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    • 3. 发明授权
    • Troxerutin with a high content of trihydroxyethylrutoside and process for its preparation
    • 具有高含量的三羟乙基甘油的Troxerutin及其制备方法
    • US06855697B1
    • 2005-02-15
    • US09857846
    • 1999-12-10
    • Cyril EstanoveFrançois Pruvost
    • Cyril EstanoveFrançois Pruvost
    • A61K31/7042A61K31/7048A61P7/00A61P9/14C07H17/07A61K31/7028
    • C07H17/07
    • The invention concerns novel troxerutin with high trihydroxy-ethyl-rutin content. Said troxerutin has at least 92 wt. % of 7,3′,4′-trihydroxyethyl rutin and a wettability expressed in minutes less than 10 minutes, when said wettability is measured in a test consisting in measuring the time taken by 3.5 g of said enriched troxerutin powder to leave the surface of a beaker containing 100 ml of water, at a stabilised temperature of 20° C., when said enriched troxerutin powder is poured at the surface of the water in said beaker, and a wettability less than 100 seconds when said wettability is measured in a test consisting in measuring the time taken by said enriched troxerutin to be wetted by the water contained in a receptacle, such as a beaker, when said enriched troxerutin has been deposited at the surface of the water, in the form of cores of 2 mm wide and 3 mm high weighing 63 ? 2 mg, at a stabilised temperature of 20° C. Said troxerutin has improved properties of wettability and solubility in water.
    • 本发明涉及具有高三羟基 - 乙基 - 芦丁含量的新型troxerutin。 所述troxerutin具有至少92wt。 7,3',4'-三羟基乙基芦丁的%,并且以分钟小于10分钟表示的润湿性,当所述润湿性在测量3.5g所述富集的troxerutin粉末离开表面的测试中测量时, 当在所述烧杯中将所述富集的troxerutin粉末注入水的表面时,在20℃的稳定温度下,将含有100ml水的烧杯,并且当在试验中测量所述润湿性时,润湿性小于100秒 包括当所述富集的troxerutin已经以2mm宽的芯的形式沉积在水的表面上时,测量所述富集的troxerutin被包含在容器例如烧杯中的水所吸收的时间,以及 3毫米高称重63? 2mg,在20℃的稳定温度下。所述troxerutin具有改善的润湿性和在水中的溶解性。