敏模式期间产生的休克蛋白的保护。能源可以是微波，超声波或其他能源，温度感测装置可用于控制能量源进行有效的治疗。

6. 发明授权

US07267659B2 Method and apparatus for transferring medically effective substances into cells 失效
标题翻译：将药物有效物质转运到细胞中的方法和装置
公开(公告)号：US07267659B2
公开(公告)日：2007-09-11
申请号：US10445378
申请日：2003-05-23
申请人： Friedrich Ueberle
发明人： Friedrich Ueberle
IPC分类号： A61B17/20
CPC分类号： C12N15/87 , C12M35/04
摘要： A method and a apparatus for transferring medically effective substances in the form of molecules, such as DNA, oligos, certain chemicals, etc., into the living cells of humans, animals and/or plants using acoustic energy or through cavitation which is produced by acoustic energy in vitro, ex vivo and in vivo. Via suitable sensors, the lifetime of the cavitation bubbles is determined or specified, which then for its part acts as the criterion or the function for controlling the acoustic intensity and thus also the cavitation intensity.
摘要翻译：一种使用声能或空穴作用将诸如DNA，寡聚物，某些化学物质等分子形式的医学上有效的物质转移到人，动物和/或植物的活细胞中的方法和装置，声能在体外，离体和体内。通过适当的传感器，确定或指定空化气泡的寿命，然后其作为标准或用于控制声强度以及因此也作为空化强度的功能。

7. 发明授权

US5810748A Device for locating and crushing concrements 失效
标题翻译：用于定位和破碎混凝土的装置
公开(公告)号：US5810748A
公开(公告)日：1998-09-22
申请号：US871682
申请日：1997-06-09
申请人： Friedrich Ueberle
发明人： Friedrich Ueberle
IPC分类号： A61B8/00 , A61B8/08 , A61B17/22 , A61B17/225
CPC分类号： A61B17/2251 , A61B8/0833 , A61B8/4281 , A61B2017/2253
摘要： The device for locating and crushing concrements has a shock wave generator, a coupling arrangement and a locating arrangement. The coupling arrangement consists of a ring-shaped coupling cushion which has a central passage and essentially symmetrically surrounds the locating arrangement.
摘要翻译：用于定位和破碎混凝土的装置具有冲击波发生器，联接装置和定位装置。联接装置包括环形联接垫，其具有中心通道并且基本上对称地围绕定位装置。

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